bay-1000394 and Thyroid-Neoplasms

bay-1000394 has been researched along with Thyroid-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for bay-1000394 and Thyroid-Neoplasms

ArticleYear
Potent effects of roniciclib alone and with sorafenib against well-differentiated thyroid cancer.
    Endocrine-related cancer, 2018, Volume: 25, Issue:10

    Activation of cyclin-dependent kinase activity is frequently observed in many human cancers; therefore, cyclin-dependent kinases that promote cell cycle transition and cell proliferation may be potential targets in the treatment of malignancy. The therapeutic effects of roniciclib, a cyclin-dependent kinase inhibitor for papillary and follicular thyroid cancer (designated as well-differentiated thyroid cancer), were investigated in this study. Roniciclib inhibited cell proliferation in two papillary and two follicular thyroid cancer cell lines in a dose-dependent manner. Roniciclib activated caspase-3 activity and induced apoptosis. Cell cycle progression was arrested in the G2/M phase. Roniciclib treatment

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Phosphorylation; Pyrimidines; Signal Transduction; Sorafenib; Sulfoxides; Thyroid Neoplasms

2018