bastadin-4 and Leukemia-P388

Further investigation of the Bismarck Archipelago (Papua New Guinea) marine sponge Ianthella basta for biologically active constituents has led to the isolation of hemibastadins 1 (2), 2 (3), and 3 (4) and the new brominated tyrosine derivatives hemibastadinols 1-3 (9, 13, and 14). Isolation and structure elucidation of the monomethyl ether derivatives (7 and 8) of hemibastadins 1 and 2 and the 3-bromotyramine amide of oxalic acid amide (1a) concluded our chemical investigation of I. basta. The hemibastadins and hemibastadinols represent important biosynthetic links to a series of bromotyrosine tetramers collectively known as the bastadins. The antimicrobial activity of the bastadins, hemibastadins, and hemibastadinols is summarized.

Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Chromatography, Liquid; Fungi; Humans; Leukemia P388; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; New Guinea; Oximes; Phenols; Porifera; Spectrophotometry, Ultraviolet