bastadin-4 and Atherosclerosis

bastadin-4 has been researched along with Atherosclerosis* in 1 studies

*Atherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA. [MeSH]

Other Studies

1 other study(ies) available for bastadin-4 and Atherosclerosis

Article	Year
Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages. Bioorganic & medicinal chemistry letters, 2015, Nov-15, Volume: 25, Issue:22 The formation of foam cells in macrophages has been suggested to play an essential role in the progression of early atherosclerotic lesions in vivo and, thus, its suppression is considered to be one of the major approaches for the treatment of atherosclerosis. We isolated eight brominated-tyrosine derivatives, bastadins, from the EtOH extract of the marine sponge Ianthella vasta as inhibitors of the formation of foam cells induced by acetylated low-density lipoproteins in human monocyte-derived macrophages. Bastadin 6 was the strongest inhibitor of foam cell formation due to its suppression of acyl-coenzyme A:cholesterol acyltransferase. Topics: Animals; Atherosclerosis; CHO Cells; Cholesterol Esters; Cricetulus; Enzyme Activation; Ethanol; Foam Cells; Halogenated Diphenyl Ethers; Halogenation; Humans; Sterol O-Acyltransferase; Tyrosine	2015

Article

Year

Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages.

Bioorganic & medicinal chemistry letters, 2015, Nov-15, Volume: 25, Issue:22

The formation of foam cells in macrophages has been suggested to play an essential role in the progression of early atherosclerotic lesions in vivo and, thus, its suppression is considered to be one of the major approaches for the treatment of atherosclerosis. We isolated eight brominated-tyrosine derivatives, bastadins, from the EtOH extract of the marine sponge Ianthella vasta as inhibitors of the formation of foam cells induced by acetylated low-density lipoproteins in human monocyte-derived macrophages. Bastadin 6 was the strongest inhibitor of foam cell formation due to its suppression of acyl-coenzyme A:cholesterol acyltransferase.

Topics: Animals; Atherosclerosis; CHO Cells; Cholesterol Esters; Cricetulus; Enzyme Activation; Ethanol; Foam Cells; Halogenated Diphenyl Ethers; Halogenation; Humans; Sterol O-Acyltransferase; Tyrosine

2015