barbital has been researched along with Substance Withdrawal Syndrome in 73 studies
5,5-diethylbarbituric acid : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by two ethyl groups. Formerly used as a hypnotic (sleeping aid).
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effective doses of these compounds were lower than those required to prevent seizures due to NMDA in naive animals; these were in turn lower than those needed to prevent the convulsive effects of the alpha-aminobutyric acid (GABA) antagonist, bicuculline." | 3.69 | Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence. ( Butterworth, AR; Little, HJ; Rabbani, M; Wright, J; Zhou, Q, 1994) |
| "Following withdrawal from chronic barbital administration, 6-hydroxydopamine pretreated rats show a greater number and an earlier onset of spontaneous convulsive seizures than do rats pretreated with the saline-ascorbic acid vehicle." | 3.65 | Effect of 6-hydroxydopamine pretreatment on spontaneous convulsions induced by barbital withdrawal. ( Morgan, WW, 1976) |
| "Definitions of Delirium Tremens (DT) and related clinical states are discussed together with the concepts of aetiology and pathogenesis in relation to psychiatric disease." | 2.36 | Delirium tremens and related clinical states. Aetiology, pathophysiology and treatment. ( Hemmingsen, R; Kramp, P; Rafaelsen, OJ, 1979) |
| " In the test of physical dependence-producing potential with the drug-admixed food method in rats, vigabatrin and diazepam were given to rats mixed with food for 28 days in an increasing dosage schedule, followed by feeding a drug-free diet to observe withdrawal signs for 7 days." | 1.30 | Drug dependence study on vigabatrin in rhesus monkeys and rats. ( Takada, K; Yanagita, T, 1997) |
| " N-ethylcarboxamide adenosine administered during the period of chronic administration of barbital significantly reduced the withdrawal syndrome." | 1.29 | Purinergic drugs and calcium channel antagonists attenuate the withdrawal syndrome from barbital. ( Contreras, E; Germany, A, 1994) |
| "After the termination of drug treatment, the body weight loss and withdrawal scores were significantly suppressed in the group coadministered flunarizine, but not in that coadministered diltiazem." | 1.29 | Effects of flunarizine and diltiazem on physical dependence on barbital in rats. ( Misawa, M; Mizoguchi, H; Noguchi, H; Suzuki, T; Yoshii, T, 1993) |
| "After stopping the treatment, the body weight and food consumption in the diazepam 100 and 300 mg/kg groups tended to decrease or decreased to values lower than those in the control group, whereas these parameters in the S-(+)-DN-2327 30, 100 and 300 mg/kg groups were comparable to the control group values." | 1.29 | A nonbenzodiazepine partial agonist, S-(+)-DN-2327, has minimal physical dependence-producing liability, but shows cross-dependence on barbital in rats. ( Awasaki, Y; Inui, Y; Nishida, N; Yamamoto, M, 1996) |
| "Barbital treated rats were divided into convulsing and non-convulsing groups." | 1.28 | Nerve growth factor (NGF) in rat brain following long-term barbital treatment: relation to convulsions and cognitive function. ( Archer, T; Lärkfors, L; Wahlström, G, 1992) |
| "In animals which had spontaneous seizures, 4- to 6-Hz bursts occurred in the motor cortex, whereas this abnormality did not occur in the motor cortex in animals which did not have spontaneous generalized seizures." | 1.27 | Cortical and subcortical EEG patterns during moderate-intensity barbiturate withdrawal. ( Hinman, DJ; Okamoto, M, 1984) |
| "Motor activity and withdrawal convulsions were monitored continuously by an activity recording device." | 1.27 | Physical dependence produced by long duration, low dose chronic barbital treatment. ( Hinman, DJ; Okamoto, M, 1984) |
| "Barbital was applied on a schedule of gradually increasing dosages from 0." | 1.27 | Effects of propranolol on barbital dependence formation and withdrawal signs. ( Hiramori, T; Nakao, K; Tagashira, E; Urano, T; Yanaura, S, 1983) |
| "Nine convulsions occurred in 29 rats withdrawn from barbital and infused intracerebroventricularly with APH, this contrasted markedly with 61 convulsions seen in 29 animals withdrawn from the drug and infused with saline." | 1.27 | 2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats. ( McCaslin, PP; Morgan, WW, 1987) |
| " During chronic administration of brotizolam, triazolam and diazepam all animals gained body weight." | 1.27 | Physical dependence capacity of brotizolam in rhesus monkeys. 2nd communication: primary dependence and barbital substitution. ( Stockhaus, K, 1986) |
| " Dose-response curves for the convulsive effect of pentylenetetrazol obtained at the peak of the withdrawal signs shifted greatly to the left in alcohol withdrawn animals but less in barbital withdrawn animals." | 1.27 | Differentiation of alcohol and barbital physical dependence. ( Kaneda, H; Kaneto, H; Kawatani, S, 1986) |
| " These effects were interpreted to be a consequence of changes in the sensitivity of central GABAA and/or noradrenergic receptors induced by depression due to long-term administration of barbital." | 1.27 | Central nervous system supersensitivity and withdrawal from long-term treatment with barbital. ( Palermo-Neto, J; Sandoval, MR, 1985) |
| " The controls were comprised of naive rats (G-VI) and naive rats dosed in the same manner as the dependent rats." | 1.26 | Participant of serotonin turnover rate in the brain on barbital withdrawal convulsion. ( Hiramori, T; Nakao, K; Tagashira, E; Urano, T; Yanaura, S, 1982) |
| "Viloxazine did not suppress the morphine and barbital withdrawal signs in monkeys that had been made physically dependent on these drugs and withdrawal." | 1.26 | Drug dependence potential of viloxazine hydrochloride tested in rhesus monkeys. ( Kiyohara, H; Wakasa, Y; Yanagita, T, 1980) |
| "Zopiclone was self-administered by rhesus monkeys relatively frequently by the intravenous route; the infrequent intragastric rate was similar to or slightly higher than with diazepam." | 1.26 | Dependence potential of zopiclone studied in monkeys. ( Yanagita, T, 1982) |
| "The barbital treatment induced a clear tolerance to the hexobarbital, which still could be detected on day 28 of abstinence." | 1.26 | The effects of atropine on the tolerance and the convulsions seen after withdrawal from forced barbital drinking in the rat. ( Wahlström, G, 1978) |
| "Rats exposed to chronic intake of sodium barbital maintained high circulating levels of barbital in blood and brain and exhibited increased sensitivity ot audiogenic convulsions during the withdrawal period." | 1.26 | Changes in brain levels of cyclic nucleotides and gamma-aminobutyric acid in barbiturate dependence and withdrawal. ( Hawkins, TD; Kant, GJ; Lenox, RH; Meyerhoff, JL; Wray, HL, 1979) |
| "Barbital solution was given as the only drinking fluid to male rats for 50 weeks (daily dose around 200 mg/kg)." | 1.26 | Activity pattern and convulsions in the abstinence period after barbital treatment in the rat. ( Larsson, R; Wahlström, G, 1977) |
| "After "chronically equivalent" barbital and pentobarbital dosing for 5 weeks, treatments were abruptly stopped and the animals were carefully observed for signs of barbiturate withdrawal." | 1.26 | Physical dependence to barbital compared to pentobarbital. III. Withdrawal characteristics. ( Boisse, NR; Okamoto, M, 1978) |
| " The rate of barbiturate elimination after chronically equivalent pentobarbital dosing was reduced by barbital substitution or by first-order pentobarbital dose reduction, with the result that withdrawal signs became mild and appeared later (3 days postdrug)." | 1.26 | Physical dependence to barbital compared to pentobarbital. IV. Influence of elimination kinetics. ( Boisse, NR; Okamoto, M, 1978) |
| "Barbital was assayed by gas chromatography." | 1.26 | Osmotic minipumps for administration of barbital to mice: demonstration of functional tolerance and physical dependence. ( Goldstein, DB; Siew, C, 1978) |
| "After chronic administration of sodium barbitone to rats, a marked increase incorporation of [14C]-Leucine into isolated nerve endings was observed." | 1.26 | Effect of chronic administration and withdrawal of sodium barbitone on protein synthesis of rat brain. ( Arnaiz, GR; Leite, JR, 1978) |
| " The average weekly dosage was around 215 mg/kg in groups 1, 3 and 5." | 1.26 | Studies on acute tolerance to ethanol in the abstinence period after long-term barbital treatment in the rat. ( Wahlström, G, 1979) |
| "The effect of electrically induced convulsions was tested on the tolerance to hexobarbital after chronic barbital treatment in male rats." | 1.26 | The interaction between electrically induced convulsions and tolerance in the abstinence period after chronic barbital treatments in the rat. ( Wahlström, G, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 61 (83.56) | 18.7374 |
| 1990's | 12 (16.44) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| OSGOOD, CW | 1 |
| Palermo-Neto, J | 3 |
| De Lima, TC | 1 |
| Tagashira, E | 5 |
| Hiramori, T | 5 |
| Urano, T | 5 |
| Nakao, K | 4 |
| Yanaura, S | 6 |
| Persson, SA | 1 |
| Wahlström, G | 13 |
| Okamoto, M | 8 |
| Hinman, DJ | 4 |
| Jänicke, UA | 1 |
| Coper, H | 1 |
| Bourn, WM | 4 |
| Garrett, RL | 1 |
| Yanagita, T | 3 |
| Wakasa, Y | 1 |
| Kiyohara, H | 1 |
| Kuroiwa, Y | 1 |
| Lund, S | 1 |
| Starklint, JF | 1 |
| Vaag, UH | 1 |
| Wang, AG | 1 |
| Saban, R | 2 |
| Capaz, FR | 1 |
| De Moraes, S | 2 |
| Nordberg, A | 5 |
| Kaneto, H | 3 |
| Kosaka, N | 1 |
| Takasu, M | 1 |
| Mino, T | 1 |
| Ling, GS | 1 |
| Nozaki, M | 1 |
| Larsson, C | 1 |
| Aaronson, LM | 1 |
| Reigel, CE | 2 |
| Germany, A | 1 |
| Contreras, E | 1 |
| Rabbani, M | 1 |
| Wright, J | 1 |
| Butterworth, AR | 1 |
| Zhou, Q | 1 |
| Little, HJ | 1 |
| Suzuki, T | 5 |
| Mizoguchi, H | 2 |
| Noguchi, H | 1 |
| Yoshii, T | 2 |
| Misawa, M | 4 |
| Motegi, H | 2 |
| Awano, H | 1 |
| Inui, Y | 1 |
| Yamamoto, M | 1 |
| Awasaki, Y | 1 |
| Nishida, N | 1 |
| Matz, R | 1 |
| Takada, K | 1 |
| Hemmingsen, R | 1 |
| Kramp, P | 2 |
| Rafaelsen, OJ | 1 |
| Miyasato, K | 2 |
| Lenox, RH | 1 |
| Wray, HL | 1 |
| Kant, GJ | 1 |
| Hawkins, TD | 1 |
| Meyerhoff, JL | 1 |
| Rønsted, P | 1 |
| Hansen, T | 1 |
| Morgan, WW | 8 |
| Huffman, RD | 1 |
| Pfeil, KA | 3 |
| Gonzales, EG | 3 |
| Larsson, R | 1 |
| Gildea, ML | 1 |
| Boisse, NR | 2 |
| Siew, C | 1 |
| Goldstein, DB | 1 |
| Leite, JR | 1 |
| Arnaiz, GR | 1 |
| Sorensen, A | 1 |
| Otani, K | 1 |
| Koike, Y | 3 |
| Archer, T | 2 |
| Lärkfors, L | 1 |
| Barros, HM | 1 |
| Tannhauser, MA | 1 |
| Tannhauser, SL | 1 |
| Tannhauser, M | 1 |
| McCaslin, PP | 3 |
| Gray, PL | 1 |
| Taberner, PV | 1 |
| Lane, SJ | 1 |
| Eriksson, B | 1 |
| Chida, Y | 1 |
| Mohammed, AK | 1 |
| Tiger, G | 1 |
| Björklund, PE | 1 |
| Stenström, A | 1 |
| Magnusson, O | 1 |
| Fowler, CJ | 1 |
| Kaneda, H | 2 |
| Kawatani, S | 2 |
| Stockhaus, K | 1 |
| Sandoval, MR | 2 |
| Tewari, S | 1 |
| Greenberg, SA | 1 |
| Do, K | 1 |
| Grey, PA | 1 |
2 reviews available for barbital and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Barbiturate tolerance and physical dependence: contribution of pharmacological factors.
Topics: Anesthesia; Animals; Barbital; Barbiturates; Cats; Central Nervous System Depressants; Drug Administ | 1984 |
Delirium tremens and related clinical states. Aetiology, pathophysiology and treatment.
Topics: Adrenal Insufficiency; Alcohol Withdrawal Delirium; Animals; Antipsychotic Agents; Avitaminosis; Bar | 1979 |
2 trials available for barbital and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Barbital and diazepam plasma levels during treatment of delirium tremens.
Topics: Alcohol Withdrawal Delirium; Barbital; Barbiturates; Clinical Trials as Topic; Diazepam; Double-Blin | 1979 |
[Treatment of abstinence].
Topics: Alcoholism; Apomorphine; Barbital; Benzodiazepines; Clinical Trials as Topic; Humans; Substance With | 1976 |
69 other studies available for barbital and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Convulsive seizures following barbiturate withdrawal.
Topics: Barbital; Barbiturates; Behavior, Addictive; Humans; Psychoses, Substance-Induced; Seizures; Substan | 1947 |
Effects of withdrawal from long-term barbital treatment on open-field behaviour and seizure susceptibility of rats.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Behavior, Animal; Exploratory Behavior; Human | 1982 |
Participant of serotonin turnover rate in the brain on barbital withdrawal convulsion.
Topics: Animals; Barbital; Barbiturates; Brain; Chlorpromazine; Humans; Hydroxyindoleacetic Acid; Male; Nitr | 1982 |
Formation of physical dependence on barbiturates and cerebral monoamines.
Topics: alpha-Methyltyrosine; Animals; Barbital; Barbiturates; Biogenic Amines; Body Weight; Brain; Catechol | 1983 |
Studies on interactions between striatal dopaminergic and cholinergic mechanisms in the early abstinence after chronic treatment with barbital in the rat.
Topics: Acetylcholine; Animals; Barbital; Barbiturates; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; H | 1984 |
Cortical and subcortical EEG patterns during moderate-intensity barbiturate withdrawal.
Topics: Animals; Barbital; Barbiturates; Behavior, Animal; Cats; Cerebral Cortex; Electroencephalography; Fe | 1984 |
Sleep patterns in cats during chronic low-dose barbiturate treatment and withdrawal.
Topics: Animals; Arousal; Barbital; Barbiturates; Cats; Cerebral Cortex; Dose-Response Relationship, Drug; E | 1984 |
Repeated withdrawal from barbital as a drive for 'drug taking behavior' in rats.
Topics: Animals; Barbital; Barbiturates; Behavior, Animal; Body Temperature; Body Weight; Drinking; Drug Tol | 1984 |
Physical dependence produced by long duration, low dose chronic barbital treatment.
Topics: Animals; Barbital; Barbiturates; Body Weight; Cats; Central Nervous System; Female; Humans; Male; Mo | 1984 |
Effects of central monoamine compounds on tranylcypromine-induced barbital-withdrawal convulsions.
Topics: alpha-Methyltyrosine; Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Humans; Mal | 1983 |
Effects of propranolol on barbital dependence formation and withdrawal signs.
Topics: Animals; Anticonvulsants; Barbital; Barbiturates; Drug Interactions; Humans; Male; Propranolol; Rats | 1983 |
Increased susceptibility of audiogenic rats to barbital withdrawal convulsions.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Disease Susceptibility; Humans; Rats; Rats, I | 1983 |
Drug dependence potential of viloxazine hydrochloride tested in rhesus monkeys.
Topics: Animals; Barbital; Behavior, Animal; Female; Haplorhini; Humans; Macaca mulatta; Male; Morphine Depe | 1980 |
Specific action of tranylcypromine to precipitate barbital withdrawal convulsions.
Topics: Animals; Barbital; Barbiturates; Humans; Monoamine Oxidase Inhibitors; Pentylenetetrazole; Rats; Rat | 1982 |
[Choice of drug treatment of alcohol withdrawal symptoms in Denmark].
Topics: Alcohol Withdrawal Delirium; Barbital; Barbiturates; Chlordiazepoxide; Denmark; Ethanol; Humans; Sub | 1983 |
Adrenoceptor supersensitivity in the isolated rat vas deferens during barbital withdrawal.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Humans; In Vitro Techniques; Male; Muscle Con | 1982 |
Atropine modulates changes in striatal muscarinic receptor binding sites in barbital abstinence in the rat.
Topics: Animals; Atropine; Barbital; Barbiturates; Corpus Striatum; Humans; Male; Rats; Rats, Inbred Strains | 1982 |
[Studies on the physical dependence liability to guanabenz].
Topics: Analgesics; Animals; Antihypertensive Agents; Barbital; Body Weight; Drug Synergism; Guanabenz; Guan | 1982 |
Dependence potential of zopiclone studied in monkeys.
Topics: Administration, Oral; Animals; Azabicyclo Compounds; Barbital; Diazepam; Female; Humans; Hypnotics a | 1982 |
Effect of sodium barbital dependence on chronic spinal rats monitored by spontaneous hind leg movements.
Topics: Animals; Barbital; Barbiturates; Cordotomy; Female; Hindlimb; Humans; Movement; Rats; Substance With | 1981 |
Increased number of muscarinic binding sites in brain following chronic barbiturate treatment to rat.
Topics: Animals; Barbital; Barbiturates; Cerebellum; Corpus Striatum; Hippocampus; Humans; Male; Medulla Obl | 1980 |
Atropine in the abstinence after chronic barbital treatment in the rat.
Topics: Animals; Atropine; Barbital; Barbiturates; Dose-Response Relationship, Drug; Drug Tolerance; Hexobar | 1980 |
Comparison of ethanol and barbiturate physical dependence.
Topics: Alcoholism; Animals; Barbital; Barbiturates; Cats; Central Nervous System Depressants; Dose-Response | 1981 |
Effects of barbital or diazepam withdrawal on seizure thresholds to bicuculline, picrotoxin and flurazepam.
Topics: Animals; Barbital; Bicuculline; Convulsants; Diazepam; Flurazepam; Male; Picrotoxin; Rats; Rats, Spr | 1995 |
Purinergic drugs and calcium channel antagonists attenuate the withdrawal syndrome from barbital.
Topics: Adenosine; Animals; Barbital; Behavior, Animal; Calcium Channel Blockers; Drug Tolerance; Male; Mice | 1994 |
Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence.
Topics: 2-Amino-5-phosphonovalerate; Animals; Barbital; Bicuculline; Cerebral Cortex; Dizocilpine Maleate; H | 1994 |
Cross-substitution of diazepam for barbital results in only a low incidence of audiogenic seizures upon withdrawal in dependent rats.
Topics: Acoustic Stimulation; Animals; Barbital; Diazepam; Male; Rats; Rats, Sprague-Dawley; Seizures; Subst | 1994 |
Effects of flunarizine and diltiazem on physical dependence on barbital in rats.
Topics: Animals; Barbital; Calcium Channel Blockers; Calcium Channels; Diltiazem; Flunarizine; Male; Postura | 1993 |
Effects of nifedipine on physical dependence on barbital or diazepam in rats.
Topics: Analysis of Variance; Animals; Barbital; Body Weight; Calcium Channel Blockers; Calcium Channels; Di | 1995 |
A nonbenzodiazepine partial agonist, S-(+)-DN-2327, has minimal physical dependence-producing liability, but shows cross-dependence on barbital in rats.
Topics: Animals; Anti-Anxiety Agents; Area Under Curve; Barbital; Behavior, Animal; Binding, Competitive; Bo | 1996 |
Alcohol withdrawal syndrome.
Topics: Alcohol Withdrawal Delirium; Barbital; Humans; Hypnotics and Sedatives; Pentobarbital; Substance Wit | 1997 |
Drug dependence study on vigabatrin in rhesus monkeys and rats.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Barbital; Conditioning, Operant; Female; gamma-Aminobu | 1997 |
The effects of atropine on the tolerance and the convulsions seen after withdrawal from forced barbital drinking in the rat.
Topics: Animals; Atropine; Barbital; Barbiturates; Drug Tolerance; Electroencephalography; Hexobarbital; Hum | 1978 |
[Experimental study on development of physical dependence on alcohol and cross physical dependence liability of diazepam and barbital to alcohol in rhesus monkeys (author's transl)].
Topics: Alcoholism; Animals; Barbital; Barbiturates; Body Weight; Diazepam; Female; Haplorhini; Humans; Maca | 1978 |
[Experimental studies of alcoholism].
Topics: Alcoholic Intoxication; Alcoholism; Animals; Barbital; Diazepam; Dogs; Ethanol; Female; Haplorhini; | 1979 |
Changes in brain levels of cyclic nucleotides and gamma-aminobutyric acid in barbiturate dependence and withdrawal.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Brain; Cyclic AMP; Cyclic GMP; gamma-Aminobut | 1979 |
Effect of synthesis inhibition on the levels of brain catecholamines in barbital-dependent rats.
Topics: Animals; Barbital; Barbiturates; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Body Weight; | 1978 |
Catecholamine concentration in discrete brain areas following the withdrawal of barbital dependent rats.
Topics: Animals; Barbital; Barbiturates; Body Weight; Brain; Brain Stem; Cerebral Cortex; Corpus Striatum; D | 1977 |
Activity pattern and convulsions in the abstinence period after barbital treatment in the rat.
Topics: Animals; Barbital; Barbiturates; Circadian Rhythm; Humans; Male; Motor Activity; Rats; Seizures; Sub | 1977 |
Noradrenergic supersensitivity in the rat vas deferens during barbital withdrawal.
Topics: Animals; Barbital; Barbiturates; Carbachol; Humans; In Vitro Techniques; Male; Muscle Contraction; M | 1977 |
Effect of long-term forced oral barbital administration on endogenous acetylcholine in different regions of rat brain.
Topics: Acetylcholine; Animals; Barbital; Barbiturates; Brain Chemistry; Cerebellum; Cerebral Cortex; Corpus | 1977 |
The effect of delta-9-tetrahydrocannabinol on barbiturate withdrawal convulsions in the rat.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Dronabinol; | 1977 |
Physical dependence to barbital compared to pentobarbital. III. Withdrawal characteristics.
Topics: Animals; Barbital; Barbiturates; Cats; Humans; Pentobarbital; Substance Withdrawal Syndrome; Substan | 1978 |
Physical dependence to barbital compared to pentobarbital. IV. Influence of elimination kinetics.
Topics: Animals; Barbital; Barbiturates; Cats; Humans; Kinetics; Pentobarbital; Peritoneal Dialysis; Substan | 1978 |
Osmotic minipumps for administration of barbital to mice: demonstration of functional tolerance and physical dependence.
Topics: Animals; Barbital; Barbiturates; Drug Tolerance; Humans; Male; Mice; Seizures; Substance Withdrawal | 1978 |
Effect of alpha-methyl-p-tyrosine on the incidence of spontaneous convulsions observed following barbital withdrawal.
Topics: Animals; Barbital; Barbiturates; Brain Chemistry; Dopamine; Humans; Male; Methyltyrosines; Norepinep | 1978 |
Effect of chronic administration and withdrawal of sodium barbitone on protein synthesis of rat brain.
Topics: Animals; Barbital; Barbiturates; Brain; Drug Tolerance; Female; Humans; Leucine; Nerve Tissue Protei | 1978 |
Studies on acute tolerance to ethanol in the abstinence period after long-term barbital treatment in the rat.
Topics: Animals; Barbital; Barbiturates; Brain; Drug Tolerance; Ethanol; Hexobarbital; Humans; Male; Rats; S | 1979 |
The interaction between electrically induced convulsions and tolerance in the abstinence period after chronic barbital treatments in the rat.
Topics: Animals; Barbital; Barbiturates; Drug Tolerance; Electroshock; Hexobarbital; Humans; Male; Rats; Sei | 1976 |
Effect of 6-hydroxydopamine pretreatment on spontaneous convulsions induced by barbital withdrawal.
Topics: Animals; Ascorbic Acid; Barbital; Barbiturates; Body Weight; Dopamine; Humans; Hydroxydopamines; Mal | 1976 |
The interaction between spontaneous convulsions and tolerance to hexobarbital in the abstinence after chronic barbital treatments in the rat.
Topics: Animals; Barbital; Barbiturates; Drug Tolerance; Hexobarbital; Humans; Male; Rats; Seizures; Substan | 1976 |
Susceptibility to, tolerance to, and physical dependence on ethanol and barbital in two inbred strains of rats.
Topics: Animals; Barbital; Drug Tolerance; Ethanol; Male; Motor Activity; Rats; Rats, Inbred F344; Rats, Inb | 1992 |
Nerve growth factor (NGF) in rat brain following long-term barbital treatment: relation to convulsions and cognitive function.
Topics: Animals; Barbital; Brain; Cerebral Cortex; Hippocampus; Learning Disabilities; Male; Nerve Growth Fa | 1992 |
Enhanced detection of hyperactivity after drug withdrawal with a simple modification of the open-field apparatus.
Topics: Animals; Barbital; Ethanol; Motor Activity; Psychopharmacology; Rats; Rats, Inbred Strains; Substanc | 1991 |
Increased response of cerebellar cGMP to kainate but not NMDA or quisqualate following barbital withdrawal from dependent rats.
Topics: Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum; Cyclic GMP; Dose-Response Relationship, | 1989 |
2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum | 1987 |
Evidence for GABA tolerance in barbiturate-dependent and withdrawn mice.
Topics: Animals; Barbital; Barbiturates; Drug Tolerance; Female; gamma-Aminobutyric Acid; Humans; Imidazoles | 1985 |
Development of tolerance to chronic barbital treatment in the cerebellar cyclic guanosine monophosphate system and its response to subsequent barbital abstinence.
Topics: Animals; Barbital; Barbiturates; Cerebellum; Cerebral Cortex; Cyclic GMP; Drug Tolerance; Female; Hu | 1985 |
[3H]muscimol and [3H]quinuclidinyl benzilate binding in rat cortex in the abstinence after long-term barbital treatment.
Topics: Animals; Barbital; Barbiturates; Cerebral Cortex; Male; Muscimol; Rats; Rats, Inbred Strains; Recept | 1986 |
Anticonvulsive activity of several excitatory amino acid antagonists against barbital withdrawal-induced spontaneous convulsions.
Topics: Amino Acids; Animals; Anticonvulsants; Barbital; Barbiturates; Dicarboxylic Acids; Female; Glutamate | 1988 |
Cross-physical dependence of several drugs in methaqualone-dependent rats.
Topics: Animals; Barbital; Diazepam; Ethanol; Male; Methaqualone; Pentobarbital; Postural Balance; Psychomot | 1988 |
Impaired performance of rats in the Morris swim-maize test late in abstinence following long-term sodium barbital treatment.
Topics: Animals; Barbital; Barbiturates; Biogenic Amines; Brain Chemistry; Carbachol; Inositol Phosphates; M | 1987 |
Pharmacological characterization of alcohol and barbital physical dependence in mice.
Topics: Animals; Atropine; Barbital; Barbiturates; Clonidine; Ethanol; Male; Mice; Muscimol; Propranolol; Su | 1987 |
Physical dependence capacity of brotizolam in rhesus monkeys. 2nd communication: primary dependence and barbital substitution.
Topics: Animals; Azepines; Barbital; Barbiturates; Body Weight; Diazepam; Female; Hypnotics and Sedatives; M | 1986 |
GABAergic influences on barbital withdrawal induced convulsions.
Topics: Animals; Barbital; Barbiturates; Corpus Striatum; gamma-Aminobutyric Acid; Male; Pentobarbital; Rats | 1986 |
Differentiation of alcohol and barbital physical dependence.
Topics: Animals; Barbital; Barbiturates; Diazepam; Ethanol; Ethosuximide; Male; Mice; Morphine; Naloxone; Pe | 1986 |
[Sex differences in the physical dependence on barbital in rats].
Topics: Animals; Barbital; Barbiturates; Body Weight; Brain; Female; Male; Rats; Rats, Inbred Strains; Sex F | 1986 |
The response of rat brain protein synthesis to ethanol and sodium barbital.
Topics: Alcoholism; Animals; Barbital; Barbiturates; Brain; Carbon Radioisotopes; Cycloheximide; Drug Intera | 1987 |
Central nervous system supersensitivity and withdrawal from long-term treatment with barbital.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Brain; Dose-Response Relationship, Drug; Male | 1985 |