barbital has been researched along with Seizures in 51 studies
5,5-diethylbarbituric acid : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by two ethyl groups. Formerly used as a hypnotic (sleeping aid).
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effective doses of these compounds were lower than those required to prevent seizures due to NMDA in naive animals; these were in turn lower than those needed to prevent the convulsive effects of the alpha-aminobutyric acid (GABA) antagonist, bicuculline." | 3.69 | Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence. ( Butterworth, AR; Little, HJ; Rabbani, M; Wright, J; Zhou, Q, 1994) |
| "Following withdrawal from chronic barbital administration, 6-hydroxydopamine pretreated rats show a greater number and an earlier onset of spontaneous convulsive seizures than do rats pretreated with the saline-ascorbic acid vehicle." | 3.65 | Effect of 6-hydroxydopamine pretreatment on spontaneous convulsions induced by barbital withdrawal. ( Morgan, WW, 1976) |
| "Barbital treated rats were divided into convulsing and non-convulsing groups." | 1.28 | Nerve growth factor (NGF) in rat brain following long-term barbital treatment: relation to convulsions and cognitive function. ( Archer, T; Lärkfors, L; Wahlström, G, 1992) |
| "In animals which had spontaneous seizures, 4- to 6-Hz bursts occurred in the motor cortex, whereas this abnormality did not occur in the motor cortex in animals which did not have spontaneous generalized seizures." | 1.27 | Cortical and subcortical EEG patterns during moderate-intensity barbiturate withdrawal. ( Hinman, DJ; Okamoto, M, 1984) |
| " The "low" level chronic dosing merely prolonged the time required to develop physical dependence of severity comparable to that produced by shorter durations of "high" level chronic dosing." | 1.27 | Physical dependence produced by long duration, low dose chronic barbital treatment. ( Hinman, DJ; Okamoto, M, 1984) |
| "Nine convulsions occurred in 29 rats withdrawn from barbital and infused intracerebroventricularly with APH, this contrasted markedly with 61 convulsions seen in 29 animals withdrawn from the drug and infused with saline." | 1.27 | 2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats. ( McCaslin, PP; Morgan, WW, 1987) |
| " Withdrawal of barbital induced a significant leftward displacement of the dose-response curves obtained for the convulsive effects of strychnine, picrotoxin and 3-mercaptopropionic acid." | 1.27 | Central nervous system supersensitivity and withdrawal from long-term treatment with barbital. ( Palermo-Neto, J; Sandoval, MR, 1985) |
| " The controls were comprised of naive rats (G-VI) and naive rats dosed in the same manner as the dependent rats." | 1.26 | Participant of serotonin turnover rate in the brain on barbital withdrawal convulsion. ( Hiramori, T; Nakao, K; Tagashira, E; Urano, T; Yanaura, S, 1982) |
| "Prior to the maximum abstinence convulsions the QNB binding was higher in rats without recorded spontaneous convulsions in comparison to rats with convulsions." | 1.26 | Changes in populations of cholinergic binding sites in brain after chronic exposure to barbital in rats. ( Nordberg, A; Wahlström, G, 1982) |
| "For the former, the MES test, clonic seizures induced by pentylenetetrazol, 90 mg/kg, s." | 1.26 | Differential selectivity of several barbiturates on experimental seizures and neurotoxicity in the mouse. ( Blake, GJ; Gilbert, MB; Raines, A; Richardson, B, 1979) |
| "The barbital treatment induced a clear tolerance to the hexobarbital, which still could be detected on day 28 of abstinence." | 1.26 | The effects of atropine on the tolerance and the convulsions seen after withdrawal from forced barbital drinking in the rat. ( Wahlström, G, 1978) |
| "Rats exposed to chronic intake of sodium barbital maintained high circulating levels of barbital in blood and brain and exhibited increased sensitivity ot audiogenic convulsions during the withdrawal period." | 1.26 | Changes in brain levels of cyclic nucleotides and gamma-aminobutyric acid in barbiturate dependence and withdrawal. ( Hawkins, TD; Kant, GJ; Lenox, RH; Meyerhoff, JL; Wray, HL, 1979) |
| "Barbital solution was given as the only drinking fluid to male rats for 50 weeks (daily dose around 200 mg/kg)." | 1.26 | Activity pattern and convulsions in the abstinence period after barbital treatment in the rat. ( Larsson, R; Wahlström, G, 1977) |
| "Barbital was assayed by gas chromatography." | 1.26 | Osmotic minipumps for administration of barbital to mice: demonstration of functional tolerance and physical dependence. ( Goldstein, DB; Siew, C, 1978) |
| "The effect of electrically induced convulsions was tested on the tolerance to hexobarbital after chronic barbital treatment in male rats." | 1.26 | The interaction between electrically induced convulsions and tolerance in the abstinence period after chronic barbital treatments in the rat. ( Wahlström, G, 1976) |
| " Principal features of the complex results include: double peaks in the time course of convulsion thresholds (Pc); an early peak and a shoulder in the time course of pressures reversing anesthesia (Pa); far steeper dose-response curves for Pa than for Pc; selectively greater anticonvulsant effect for phenobarbital than for the other barbiturates; and enhancement of Pa with simultaneous depression of Pc by reserpine in phenobarbital-pretreated mice." | 1.26 | Interaction of central nervous system effects of high pressures with barbiturates. ( Beaver, RW; Brauer, RW; Lahser, S, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (88.24) | 18.7374 |
| 1990's | 4 (7.84) | 18.2507 |
| 2000's | 2 (3.92) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DAVIDOFF, E | 1 |
| DOOLITTLE, GM | 1 |
| OSGOOD, CW | 1 |
| BARANY, EH | 1 |
| STEIN-JENSEN, E | 1 |
| CAHEN, RL | 1 |
| RISING, JD | 1 |
| WAY, EL | 1 |
| RUBINSTEIN, HS | 1 |
| COLE, VV | 1 |
| HULPIEU, HR | 1 |
| BELINKOFF, S | 1 |
| ESSIG, CF | 1 |
| FLANARY, HG | 1 |
| NIPPERT, F | 1 |
| BROWNE, O | 1 |
| KELLAWAY, P | 1 |
| MERCIER, J | 1 |
| BRODY, M | 1 |
| RUSKIN, DB | 1 |
| BELFORD, J | 1 |
| BONNYCASTLE, DD | 1 |
| Palermo-Neto, J | 3 |
| De Lima, TC | 1 |
| Tagashira, E | 3 |
| Hiramori, T | 3 |
| Urano, T | 3 |
| Nakao, K | 3 |
| Yanaura, S | 3 |
| Persson, SA | 1 |
| Wahlström, G | 8 |
| Hinman, DJ | 2 |
| Okamoto, M | 2 |
| Bourn, WM | 4 |
| Garrett, RL | 1 |
| Kuroiwa, Y | 1 |
| Saban, R | 1 |
| Capaz, FR | 1 |
| De Moraes, S | 1 |
| Nordberg, A | 2 |
| Larsson, C | 1 |
| Flint, BA | 1 |
| Ho, IK | 1 |
| Reigel, CE | 2 |
| Rabbani, M | 1 |
| Wright, J | 1 |
| Butterworth, AR | 1 |
| Zhou, Q | 1 |
| Little, HJ | 1 |
| Kansal, DK | 2 |
| Chakrabarti, A | 2 |
| Raines, A | 2 |
| Blake, GJ | 1 |
| Richardson, B | 1 |
| Gilbert, MB | 1 |
| Lenox, RH | 1 |
| Wray, HL | 1 |
| Kant, GJ | 1 |
| Hawkins, TD | 1 |
| Meyerhoff, JL | 1 |
| Larsson, R | 1 |
| Gildea, ML | 1 |
| Siew, C | 1 |
| Goldstein, DB | 1 |
| Morgan, WW | 3 |
| Pfeil, KA | 1 |
| Gonzales, EG | 1 |
| Helke, CJ | 1 |
| Mann, PA | 1 |
| Isom, GE | 1 |
| Beaver, RW | 1 |
| Brauer, RW | 1 |
| Lahser, S | 1 |
| Archer, T | 1 |
| Lärkfors, L | 1 |
| McCaslin, PP | 1 |
| Sandoval, MR | 2 |
51 other studies available for barbital and Seizures
| Article | Year |
|---|---|
Use of delvinal sodium vinobarbital in the treatment of serial seizures and status epilepticus.
Topics: Barbital; Barbiturates; Seizures; Sodium; Status Epilepticus | 1948 |
Convulsive seizures following barbiturate withdrawal.
Topics: Barbital; Barbiturates; Behavior, Addictive; Humans; Psychoses, Substance-Induced; Seizures; Substan | 1947 |
The action of di-allyl-barbituric acid on the electrically induced epileptic fit.
Topics: Anesthesia; Anesthesiology; Barbital; Barbiturates; Epilepsy; Humans; Seizures; Therapeutics | 1946 |
On the anticonvulsant activity of various nitrogen heterocycles; alkylthioetherbarbiturates and phenylalkylthiomethylhydantoins.
Topics: Anticonvulsants; Barbital; Barbiturates; Hydantoins; Nitrogen; Seizures; Spasm | 1946 |
The comparative value of pentothal sodium, curare, and magnesium sulfate for the modification of metrazol convulsions.
Topics: Anesthesia; Anesthesiology; Barbital; Curare; Magnesium; Magnesium Sulfate; Pentylenetetrazole; Seiz | 1946 |
Barbiturate antagonism of isonipecaine convulsions and isonipecaine potentiation of barbiturate depression.
Topics: Aged; Barbital; Barbiturates; Depression; Humans; Isonipecotic Acids; Seizures | 1946 |
The fear-allaying effect of pentothal sodium in electro-shock therapy.
Topics: Barbital; Barbiturates; Convulsive Therapy; Fear; Seizures; Sodium; Therapeutics; Thiopental | 1946 |
A method for determining the relative anticonvulsive activity of barbiturates.
Topics: Barbital; Barbiturates; Humans; Seizures; Therapeutics | 1946 |
Convulsions during anesthesia treated with intravenous sodium pentothal.
Topics: Anesthesia; Anesthesiology; Barbital; Ether; Ethers; Iatrogenic Disease; Seizures; Sodium; Thiopenta | 1946 |
Convulsions in cats following withdrawal of barbital sodium.
Topics: Animals; Barbital; Cats; Seizures; Sodium | 1959 |
[Prospects of epileptasid-luminal therapy of canine distemper convulsions].
Topics: Animals; Barbital; Distemper; Dogs; Seizures; Venoms | 1950 |
The treatment of eclampsia; preliminary report on the present Rotunda treatment of eclampsia by soluble sodium thiopentone and concentrated salt-free dextrose solution, with particular reference to the control of convulsions.
Topics: Barbital; Eclampsia; Female; Glucose; Pregnancy; Seizures; Sodium; Sodium Chloride; Sodium Chloride, | 1950 |
The use of sedative-induced sleep as an aid to electroencephalographic diagnosis in children.
Topics: Barbital; Electroencephalography; Hypnotics and Sedatives; Seizures; Sleep | 1950 |
[Molecular structure and anticonvulsive power. Effect of gardenal, metabromogardenal and sodium bromide on audiogenic crisis of the white rat].
Topics: Animals; Barbital; Bromides; Molecular Structure; Phenobarbital; Rats; Seizures; Sodium Compounds | 1950 |
Modification of the electroshock convulsion by means of curare, intravenous barbiturate and an airway.
Topics: Barbital; Barbiturates; Convulsive Therapy; Curare; Electroshock; Humans; Seizures | 1951 |
Comparative results in seizure control using phenobarbital, dilantin, and mesantoin.
Topics: Barbital; Epilepsy; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Seizures | 1950 |
The effect of some anticonvulsant agents upon agene-induced convulsions in dogs.
Topics: Animals; Anticonvulsants; Barbital; Chlorides; Dogs; Nitrogen Compounds; Seizures | 1950 |
Effects of withdrawal from long-term barbital treatment on open-field behaviour and seizure susceptibility of rats.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Behavior, Animal; Exploratory Behavior; Human | 1982 |
Participant of serotonin turnover rate in the brain on barbital withdrawal convulsion.
Topics: Animals; Barbital; Barbiturates; Brain; Chlorpromazine; Humans; Hydroxyindoleacetic Acid; Male; Nitr | 1982 |
Studies on interactions between striatal dopaminergic and cholinergic mechanisms in the early abstinence after chronic treatment with barbital in the rat.
Topics: Acetylcholine; Animals; Barbital; Barbiturates; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; H | 1984 |
Cortical and subcortical EEG patterns during moderate-intensity barbiturate withdrawal.
Topics: Animals; Barbital; Barbiturates; Behavior, Animal; Cats; Cerebral Cortex; Electroencephalography; Fe | 1984 |
Physical dependence produced by long duration, low dose chronic barbital treatment.
Topics: Animals; Barbital; Barbiturates; Body Weight; Cats; Central Nervous System; Female; Humans; Male; Mo | 1984 |
Effects of central monoamine compounds on tranylcypromine-induced barbital-withdrawal convulsions.
Topics: alpha-Methyltyrosine; Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Humans; Mal | 1983 |
Increased susceptibility of audiogenic rats to barbital withdrawal convulsions.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Disease Susceptibility; Humans; Rats; Rats, I | 1983 |
Specific action of tranylcypromine to precipitate barbital withdrawal convulsions.
Topics: Animals; Barbital; Barbiturates; Humans; Monoamine Oxidase Inhibitors; Pentylenetetrazole; Rats; Rat | 1982 |
Adrenoceptor supersensitivity in the isolated rat vas deferens during barbital withdrawal.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Humans; In Vitro Techniques; Male; Muscle Con | 1982 |
Changes in populations of cholinergic binding sites in brain after chronic exposure to barbital in rats.
Topics: Animals; Barbital; Barbiturates; Binding Sites; Brain; Cerebral Cortex; Male; Quinuclidinyl Benzilat | 1982 |
Increased number of muscarinic binding sites in brain following chronic barbiturate treatment to rat.
Topics: Animals; Barbital; Barbiturates; Cerebellum; Corpus Striatum; Hippocampus; Humans; Male; Medulla Obl | 1980 |
Continuous administration of barbital by pellet implantation.
Topics: Animals; Barbital; Barbiturates; Behavior, Animal; Body Temperature; Body Weight; Drug Implants; Dru | 1980 |
Effects of barbital or diazepam withdrawal on seizure thresholds to bicuculline, picrotoxin and flurazepam.
Topics: Animals; Barbital; Bicuculline; Convulsants; Diazepam; Flurazepam; Male; Picrotoxin; Rats; Rats, Spr | 1995 |
Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence.
Topics: 2-Amino-5-phosphonovalerate; Animals; Barbital; Bicuculline; Cerebral Cortex; Dizocilpine Maleate; H | 1994 |
Cross-substitution of diazepam for barbital results in only a low incidence of audiogenic seizures upon withdrawal in dependent rats.
Topics: Acoustic Stimulation; Animals; Barbital; Diazepam; Male; Rats; Rats, Sprague-Dawley; Seizures; Subst | 1994 |
An observational study on neurobehavioural effects of acute oxydemeton-methyl (insecticide and acaricide) exposure in rats.
Topics: Animals; Barbital; Behavior, Animal; Convulsants; Electroshock; Exploratory Behavior; Female; Hypnot | 2000 |
Neurobehavioural study of subchronic administration of oxydemeton-methyl (insecticide and acaricide) in rats.
Topics: Animals; Antipsychotic Agents; Barbital; Behavior, Animal; Catalepsy; Convulsants; Electroshock; Exp | 2001 |
Differential selectivity of several barbiturates on experimental seizures and neurotoxicity in the mouse.
Topics: Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Male; Mice; Neuromuscular Disease | 1979 |
The effects of atropine on the tolerance and the convulsions seen after withdrawal from forced barbital drinking in the rat.
Topics: Animals; Atropine; Barbital; Barbiturates; Drug Tolerance; Electroencephalography; Hexobarbital; Hum | 1978 |
Changes in brain levels of cyclic nucleotides and gamma-aminobutyric acid in barbiturate dependence and withdrawal.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Brain; Cyclic AMP; Cyclic GMP; gamma-Aminobut | 1979 |
Activity pattern and convulsions in the abstinence period after barbital treatment in the rat.
Topics: Animals; Barbital; Barbiturates; Circadian Rhythm; Humans; Male; Motor Activity; Rats; Seizures; Sub | 1977 |
The effect of delta-9-tetrahydrocannabinol on barbiturate withdrawal convulsions in the rat.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Dronabinol; | 1977 |
Osmotic minipumps for administration of barbital to mice: demonstration of functional tolerance and physical dependence.
Topics: Animals; Barbital; Barbiturates; Drug Tolerance; Humans; Male; Mice; Seizures; Substance Withdrawal | 1978 |
Effect of alpha-methyl-p-tyrosine on the incidence of spontaneous convulsions observed following barbital withdrawal.
Topics: Animals; Barbital; Barbiturates; Brain Chemistry; Dopamine; Humans; Male; Methyltyrosines; Norepinep | 1978 |
Antiextensor effects of 3,3-diphenyl-n-propylamine in the mouse.
Topics: Animals; Barbital; Behavior, Animal; Drug Interactions; Male; Mice; Mice, Inbred ICR; Motor Activity | 1978 |
A model for the rapid induction of barbiturate tolerance.
Topics: Animals; Barbital; Barbiturates; Brain; Drug Tolerance; Lethal Dose 50; Mice; Pentobarbital; Pentyle | 1978 |
The interaction between electrically induced convulsions and tolerance in the abstinence period after chronic barbital treatments in the rat.
Topics: Animals; Barbital; Barbiturates; Drug Tolerance; Electroshock; Hexobarbital; Humans; Male; Rats; Sei | 1976 |
Interaction of central nervous system effects of high pressures with barbiturates.
Topics: Animals; Atmosphere Exposure Chambers; Atmospheric Pressure; Barbital; Barbiturates; Female; Mice; P | 1977 |
Effect of 6-hydroxydopamine pretreatment on spontaneous convulsions induced by barbital withdrawal.
Topics: Animals; Ascorbic Acid; Barbital; Barbiturates; Body Weight; Dopamine; Humans; Hydroxydopamines; Mal | 1976 |
The interaction between spontaneous convulsions and tolerance to hexobarbital in the abstinence after chronic barbital treatments in the rat.
Topics: Animals; Barbital; Barbiturates; Drug Tolerance; Hexobarbital; Humans; Male; Rats; Seizures; Substan | 1976 |
Nerve growth factor (NGF) in rat brain following long-term barbital treatment: relation to convulsions and cognitive function.
Topics: Animals; Barbital; Brain; Cerebral Cortex; Hippocampus; Learning Disabilities; Male; Nerve Growth Fa | 1992 |
2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum | 1987 |
GABAergic influences on barbital withdrawal induced convulsions.
Topics: Animals; Barbital; Barbiturates; Corpus Striatum; gamma-Aminobutyric Acid; Male; Pentobarbital; Rats | 1986 |
Central nervous system supersensitivity and withdrawal from long-term treatment with barbital.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Brain; Dose-Response Relationship, Drug; Male | 1985 |