barbital has been researched along with Porphyria, Acute Intermittent in 2 studies
5,5-diethylbarbituric acid : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by two ethyl groups. Formerly used as a hypnotic (sleeping aid).
Porphyria, Acute Intermittent: An autosomal dominant porphyria that is due to a deficiency of HYDROXYMETHYLBILANE SYNTHASE in the LIVER, the third enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features are recurrent and life-threatening neurologic disturbances, ABDOMINAL PAIN, and elevated level of AMINOLEVULINIC ACID and PORPHOBILINOGEN in the urine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral griseofulvin induced an increase in mitochondrial cytochrome P-450 levels, while chronic Isoflurane produced a reduction on its levels, without alterations on microsomal cytochrome P-450." | 1.34 | Metabolization of porphyrinogenic agents in brain: involvement of the phase I drug metabolizing system. A comparative study in liver and kidney. ( Batlle, AM; Buzaleh, AM; Lavandera, JV, 2007) |
| " ALA-S activity was induced by acute administration of anaesthetics (89%), veronal (240%) and ethanol (80%), while ALA-S mRNA expression augmented by chronic administration of enflurane, AIA and veronal." | 1.33 | Heme oxygenase, aminolevulinate acid synthetase and the antioxidant system in the brain of mice treated with porphyrinogenic drugs. ( Batlle, A; Buzaleh, AM; Gerez, E; Martinez, Mdel C; Rodriguez, JA, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodriguez, JA | 1 |
| Martinez, Mdel C | 1 |
| Gerez, E | 1 |
| Batlle, A | 1 |
| Buzaleh, AM | 2 |
| Lavandera, JV | 1 |
| Batlle, AM | 1 |
2 other studies available for barbital and Porphyria, Acute Intermittent
| Article | Year |
|---|---|
Heme oxygenase, aminolevulinate acid synthetase and the antioxidant system in the brain of mice treated with porphyrinogenic drugs.
Topics: 5-Aminolevulinate Synthetase; Animals; Antioxidants; Barbital; Brain; Enflurane; Ethanol; Gene Expre | 2005 |
Metabolization of porphyrinogenic agents in brain: involvement of the phase I drug metabolizing system. A comparative study in liver and kidney.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Barbital; Brain; Cytochrome P-450 Enzyme Syst | 2007 |