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barbital and Experimental Hepatoma

barbital has been researched along with Experimental Hepatoma in 7 studies

5,5-diethylbarbituric acid : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by two ethyl groups. Formerly used as a hypnotic (sleeping aid).

Research Excerpts

ExcerptRelevanceReference
"Barbital was also ineffective for maintenance of primary cultured hepatocytes but not toxic to the cells."1.28Influence of liver tumor promoters and structurally related chemicals on survival of normal adult rat hepatocytes in primary culture. ( Bai, L; Miyazaki, M; Sato, J, 1990)
" In contrast, only DEHP and BBS induced toxic renal lesions."1.27The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car ( Anderson, LM; Diwan, BA; Hagiwara, A; Lindsey, K; Ward, JM, 1988)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19905 (71.43)18.7374
1990's2 (28.57)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Matsuyama, M1
Amo, H1
Gerez, E1
Vazquez, E1
Caballero, F1
Polo, C1
Batlle, A1
Miyazaki, M1
Bai, L1
Sato, J1
Hagiwara, A2
Diwan, BA4
Ward, JM4
Anderson, LM1
Lindsey, K1
Rice, JM2
Nims, RW1
Lubet, RA1
Hu, H1
Ohshima, M1
Dove, LF1

Other Studies

7 other studies available for barbital and Experimental Hepatoma

ArticleYear
Promoting effects of long-term administration of barbital on spontaneous hepatic tumorigenesis in B6C3F1 mice.
    Nihon eiseigaku zasshi. Japanese journal of hygiene, 1983, Volume: 37, Issue:6

    Topics: Administration, Oral; Animals; Barbital; Barbiturates; Female; Liver Neoplasms, Experimental; Male;

1983
Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: effect of veronal.
    General pharmacology, 1997, Volume: 29, Issue:4

    Topics: 5-Aminolevulinate Synthetase; Animals; Barbital; Catalase; Cytochrome P-450 Enzyme System; Glucuroni

1997
Influence of liver tumor promoters and structurally related chemicals on survival of normal adult rat hepatocytes in primary culture.
    Journal of cancer research and clinical oncology, 1990, Volume: 116, Issue:3

    Topics: Animals; Barbital; Butylated Hydroxytoluene; Carcinogens; Cell Survival; Cells, Cultured; DDT; DNA;

1990
Barbital sodium, a tumor promoter for kidney tubules, urinary bladder, and liver of the F344 rat, induces persistent increases in levels of DNA synthesis in renal tubules but not in urinary bladder epithelium or hepatocytes.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1989, Volume: 13, Issue:2

    Topics: Animals; Barbital; Barbiturates; Cell Nucleus; DNA; Epithelial Cells; Immunohistochemistry; Kidney N

1989
The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car
    Toxicology and applied pharmacology, 1988, Volume: 96, Issue:3

    Topics: Acetaminophen; Animals; Autoradiography; Barbital; Barbiturates; Diethylhexyl Phthalate; DNA; Immuno

1988
P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats.
    Cancer research, 1988, May-01, Volume: 48, Issue:9

    Topics: Animals; Barbital; Barbiturates; Body Weight; Cytochrome P-450 Enzyme System; Diethylnitrosamine; En

1988
Comparative tumor-promoting activities of phenobarbital, amobarbital, barbital sodium, and barbituric acid on livers and other organs of male F344/NCr rats following initiation with N-nitrosodiethylamine.
    Journal of the National Cancer Institute, 1985, Volume: 74, Issue:2

    Topics: Amobarbital; Animals; Barbital; Barbiturates; Body Weight; Diethylnitrosamine; Liver Neoplasms, Expe

1985