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barbital and Cancer of Kidney

barbital has been researched along with Cancer of Kidney in 13 studies

5,5-diethylbarbituric acid : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by two ethyl groups. Formerly used as a hypnotic (sleeping aid).

Research Excerpts

ExcerptRelevanceReference
"The renal tumor promoting activity of barbital sodium (BBNa) and the role of renal tubular cell hyperplasia in tumor promotion following initiation with streptozotocin (STZ) was investigated."7.68Amelioration of sodium barbital-induced nephropathy and regenerative tubular hyperplasia after a single injection of streptozotocin does not abolish the renal tumor promoting effect of barbital sodium in male F344/NC4 rats. ( Diwan, BA; Konishi, N; Ward, JM, 1990)
"The renal tumor promoting activity of barbital sodium (BBNa) and the role of renal tubular cell hyperplasia in tumor promotion following initiation with streptozotocin (STZ) was investigated."3.68Amelioration of sodium barbital-induced nephropathy and regenerative tubular hyperplasia after a single injection of streptozotocin does not abolish the renal tumor promoting effect of barbital sodium in male F344/NC4 rats. ( Diwan, BA; Konishi, N; Ward, JM, 1990)
" Furthermore, initiation-promotion experiments demonstrated a strong correlation between the dose-response of cell proliferation and the incidence of preneoplastic and neoplastic lesions."2.38Cell proliferation and renal carcinogenesis. ( Short, BG, 1993)
" Rats were dosed with sodium barbital in the feed at 0, 50, 250, 500, 1000, 2000 or 4000 p."1.31Promotion by sodium barbital induces early development but does not increase the multiplicity of hereditary renal tumors in Eker rats. ( David, CS; Donner, EM; Everitt, JI; Goldsworthy, TL; Harden, R; Janszen, DB; Wolf, DC, 2000)
" In contrast, only DEHP and BBS induced toxic renal lesions."1.27The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car ( Anderson, LM; Diwan, BA; Hagiwara, A; Lindsey, K; Ward, JM, 1988)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19904 (30.77)18.7374
1990's7 (53.85)18.2507
2000's1 (7.69)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mantle, PG1
Dobrota, M1
Gillett, CE1
Odell, EW1
Pinder, SE1
Short, BG1
Waalkes, MP1
Diwan, BA9
Ward, JM9
Devor, DE1
Goyer, RA1
Anderson, LM2
Henneman, JR1
Rice, JM4
Kurata, Y2
Uno, H1
Wolf, DC1
Goldsworthy, TL1
Janszen, DB1
Harden, R1
Donner, EM1
David, CS1
Everitt, JI1
Konishi, N2
Donovan, PJ1
Hagiwara, A2
Ohshima, M1
Nims, RW1
Hu, H1
Lubet, RA1
Lindsey, K1

Reviews

1 review available for barbital and Cancer of Kidney

ArticleYear
Cell proliferation and renal carcinogenesis.
    Environmental health perspectives, 1993, Volume: 101 Suppl 5

    Topics: Alpha-Globulins; Animals; Barbital; Cell Division; Dimethylnitrosamine; DNA Damage; Female; Humans;

1993

Other Studies

12 other studies available for barbital and Cancer of Kidney

ArticleYear
Oncological outcomes in rats given nephrocarcinogenic exposure to dietary ochratoxin a, followed by the tumour promoter sodium barbital for life: a pilot study.
    Toxins, 2010, Volume: 2, Issue:4

    Topics: Animals; Barbital; Female; Kidney Neoplasms; Male; Mammary Neoplasms, Experimental; Mycotoxins; Ochr

2010
Renal tubular tumors and atypical hyperplasias in B6C3F1 mice exposed to lead acetate during gestation and lactation occur with minimal chronic nephropathy.
    Cancer research, 1995, Nov-15, Volume: 55, Issue:22

    Topics: Animals; Barbital; Carcinogens; Chronic Disease; Female; Fetus; Hyperplasia; Kidney Neoplasms; Kidne

1995
Transplacental carcinogenesis by cisplatin in F344/NCr rats: promotion of kidney tumors by postnatal administration of sodium barbital.
    Toxicology and applied pharmacology, 1995, Volume: 132, Issue:1

    Topics: Animals; Barbital; Body Weight; Carcinogenicity Tests; Carcinogens; Cisplatin; Drug Synergism; Femal

1995
Pathology of preneoplastic and neoplastic renal tubular lesions induced in F-344 rats by sodium barbital, a nongenotoxic renal carcinogen and nephrotoxin.
    Toxicologic pathology, 1993, Volume: 21, Issue:1

    Topics: Adenoma; Animals; Barbital; Carcinogens; Carcinoma, Renal Cell; Hyperplasia; Immunohistochemistry; K

1993
Promotion by sodium barbital induces early development but does not increase the multiplicity of hereditary renal tumors in Eker rats.
    Carcinogenesis, 2000, Volume: 21, Issue:8

    Topics: Animals; Barbital; Cell Division; Cocarcinogenesis; Dose-Response Relationship, Drug; Genetic Predis

2000
Lack of renal tumour-initiating activity of a single dose of potassium bromate, a genotoxic renal carcinogen in male F344/NCr rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1992, Volume: 30, Issue:3

    Topics: Animals; Barbital; Body Weight; Bromates; Carcinogens; Kidney Neoplasms; Male; Organ Size; Rats; Rat

1992
Differential effects of renal carcinogens and tumor promoters on growth promotion and inhibition of gap junctional communication in two rat renal epithelial cell lines.
    Carcinogenesis, 1990, Volume: 11, Issue:6

    Topics: Acetates; Animals; Barbital; Barbiturates; Carcinogens; Cell Communication; Cell Division; Cell Line

1990
Amelioration of sodium barbital-induced nephropathy and regenerative tubular hyperplasia after a single injection of streptozotocin does not abolish the renal tumor promoting effect of barbital sodium in male F344/NC4 rats.
    Carcinogenesis, 1990, Volume: 11, Issue:12

    Topics: Adenoma; Animals; Barbital; Body Weight; DNA; Hyperplasia; Kidney; Kidney Neoplasms; Liver; Male; Ne

1990
Barbital sodium, a tumor promoter for kidney tubules, urinary bladder, and liver of the F344 rat, induces persistent increases in levels of DNA synthesis in renal tubules but not in urinary bladder epithelium or hepatocytes.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1989, Volume: 13, Issue:2

    Topics: Animals; Barbital; Barbiturates; Cell Nucleus; DNA; Epithelial Cells; Immunohistochemistry; Kidney N

1989
Promotion by sodium barbital of renal cortical and transitional cell tumors, but not intestinal tumors, in F344 rats given methyl(acetoxymethyl)nitrosamine, and lack of effect of phenobarbital, amobarbital, or barbituric acid on development of either rena
    Carcinogenesis, 1989, Volume: 10, Issue:1

    Topics: Adenoma; Amobarbital; Animals; Barbital; Barbiturates; Carcinogens; Carcinoma; Carcinoma, Renal Cell

1989
Tumor promoting activities of ethylphenylacetylurea and diethylacetylurea, the ring hydrolysis products of barbiturate tumor promoters phenobarbital and barbital, in rat liver and kidney initiated by N-nitrosodiethylamine.
    Carcinogenesis, 1989, Volume: 10, Issue:1

    Topics: Animals; Barbital; Body Weight; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enz

1989
The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car
    Toxicology and applied pharmacology, 1988, Volume: 96, Issue:3

    Topics: Acetaminophen; Animals; Autoradiography; Barbital; Barbiturates; Diethylhexyl Phthalate; DNA; Immuno

1988