bambermycins and Body-Weight

The effects of hen age, Escherichia coli, and dietary Bio-Mos and Flavomycin on poult performance from 1 to 21 d were studied. Day-of-hatch BUTA (BIG-6) male poults were gavaged orally (1 mL) with approximately 10(8) cfu/mL E. coli composed of four serotypes or sterile carrier broth. A mixture of the same E. coli cultures was added to the poults' water troughs to attain a concentration of approximately 10(6) cfu/mL on a weekly basis to ensure a continuous bacterial challenge. Within each E. coli split plot treatment group, poults from hens of different ages (33 and 58 wk of age) were fed diets containing Bio-Mos (1 g/kg feed), Flavomycin (2.2 mg active ingredient/kg feed), Bio-Mos plus Flavomycin, or a control diet, in a randomized complete block design. This experiment yielded eight treatments per challenge group. At Weeks 1 and 3, eight birds from each treatment from the E. coli challenged and unchallenged groups were randomly chosen for bacterial sampling of liver and intestinal tissue for coliforms, aerobic bacteria, and Lactobacillus spp. E. coli isolates from tissue samples were O serotyped. During E. coli challenge, dietary Bio-Mos and Flavomycin improved poult BW and BW gains (P < or = 0.05). When poults were not challenged with E. coli, poults from old hens had improved BW and cumulative BW gains over poults from young hens (P < or = 0.05). Cumulative 3-wk BW gains for unchallenged poults from young hens were improved by Bio-Mos and Flavomycin (P < or = 0.05) alone and in combination when compared to the control diet. Two of the four E. coli serotypes administered were recovered. Several serotypes were recovered that were not administered. It may be concluded that dietary Bio-Mos and Flavomycin can improve the overall performance of poults, especially when they are faced with an E. coli challenge.

Topics: Age Factors; Animals; Anti-Bacterial Agents; Bambermycins; Body Weight; Chickens; Colony Count, Microbial; Disease Susceptibility; Drug Combinations; Escherichia coli; Escherichia coli Infections; Male; Poultry Diseases; Serotyping

A study was conducted to evaluate the effects of mannanoligosaccharides (MOS), bambermycins (BAM), and virginiamycin (VIR) on the growth performance of male turkeys. Hybrid Large White male poults were assigned to six dietary treatments: control, MOS, BAM, VIR, MOS+BAM (MB), and MOS+VIR (MV). All diets were formulated to meet NRC (1994) nutrient requirements. There were eight replicate floor pens per treatment with 20 birds per pen reared from 1 to 140 d. Body weight and feed conversion (FC) were collected at 3-wk intervals and at 20 wk of age. Mortality and culled birds were recorded daily. All treatments except MV significantly (P < 0.05) increased 20 wk BW. Body weight was increased at 12 wk by BAM, whereas VIR increased BW at Weeks 12 and 15. All treatments improved FC for Weeks 0 to 3, whereas VIR, MB, and MV improved FC for Weeks 0 to 12 and 0 to 18. There were no treatment effects on cumulative mortality or cull rate. Dietary supplemental MOS, BAM, and VIR resulted in improved growth performance of Large White turkeys. These results indicate that MOS may be utilized as an alternative to antibiotic growth promotants to improve turkey performance.

Topics: Animal Feed; Animals; Anti-Bacterial Agents; Bambermycins; Body Weight; Dietary Supplements; Energy Metabolism; Male; Mannose; Oligosaccharides; Random Allocation; Turkeys; Virginiamycin; Weight Gain

Intestinal colonization and shedding of pathogenic bacteria in animal feces is an important factor in both human food safety and animal health. The effect of broiler feed additives flavophospholipol (FPL; Flavomycin, bambermycins) and salinomycin sodium (SAL; Sacox) given singly on the excretion of Salmonella enteritidis, Campylobacter jejuni, and Clostridium perfringens was studied following controlled infection. The incidence of shedding (number of birds with positive fecal cultures) and the degree of shedding (cfu per gram of feces in positive birds) were measured to determine the influence of these two common feed additive antibiotics on shedding rates of potential pathogens. A total of 216 Ross broiler chickens, housed in battery cages, were fed either an unmedicated feed (controls), feed containing FPL, or feed containing SAL. Feed treatment groups were subdivided into three bacterial challenge groups of 24 chicks, each receiving only one of the pathogens. Bacterial challenge was administered orally on Days 11 and 12 for Salmonella and Campylobacter and on Days 2 and 3 for Clostridium. Fecal samples were collected weekly up to 6 wk of age and cultured for presence of the target organism. The shedding rate was determined by decimal dilutions of the fecal samples. Feeding FPL resulted in a reduced (P < or = 0.05) degree and incidence of Salmonella and Clostridium shedding at 6 wk. Feeding SAL reduced (P < or = 0.05) the incidence of Salmonella shedding at 6 wk. Neither feed additive affected the incidence nor the degree of Campylobacter shedding. The results of this study indicate that these feed additives may reduce the incidence of these potential human and animal pathogens in preslaughter broilers.

Topics: Animal Feed; Animals; Anti-Bacterial Agents; Bambermycins; Body Weight; Campylobacter jejuni; Chickens; Clostridium perfringens; Coccidiostats; Eating; Feces; Pyrans; Salmonella enteritidis

The objective of the study was to determine the effects of two enzyme preparations containing beta-glucanase and xylanase activities on barley- and wheat-based diets, respectively, for broilers, in combination with flavomycin. In addition, the stability of the enzyme preparations after pelleting was measured. Temperatures recorded during the pelleting process reached 75 to 80 C, and the activities recovered with respect to the amounts present in the mash feed before pelleting were 80% or higher. Two performance experiments were conducted simultaneously under the same conditions over 6 wk. In addition, intestinal viscosity and incidence of vent pasting were measured and carcasses were eviscerated to determine abdominal fat, carcass yield, and percentage weight of intestines and viscera. Twenty-four pens (12 per sex), each containing 75 chickens were used in each experiment. Wheat- or barley-based diets were supplemented with flavomycin and a xylanase or a beta-glucanase preparation, respectively, in a 2 x 2 factorial arrangement of treatments. In the wheat diets, xylanase and flavomycin improved feed efficiency, in parallel with a reduction of intestinal viscosity. Xylanase reduced the incidence of vent pasting and the percentage viscera, especially of intestines, and increased abdominal fat. In the barley diets, beta-glucanase and flavomycin improved feed conversion. beta-Glucanase also reduced intestinal viscosity and vent pasting. Both beta-glucanase and flavomycin reduced percentage intestines, but the effects were not additive. In general, the effects of the enzyme preparations and flavomycin were independent, except for percentage intestines with beta-glucanase.

Topics: Animal Feed; Animals; Anti-Bacterial Agents; Bambermycins; Body Composition; Body Weight; Cellulase; Chickens; Dietary Supplements; Eating; Female; Food Analysis; Gastrointestinal Motility; Glycoside Hydrolases; Hordeum; Intestines; Male; Meat; Temperature; Triticum; Weight Gain; Xylan Endo-1,3-beta-Xylosidase; Xylosidases

Broilers were grown to 49 days of age on diets supplemented with bambermycins (BAM, 2.2 ppm), bacitracin methylene disalicylate (BMD, 27.5 ppm), virginiamycin (VM, 11 ppm), or an unmedicated control. Samples of birds were processed for dressing percentage and parts yield. There were no significant (P greater than .05) effects of antibiotics on final body weight, feed conversion, or mortality. In male broilers, BMD and VM significantly (P less than or equal to .05) increased dressing percentage and percentage yield and reduced the skeletal rack as a percentage of postchill weight compared to those fed the nonmedicated control. All antibiotics significantly increased breast skin weight and breast skin as a percentage of postchill weight of as compared with those fed the unmedicated control. In female broilers, BAM and BMD significantly increased dressing percentage and percentage yield and increased breast weight and breast as percentage of postchill weight as compared with those fed the unmedicated control diet. Females fed BMD also had significantly heavier leg quarters and breast skin than those fed the unmediated control. Females fed VM had increased breast skin weight and breast skin as a percentage of postchill weight than those fed the unmedicated control. The results of the present study indicate that antibiotics may influence dressing percentage and parts yield in the absence of improvements in body weight gain or feed utilization.

Topics: Analysis of Variance; Animals; Bacitracin; Bambermycins; Body Weight; Chickens; Female; Male; Organ Size; Virginiamycin

Two experiments, each consisting of two trials, were conducted with day-old Nicholas Large White turkey poults to compare the effectiveness of four antibiotics for growth promotion and the utilization of sulfur amino acids. A corn-soybean meal basal diet that contained no supplemental methionine, choline, or inorganic sulfate was used in order to furnish nutritional stress. The diet was calculated to contain 25.4% protein, .448% methionine, .403% cystine, 1014 mg/kg choline, and 2990 kcal metabolizable energy/kg. In Experiment 1, a 2 X 4 factorial arrangement of treatments was used. This included two levels, (0% (control) and .18%), of supplemental DL-methionine and no antibiotic or bacitracin MD, flavomycin, or virginiamycin; antibiotics were fed at 50, 2, and 20 g/ton, respectively. In Experiment 2, lincomycin also was included as a treatment (at 4 g per ton) resulting in a 2 X 5 factorial arrangement of treatments. Only the addition of Virginiamycin to the control diet in Experiment 1 resulted in significantly increased body weights. Supplementation by .18% methionine increased body weights and feed efficiency. In addition, all three antibiotics increased body weights significantly when added to the .18% methionine diets. Feed efficiency values were improved by all four antibiotics at both methionine levels. In Experiment 2, increases in body weights similar to those in Experiment 1 were obtained with the addition of .18% methionine to the basal diets. Addition of lincomycin and virginiamycin improved body weights and feed efficiencies in the presence and absence of supplemental methionine.

Topics: Animals; Anti-Bacterial Agents; Bacitracin; Bambermycins; Body Weight; Lincomycin; Methionine; Turkeys; Virginiamycin

Experiments were carried out with a total of 144 geese of the Benkovska breed divided into 6 groups of 24 birds each. The average weight was 3.5 kg, the birds being compulsory fattened with steamed maize over an average period of 27 days. Flavophospholipol (flavofarm-NIHFI) was given at rates of 0, 4, 8, 12, and 16 ppm. The method of positive control check was employed--a group which was offered zinc-bacitracin--(bacifarmin) at 30 ppm. Under the effect of flavophospholipol the weight gain was 2.2 to 21.2 per cent higher, and the weight of the liver rose by 1.4-23.1 per cent. The intake of maize per kg of gain dropped by 2.5 to 15.7 per cent, and it was 1.8 to 16.9 per cent lower per kg of liver. When flavophospholipol was given at 16 ppm, a maximum effect was produced--21.0 percent higher gain, 23.1 per cent increase of the liver weight, 15.7 per cent drop of maize intake per kg of gain, and 16.9 per cent drop of maize intake per kg of liver. With geese that were offered bacifarmin these indices were 3.3, 11.9,, 4.8, and 10.7 per cent, respectively. The amount of flavophospholipol used correlated positively with its ergotropic effect. The liver quality with geese treated with flavophospholipol and bacifarmin was higher. No residual amounts of flavophospholipol were found in the meat, liver and viscera of the treated birds.

Topics: Animal Feed; Animals; Anti-Bacterial Agents; Bacitracin; Bambermycins; Body Burden; Body Weight; Feeding Behavior; Female; Geese; Male

Experiments were conducted at three geographic locations in the United States (Arkansas, Colorado, and Minnesota) to examine the response of Large White turkeys to bambermycins in the presence of halofuginone. Each location utilized diets commonly used at that station for growing turkeys. All diets contained 3 ppm halofuginone, and were supplemented with 0, 1, 2, or 4 g bambermycins/ton (908 kg). Bambermycins was fed from day-old to marketing; halofuginone was removed from feed for 3 days prior to marketing. Although there were some significant differences in final body weights or feed utilization among locations, there were no significant interactions of location X bambermycins. Body weight of males was significantly (P less than .05) improved by the addition of 2 g bambermycins/ton. Body weight of females was significantly (P less than .05) improved by all levels of bambermycins; 4 g/ton stimulated significantly (P less than .05) superior gains than 1 or 2 g/ton. When body weight for both sexes was combined, bambermycins at 2 and 4 g/ton resulted in significant (P less than .05) improvements in body weight. Feed utilization, expressed as units of feed per unit of gain, was not significantly influenced by dietary treatment. There were no significant differences in mortality related to location or dietary treatment.

Topics: Animals; Anti-Bacterial Agents; Arkansas; Bambermycins; Body Weight; Coccidiostats; Colorado; Female; Food Additives; Male; Minnesota; Piperidines; Quinazolines; Quinazolinones; Sex Factors; Turkeys

A study of the growth-promoting effects of penicillin, oxytetracycline, lincomycin, bambermycin , and tylan was made over a 2-year period involving 2030 broiler chicks in 11 experiments. The laboratory used for this study has been subjected to the continuous use of low level dietary antibiotics for over 30 years. Results show that growth promotion by penicillin, oxytetracycline, and lincomycin were still significant (P less than .01). The effect of tylan was also significant (P less than .05). The antibiotics tended to promote better growth effects in chicks from young breeder hens. Significant growth improvement by antibiotics was observed in nutritionally adequate diets regardless of the presence or absence of soybean meal and excesses of certain vitamins and minerals.

Topics: Animals; Anti-Bacterial Agents; Bambermycins; Body Weight; Chickens; Female; Food Additives; Leucomycins; Lincomycin; Male; Oxytetracycline; Penicillins; Tylosin

Bambermycins and bambermycins plus roxarsone were fed to broilers in ten consecutive experiments to determine if response (measured by body weight and feed efficiency) was continuous over a long term. Bambermycins was added at 1.1 ppm (1 to 44 days) and 2.2 ppm (45 to 51 days) to both test rations. In addition, one test ration contained roxarsone (3-nitro-4-hydroxyphenylarsonic acid) at 50 ppm (1 to 44 days). Each experiment was conducted with 1,080 commercial broiler cross-run chickens. Broilers fed bambermycins and bambermycins plus roxarsone were heavier (P less than .05) than controls in every experiment. Bambermycins plus roxarsone treated broilers were heavier (P less than .05) than bambermycins treated broilers in 2 out of 10 experiments. Broilers fed bambermycins converted feed more efficiently (P less than .05) than controls in 6 of 10 experiments and were more efficient (P less than .05) than bambermycins plus roxarsone fed broilers in 1 of 10 experiments. Bambermycins plus roxarsone treated broilers were more efficient (P less than .05) than controls in 5 of 10 experiments. These findings indicate that over a long term bambermycins and bambermycins plus roxarsone consistently and significantly (P less than .05) increased broiler body weights over controls, although the addition of roxarsone was not always effective in increasing body weights or improving feed efficiency over bambermycins fed alone.

Topics: Animals; Anti-Bacterial Agents; Arsenicals; Bambermycins; Body Weight; Chickens; Diet; Drug Combinations; Female; Food Additives; Male; Roxarsone; Seasons; Sex Factors

The single oral application of Flavophospholipol--NIHFI (0.8 per cent premix) at rates with regard to the active ingredient per kg of live weight of 5, 10, and 15 g to albino mice and rats, and 15, 20, and 30 g to week-old broiler birds did not produce toxicity. Besides, it was well tolerated in tests with broiler birds in amounts 50 times as high as the stimulant dose (4 g/t feed). The oral administration with the feed at the rate of 80 g/t to newly hatched broiler chicks in the course of sixty days did not either produce toxic effects or changes whatever in the physiological and biochemical indices studied and in the microstructure of the viscera. It was found to stimulate growth and increase the erythrocyte count. Under the conditions of testing the subchronic toxicity of flavophospholipol amounts of 400 and 2000 g/t feed led to the lowering of the consumption rate and the body weight as well as to the increase in the blood sugar. At 2000 g/t it lowered the amount of hemoglobin in the blood, and partially increased the activity of SGPT.

Topics: Animal Feed; Animals; Anti-Bacterial Agents; Bambermycins; Body Weight; Chickens; Dose-Response Relationship, Drug; Drug Tolerance; Female; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains; Time Factors

Twenty broiler chickens were fed bambermycins (Flavomycin; an antibiotic produced by Streptomyces) at the rate of 3 g/ton (US) for 63 days, and 20 control birds were fed nonmedicated feed. The birds were inoculated (dosed) on the 10th and 11th feeding day with Salmonella typhimurium. The study evaluated the effects of bambermycins on Salmonella incidence, shedding, and antimicrobial resistance. Bambermycins had no effect on body weights, duration of shedding of salmonellae, number of salmonellae shed on postdosing day 3, tissue recoverability of salmonellae, and total number of resistance patterns. Bambermycins resulted in the decrease of salmonellae to be more gradual; however, both treatments were comparable at the end of the study. The majority of S typhimurium from bambermycins-treated birds maintained the original antibiogram of streptomycin, sulfadiazine, and nalidixic acid. The salmonellae isolated from the control birds were more resistant to 2 drugs (varying antibiograms). Bambermycins as a feed additive in broiler diets given at the dose level of 3 g/ton had no detrimental effects based on salmonellae shedding and antimicrobial resistance.

Topics: Animals; Anti-Bacterial Agents; Bambermycins; Body Weight; Chickens; Diet; Drug Resistance, Microbial; Feces; Liver; Poultry Diseases; Salmonella Infections, Animal; Salmonella typhimurium; Spleen

Experiments with calves of initial weight of about 178 kg revealed that salimycin given with the feed at the rate of 0.5 mg/kg for 24 hours in the course of 269 days, and monensin used for comparison at 0.7 mg/kg for 24 hours led to the increase in the weight gain by 4.3 and 6 per cent, respectively. An increase in the conversion of forage was also established--6.3 and 9.5 per cent, respectively. Up to the sixth month of age the rise of the weight gain (as against the negative control group) with the calves treated with salimycin (11.7 per cent) was higher than that with calves that were given monensin (9.9 per cent). The combined application of salimycin (0.5 mg/kg for 24 h) and flavophospholipol (0.1 mg/kg for 24 h) led to the slight enhancement of the nutritive effect: with regard to the weight gain--by 1.7 per cent, and with regard to the conversion of forage--by 2.8 per cent.

Topics: Animal Feed; Animals; Anti-Bacterial Agents; Bambermycins; Body Weight; Cattle; Drug Synergism; Growth Substances; Male; Nutritive Value; Pyrans; Time Factors

Five experiments (five different locations) with a total of 1,230 pigs (135 pens) were conducted in Minnesota, Missouri and Indiana to study the effects of supplementary bambermycins (2.2 ppm) and tylosin (44 or 22 ppm) in swine diets. The antibiotics were fed during the growing and finishing periods, and effects on rate of gain and efficiency of feed conversion were measured. A significant improvement in ADG and F:G over the control pigs was observed with the bambermycins treatment. A numerical but nonsignificant improvement in ADG and a significant improvement in F:G over control were observed with the tylosin treatment. The performance was divided into growing and finishing periods. In the growing period, bambermycins and tylosin numerically but nonsignificantly improved ADG and F:G over control pigs. The finishing period response to bambermycins was significantly improved for ADG and F:G. The tylosin finisher response was numerically but nonsignificantly improved for ADG and F:G over negative control. Significant location effects were observed. This result would be expected due to variation in genetic background of the experimental animals and differences in housing, environment and management.

Topics: Animal Feed; Animals; Anti-Bacterial Agents; Bambermycins; Body Weight; Leucomycins; Swine