bakuchiol and Diabetes-Mellitus--Type-2

bakuchiol has been researched along with Diabetes-Mellitus--Type-2* in 1 studies

Other Studies

1 other study(ies) available for bakuchiol and Diabetes-Mellitus--Type-2

Article	Year
Isolation and antihyperglycemic activity of bakuchiol from Otholobium pubescens (Fabaceae), a Peruvian medicinal plant used for the treatment of diabetes. Biological & pharmaceutical bulletin, 1999, Volume: 22, Issue:10 The known compound bakuchiol (1) was isolated from an extract of Otholobium pubescens (Fabaceae) by bioassay-guided fractionation using the db/db mouse model for type 2 diabetes. Oral administration of 1 reduced blood glucose levels in a dose-dependent fashion in db/db mice and did not display a hypoglycemic effect when tested in lean mice at 250 mg/kg q.d. Compound 1 was further evaluated in a new rodent model for type 2 diabetes, the fat-fed, streptozotocin (STZ)-treated rat. In this model, an oral dose of 1 at 150 mg/kg q.d. significantly lowered plasma glucose and triglyceride levels. Topics: Analysis of Variance; Animals; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Peru; Phenols; Plants, Medicinal; Rats; Rosales; Streptozocin; Time Factors	1999

Article

Year

Isolation and antihyperglycemic activity of bakuchiol from Otholobium pubescens (Fabaceae), a Peruvian medicinal plant used for the treatment of diabetes.

Biological & pharmaceutical bulletin, 1999, Volume: 22, Issue:10

The known compound bakuchiol (1) was isolated from an extract of Otholobium pubescens (Fabaceae) by bioassay-guided fractionation using the db/db mouse model for type 2 diabetes. Oral administration of 1 reduced blood glucose levels in a dose-dependent fashion in db/db mice and did not display a hypoglycemic effect when tested in lean mice at 250 mg/kg q.d. Compound 1 was further evaluated in a new rodent model for type 2 diabetes, the fat-fed, streptozotocin (STZ)-treated rat. In this model, an oral dose of 1 at 150 mg/kg q.d. significantly lowered plasma glucose and triglyceride levels.

Topics: Analysis of Variance; Animals; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Peru; Phenols; Plants, Medicinal; Rats; Rosales; Streptozocin; Time Factors

1999