Page last updated: 2024-08-24

baicalin and Depression

baicalin has been researched along with Depression in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's10 (50.00)24.3611
2020's10 (50.00)2.80

Authors

AuthorsStudies
Fujita, Y; Hashimoto, K; Iwata, M; Oda, Y; Shirayama, Y1
Cheng, Y; Lu, Y; Pei, L; Sun, G; Wang, Z1
Bai, M; Jin, X; Li, C; Li, Y; Lu, S; Shen, J; Xu, E; Zhu, L1
Cheng, YT; Lu, Y; Pei, L; Sun, GQ; Wang, Z1
Feng, D; Ma, Z; Rui, W; Wang, Z1
Li, X; Liu, A; Liu, Q; Liu, Y; Ma, J; Yang, Z1
Fang, A; Li, Y; Wu, B; Wu, X; Zhang, Y1
Deng, X; Fu, Q; Fu, X; Jiao, J; Ma, S; Ma, Z; Qin, T; Yu, J1
Cao, Z; Du, Y; Jia, Z; Lu, Y; Pei, L; Sun, G; Xiao, Z; Yang, J1
Cao, Z; Chen, Y; Chu, L; Jia, Z; Lu, Y; Pei, L; Yang, J; Zhang, J; Zhang, S; Zhao, J1
Liu, C; Liu, X1
Deng, R; Du, Q; Gao, C; Li, W; Shen, J; Wang, Q; Xu, A1
Deng, XY; Fu, Q; Li, YQ; Ma, SP; Ma, ZQ; Qu, R; Shang, ZY; Zeng, MJ; Zhang, CY; Zhao, F; Zhou, LP1
Dong, Y; Li, L; Liu, L; Shan, X; Wang, H; Xia, B1
Deng, X; Li, Y; Liu, D; Liu, K; Ma, S; Ma, Z; Qu, R; Xu, L; Zhang, R1
Deng, XY; Guo, LT; Ji, ZY; Ma, SP; Ma, ZQ; Su, J; Wang, SQ; Xu, LX; Zhang, RY; Zhao, QW1
Chu, L; Guan, Z; Liu, Y; Lu, Y; Pei, L; Sun, G; Yang, F; Zhang, Z; Zhao, J1
Ma, SP; Qu, R; Yang, SJ; Yin, ZJ; Yu, HY1
Dong, Y; Ma, J; Pan, X; Su, G; Wang, F; Wu, C; Yang, J; Zhang, K1
Jiao, S; Li, J; Li, YC; Shen, JD; Wang, R; Yi, LT1

Other Studies

20 other study(ies) available for baicalin and Depression

ArticleYear
The Toll-like receptor 4 antagonist TAK-242 induces antidepressant-like effects in a rat learned helplessness model of depression through BDNF-TrkB signaling and AMPA receptor activation.
    Behavioural brain research, 2022, 04-09, Volume: 423

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Flavonoids; Helplessness, Learned; Male; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, AMPA; Signal Transduction; Sulfonamides; Toll-Like Receptor 4

2022
Baicalin Coadministration with Lithium Chloride Enhanced Neurogenesis via GSK3β Pathway in Corticosterone Induced PC-12 Cells.
    Biological & pharmaceutical bulletin, 2022, May-01, Volume: 45, Issue:5

    Topics: Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Flavonoids; Glycogen Synthase Kinase 3 beta; Hippocampus; Lithium Chloride; Neurogenesis

2022
Baicalin ameliorates CUMS-induced depression-like behaviors through activating AMPK/PGC-1α pathway and enhancing NIX-mediated mitophagy in mice.
    European journal of pharmacology, 2023, Jan-05, Volume: 938

    Topics: AMP-Activated Protein Kinases; Animals; Depression; Membrane Proteins; Mice; Mitochondrial Proteins; Mitophagy; Molecular Docking Simulation; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

2023
Baicalin Ameliorates Corticosterone-Induced Depression by Promoting Neurodevelopment of Hippocampal via mTOR/GSK3β Pathway.
    Chinese journal of integrative medicine, 2023, Volume: 29, Issue:5

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Fluoxetine; Glycogen Synthase Kinase 3 beta; Hippocampus; Male; Mammals; Mice; Reproducibility of Results; RNA, Messenger; TOR Serine-Threonine Kinases

2023
Baicalin attenuates chronic unpredictable mild stress-induced hippocampal neuronal apoptosis through regulating SIRT1/PARP1 signaling pathway.
    Behavioural brain research, 2023, 03-12, Volume: 441

    Topics: Animals; Antidepressive Agents; Apoptosis; Depression; Disease Models, Animal; Flavonoids; Hippocampus; Mice; Neurons; Poly (ADP-Ribose) Polymerase-1; Signal Transduction; Sirtuin 1; Stress, Psychological

2023
Widely targeted metabolomics unveils baicalin-induced hippocampal metabolic alternations in a rat model of chronic unpredictable mild stress.
    Journal of pharmaceutical and biomedical analysis, 2024, Jan-05, Volume: 237

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Hippocampus; Metabolomics; Mice; Rats; Stress, Psychological; Sucrose

2024
Baicalin attenuates inflammatory pain associated depressive symptoms via Akt-mediated adult hippocampal neurogenesis.
    Metabolic brain disease, 2020, Volume: 35, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Depression; Flavonoids; Hippocampus; Hyperalgesia; Inflammation; Male; Mice; Neural Stem Cells; Neurogenesis; Pain Measurement; Proto-Oncogene Proteins c-akt; Signal Transduction

2020
A New Perspective on Ameliorating Depression-Like Behaviors: Suppressing Neuroinflammation by Upregulating PGC-1α.
    Neurotoxicity research, 2021, Volume: 39, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Depression; Dose-Response Relationship, Drug; Flavonoids; Hindlimb Suspension; Hippocampus; Humans; Inflammation; Inflammation Mediators; Male; Mice; Mice, Inbred ICR; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Up-Regulation

2021
Baicalin promotes hippocampal neurogenesis via the Wnt/β-catenin pathway in a chronic unpredictable mild stress-induced mouse model of depression.
    Biochemical pharmacology, 2021, Volume: 190

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Depression; Doublecortin Protein; Flavonoids; Hippocampus; Male; Mice; Mice, Inbred ICR; Neurogenesis; Stress, Psychological; Wnt Signaling Pathway

2021
Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway.
    Behavioural brain research, 2021, 09-24, Volume: 414

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluoxetine; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Neuroprotective Agents; Random Allocation; Signal Transduction; Stress, Psychological

2021
Baicalin ameliorates chronic unpredictable mild stress-induced depressive behavior: Involving the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex.
    International immunopharmacology, 2017, Volume: 48

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Flavonoids; Inflammasomes; Interleukin-1beta; Interleukin-6; Locomotion; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Prefrontal Cortex; Rats, Sprague-Dawley; Stress, Psychological

2017
Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression.
    Molecular neurobiology, 2018, Volume: 55, Issue:12

    Topics: Adaptor Proteins, Signal Transducing; Animals; Anxiety; Behavior, Animal; Brain; Cell Line, Tumor; Corticosterone; Depression; Disease Models, Animal; Emotions; Flavonoids; Humans; Male; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Olfactory Bulb; Receptors, Glucocorticoid; Signal Transduction

2018
Baicalin exerts neuroprotective effects via inhibiting activation of GSK3β/NF-κB/NLRP3 signal pathway in a rat model of depression.
    International immunopharmacology, 2018, Volume: 64

    Topics: Animals; Apoptosis; Depression; Doublecortin Protein; Flavonoids; Glycogen Synthase Kinase 3 beta; Hippocampus; Male; Motor Activity; Neuroprotective Agents; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Signal Transduction; Stress, Psychological

2018
Anti-Depressive Effectiveness of Baicalin In Vitro and In Vivo.
    Molecules (Basel, Switzerland), 2019, Jan-17, Volume: 24, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Cell Survival; Chronic Disease; Cytokines; Depression; Disease Models, Animal; Flavonoids; Hindlimb Suspension; HMGB1 Protein; Inflammation Mediators; Mice, Inbred ICR; NF-kappa B; PC12 Cells; Rats; Signal Transduction; Stress, Psychological; Swimming; Toll-Like Receptor 4

2019
Baicalin exerts antidepressant effects through Akt/FOXG1 pathway promoting neuronal differentiation and survival.
    Life sciences, 2019, Mar-15, Volume: 221

    Topics: Animals; Antidepressive Agents; Cell Differentiation; Depression; Disease Models, Animal; Doublecortin Protein; Fibroblast Growth Factor 2; Flavonoids; Forkhead Transcription Factors; Hippocampus; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Nerve Tissue Proteins; Neurogenesis; Neurons; Proto-Oncogene Proteins c-akt; Signal Transduction; Stress, Psychological

2019
Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway.
    Journal of neuroinflammation, 2019, May-08, Volume: 16, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Depression; Flavonoids; Forkhead Box Protein O1; Inflammation; Male; Mice; Mice, Inbred ICR; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psychological Distress; Signal Transduction; Toll-Like Receptor 4

2019
Baicalin regulates depression behavior in mice exposed to chronic mild stress via the Rac/LIMK/cofilin pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 116

    Topics: Actin Depolymerizing Factors; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Chronic Disease; Depression; Disks Large Homolog 4 Protein; Flavonoids; Hippocampus; Lim Kinases; Male; Mice; Neurons; rac GTP-Binding Proteins; Receptor, trkB; RNA, Messenger; Signal Transduction; Stress, Psychological; Swimming; Synaptophysin

2019
Baicalin Reverses Depressive-Like Behaviours and Regulates Apoptotic Signalling Induced by Olfactory Bulbectomy.
    Phytotherapy research : PTR, 2016, Volume: 30, Issue:3

    Topics: Animals; Antidepressive Agents; Apoptosis; Apoptotic Protease-Activating Factor 1; Behavior, Animal; Caspases; Depression; Depressive Disorder, Major; Flavonoids; Glutathione Peroxidase; Hippocampus; Male; Malondialdehyde; Olfactory Bulb; Oxidative Stress; Phytotherapy; Plant Extracts; Rats, Wistar; Scutellaria; Signal Transduction; Superoxide Dismutase; Synaptophysin

2016
Baicalin promotes hippocampal neurogenesis via SGK1- and FKBP5-mediated glucocorticoid receptor phosphorylation in a neuroendocrine mouse model of anxiety/depression.
    Scientific reports, 2016, 08-09, Volume: 6

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Doublecortin Protein; Flavonoids; Hippocampus; Immediate-Early Proteins; Male; Mice; Mice, Inbred C57BL; Neurogenesis; Neurosecretory Systems; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, Glucocorticoid; Tacrolimus Binding Proteins

2016
Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: involving the inhibition of cyclooxygenase-2 in rat brain.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Jan-10, Volume: 40

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Corticosterone; Cyclooxygenase 2 Inhibitors; Depression; Depressive Disorder; Dinoprostone; Flavonoids; Hindlimb Suspension; Male; Rats; Rats, Wistar; Stress, Psychological; Swimming

2013