baicalein and Edema

baicalein has been researched along with Edema* in 2 studies

Other Studies

2 other study(ies) available for baicalein and Edema

Article	Year
Conferin, potent antioxidant and anti-inflammatory isoflavone from Caragana conferta Benth. Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:3 Conferin (1), a new isoflavone, has been isolated from the ethyl acetate soluble fraction of Caragana conferta Benth. along with seven known compounds, namely biochanin A (2), p-hydroxybenzoic acid (3), 3,5-dimethoxybenzoic acid (4), ursolic acid (5), erythrodiol (6), pinoresinol (7), and syringresinol (8), reported for the first time from this species. The structure of the new isoflavone was deduced on the basis of spectroscopic studies. Compounds 1 and 2 were investigated for biological activities and showed significant anti-inflammatory activity in carrageenan induced paw edema of rats. Evaluation of antioxidant activity by the radical scavenging method indicated that compound 1 is a potent antioxidant while 2 is moderately active. It was also shown that the reducing capability of compound 2 was remarkably increased in a concentration dependent manner as compared to 1. Compound 1 showed moderate inhibitory activity against the enzyme lipoxygenase, while 2 showed weak activity. Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Caragana; Edema; Free Radical Scavengers; Isoflavones; Lipoxygenase; Lipoxygenase Inhibitors; Molecular Structure; Rats; Spectrum Analysis	2010
3-Formylchromones: potential antiinflammatory agents. European journal of medicinal chemistry, 2010, Volume: 45, Issue:9 The synthesis and characterization of 3-formylchromone (1) and its derivatives 2-24 and evaluation of their potential antiinflammatory activities is reported here. These compounds were characterized by (1)H NMR, EI MS, IR, and UV spectroscopic techniques and elemental analysis. The synthesized compounds were evaluated by using various in vitro and in vivo assay models for antiinflammatory activity and their effects were compared with known standard drug such as aspirin and indomethacin. Among all tested compounds, 1, 2, 5, 6, 9, 14, 16-19, 21-23, showed promising antiinflammatory activities. The results and SAR has been discussed in this report. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromones; Cyclooxygenase Inhibitors; Edema; Female; Inflammation; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Respiratory Burst; Xanthine; Xanthine Oxidase	2010

Article

Year

Conferin, potent antioxidant and anti-inflammatory isoflavone from Caragana conferta Benth.

Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:3

Conferin (1), a new isoflavone, has been isolated from the ethyl acetate soluble fraction of Caragana conferta Benth. along with seven known compounds, namely biochanin A (2), p-hydroxybenzoic acid (3), 3,5-dimethoxybenzoic acid (4), ursolic acid (5), erythrodiol (6), pinoresinol (7), and syringresinol (8), reported for the first time from this species. The structure of the new isoflavone was deduced on the basis of spectroscopic studies. Compounds 1 and 2 were investigated for biological activities and showed significant anti-inflammatory activity in carrageenan induced paw edema of rats. Evaluation of antioxidant activity by the radical scavenging method indicated that compound 1 is a potent antioxidant while 2 is moderately active. It was also shown that the reducing capability of compound 2 was remarkably increased in a concentration dependent manner as compared to 1. Compound 1 showed moderate inhibitory activity against the enzyme lipoxygenase, while 2 showed weak activity.

Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Caragana; Edema; Free Radical Scavengers; Isoflavones; Lipoxygenase; Lipoxygenase Inhibitors; Molecular Structure; Rats; Spectrum Analysis

2010

3-Formylchromones: potential antiinflammatory agents.

European journal of medicinal chemistry, 2010, Volume: 45, Issue:9

The synthesis and characterization of 3-formylchromone (1) and its derivatives 2-24 and evaluation of their potential antiinflammatory activities is reported here. These compounds were characterized by (1)H NMR, EI MS, IR, and UV spectroscopic techniques and elemental analysis. The synthesized compounds were evaluated by using various in vitro and in vivo assay models for antiinflammatory activity and their effects were compared with known standard drug such as aspirin and indomethacin. Among all tested compounds, 1, 2, 5, 6, 9, 14, 16-19, 21-23, showed promising antiinflammatory activities. The results and SAR has been discussed in this report.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromones; Cyclooxygenase Inhibitors; Edema; Female; Inflammation; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Respiratory Burst; Xanthine; Xanthine Oxidase

2010