bafilomycin-d and Glioma

bafilomycin-d has been researched along with Glioma* in 2 studies

Other Studies

2 other study(ies) available for bafilomycin-d and Glioma

ArticleYear
Bioactive Bafilomycins and a New N-Arylpyrazinone Derivative from Marine-derived Streptomyces sp. HZP-2216E.
    Planta medica, 2017, Volume: 83, Issue:18

    A MeOH extract prepared from culture of an actinomycete

    Topics: Anti-Infective Agents; Cell Line, Tumor; Cell Proliferation; Glioma; Humans; Macrolides; Magnetic Resonance Spectroscopy; Methicillin-Resistant Staphylococcus aureus; Pyrazines; Streptomyces; Ulva

2017
A unique indolizinium alkaloid streptopertusacin A and bioactive bafilomycins from marine-derived Streptomyces sp. HZP-2216E.
    Phytochemistry, 2017, Volume: 144

    Streptopertusacin A, a unique indolizinium alkaloid existing as a zwitterion, and six bafilomycins including two previously undescribed ones of 21,22-en-bafilomycin D and 21,22-en-9-hydroxybafilomycin D were isolated from a culture of the seaweed-derived Streptomyces sp. HZP-2216E. Structures of these isolated compounds were determined based on extensive NMR spectroscopic analyses, HRESIMS and MS-MS data. The stereochemical assignments were achieved by NOE information, chemical degradation, Marfey's method, and electronic circular dichroism (ECD) calculation. Streptopertusacin A is the first example of this type of indolizinium alkaloid from microorganisms and showed moderate activity against the growth of methicillin-resistant Staphylococcus aureus (MRSA). 21,22-en-bafilomycin D and 21,22-en-9-hydroxybafilomycin D had potent activities in inhibiting the proliferation of glioma cells and the growth of MRSA.

    Topics: Animals; Anti-Bacterial Agents; Cell Proliferation; Dose-Response Relationship, Drug; Glioma; Humans; Macrolides; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Conformation; Phenazines; Rats; Streptomyces; Structure-Activity Relationship; Tumor Cells, Cultured

2017