bafilomycin-a1 and Astrocytoma

Autophagy is a key cellular process that involves constituent degradation and recycling during cellular development and homeostasis. Autophagy also plays key roles in antimicrobial host defense and numerous pathogenic organisms have developed strategies to take advantage of and/or modulate cellular autophagy. Several pharmacologic compounds, such as BafilomycinA1, an autophagy inducer, and Rapamycin, an autophagy inhibitor, have been used to modulate autophagy, and their effects upon notable autophagy markers, such as LC3 protein lipidation and Sequestosome-1/p62 alterations are well defined. We sought to understand whether such autophagy modulators have a more global effect upon host cells and used a recently developed aptamer-based proteomic platform (SOMAscan

Topics: Astrocytes; Astrocytoma; Autophagy; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Cytokines; Gene Expression Regulation, Neoplastic; Humans; Macrolides; Microtubule-Associated Proteins; Proteome; Sequestosome-1 Protein; Sirolimus