bacteriochlorin has been researched along with Head-and-Neck-Neoplasms* in 1 studies
1 other study(ies) available for bacteriochlorin and Head-and-Neck-Neoplasms
| Article | Year |
|---|---|
Synthesis, Tumor Specificity, and Photosensitizing Efficacy of Erlotinib-Conjugated Chlorins and Bacteriochlorins: Identification of a Highly Effective Candidate for Photodynamic Therapy of Cancer.
Erlotinib was covalently linked to 3-(1'-hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH) and structurally related chlorins and bacteriochlorins at different positions of the tetrapyrrole ring. The functional consequence of each modification was determined by quantifying the uptake and subcellular deposition of the erlotinib conjugates, cellular response to therapeutic light treatment in tissue cultures, and in eliminating of corresponding tumors grown as a xenograft in SCID mice. The experimental human cancer models the established cell lines UMUC3 (bladder), FaDu (hypopharynx), and primary cultures of head and neck tumor cells. The effectiveness of the compounds was compared to that of HPPH. Furthermore, specific functional contribution of the carboxylic acid side group at position 17 Topics: Animals; Cell Line, Tumor; Cell Survival; Coculture Techniques; Erlotinib Hydrochloride; Female; Head and Neck Neoplasms; Humans; Mice; Mice, SCID; Photochemotherapy; Photosensitizing Agents; Porphyrins; Stereoisomerism; Structure-Activity Relationship; Survival Rate | 2021 |