bacoside-a3 has been researched along with Neuroblastoma* in 1 studies
1 other study(ies) available for bacoside-a3 and Neuroblastoma
| Article | Year |
|---|---|
Comparative evaluation of four triterpenoid glycoside saponins of bacoside A in alleviating sub-cellular oxidative stress of N2a neuroblastoma cells.
To examine the neuroprotective property of triterpenoid glycoside saponins of Bacopa monnieri (L.) Wettst. bacoside A and its components against H. The cytoprotective effects of individual bacoside A components were evaluated towards oxidative stressed neuronal cells. Bacoside A was screened for neuronal cell viability (MTT assay) and change in intracellular reactive oxygen species (ROS), anti-apoptotic properties and mitochondrial membrane potential (MMP) using fluorescence microscopy.. Different bacoside A components showed decrease in N2a cell viability below 100 (%) after bacoside A concentration of 0.4 mg/ml. Further, cytoprotective effect of optimized dose of bacoside A was analysed for alleviating oxidative stressed, apoptosis and MMP in H. Amongst four different bacoside A components, bacoside A3 and bacopaside II showed comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS, suggesting better regulation of cyto-(neuronal) protection of N2a cells. Topics: Animals; Antioxidants; Cell Line, Tumor; Cell Survival; Cytoprotection; Glycosides; Hydrogen Peroxide; Mice; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidative Stress; Saponins; Triterpenes | 2018 |