Page last updated: 2024-10-23

baclofen and Tetanus

baclofen has been researched along with Tetanus in 32 studies

Tetanus: A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form.

Research Excerpts

ExcerptRelevanceReference
"After making a bibliographic search in our country and demonstrating the lack of original articles or communications on treatment with intrathecal baclofen for the generalized forms of tetanus, our objective is to present this treatment based on the successful experience of one clinical case."8.84[Tetanus treated with continuous baclofen intrathecal perfusion]. ( Almirall, J; Balanzó, X; Mauri, M; Miró, G; Solsona, M; Yébenes, JC, 2007)
"Spasms in patients with generalized tetanus can be suppressed by a spinal intrathecal infusion of baclofen."8.79Intrathecal baclofen in tetanus: four cases and a review of reported cases. ( Dressnandt, J; Klingelhöfer, J; Konstanzer, A; Pfab, R; Weinzierl, FX, 1997)
"A 6-months pregnant woman suffering from severe tetanus was successfully treated with intrathecal baclofen."7.71Intrathecal baclofen for severe tetanus in a pregnant woman. ( Benhamou, D; Engrand, N; Van De Perre, P; Vilain, G, 2001)
"We report the case of a 92-year-old man suffering from tetanus, who fully recovered after a myorelaxant treatment based solely on intrathecal baclofen administration."7.69[Continuous intrathecal injection of baclofen in generalized tetanus. A therapeutic alternative]. ( Clavel, M; Desachy, A; François, B; Gastinne, H; Salle, JY; Vignon, P, 1997)
"A study was conducted to evaluate repeated intrathecal injections of baclofen, without artificial ventilation, in the treatment of severe tetanus."7.68Treatment of severe tetanus by intrathecal injections of baclofen without artificial ventilation. ( Demazière, J; Gaye, M; Marcoux, L; Ndiaye, M; Saissy, JM; Seck, M; Vitris, M, 1992)
"Case report of a 48-year-old man with a severe tetanus managed with conventional treatment associated with subarachnoid administration of baclofen."7.68[Severe tetanus and intrathecal baclofen]. ( Diatta, B; Gohard, R; Raux, O; Saissy, JM, 1990)
"The current strategies involved in treating tetanus are discussed."6.43Tetanus in a subcutaneous drug abuser: ineffectiveness of intrathecal baclofen. ( Bellamy, MC; Thomas, RM, 2006)
"I."5.31[Value of intrathecal baclofen in the treatment of severe tetanus in the tropical milieu]. ( Benhamou, D; Engrand, N; Rouamba, A; Vilain, G, 2000)
"After making a bibliographic search in our country and demonstrating the lack of original articles or communications on treatment with intrathecal baclofen for the generalized forms of tetanus, our objective is to present this treatment based on the successful experience of one clinical case."4.84[Tetanus treated with continuous baclofen intrathecal perfusion]. ( Almirall, J; Balanzó, X; Mauri, M; Miró, G; Solsona, M; Yébenes, JC, 2007)
"Spasms in patients with generalized tetanus can be suppressed by a spinal intrathecal infusion of baclofen."4.79Intrathecal baclofen in tetanus: four cases and a review of reported cases. ( Dressnandt, J; Klingelhöfer, J; Konstanzer, A; Pfab, R; Weinzierl, FX, 1997)
"A 6-months pregnant woman suffering from severe tetanus was successfully treated with intrathecal baclofen."3.71Intrathecal baclofen for severe tetanus in a pregnant woman. ( Benhamou, D; Engrand, N; Van De Perre, P; Vilain, G, 2001)
"We report the case of a 92-year-old man suffering from tetanus, who fully recovered after a myorelaxant treatment based solely on intrathecal baclofen administration."3.69[Continuous intrathecal injection of baclofen in generalized tetanus. A therapeutic alternative]. ( Clavel, M; Desachy, A; François, B; Gastinne, H; Salle, JY; Vignon, P, 1997)
"A study was conducted to evaluate repeated intrathecal injections of baclofen, without artificial ventilation, in the treatment of severe tetanus."3.68Treatment of severe tetanus by intrathecal injections of baclofen without artificial ventilation. ( Demazière, J; Gaye, M; Marcoux, L; Ndiaye, M; Saissy, JM; Seck, M; Vitris, M, 1992)
"Case report of a 48-year-old man with a severe tetanus managed with conventional treatment associated with subarachnoid administration of baclofen."3.68[Severe tetanus and intrathecal baclofen]. ( Diatta, B; Gohard, R; Raux, O; Saissy, JM, 1990)
"Without timely diagnosis and proper treatment, severe tetanus is fatal (mortality is also influenced by the comorbidities of the patient)."2.50Pharmacological management of tetanus: an evidence-based review. ( Fernando, D; Rajapakse, S; Rodrigo, C, 2014)
"The current strategies involved in treating tetanus are discussed."2.43Tetanus in a subcutaneous drug abuser: ineffectiveness of intrathecal baclofen. ( Bellamy, MC; Thomas, RM, 2006)
"I."1.31[Value of intrathecal baclofen in the treatment of severe tetanus in the tropical milieu]. ( Benhamou, D; Engrand, N; Rouamba, A; Vilain, G, 2000)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19905 (15.63)18.7374
1990's13 (40.63)18.2507
2000's10 (31.25)29.6817
2010's4 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dapul, G1
Patel, P1
Pannu, T1
Meythaler, J1
Rodrigo, C1
Fernando, D1
Rajapakse, S1
Cabrerizo García, JL1
Homs Gimeno, CA1
Pacheco Arancibia, G1
Zalba Etayo, B1
Sánchez Marteles, M1
Livorsi, DJ1
Eaton, M1
Glass, J1
Montes, MI1
Hernández Ortiz, OH1
Guerra Palacio, A1
Santos, ML1
Mota-Miranda, A1
Alves-Pereira, A1
Gomes, A1
Correia, J1
Marçal, N1
Guglani, L1
Lodha, R1
Thomas, RM1
Bellamy, MC1
Solsona, M1
Miró, G1
Yébenes, JC1
Balanzó, X1
Almirall, J1
Mauri, M1
Brock, H1
Moosbauer, W1
Gabriel, C1
Necek, S1
Bidal, D1
Sicignano, A1
Lorini, FL1
Silbernt, PL1
Stolp-Smith, KA1
Pellanda, A1
Caldiroli, D1
Vaghi, GM1
Bonelli, S1
François, B1
Clavel, M1
Desachy, A1
Vignon, P1
Salle, JY1
Gastinne, H1
Dressnandt, J1
Konstanzer, A1
Weinzierl, FX1
Pfab, R1
Klingelhöfer, J1
Engrand, N5
Guerot, E1
Rouamba, A2
Vilain, G3
Boots, RJ1
Lipman, J1
O'Callaghan, J1
Scott, P1
Fraser, J1
Trampitsch, E1
Krumpholz, R1
Likar, R1
Oher, M1
Gulle, D1
Van De Perre, P1
Benhamou, D3
Kessler, HJ1
Patschke, D1
Saissy, JM5
Demazière, J4
Vitris, M4
Seck, M4
Marcoux, L4
Gaye, M2
Ndiaye, M3
Gaye, N1
Raux, O1
Gohard, R1
Diatta, B1
Müller, H3
Börner, U3
Zierski, J3
Hempelmann, G3
Romijn, JA1
van Lieshout, JJ1
Velis, DN1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial[NCT02999815]Phase 1/Phase 2272 participants (Actual)Interventional2017-02-13Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for baclofen and Tetanus

ArticleYear
Pharmacological management of tetanus: an evidence-based review.
    Critical care (London, England), 2014, Mar-26, Volume: 18, Issue:2

    Topics: Animals; Baclofen; Benzodiazepines; Disease Management; Evidence-Based Medicine; Humans; Magnesium S

2014
Tetanus in a subcutaneous drug abuser: ineffectiveness of intrathecal baclofen.
    Anaesthesia and intensive care, 2006, Volume: 34, Issue:6

    Topics: Adult; Baclofen; Clostridium tetani; Drug Administration Routes; Female; Heroin Dependence; Humans;

2006
[Tetanus treated with continuous baclofen intrathecal perfusion].
    Medicina intensiva, 2007, Volume: 31, Issue:4

    Topics: Aged; Baclofen; Humans; Male; Muscle Relaxants, Central; Spine; Tetanus

2007
Intrathecal baclofen in tetanus: four cases and a review of reported cases.
    Intensive care medicine, 1997, Volume: 23, Issue:8

    Topics: Adult; Aged; Antidotes; Baclofen; Female; Flumazenil; GABA Agonists; Humans; Injections, Spinal; Mal

1997

Trials

1 trial available for baclofen and Tetanus

ArticleYear
Intrathecal baclofen for the treatment of tetanus.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004, Feb-01, Volume: 38, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Baclofen; Female; Humans; Injections, Spinal; Male; Middle Aged; Mus

2004

Other Studies

27 other studies available for baclofen and Tetanus

ArticleYear
Treatment of severe tetanus with intrathecal baclofen via implantable infusion device: a case report.
    Neuromodulation : journal of the International Neuromodulation Society, 2014, Volume: 17, Issue:8

    Topics: Adult; Baclofen; Humans; Infusion Pumps, Implantable; Male; Muscle Relaxants, Central; Tetanus

2014
[Treatment of tetanus with intrathecal baclofen].
    Anales de medicina interna (Madrid, Spain : 1984), 2008, Volume: 25, Issue:7

    Topics: Aged, 80 and over; Baclofen; Humans; Injections, Spinal; Male; Muscle Relaxants, Central; Tetanus

2008
Generalized tetanus despite prior vaccination and a protective level of anti-tetanus antibodies.
    The American journal of the medical sciences, 2010, Volume: 339, Issue:2

    Topics: Adult; Anti-Bacterial Agents; Antibodies; Baclofen; Benzodiazepines; Humans; Immunoglobulins; Male;

2010
[Electroencephalographic burst-suppression pattern due to baclofen intoxication].
    Medicina intensiva, 2011, Volume: 35, Issue:9

    Topics: Baclofen; Coma; Drug Overdose; Electroencephalography; Emergencies; Fatal Outcome; Female; Humans; I

2011
Enteral baclofen in the management of tetanus-related spasms: case report and review of literature.
    Journal of tropical pediatrics, 2007, Volume: 53, Issue:2

    Topics: Baclofen; Child, Preschool; Humans; Male; Muscle Relaxants, Central; Spasm; Tetanus

2007
Treatment of severe tetanus by continuous intrathecal infusion of baclofen.
    Journal of neurology, neurosurgery, and psychiatry, 1995, Volume: 59, Issue:2

    Topics: Aged; Baclofen; Female; Humans; Injections, Spinal; Tetanus

1995
Does flumazenil antagonize baclofen?
    Intensive care medicine, 1994, Volume: 20, Issue:7

    Topics: Baclofen; Flumazenil; Humans; Tetanus

1994
Intrathecal baclofen in tetanus: alternative methods of administration.
    Anesthesiology, 1993, Volume: 79, Issue:1

    Topics: Baclofen; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Tetanus

1993
Treatment of severe tetanus by intrathecal infusion of baclofen.
    Intensive care medicine, 1993, Volume: 19, Issue:1

    Topics: Aged; Baclofen; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Male; Tetanus

1993
[Continuous intrathecal injection of baclofen in generalized tetanus. A therapeutic alternative].
    Presse medicale (Paris, France : 1983), 1997, Jun-28, Volume: 26, Issue:22

    Topics: Aged; Aged, 80 and over; Baclofen; Humans; Injections, Spinal; Male; Muscle Relaxants, Central; Teta

1997
[Continuous intrathecal baclofen in a case of generalized tetanus].
    Presse medicale (Paris, France : 1983), 1998, Feb-07, Volume: 27, Issue:5

    Topics: Baclofen; Humans; Infusions, Parenteral; Injections, Spinal; Muscle Relaxants, Central; Tetanus

1998
The efficacy of intrathecal baclofen in severe tetanus.
    Anesthesiology, 1999, Volume: 90, Issue:6

    Topics: Adolescent; Adult; Baclofen; Female; GABA Agonists; Humans; Injections, Spinal; Male; Middle Aged; T

1999
The treatment of tetanus with intrathecal baclofen.
    Anaesthesia and intensive care, 2000, Volume: 28, Issue:4

    Topics: Aged; Baclofen; Debridement; Female; Humans; Infusions, Intravenous; Male; Muscle Relaxants, Central

2000
[Continuous intrathecal administration of baclofen in severe tetanus].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2000, Volume: 35, Issue:8

    Topics: Aged; Baclofen; Critical Care; Humans; Injections, Spinal; Male; Muscle Relaxants, Central; Respirat

2000
Intrathecal baclofen for severe tetanus in a pregnant woman.
    European journal of anaesthesiology, 2001, Volume: 18, Issue:4

    Topics: Adolescent; Baclofen; Female; Humans; Infant, Newborn; Injections, Spinal; Muscle Relaxants, Central

2001
[Value of intrathecal baclofen in the treatment of severe tetanus in the tropical milieu].
    Medecine tropicale : revue du Corps de sante colonial, 2000, Volume: 60, Issue:4

    Topics: Adult; Baclofen; Burkina Faso; Cost-Benefit Analysis; Developing Countries; GABA Agonists; Humans; I

2000
About intrathecal baclofen in tetanus.
    Anaesthesia and intensive care, 2001, Volume: 29, Issue:3

    Topics: Baclofen; Humans; Injections, Spinal; Muscle Relaxants, Central; Tetanus

2001
[Histamine H2-receptor blockade and thrombosis prophylaxis with heparin in tetanus. A case report (author's transl)].
    Der Anaesthesist, 1978, Volume: 27, Issue:8

    Topics: Ampicillin; Baclofen; Cimetidine; Diazepam; Heparin; Histamine H2 Antagonists; Humans; Male; Middle

1978
Treatment of severe tetanus by intrathecal injections of baclofen without artificial ventilation.
    Intensive care medicine, 1992, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Africa; Age Factors; Aged; Baclofen; Blood Gas Analysis; Coma; Creatine Kinase; D

1992
Flumazenil counteracts intrathecal baclofen-induced central nervous system depression in tetanus.
    Anesthesiology, 1992, Volume: 76, Issue:6

    Topics: Adult; Baclofen; Central Nervous System; Depression, Chemical; Female; Flumazenil; Humans; Injection

1992
Intermittent intrathecal baclofen for severe tetanus.
    Lancet (London, England), 1991, Feb-16, Volume: 337, Issue:8738

    Topics: Adult; Baclofen; Developing Countries; Drug Administration Schedule; Female; Humans; Injections, Spi

1991
[Treatment of severe tetanus by repeated intrathecal injections of baclofen].
    Dakar medical, 1991, Volume: 36, Issue:1

    Topics: Adult; Africa; Baclofen; Female; Humans; Injections, Spinal; Tetanus

1991
[Severe tetanus and intrathecal baclofen].
    Annales francaises d'anesthesie et de reanimation, 1990, Volume: 9, Issue:2

    Topics: Baclofen; Creatine Kinase; Humans; Injections, Spinal; Male; Middle Aged; Tetanus

1990
Intrathecal baclofen in tetanus.
    Lancet (London, England), 1986, Feb-08, Volume: 1, Issue:8476

    Topics: Baclofen; Humans; Injections, Spinal; Tetanus

1986
Reversible coma due to intrathecal baclofen.
    Lancet (London, England), 1986, Sep-20, Volume: 2, Issue:8508

    Topics: Adult; Baclofen; Coma; Humans; Injections, Spinal; Male; Tetanus; Trismus

1986
Intrathecal baclofen in tetanus.
    Annals of the New York Academy of Sciences, 1988, Volume: 531

    Topics: Baclofen; Catheters, Indwelling; Electromyography; Humans; Infusion Pumps; Injections, Spinal; Muscl

1988
Intrathecal baclofen for treatment of tetanus-induced spasticity.
    Anesthesiology, 1987, Volume: 66, Issue:1

    Topics: Baclofen; Electroencephalography; Electromyography; Humans; Injections, Spinal; Male; Middle Aged; M

1987
chemdatabank.com