baclofen and Tetanus
baclofen has been researched along with Tetanus in 32 studies
Tetanus: A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "After making a bibliographic search in our country and demonstrating the lack of original articles or communications on treatment with intrathecal baclofen for the generalized forms of tetanus, our objective is to present this treatment based on the successful experience of one clinical case." | 8.84 | [Tetanus treated with continuous baclofen intrathecal perfusion]. ( Almirall, J; Balanzó, X; Mauri, M; Miró, G; Solsona, M; Yébenes, JC, 2007) |
| "Spasms in patients with generalized tetanus can be suppressed by a spinal intrathecal infusion of baclofen." | 8.79 | Intrathecal baclofen in tetanus: four cases and a review of reported cases. ( Dressnandt, J; Klingelhöfer, J; Konstanzer, A; Pfab, R; Weinzierl, FX, 1997) |
| "A 6-months pregnant woman suffering from severe tetanus was successfully treated with intrathecal baclofen." | 7.71 | Intrathecal baclofen for severe tetanus in a pregnant woman. ( Benhamou, D; Engrand, N; Van De Perre, P; Vilain, G, 2001) |
| "We report the case of a 92-year-old man suffering from tetanus, who fully recovered after a myorelaxant treatment based solely on intrathecal baclofen administration." | 7.69 | [Continuous intrathecal injection of baclofen in generalized tetanus. A therapeutic alternative]. ( Clavel, M; Desachy, A; François, B; Gastinne, H; Salle, JY; Vignon, P, 1997) |
| "A study was conducted to evaluate repeated intrathecal injections of baclofen, without artificial ventilation, in the treatment of severe tetanus." | 7.68 | Treatment of severe tetanus by intrathecal injections of baclofen without artificial ventilation. ( Demazière, J; Gaye, M; Marcoux, L; Ndiaye, M; Saissy, JM; Seck, M; Vitris, M, 1992) |
| "Case report of a 48-year-old man with a severe tetanus managed with conventional treatment associated with subarachnoid administration of baclofen." | 7.68 | [Severe tetanus and intrathecal baclofen]. ( Diatta, B; Gohard, R; Raux, O; Saissy, JM, 1990) |
| "The current strategies involved in treating tetanus are discussed." | 6.43 | Tetanus in a subcutaneous drug abuser: ineffectiveness of intrathecal baclofen. ( Bellamy, MC; Thomas, RM, 2006) |
| "I." | 5.31 | [Value of intrathecal baclofen in the treatment of severe tetanus in the tropical milieu]. ( Benhamou, D; Engrand, N; Rouamba, A; Vilain, G, 2000) |
| "After making a bibliographic search in our country and demonstrating the lack of original articles or communications on treatment with intrathecal baclofen for the generalized forms of tetanus, our objective is to present this treatment based on the successful experience of one clinical case." | 4.84 | [Tetanus treated with continuous baclofen intrathecal perfusion]. ( Almirall, J; Balanzó, X; Mauri, M; Miró, G; Solsona, M; Yébenes, JC, 2007) |
| "Spasms in patients with generalized tetanus can be suppressed by a spinal intrathecal infusion of baclofen." | 4.79 | Intrathecal baclofen in tetanus: four cases and a review of reported cases. ( Dressnandt, J; Klingelhöfer, J; Konstanzer, A; Pfab, R; Weinzierl, FX, 1997) |
| "A 6-months pregnant woman suffering from severe tetanus was successfully treated with intrathecal baclofen." | 3.71 | Intrathecal baclofen for severe tetanus in a pregnant woman. ( Benhamou, D; Engrand, N; Van De Perre, P; Vilain, G, 2001) |
| "We report the case of a 92-year-old man suffering from tetanus, who fully recovered after a myorelaxant treatment based solely on intrathecal baclofen administration." | 3.69 | [Continuous intrathecal injection of baclofen in generalized tetanus. A therapeutic alternative]. ( Clavel, M; Desachy, A; François, B; Gastinne, H; Salle, JY; Vignon, P, 1997) |
| "A study was conducted to evaluate repeated intrathecal injections of baclofen, without artificial ventilation, in the treatment of severe tetanus." | 3.68 | Treatment of severe tetanus by intrathecal injections of baclofen without artificial ventilation. ( Demazière, J; Gaye, M; Marcoux, L; Ndiaye, M; Saissy, JM; Seck, M; Vitris, M, 1992) |
| "Case report of a 48-year-old man with a severe tetanus managed with conventional treatment associated with subarachnoid administration of baclofen." | 3.68 | [Severe tetanus and intrathecal baclofen]. ( Diatta, B; Gohard, R; Raux, O; Saissy, JM, 1990) |
| "Without timely diagnosis and proper treatment, severe tetanus is fatal (mortality is also influenced by the comorbidities of the patient)." | 2.50 | Pharmacological management of tetanus: an evidence-based review. ( Fernando, D; Rajapakse, S; Rodrigo, C, 2014) |
| "The current strategies involved in treating tetanus are discussed." | 2.43 | Tetanus in a subcutaneous drug abuser: ineffectiveness of intrathecal baclofen. ( Bellamy, MC; Thomas, RM, 2006) |
| "I." | 1.31 | [Value of intrathecal baclofen in the treatment of severe tetanus in the tropical milieu]. ( Benhamou, D; Engrand, N; Rouamba, A; Vilain, G, 2000) |
Research
Studies (32)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.63) | 18.7374 |
| 1990's | 13 (40.63) | 18.2507 |
| 2000's | 10 (31.25) | 29.6817 |
| 2010's | 4 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Dapul, G | 1 |
| Patel, P | 1 |
| Pannu, T | 1 |
| Meythaler, J | 1 |
| Rodrigo, C | 1 |
| Fernando, D | 1 |
| Rajapakse, S | 1 |
| Cabrerizo García, JL | 1 |
| Homs Gimeno, CA | 1 |
| Pacheco Arancibia, G | 1 |
| Zalba Etayo, B | 1 |
| Sánchez Marteles, M | 1 |
| Livorsi, DJ | 1 |
| Eaton, M | 1 |
| Glass, J | 1 |
| Montes, MI | 1 |
| Hernández Ortiz, OH | 1 |
| Guerra Palacio, A | 1 |
| Santos, ML | 1 |
| Mota-Miranda, A | 1 |
| Alves-Pereira, A | 1 |
| Gomes, A | 1 |
| Correia, J | 1 |
| Marçal, N | 1 |
| Guglani, L | 1 |
| Lodha, R | 1 |
| Thomas, RM | 1 |
| Bellamy, MC | 1 |
| Solsona, M | 1 |
| Miró, G | 1 |
| Yébenes, JC | 1 |
| Balanzó, X | 1 |
| Almirall, J | 1 |
| Mauri, M | 1 |
| Brock, H | 1 |
| Moosbauer, W | 1 |
| Gabriel, C | 1 |
| Necek, S | 1 |
| Bidal, D | 1 |
| Sicignano, A | 1 |
| Lorini, FL | 1 |
| Silbernt, PL | 1 |
| Stolp-Smith, KA | 1 |
| Pellanda, A | 1 |
| Caldiroli, D | 1 |
| Vaghi, GM | 1 |
| Bonelli, S | 1 |
| François, B | 1 |
| Clavel, M | 1 |
| Desachy, A | 1 |
| Vignon, P | 1 |
| Salle, JY | 1 |
| Gastinne, H | 1 |
| Dressnandt, J | 1 |
| Konstanzer, A | 1 |
| Weinzierl, FX | 1 |
| Pfab, R | 1 |
| Klingelhöfer, J | 1 |
| Engrand, N | 5 |
| Guerot, E | 1 |
| Rouamba, A | 2 |
| Vilain, G | 3 |
| Boots, RJ | 1 |
| Lipman, J | 1 |
| O'Callaghan, J | 1 |
| Scott, P | 1 |
| Fraser, J | 1 |
| Trampitsch, E | 1 |
| Krumpholz, R | 1 |
| Likar, R | 1 |
| Oher, M | 1 |
| Gulle, D | 1 |
| Van De Perre, P | 1 |
| Benhamou, D | 3 |
| Kessler, HJ | 1 |
| Patschke, D | 1 |
| Saissy, JM | 5 |
| Demazière, J | 4 |
| Vitris, M | 4 |
| Seck, M | 4 |
| Marcoux, L | 4 |
| Gaye, M | 2 |
| Ndiaye, M | 3 |
| Gaye, N | 1 |
| Raux, O | 1 |
| Gohard, R | 1 |
| Diatta, B | 1 |
| Müller, H | 3 |
| Börner, U | 3 |
| Zierski, J | 3 |
| Hempelmann, G | 3 |
| Romijn, JA | 1 |
| van Lieshout, JJ | 1 |
| Velis, DN | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial[NCT02999815] | Phase 1/Phase 2 | 272 participants (Actual) | Interventional | 2017-02-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
4 reviews available for baclofen and Tetanus
| Article | Year |
|---|---|
Pharmacological management of tetanus: an evidence-based review.
Topics: Animals; Baclofen; Benzodiazepines; Disease Management; Evidence-Based Medicine; Humans; Magnesium S | 2014 |
Tetanus in a subcutaneous drug abuser: ineffectiveness of intrathecal baclofen.
Topics: Adult; Baclofen; Clostridium tetani; Drug Administration Routes; Female; Heroin Dependence; Humans; | 2006 |
[Tetanus treated with continuous baclofen intrathecal perfusion].
Topics: Aged; Baclofen; Humans; Male; Muscle Relaxants, Central; Spine; Tetanus | 2007 |
Intrathecal baclofen in tetanus: four cases and a review of reported cases.
Topics: Adult; Aged; Antidotes; Baclofen; Female; Flumazenil; GABA Agonists; Humans; Injections, Spinal; Mal | 1997 |
Trials
1 trial available for baclofen and Tetanus
| Article | Year |
|---|---|
Intrathecal baclofen for the treatment of tetanus.
Topics: Adult; Aged; Aged, 80 and over; Baclofen; Female; Humans; Injections, Spinal; Male; Middle Aged; Mus | 2004 |
Other Studies
27 other studies available for baclofen and Tetanus
| Article | Year |
|---|---|
Treatment of severe tetanus with intrathecal baclofen via implantable infusion device: a case report.
Topics: Adult; Baclofen; Humans; Infusion Pumps, Implantable; Male; Muscle Relaxants, Central; Tetanus | 2014 |
[Treatment of tetanus with intrathecal baclofen].
Topics: Aged, 80 and over; Baclofen; Humans; Injections, Spinal; Male; Muscle Relaxants, Central; Tetanus | 2008 |
Generalized tetanus despite prior vaccination and a protective level of anti-tetanus antibodies.
Topics: Adult; Anti-Bacterial Agents; Antibodies; Baclofen; Benzodiazepines; Humans; Immunoglobulins; Male; | 2010 |
[Electroencephalographic burst-suppression pattern due to baclofen intoxication].
Topics: Baclofen; Coma; Drug Overdose; Electroencephalography; Emergencies; Fatal Outcome; Female; Humans; I | 2011 |
Enteral baclofen in the management of tetanus-related spasms: case report and review of literature.
Topics: Baclofen; Child, Preschool; Humans; Male; Muscle Relaxants, Central; Spasm; Tetanus | 2007 |
Treatment of severe tetanus by continuous intrathecal infusion of baclofen.
Topics: Aged; Baclofen; Female; Humans; Injections, Spinal; Tetanus | 1995 |
Does flumazenil antagonize baclofen?
Topics: Baclofen; Flumazenil; Humans; Tetanus | 1994 |
Intrathecal baclofen in tetanus: alternative methods of administration.
Topics: Baclofen; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Tetanus | 1993 |
Treatment of severe tetanus by intrathecal infusion of baclofen.
Topics: Aged; Baclofen; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Male; Tetanus | 1993 |
[Continuous intrathecal injection of baclofen in generalized tetanus. A therapeutic alternative].
Topics: Aged; Aged, 80 and over; Baclofen; Humans; Injections, Spinal; Male; Muscle Relaxants, Central; Teta | 1997 |
[Continuous intrathecal baclofen in a case of generalized tetanus].
Topics: Baclofen; Humans; Infusions, Parenteral; Injections, Spinal; Muscle Relaxants, Central; Tetanus | 1998 |
The efficacy of intrathecal baclofen in severe tetanus.
Topics: Adolescent; Adult; Baclofen; Female; GABA Agonists; Humans; Injections, Spinal; Male; Middle Aged; T | 1999 |
The treatment of tetanus with intrathecal baclofen.
Topics: Aged; Baclofen; Debridement; Female; Humans; Infusions, Intravenous; Male; Muscle Relaxants, Central | 2000 |
[Continuous intrathecal administration of baclofen in severe tetanus].
Topics: Aged; Baclofen; Critical Care; Humans; Injections, Spinal; Male; Muscle Relaxants, Central; Respirat | 2000 |
Intrathecal baclofen for severe tetanus in a pregnant woman.
Topics: Adolescent; Baclofen; Female; Humans; Infant, Newborn; Injections, Spinal; Muscle Relaxants, Central | 2001 |
[Value of intrathecal baclofen in the treatment of severe tetanus in the tropical milieu].
Topics: Adult; Baclofen; Burkina Faso; Cost-Benefit Analysis; Developing Countries; GABA Agonists; Humans; I | 2000 |
About intrathecal baclofen in tetanus.
Topics: Baclofen; Humans; Injections, Spinal; Muscle Relaxants, Central; Tetanus | 2001 |
[Histamine H2-receptor blockade and thrombosis prophylaxis with heparin in tetanus. A case report (author's transl)].
Topics: Ampicillin; Baclofen; Cimetidine; Diazepam; Heparin; Histamine H2 Antagonists; Humans; Male; Middle | 1978 |
Treatment of severe tetanus by intrathecal injections of baclofen without artificial ventilation.
Topics: Adolescent; Adult; Africa; Age Factors; Aged; Baclofen; Blood Gas Analysis; Coma; Creatine Kinase; D | 1992 |
Flumazenil counteracts intrathecal baclofen-induced central nervous system depression in tetanus.
Topics: Adult; Baclofen; Central Nervous System; Depression, Chemical; Female; Flumazenil; Humans; Injection | 1992 |
Intermittent intrathecal baclofen for severe tetanus.
Topics: Adult; Baclofen; Developing Countries; Drug Administration Schedule; Female; Humans; Injections, Spi | 1991 |
[Treatment of severe tetanus by repeated intrathecal injections of baclofen].
Topics: Adult; Africa; Baclofen; Female; Humans; Injections, Spinal; Tetanus | 1991 |
[Severe tetanus and intrathecal baclofen].
Topics: Baclofen; Creatine Kinase; Humans; Injections, Spinal; Male; Middle Aged; Tetanus | 1990 |
Intrathecal baclofen in tetanus.
Topics: Baclofen; Humans; Injections, Spinal; Tetanus | 1986 |
Reversible coma due to intrathecal baclofen.
Topics: Adult; Baclofen; Coma; Humans; Injections, Spinal; Male; Tetanus; Trismus | 1986 |
Intrathecal baclofen in tetanus.
Topics: Baclofen; Catheters, Indwelling; Electromyography; Humans; Infusion Pumps; Injections, Spinal; Muscl | 1988 |
Intrathecal baclofen for treatment of tetanus-induced spasticity.
Topics: Baclofen; Electroencephalography; Electromyography; Humans; Injections, Spinal; Male; Middle Aged; M | 1987 |