baclofen has been researched along with Status Epilepticus in 12 studies
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present case demonstrates the importance of considering baclofen overdosage in cases of severe coma in combination with an abnormal EEG pattern and sinus bradycardia with normal blood pressure levels, in particular as the substance is popular in internet reports promoting baclofen as a rather harmless "fun drug." | 7.78 | Baclofen intoxication: a "fun drug" causing deep coma and nonconvulsive status epilepticus--a case report and review of the literature. ( Bangen, U; Bender, K; Eifinger, F; Herkenrath, P; Hoemberg, M; Oberthuer, A; Roth, B; Rothschild, M; Weißhaar, GF, 2012) |
| "Baclofen is an agonist of peripheral and central B gamma-aminobutyric acid receptors, whose activation causes a myorelaxation and a powerfull depression of the central nervous system." | 5.43 | Self-induced drug intoxication in baclofen: of the calm hypotonic coma in the status epilepticus. ( Aries, P; Di Constanzo, L; Drouillard, I; Montelescaut, É; Pessey, F; Sapin, J; Thill, C; Vaillant, C, 2016) |
| "The present case demonstrates the importance of considering baclofen overdosage in cases of severe coma in combination with an abnormal EEG pattern and sinus bradycardia with normal blood pressure levels, in particular as the substance is popular in internet reports promoting baclofen as a rather harmless "fun drug." | 3.78 | Baclofen intoxication: a "fun drug" causing deep coma and nonconvulsive status epilepticus--a case report and review of the literature. ( Bangen, U; Bender, K; Eifinger, F; Herkenrath, P; Hoemberg, M; Oberthuer, A; Roth, B; Rothschild, M; Weißhaar, GF, 2012) |
| "Baclofen is an agonist of peripheral and central B gamma-aminobutyric acid receptors, whose activation causes a myorelaxation and a powerfull depression of the central nervous system." | 1.43 | Self-induced drug intoxication in baclofen: of the calm hypotonic coma in the status epilepticus. ( Aries, P; Di Constanzo, L; Drouillard, I; Montelescaut, É; Pessey, F; Sapin, J; Thill, C; Vaillant, C, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thill, C | 1 |
| Di Constanzo, L | 1 |
| Pessey, F | 1 |
| Aries, P | 1 |
| Montelescaut, É | 1 |
| Sapin, J | 1 |
| Vaillant, C | 1 |
| Drouillard, I | 1 |
| Specchio, N | 1 |
| Carotenuto, A | 1 |
| Trivisano, M | 1 |
| Cappelletti, S | 1 |
| Vigevano, F | 1 |
| Fusco, L | 1 |
| Weißhaar, GF | 1 |
| Hoemberg, M | 1 |
| Bender, K | 1 |
| Bangen, U | 1 |
| Herkenrath, P | 1 |
| Eifinger, F | 1 |
| Rothschild, M | 1 |
| Roth, B | 1 |
| Oberthuer, A | 1 |
| Chandler, KE | 1 |
| Princivalle, AP | 1 |
| Fabian-Fine, R | 1 |
| Bowery, NG | 1 |
| Kullmann, DM | 1 |
| Walker, MC | 1 |
| Hyser, CL | 1 |
| Drake, ME | 1 |
| Terrence, CF | 1 |
| Fromm, GH | 1 |
| Zak, R | 1 |
| Solomon, G | 1 |
| Petito, F | 1 |
| Labar, D | 2 |
| Bekenstein, JW | 1 |
| Lothman, EW | 1 |
| George, B | 1 |
| Kulkarni, SK | 1 |
| Solomon, GE | 1 |
| Moshé, SL | 1 |
| Sperber, EF | 1 |
| Brown, LL | 1 |
| Tempel, A | 1 |
| Saltuari, L | 1 |
| Marosi, MJ | 1 |
| Kofler, M | 1 |
| Bauer, G | 1 |
12 other studies available for baclofen and Status Epilepticus
| Article | Year |
|---|---|
Self-induced drug intoxication in baclofen: of the calm hypotonic coma in the status epilepticus.
Topics: Baclofen; Coma; Drug Overdose; Female; France; Humans; Middle Aged; Muscle Hypotonia; Self-Injurious | 2016 |
Prolonged episode of dystonia and dyskinesia resembling status epilepticus following acute intrathecal baclofen withdrawal.
Topics: Baclofen; Child; Dyskinesias; Dystonia; Electroencephalography; Female; Humans; Magnetic Resonance I | 2011 |
Baclofen intoxication: a "fun drug" causing deep coma and nonconvulsive status epilepticus--a case report and review of the literature.
Topics: Adolescent; Baclofen; Bradycardia; Coma; Drug Overdose; Humans; Male; Muscle Relaxants, Central; Sei | 2012 |
Plasticity of GABA(B) receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus.
Topics: Animals; Baclofen; Cells, Cultured; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobu | 2003 |
Status epilepticus after baclofen withdrawal.
Topics: Baclofen; Humans; Hypoxia, Brain; Male; Middle Aged; Status Epilepticus; Substance Withdrawal Syndro | 1984 |
Complications of baclofen withdrawal.
Topics: Adolescent; Adult; Baclofen; Epilepsy, Tonic-Clonic; Female; Hallucinations; Humans; Male; Middle Ag | 1981 |
Baclofen-induced generalized nonconvulsive status epilepticus.
Topics: Baclofen; Electroencephalography; Female; Humans; Middle Aged; Multiple Sclerosis; Status Epilepticu | 1994 |
Dormancy of inhibitory interneurons in a model of temporal lobe epilepsy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Baclofen; Electric Stimulation; Ep | 1993 |
Protective effects of GABAergic drugs and other anticonvulsants in lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Baclofen; Clonazepam; Diazepam; Dizocilpine Maleate; Ethanol; GABA Agents; | 1996 |
Hypothesis that tiagabine-induced NCSE is associated with GABAergic hyperfunction, with GABA(B) receptors playing a critical role, is supported by a case of generalized NCSE induced by baclofen.
Topics: Anticonvulsants; Baclofen; Humans; Nipecotic Acids; Receptors, GABA; Status Epilepticus; Tiagabine | 1998 |
Age-dependent changes in substantia nigra GABA-mediated seizure suppression.
Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Dominance, Cerebral; Energy Metabolism; Flu | 1992 |
Status epilepticus complicating intrathecal baclofen overdose.
Topics: Adolescent; Animals; Baclofen; Drug Overdose; Humans; Rats; Status Epilepticus | 1992 |