baclofen has been researched along with Spastic Paraplegia, Hereditary in 15 studies
Spastic Paraplegia, Hereditary: A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if continuous intrathecal baclofen infusion (CIBI) would provide continuous relief of spasticity in patients with spasticity of cerebral origin, especially children with cerebral palsy." | 3.68 | Continuous intrathecal baclofen infusion for spasticity of cerebral origin. ( Albright, AL; Barron, WB; Fasick, MP; Janosky, J; Polinko, P, 1993) |
| "The main inclusion criteria were: spastic paraparesis with a negative laboratory and imaging work-up (apart from spinal cord atrophy), unsuccessful trial of oral anti-spasticity drugs." | 2.79 | Intrathecal baclofen therapy for the symptomatic treatment of hereditary spastic paraplegia. ( Boutos, N; Boviatsis, E; Dalivigka, Z; Flaskas, T; Gatzonis, S; Korfias, S; Margetis, K; Sakas, D; Siatouni, A; Stranjalis, G; Themistocleous, M, 2014) |
| "We report a case of Spastic paraplegia 8 (SPG8) with a novel mutation of KIAA0196 gene." | 1.48 | A novel KIAA0196 mutation in a Chinese patient with spastic paraplegia 8: A case report. ( Chen, Z; Li, S; Ma, L; Qin, W; Shi, Y; Zhang, J, 2018) |
| "Patients with hereditary spastic paraplegia (HSP), a degenerative central nervous system disorder characterized by progressive lower extremity spasticity, frequently experience symptoms of voiding dysfunction." | 1.29 | Voiding dysfunction in patients with spastic paraplegia: urodynamic evaluation and response to continuous intrathecal baclofen. ( Bushman, W; Meythaler, JM; Steers, WD, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (53.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Coulter, IC | 1 |
| Lohkamp, LN | 1 |
| Ibrahim, GM | 1 |
| Ma, L | 1 |
| Shi, Y | 1 |
| Chen, Z | 1 |
| Li, S | 1 |
| Qin, W | 1 |
| Zhang, J | 1 |
| Margetis, K | 1 |
| Korfias, S | 1 |
| Boutos, N | 1 |
| Gatzonis, S | 1 |
| Themistocleous, M | 1 |
| Siatouni, A | 1 |
| Dalivigka, Z | 1 |
| Flaskas, T | 1 |
| Stranjalis, G | 1 |
| Boviatsis, E | 1 |
| Sakas, D | 1 |
| Heetla, HW | 1 |
| Halbertsma, JP | 1 |
| Dekker, R | 1 |
| Staal, MJ | 1 |
| van Laar, T | 1 |
| Klebe, S | 1 |
| Stolze, H | 1 |
| Kopper, F | 1 |
| Lorenz, D | 1 |
| Wenzelburger, R | 1 |
| Deuschl, G | 1 |
| Volkmann, J | 1 |
| Contino, G | 1 |
| Novelli, G | 1 |
| Bushman, W | 1 |
| Steers, WD | 2 |
| Meythaler, JM | 2 |
| Broggi, G | 2 |
| Servello, D | 2 |
| Brock, S | 1 |
| Dones, I | 2 |
| Albright, AL | 1 |
| Barron, WB | 1 |
| Fasick, MP | 1 |
| Polinko, P | 1 |
| Janosky, J | 1 |
| Molteni, F | 1 |
| Mariani, G | 1 |
| Detrembleur, C | 1 |
| Lejeune, TM | 1 |
| Plaghki, L | 1 |
| Dan, B | 1 |
| Cheron, G | 1 |
| Saltuari, L | 1 |
| Kronenberg, M | 1 |
| Marosi, MJ | 1 |
| Kofler, M | 1 |
| Russegger, L | 1 |
| Rifici, C | 1 |
| Bramanti, P | 1 |
| Gerstenbrand, F | 1 |
| Tuel, SM | 1 |
| Cross, LL | 1 |
| Sesco, DC | 1 |
| Haworth, CS | 1 |
| Vanneste, J | 1 |
| Augustijn, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevalence of Comorbid Spasticity and Urinary Incontinence in Residents of a Long-Term Care Facility[NCT03250988] | 60 participants (Actual) | Observational | 2018-01-30 | Completed | |||
| A Randomized, Placebo Controlled Trial of Botulinum Toxin for Paratonic Rigidity in People With Advanced Cognitive Impairment[NCT02212119] | Phase 2 | 10 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| Study of the Efficacy of the Selective Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic Patient Following the ICF Model. A Prospective, Randomized, Controlled Single Blind Study[NCT00825097] | Phase 3 | 16 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for baclofen and Spastic Paraplegia, Hereditary
| Article | Year |
|---|---|
Hereditary spastic paraplegia: clinical genomics and pharmacogenetic perspectives.
Topics: Baclofen; GABA Agonists; Genetic Linkage; Humans; Pharmacogenetics; Spastic Paraplegia, Hereditary | 2006 |
5 trials available for baclofen and Spastic Paraplegia, Hereditary
| Article | Year |
|---|---|
Intrathecal baclofen therapy for the symptomatic treatment of hereditary spastic paraplegia.
Topics: Adult; Baclofen; Female; Humans; Infusion Pumps, Implantable; Injections, Spinal; Male; Middle Aged; | 2014 |
Objective assessment of gait after intrathecal baclofen in hereditary spastic paraplegia.
Topics: Baclofen; Biomechanical Phenomena; GABA Agonists; Gait; Humans; Injections, Spinal; Spastic Parapleg | 2005 |
The treatment of spasticity by intrathecal administration of baclofen: a preliminary personal experience.
Topics: Adult; Baclofen; Female; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Male; Middle Aged; | 1993 |
Long-term intrathecal baclofen treatment in supraspinal spasticity.
Topics: Adult; Baclofen; Brain Injuries; Cerebral Palsy; Humans; Infusion Pumps; Injections, Spinal; Male; M | 1992 |
Intrathecal baclofen in hereditary spastic paraparesis.
Topics: Baclofen; Double-Blind Method; Humans; Infusion Pumps, Implantable; Infusions, Parenteral; Injection | 1992 |
9 other studies available for baclofen and Spastic Paraplegia, Hereditary
| Article | Year |
|---|---|
Intrathecal baclofen for hereditary spastic paraplegia (HSP).
Topics: Baclofen; Humans; Injections, Spinal; Spastic Paraplegia, Hereditary | 2020 |
A novel KIAA0196 mutation in a Chinese patient with spastic paraplegia 8: A case report.
Topics: Asian People; Baclofen; Child; Electromyography; Humans; Male; Muscle Relaxants, Central; Neural Con | 2018 |
Improved gait performance in a patient with hereditary spastic paraplegia after a continuous intrathecal baclofen test infusion and subsequent pump implantation: a case report.
Topics: Baclofen; Electromyography; GABA-B Receptor Agonists; Gait Disorders, Neurologic; Humans; Infusion P | 2015 |
Voiding dysfunction in patients with spastic paraplegia: urodynamic evaluation and response to continuous intrathecal baclofen.
Topics: Adult; Baclofen; Humans; Injections, Spinal; Male; Middle Aged; Spastic Paraplegia, Hereditary; Urin | 1993 |
Continuous intrathecal baclofen infusion for spasticity of cerebral origin.
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Humans; Infusion Pumps, Implan | 1993 |
A neurophysiological method for the evaluation of motor performance in spastic walking patients.
Topics: Adult; Baclofen; Electromyography; Female; Humans; Isometric Contraction; Male; Middle Aged; Motor S | 1995 |
[Objective measures of muscle stiffness in the ankle. Evaluation of the effect of intrathecal injection of baclofen in spastic patients].
Topics: Adult; Ankle; Baclofen; Humans; Injections, Spinal; Male; Muscle Relaxants, Central; Spastic Paraple | 1998 |
Intrathecal baclofen normalizes motor strategy for squatting in familial spastic paraplegia: a case study.
Topics: Adult; Baclofen; Humans; Injections, Spinal; Male; Movement; Muscle Relaxants, Central; Spastic Para | 2000 |
Intrathecal baclofen for treatment of spasticity.
Topics: Adult; Aged; Baclofen; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Male; Paraplegi | 1990 |