baclofen has been researched along with Seizures in 103 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Baclofen toxicity results from intentional self-poisoning (acute baclofen poisoning) or accumulation of therapeutic dose in the setting of impaired kidney function." | 9.12 | Recommendations from the EXTRIP workgroup on extracorporeal treatment for baclofen poisoning. ( Berling, I; Doi, K; Galvao, T; Ghannoum, M; Gosselin, S; Hoffman, RS; Lavergne, V; Lewington, A; Nolin, TD; Roberts, DM, 2021) |
| "Insertion of an intrathecal baclofen (ITB) pump can provide significant benefits in patients with cerebral palsy (CP)." | 7.96 | Evaluation of Risk Factors for Cerebrospinal Leakage in Pediatric Patients With Cerebral Palsy Treated With Intrathecal Baclofen. ( Imerci, A; Miller, F; Rogers, KJ; Sees, JP, 2020) |
| "The present case demonstrates the importance of considering baclofen overdosage in cases of severe coma in combination with an abnormal EEG pattern and sinus bradycardia with normal blood pressure levels, in particular as the substance is popular in internet reports promoting baclofen as a rather harmless "fun drug." | 7.78 | Baclofen intoxication: a "fun drug" causing deep coma and nonconvulsive status epilepticus--a case report and review of the literature. ( Bangen, U; Bender, K; Eifinger, F; Herkenrath, P; Hoemberg, M; Oberthuer, A; Roth, B; Rothschild, M; Weißhaar, GF, 2012) |
| "Methylmalonic acid (MMA) is an endogenous convulsing compound that accumulates in methylmalonic acidemia, an inborn error of the metabolism characterized by severe neurological dysfunction, including seizures." | 7.74 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "Oral and intrathecal baclofen (ITB) have been associated with epileptic seizures." | 7.73 | Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen. ( Bethoux, FA; Boulis, N; Kellinghaus, C; Loddenkemper, T; Schuele, SU; Shook, SJ, 2005) |
| "We report the occurrence of recurrent severe generalized seizures during induction of anesthesia with propofol in a patient with syringomyelia receiving baclofen for flexor spasms undergoing neurosurgery." | 7.73 | Severe seizures during propofol induction in a patient with syringomyelia receiving baclofen. ( Manikandan, S; Neema, PK; Rathod, RC; Sinha, PK, 2005) |
| "Effects of the GABA(B) receptor agonist ((+/-)-baclofen), antagonist (phaclofen), and their combination were tested against clonic seizures induced by cocaine (75 mg/kg)." | 7.72 | Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice. ( Gasior, M; Kaminski, R; Witkin, JM, 2004) |
| "The effects of drugs affecting GABA and glutamic acid receptors on theophylline-induced seizures were investigated in mice." | 7.70 | Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. ( Amabeoku, GJ, 1999) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 7.69 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| " The influence of some GABAergic agents on tonic seizures elicited by chloroquine was investigated in mice." | 7.68 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| "The effects of some GABAergic agents on seizures induced by quinine were studied in mice." | 7.68 | Effects of some GABAergic agents on quinine-induced seizures in mice. ( Amabeoku, GJ; Chikuni, O, 1992) |
| "The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice." | 7.68 | Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents. ( Amabeoku, GJ; Chikuni, O, 1993) |
| "BHF177 exhibited pro-convulsion properties only in mice, but not in rats, indicating that this effect may be species-specific." | 5.39 | Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. ( Cates-Gatto, C; Finn, MG; Kaczanowska, K; Li, X; Markou, A; Risbrough, VB; Roberts, AJ, 2013) |
| "Baclofen (Lioresal) is a drug of choice to treat spasticity and is increasingly being administered intrathecally via an implantable pump in cases refractory to oral therapy." | 5.32 | Intrathecal baclofen withdrawal mimicking sepsis. ( Amin, Y; Kao, LW; Kirk, MA; Turner, MS, 2003) |
| "After several reports of new-onset seizures in children treated with oral baclofen at our institution, we reviewed our experience regarding possible effects of baclofen on seizure induction in a childhood movement disorders program over a 2-year period." | 5.32 | Oral baclofen in cerebral palsy: possible seizure potentiation? ( Hansel, CR; Hansel, DE; Hoon, AH; Johnston, MV; Levey, EB; Madden, L; Reinhardt, EM; Shindle, MK, 2003) |
| "tended to decrease seizure intensity and at a dose of 10 mg/kg was ineffective at all." | 5.29 | Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice. ( Georgiev, VP; Kambourova, TS; Lazarova, MB, 1995) |
| "Behavioral characteristics of seizures have age-dependent features, which suggests that effective treatment of seizures may be age-specific as well." | 5.29 | Age-dependent effects of gamma-aminobutyric acid agents on flurothyl seizures. ( Moshé, SL; Ortíz, J; Ptachewich, Y; Shinnar, S; Velísek, L; Velísková, J, 1995) |
| "In mice, tonic convulsive seizure induced by intravenous administration of caffeine (adenosine A1, A2 receptors antagonist) was significantly potentiated by any one of L-PIA (adenosine A1 receptor agonist), NECA (adenosine A2 receptor agonist) and 2-ClAd (adenosine A1, A2 receptors agonist)." | 5.28 | [Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice]. ( Inano, S, 1992) |
| "Baclofen toxicity results from intentional self-poisoning (acute baclofen poisoning) or accumulation of therapeutic dose in the setting of impaired kidney function." | 5.12 | Recommendations from the EXTRIP workgroup on extracorporeal treatment for baclofen poisoning. ( Berling, I; Doi, K; Galvao, T; Ghannoum, M; Gosselin, S; Hoffman, RS; Lavergne, V; Lewington, A; Nolin, TD; Roberts, DM, 2021) |
| " He developed acute kidney injury at hospital secondary to vancomycin use, and mental status declined." | 5.05 | Encephalopathy of Unknown Origin in a Baclofen Patient: Case Report and Review of the Literature. ( Abraham, M; Behmer Hansen, R; Gold, J; Lad, M; Mammis, A; Zhao, K, 2020) |
| "Insertion of an intrathecal baclofen (ITB) pump can provide significant benefits in patients with cerebral palsy (CP)." | 3.96 | Evaluation of Risk Factors for Cerebrospinal Leakage in Pediatric Patients With Cerebral Palsy Treated With Intrathecal Baclofen. ( Imerci, A; Miller, F; Rogers, KJ; Sees, JP, 2020) |
| " Furthermore, we successfully induced absence seizure by injecting seizure-inducing drugs (baclofen) at a local target region and observed distinctive changes in neural signal patterns." | 3.81 | A multichannel neural probe with embedded microfluidic channels for simultaneous in vivo neural recording and drug delivery. ( Cho, IJ; Kim, J; Lee, CJ; Lee, HJ; Son, Y; Yoon, ES, 2015) |
| "Previous studies have demonstrated that kainic acid (KA)-induced seizures can cause the enhancement of excitation and lead to neuronal death in rat hippocampus." | 3.78 | Neuroprotection of co-activation of GABA receptors by preventing caspase-3 denitrosylation in KA-induced seizures. ( Li, C; Wei, XW; Wu, YP; Xu, B; Yan, H; Zhang, GY, 2012) |
| "The present case demonstrates the importance of considering baclofen overdosage in cases of severe coma in combination with an abnormal EEG pattern and sinus bradycardia with normal blood pressure levels, in particular as the substance is popular in internet reports promoting baclofen as a rather harmless "fun drug." | 3.78 | Baclofen intoxication: a "fun drug" causing deep coma and nonconvulsive status epilepticus--a case report and review of the literature. ( Bangen, U; Bender, K; Eifinger, F; Herkenrath, P; Hoemberg, M; Oberthuer, A; Roth, B; Rothschild, M; Weißhaar, GF, 2012) |
| "Epileptic seizures associated with intrathecal baclofen (ITB) application have been observed in patients with traumatic brain injury." | 3.77 | Seizure after intrathecal baclofen bolus in a multiple sclerosis patient treated with oxcarbazepine. ( Bramanti, P; D'Aleo, G; Kofler, M; Rifici, C; Saltuari, L; Sessa, E, 2011) |
| "Past work has demonstrated that kainic acid (KA)-induced seizures could cause the enhancement of excitation and lead to neuronal death in rat hippocampus." | 3.76 | Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure. ( Han, D; Li, C; Pei, DS; Wang, WW; Xu, B; Yu, HM; Yu, XJ; Zhang, GY; Zhu, J, 2010) |
| "Methylmalonic acid (MMA) is an endogenous convulsing compound that accumulates in methylmalonic acidemia, an inborn error of the metabolism characterized by severe neurological dysfunction, including seizures." | 3.74 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "We report the occurrence of recurrent severe generalized seizures during induction of anesthesia with propofol in a patient with syringomyelia receiving baclofen for flexor spasms undergoing neurosurgery." | 3.73 | Severe seizures during propofol induction in a patient with syringomyelia receiving baclofen. ( Manikandan, S; Neema, PK; Rathod, RC; Sinha, PK, 2005) |
| "Oral and intrathecal baclofen (ITB) have been associated with epileptic seizures." | 3.73 | Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen. ( Bethoux, FA; Boulis, N; Kellinghaus, C; Loddenkemper, T; Schuele, SU; Shook, SJ, 2005) |
| "Effects of the GABA(B) receptor agonist ((+/-)-baclofen), antagonist (phaclofen), and their combination were tested against clonic seizures induced by cocaine (75 mg/kg)." | 3.72 | Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice. ( Gasior, M; Kaminski, R; Witkin, JM, 2004) |
| "The effects of drugs affecting GABA and glutamic acid receptors on theophylline-induced seizures were investigated in mice." | 3.70 | Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. ( Amabeoku, GJ, 1999) |
| "The possible anticonvulsant action of baclofen, a GABAB (gamma-aminobutyric acid) receptor agonist, was studied using two types of motor seizures (minimal, clonic and generalized tonicoclonic) elicited by pentylenetetrazol in adult rats and rat pups, 7, 12, 18, and 25 days old." | 3.69 | Moderate anticonvulsant action of baclofen does not change during development. ( Haugvicová, R; Kubová, H; Mares, P, 1996) |
| " also induced seizures after treatment with a subthreshold dose of pentylenetetrazole (40 mg/kg i." | 3.69 | Comparative in vivo and in vitro studies with the potent GABAB receptor antagonist, CGP 56999A. ( Badran, S; Olpe, HR; Schmutz, M, 1997) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 3.69 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| "The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice." | 3.68 | Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents. ( Amabeoku, GJ; Chikuni, O, 1993) |
| " Injections of the GABAA-agonist piperidine-4-sulfonic acid and the GABAB-agonist (-)baclofen in the CeM markedly facilitated myoclonic and clonic seizures, but had different effects on tonic seizures." | 3.68 | The central medial nucleus: thalamic site of seizure regulation. ( Ferrendelli, JA; Miller, JW, 1990) |
| "This study determined the effects of discrete microinjections of GABA agonists in the cholinergic nuclei of the pontomesencephalic tegmentum on spontaneous behavior and seizures induced by intravenous pentylenetetrazol, bicuculline or strychnine, in the rat." | 3.68 | The role of the laterodorsal tegmental nucleus of the rat in experimental seizures. ( Bardgett, ME; Gray, BC; Miller, JW, 1991) |
| " The influence of some GABAergic agents on tonic seizures elicited by chloroquine was investigated in mice." | 3.68 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| "The effects of some GABAergic agents on seizures induced by quinine were studied in mice." | 3.68 | Effects of some GABAergic agents on quinine-induced seizures in mice. ( Amabeoku, GJ; Chikuni, O, 1992) |
| "Baclofen and phenobarbital were tested for anticonvulsant efficacy against limbic seizures produced by i." | 3.67 | Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome. ( Armstrong, DR; Ault, B; Gruenthal, M; Nadler, JV, 1986) |
| "Pain is one of the most common symptoms in children and young people (CYP) with life-limiting conditions (LLCs) which include a wide range of diagnoses including cancer." | 2.52 | Pharmacological interventions for pain in children and adolescents with life-limiting conditions. ( Beecham, E; Bluebond-Langner, M; Candy, B; Howard, R; Jones, L; Laddie, J; McCulloch, R; Rees, H; Vickerstaff, V, 2015) |
| "Drug-induced seizures are in view of a constantly ageing population and increasingly frequent polypharmacotherapy an increasing problem in daily routine praxis." | 2.49 | [Drug-induced seizures]. ( Block, F; Dafotakis, M, 2013) |
| "Agitation, convulsions and ataxia were also seen." | 2.39 | Baclofen poisoning in children. ( Cooke, DE; Glasstone, MA, 1994) |
| "Drug-induced convulsions-often caused by the inhibition of GABA receptors and stimulation of glutamate receptors-are difficult to predict in animals." | 1.91 | Motor-evoked potentials after focal electrical stimulation predict drug-induced convulsion potentials in rats. ( Fujiki, M; Kuga, K; Ozaki, H, 2023) |
| "Dystonia is associated with severe sweating and was confused with a seizure event." | 1.72 | Status Dystonicus with Atypical Presentation in Developmentally Delay Child: A Case Report. ( Dahal, S; Khati, N; Maharjan, G; Yadav, P; Yadav, SK, 2022) |
| " Baclofen is known to produce anticonvulsant effects in the DBA/2J mouse audiogenic seizure test (AGS), suggesting it may be a suitable assay for assessing pharmacodynamic effects." | 1.43 | Anticonvulsant effects of structurally diverse GABA(B) positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model. ( Brown, JW; Ma, J; Moeller, A; Nimmrich, V; Rueter, LE; Schmidt, M; Turner, SC; van der Kam, E; Zhang, M, 2016) |
| "Seizure was confirmed using electroencephalography (EEG) data obtained from the Laxtha EEG-monitoring device in the EEG recording room and EEG was monitored 5-15 min after PTZ injection." | 1.39 | Decreased GABABR expression and increased neuronal cell death in developing rat brain after PTZ-induced seizure. ( Al-Qahtani, MH; Ansari, SA; Bibi, F; Karim, S; Kim, MO; Naseer, MI; Ullah, I; Ullah, N, 2013) |
| "BHF177 exhibited pro-convulsion properties only in mice, but not in rats, indicating that this effect may be species-specific." | 1.39 | Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. ( Cates-Gatto, C; Finn, MG; Kaczanowska, K; Li, X; Markou, A; Risbrough, VB; Roberts, AJ, 2013) |
| " Finally, the chronic administration of STX209 in juvenile mice corrected the increased spine density in Fmr1-knockout mice without affecting spine density in wild-type mice." | 1.38 | Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen. ( Bear, MF; Brynczka, C; Carpenter, RL; Hammond, RS; Healy, AM; Henderson, C; Kind, PC; Kinoshita, MN; Paylor, R; Postma, FR; Rush, R; Shumway, M; Thomas, A; Vanderklish, PW; Warren, ST; Wijetunge, L, 2012) |
| "Finally, audiogenic seizures could be induced in wild-type mice by coadministering CGP 46381 and the mGluR5-positive allosteric modulator 3-cyano-N-(1,2 diphenyl-1H-pyrazol-5-yl) benzamide." | 1.35 | Increased GABA(B) receptor-mediated signaling reduces the susceptibility of fragile X knockout mice to audiogenic seizures. ( Hampson, DR; Heximer, SP; Pacey, LK, 2009) |
| "It suppressed tonic phase of generalized seizures induced by pentetrazol in 7-, 12- and 18-day-old rats and increased their latency in 7- and 12-day-old animals." | 1.35 | Anticonvulsant action of GABA-B receptor agonist SKF97541 differs from that of baclofen. ( Mares, P, 2008) |
| "Baclofen was administered intraperitoneally in doses of 3 or 6 mg/kg." | 1.34 | Effects of a GABA-B receptor agonist baclofen on cortical epileptic afterdischarges in rats. ( Kubová, H; Lindovský, J; Mares, P; Slamberová, R, 2007) |
| "Seizures were reported in four cases, a decreased level of consciousness (GCS < 9) occurred in eight patients and delirium was recorded in eight patients." | 1.33 | Baclofen overdose: defining the spectrum of toxicity. ( Isbister, GK; Leung, NY; Whyte, IM, 2006) |
| "P(2)X(7) receptor immunoreactivity in seizure-resistant (SR) gerbils was similar to that in pre-seizure group of seizure-sensitive (SS) gerbils." | 1.32 | GABA(B) receptor-mediated regulation of P2X7 receptor expression in the gerbil hippocampus. ( An, SJ; Hwang, IK; Kang, TC; Park, SK; Won, MH, 2004) |
| "After several reports of new-onset seizures in children treated with oral baclofen at our institution, we reviewed our experience regarding possible effects of baclofen on seizure induction in a childhood movement disorders program over a 2-year period." | 1.32 | Oral baclofen in cerebral palsy: possible seizure potentiation? ( Hansel, CR; Hansel, DE; Hoon, AH; Johnston, MV; Levey, EB; Madden, L; Reinhardt, EM; Shindle, MK, 2003) |
| "Baclofen (Lioresal) is a drug of choice to treat spasticity and is increasingly being administered intrathecally via an implantable pump in cases refractory to oral therapy." | 1.32 | Intrathecal baclofen withdrawal mimicking sepsis. ( Amin, Y; Kao, LW; Kirk, MA; Turner, MS, 2003) |
| "Experimental absence seizures are associated with perturbations in the presynaptic release of GABA and glutamate within thalamocortical circuitry." | 1.31 | Modulation of absence seizures by the GABA(A) receptor: a critical rolefor metabotropic glutamate receptor 4 (mGluR4). ( Banerjee, PK; Burnham, M; Hampson, D; Snead, OC, 2000) |
| "Most baclofen effects were reversed by the GABA(B) receptor antagonist CGP 35348 (1 mM; n = 4)." | 1.30 | GABA(B) receptor activation promotes seizure activity in the juvenile rat hippocampus. ( Avoli, M; Kurcewicz, I; Louvel, J; Motalli, R; Pumain, R; Tancredi, V; Wan-Chow-Wah, D, 1999) |
| "In addition, the lowering of tonic seizure threshold observed with thalamic lesions was reversed by these (-)baclofen injections." | 1.29 | An ascending seizure-controlling pathway in the medial brainstem and thalamus. ( Bardgett, ME; Gray, BC; Miller, JW; Turner, GM, 1993) |
| "Since repeated seizures and a number of pharmacological agents are known to alter the onset and duration of seizure activity, a relationship between the changes in excitability and the onset of the seizure activity was tested using MK-801, ketamine, bicuculline, diazepam, phenobarbital, baclofen and repeated seizures." | 1.29 | Alterations in both excitation and inhibition occur before the onset of seizure activity in the hippocampus. ( Stringer, JL, 1993) |
| "Isoguvacine pre-treatment prevented the increase in DOPAC concentrations in the median eminence produced by SR 95531." | 1.29 | GABAergic regulation of tuberoinfundibular dopaminergic neurons in the male rat. ( Goudreau, JL; Lookingland, KJ; Moore, KE; Wagner, EJ, 1994) |
| "tended to decrease seizure intensity and at a dose of 10 mg/kg was ineffective at all." | 1.29 | Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice. ( Georgiev, VP; Kambourova, TS; Lazarova, MB, 1995) |
| "Behavioral characteristics of seizures have age-dependent features, which suggests that effective treatment of seizures may be age-specific as well." | 1.29 | Age-dependent effects of gamma-aminobutyric acid agents on flurothyl seizures. ( Moshé, SL; Ortíz, J; Ptachewich, Y; Shinnar, S; Velísek, L; Velísková, J, 1995) |
| "In mice, tonic convulsive seizure induced by intravenous administration of caffeine (adenosine A1, A2 receptors antagonist) was significantly potentiated by any one of L-PIA (adenosine A1 receptor agonist), NECA (adenosine A2 receptor agonist) and 2-ClAd (adenosine A1, A2 receptors agonist)." | 1.28 | [Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice]. ( Inano, S, 1992) |
| "When baclofen (2 microM) was added to the picrotoxin containing medium, SLE's occurred both in the entorhinal cortex and in area CA3, suggesting that inhibition of inhibitory interneurons by baclofen could overcome the "filtering" of projected activity from the entorhinal cortex to the hippocampus." | 1.28 | Regional and time dependent variations of low Mg2+ induced epileptiform activity in rat temporal cortex slices. ( Dreier, JP; Heinemann, U, 1991) |
| "Baclofen infusions were found to have no effect on seizures." | 1.28 | Evidence for the involvement of nigral GABAA receptors in seizures of adult rats. ( Moshé, SL; Sperber, EF; Wurpel, JN; Zhao, DY, 1989) |
| "All-or-none electrographic seizures (EGSs) were studied in hippocampal slices from young (21- to 38-day-old) rats in medium containing low (0 mM) or physiological (0." | 1.28 | Regenerative, all-or-none electrographic seizures in the rat hippocampal slice in Mg-free and physiological medium. ( Anderson, WW; Stasheff, SF; Swartzwelder, HS; Wilson, WA, 1990) |
| "Like 1 and 2, tonic-clonic seizures were induced when trans-3 or -4 were administered to mice intracerebroventricularly." | 1.27 | Stereoselective syntheses of the trans-decahydroquinoline-5-carboxylic acid epimers. Diastereomeric zwitterionic probes of gamma-aminobutyric acid related biological properties in vitro and in vivo. ( Enna, SJ; Fung, YK; Patch, RJ; Witiak, DT, 1986) |
| "Baclofen has been reported to be epileptogenic in man, but many animal studies have demonstrated an anticonvulsant effect." | 1.27 | Baclofen. Its effect on seizure frequency. ( Fromm, GH; Roussan, MS; Terrence, CF, 1983) |
| "Pentobarbital was also effective against bicuculline whereas only hypnotic doses of phenobarbital provided some protection against bicuculline- (8 mg/kg, IP) induced convulsions." | 1.27 | Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats. ( Mehta, AK; Ticku, MK, 1988) |
| " THIP, even at toxic doses, did not alter the anti-PTZ activity of either pentobarbital or phenobarbital." | 1.27 | Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice. ( Chweh, AY; Swinyard, EA; Ulloque, RA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (22.33) | 18.7374 |
| 1990's | 35 (33.98) | 18.2507 |
| 2000's | 20 (19.42) | 29.6817 |
| 2010's | 17 (16.50) | 24.3611 |
| 2020's | 8 (7.77) | 2.80 |
| Authors | Studies |
|---|---|
| Wall, GM | 1 |
| Baker, JK | 1 |
| Witiak, DT | 1 |
| Patch, RJ | 1 |
| Enna, SJ | 1 |
| Fung, YK | 1 |
| Nakada, K | 1 |
| Yoshikawa, M | 1 |
| Ide, S | 1 |
| Suemasa, A | 1 |
| Kawamura, S | 1 |
| Kobayashi, T | 1 |
| Masuda, E | 1 |
| Ito, Y | 1 |
| Hayakawa, W | 1 |
| Katayama, T | 1 |
| Yamada, S | 1 |
| Arisawa, M | 1 |
| Minami, M | 1 |
| Shuto, S | 1 |
| Kuga, K | 1 |
| Ozaki, H | 1 |
| Fujiki, M | 1 |
| Yadav, SK | 1 |
| Yadav, P | 1 |
| Maharjan, G | 1 |
| Dahal, S | 1 |
| Khati, N | 1 |
| Malalla, H | 1 |
| Gorman, KM | 1 |
| Gold, J | 1 |
| Zhao, K | 1 |
| Abraham, M | 1 |
| Behmer Hansen, R | 1 |
| Lad, M | 1 |
| Mammis, A | 1 |
| Meher, RK | 1 |
| Aghoram, R | 1 |
| Nair, PP | 1 |
| Imerci, A | 1 |
| Rogers, KJ | 1 |
| Miller, F | 1 |
| Sees, JP | 1 |
| Nieto, A | 1 |
| Bailey, T | 1 |
| Kaczanowska, K | 2 |
| McDonald, P | 1 |
| Ghannoum, M | 1 |
| Berling, I | 1 |
| Lavergne, V | 1 |
| Roberts, DM | 1 |
| Galvao, T | 1 |
| Hoffman, RS | 1 |
| Nolin, TD | 1 |
| Lewington, A | 1 |
| Doi, K | 1 |
| Gosselin, S | 1 |
| Downes, MA | 1 |
| Sadler, CW | 1 |
| Vidler, S | 1 |
| Lovett, CJ | 1 |
| Pommier, P | 1 |
| Debaty, G | 1 |
| Bartoli, M | 1 |
| Viglino, D | 1 |
| Carpentier, F | 1 |
| Danel, V | 1 |
| Maxime, M | 1 |
| Lee, HJ | 1 |
| Son, Y | 1 |
| Kim, J | 1 |
| Lee, CJ | 1 |
| Yoon, ES | 1 |
| Cho, IJ | 1 |
| Beecham, E | 1 |
| Candy, B | 1 |
| Howard, R | 1 |
| McCulloch, R | 1 |
| Laddie, J | 1 |
| Rees, H | 1 |
| Vickerstaff, V | 1 |
| Bluebond-Langner, M | 1 |
| Jones, L | 1 |
| Brown, JW | 1 |
| Moeller, A | 1 |
| Schmidt, M | 1 |
| Turner, SC | 1 |
| Nimmrich, V | 1 |
| Ma, J | 1 |
| Rueter, LE | 1 |
| van der Kam, E | 1 |
| Zhang, M | 1 |
| Charifou, Y | 1 |
| Martinet, O | 1 |
| Jabot, J | 1 |
| Gauzere, BA | 1 |
| Allyn, J | 1 |
| Vandroux, D | 1 |
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7 reviews available for baclofen and Seizures
| Article | Year |
|---|---|
Encephalopathy of Unknown Origin in a Baclofen Patient: Case Report and Review of the Literature.
Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Baclofen; Brain Diseases; Electroencephalography; | 2020 |
GABA
Topics: Baclofen; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Re | 2022 |
Recommendations from the EXTRIP workgroup on extracorporeal treatment for baclofen poisoning.
Topics: Baclofen; Cohort Studies; Drug Overdose; Humans; Poisoning; Renal Dialysis; Seizures | 2021 |
Pharmacological interventions for pain in children and adolescents with life-limiting conditions.
Topics: Adolescent; Alendronate; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Child; Child, Preschool | 2015 |
[Drug-induced seizures].
Topics: Analgesics, Opioid; Anesthetics; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents; Anti | 2013 |
Baclofen poisoning in children.
Topics: Ataxia; Baclofen; Central Nervous System; Child; Child, Preschool; Cohort Studies; Drug Overdose; Fe | 1994 |
Baclofen intoxication: report of four cases and review of the literature.
Topics: Adult; Baclofen; Female; Humans; Male; Mental Disorders; Middle Aged; Seizures; Suicide, Attempted | 1992 |
1 trial available for baclofen and Seizures
| Article | Year |
|---|---|
Long-term intrathecal baclofen treatment in supraspinal spasticity.
Topics: Adult; Baclofen; Brain Injuries; Cerebral Palsy; Humans; Infusion Pumps; Injections, Spinal; Male; M | 1992 |
95 other studies available for baclofen and Seizures
| Article | Year |
|---|---|
Metabolism of 3-(p-chlorophenyl)pyrrolidine. Structural effects in conversion of a prototype gamma-aminobutyric acid prodrug to lactam and gamma-aminobutyric acid type metabolites.
Topics: Amino Acids; Animals; Baclofen; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure | 1989 |
Stereoselective syntheses of the trans-decahydroquinoline-5-carboxylic acid epimers. Diastereomeric zwitterionic probes of gamma-aminobutyric acid related biological properties in vitro and in vivo.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Magnet | 1986 |
Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports.
Topics: Animals; Anticonvulsants; Brain; Cyclopropanes; GABA Modulators; GABA Plasma Membrane Transport Prot | 2013 |
Motor-evoked potentials after focal electrical stimulation predict drug-induced convulsion potentials in rats.
Topics: Animals; Baclofen; Electric Stimulation; Evoked Potentials, Motor; Male; Muscle, Skeletal; Pilocarpi | 2023 |
Status Dystonicus with Atypical Presentation in Developmentally Delay Child: A Case Report.
Topics: Baclofen; Child; Child, Preschool; Dystonia; Dystonic Disorders; Female; Gabapentin; Humans; Seizure | 2022 |
Does baclofen for the management of spasticity increase the risk of seizures?
Topics: Baclofen; Humans; Muscle Relaxants, Central; Muscle Spasticity; Seizures | 2023 |
Adrenoleukodystrophy presenting as glue sniffing.
Topics: Adrenocorticotropic Hormone; Adrenoleukodystrophy; Aftercare; Baclofen; Child; Cognitive Dysfunction | 2020 |
Evaluation of Risk Factors for Cerebrospinal Leakage in Pediatric Patients With Cerebral Palsy Treated With Intrathecal Baclofen.
Topics: Adolescent; Baclofen; Cerebral Palsy; Cerebrospinal Fluid Leak; Child; Child, Preschool; Female; Hum | 2020 |
Difficult to sedate case of acute behavioural disturbance secondary to baclofen withdrawal.
Topics: Adult; Antipsychotic Agents; Baclofen; Benzodiazepines; Diazepam; Droperidol; Humans; Male; Problem | 2019 |
Severity of deliberate acute baclofen poisoning: a nonconcurrent cohort study.
Topics: Adult; Alcoholism; Baclofen; Dose-Response Relationship, Drug; Drug Overdose; Endpoint Determination | 2014 |
A multichannel neural probe with embedded microfluidic channels for simultaneous in vivo neural recording and drug delivery.
Topics: Action Potentials; Animals; Baclofen; Brain; Drug Delivery Systems; Male; Mice; Mice, Inbred C57BL; | 2015 |
Anticonvulsant effects of structurally diverse GABA(B) positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model.
Topics: Acoustic Stimulation; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Anticonvuls | 2016 |
Baclofen intoxication cases in an intensive care unit.
Topics: Adult; Aged; Baclofen; Critical Care; Drug Overdose; Female; France; Hemofiltration; Humans; Intensi | 2016 |
Increased GABA(B) receptor-mediated signaling reduces the susceptibility of fragile X knockout mice to audiogenic seizures.
Topics: Animals; Baclofen; Disease Susceptibility; Female; Fragile X Mental Retardation Protein; Male; Mice; | 2009 |
Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure.
Topics: Animals; Apoptosis; Baclofen; Disease Models, Animal; Disks Large Homolog 4 Protein; GABA Agonists; | 2010 |
Seizure after intrathecal baclofen bolus in a multiple sclerosis patient treated with oxcarbazepine.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Baclofen; Benzodiazepines; Carbamazepine; Female; GABA | 2011 |
Stimulus-induced rhythmic, periodic, or ictal discharges in a 13-year-old girl after an overdose and respiratory arrest.
Topics: Adolescent; Baclofen; Bupropion; Drug Overdose; Female; Heart Arrest; Humans; Periodicity; Seizures | 2011 |
Decreased GABABR expression and increased neuronal cell death in developing rat brain after PTZ-induced seizure.
Topics: Animals; Animals, Newborn; Baclofen; Caspase 3; Cell Death; Disease Models, Animal; Electroencephalo | 2013 |
Neuroprotection of co-activation of GABA receptors by preventing caspase-3 denitrosylation in KA-induced seizures.
Topics: Animals; Apoptosis; Baclofen; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Caspase 3; Caspase I | 2012 |
Baclofen intoxication: a "fun drug" causing deep coma and nonconvulsive status epilepticus--a case report and review of the literature.
Topics: Adolescent; Baclofen; Bradycardia; Coma; Drug Overdose; Humans; Male; Muscle Relaxants, Central; Sei | 2012 |
Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen.
Topics: Animals; Baclofen; Behavior, Animal; Dendritic Spines; Disease Models, Animal; Drinking Water; Fragi | 2012 |
Functional aspects of neuroprotective effects of new salts and compositions of baclofen in the convulsive syndrome caused by electroshock.
Topics: Animals; Baclofen; Carboxylic Acids; Electric Stimulation; Electroshock; Male; Neuroprotective Agent | 2012 |
Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice.
Topics: Animals; Anxiety; Baclofen; Chlordiazepoxide; Dose-Response Relationship, Drug; GABA-B Receptor Agon | 2013 |
Intrathecal baclofen withdrawal mimicking sepsis.
Topics: Baclofen; Child, Preschool; Clinical Protocols; Decerebrate State; Diagnosis, Differential; Emergenc | 2003 |
Oral baclofen in cerebral palsy: possible seizure potentiation?
Topics: Administration, Oral; Baclofen; Cerebral Palsy; Child; Humans; Retrospective Studies; Seizures | 2003 |
GABA(B) receptor-mediated regulation of P2X7 receptor expression in the gerbil hippocampus.
Topics: Analysis of Variance; Animals; Baclofen; Bicuculline; Cell Count; GABA Agonists; GABA Antagonists; G | 2004 |
Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice.
Topics: Animals; Baclofen; Cocaine; Dopamine Uptake Inhibitors; GABA-A Receptor Agonists; GABA-A Receptor An | 2004 |
Effects of GABAergic transmissions on the immunoreactivities of calcium binding proteins in the gerbil hippocampus.
Topics: Animals; Baclofen; Bicuculline; Calbindin 2; Calbindins; Calcium-Binding Proteins; Cell Count; GABA | 2005 |
Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen.
Topics: Adult; Baclofen; Brain; Case-Control Studies; Cohort Studies; Female; GABA Agonists; Humans; Inciden | 2005 |
Severe seizures during propofol induction in a patient with syringomyelia receiving baclofen.
Topics: Baclofen; Humans; Male; Middle Aged; Propofol; Receptors, GABA-B; Seizures; Syringomyelia | 2005 |
The effect of topiramate on GABA(B) receptor, vesicular GABA transporter and paired-pulse inhibition in the gerbil hippocampus.
Topics: Animals; Baclofen; Blotting, Western; Dentate Gyrus; Excitatory Postsynaptic Potentials; Fructose; G | 2005 |
Baclofen overdose: defining the spectrum of toxicity.
Topics: Adolescent; Adult; Age Distribution; Australia; Baclofen; Cardiovascular Diseases; Consciousness Dis | 2006 |
Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen.
Topics: Baclofen; Humans; Incidence; Injections, Spinal; Seizures | 2006 |
Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients?
Topics: Analysis of Variance; Animals; Baclofen; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relati | 2007 |
The involvement of the substantia nigra pars reticulata in hypoglycemic seizures.
Topics: Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Fasting; GABA-A Receptor Agonists; gamm | 2007 |
Anticonvulsant action of GABA-B receptor agonist SKF97541 differs from that of baclofen.
Topics: Age Factors; Animals; Anticonvulsants; Baclofen; Disease Models, Animal; Dose-Response Relationship, | 2008 |
Effects of a GABA-B receptor agonist baclofen on cortical epileptic afterdischarges in rats.
Topics: Animals; Baclofen; Cerebral Cortex; GABA Agonists; Male; Rats; Receptors, GABA-B; Seizures; Severity | 2007 |
Effect of dopaminergic and GABA-ergic drugs given alone or in combination on the anticonvulsant action of phenobarbital and diphenylhydantoin in the electroshock test in mice.
Topics: Amantadine; Aminooxyacetic Acid; Amphetamine; Animals; Apomorphine; Baclofen; Dopamine; Electroshock | 1980 |
Effect of baclofen on seizure frequency.
Topics: Baclofen; Humans; Seizures | 1984 |
[Electroencephalographic changes induced by baclofen].
Topics: Adult; Aged; Baclofen; Electroencephalography; Evoked Potentials; Female; Humans; Male; Middle Aged; | 1982 |
Baclofen. Its effect on seizure frequency.
Topics: Adult; Baclofen; Epilepsy; Female; Humans; Male; Seizures | 1983 |
Antagonism of intrastriatal and intravenous kainic acid by 1-nuciferine: comparison with various anticonvulsants and GABAmimetics.
Topics: Animals; Aporphines; Baclofen; Behavior, Animal; Choline O-Acetyltransferase; Corpus Striatum; Diaze | 1980 |
Baclofen as an anticonvulsant in experimental models of convulsions.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Baclofen; Disease Models, Animal; Dose-Resp | 1981 |
Age-dependent effects of gamma-aminobutyric acid agents on flurothyl seizures.
Topics: Age Factors; Animals; Anticonvulsants; Baclofen; Convulsants; Flurothyl; GABA Agents; GABA Agonists; | 1995 |
Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice.
Topics: Angiotensin II; Animals; Baclofen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug In | 1995 |
GABAergic regulation of tuberoinfundibular dopaminergic neurons in the male rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Baclofen; Dopamine; GABA Agonists; GABA Antagonists; gamma- | 1994 |
The effects of GABAB ligands on alcohol withdrawal in mice.
Topics: Animals; Baclofen; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Ethanol; Female; GA | 1994 |
GABA in the inferior colliculus plays a critical role in control of audiogenic seizures.
Topics: Acoustic Stimulation; Amino Acids; Animals; Baclofen; Cyclohexanecarboxylic Acids; gamma-Aminobutyri | 1994 |
The influence of thalamic GABA transmission on the susceptibility of adult rats to flurothyl induced seizures.
Topics: Aminocaproates; Animals; Anticonvulsants; Baclofen; Behavior, Animal; Bicuculline; Flurothyl; gamma- | 1993 |
Alterations in both excitation and inhibition occur before the onset of seizure activity in the hippocampus.
Topics: Animals; Baclofen; Bicuculline; Diazepam; Electric Stimulation; Evoked Potentials; Hippocampus; Keta | 1993 |
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; M | 1993 |
An ascending seizure-controlling pathway in the medial brainstem and thalamus.
Topics: Animals; Arousal; Baclofen; Brain Diseases; Female; Neural Pathways; Rats; Seizures; Sleep; Tegmentu | 1993 |
Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Baclofen; Dose-Response Relationship, Drug; Epilepsy, Tonic- | 1996 |
Moderate anticonvulsant action of baclofen does not change during development.
Topics: Animals; Anticonvulsants; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; Male; Pentylene | 1996 |
Flumazenil-induced seizure accompanying benzodiazepine and baclofen intoxication.
Topics: Adult; Antidotes; Baclofen; Benzodiazepines; Drug Interactions; Drug Overdose; Female; Flumazenil; H | 1996 |
Relation of the [3H] gamma-hydroxybutyric acid (GHB) binding site to the gamma-aminobutyric acidB (GABAB) receptor in rat brain.
Topics: Animals; Autoradiography; Baclofen; Benzocycloheptenes; Binding Sites; Brain; GABA Agonists; GABA An | 1996 |
Comparative in vivo and in vitro studies with the potent GABAB receptor antagonist, CGP 56999A.
Topics: Animals; Baclofen; Cerebral Cortex; Convulsants; Dose-Response Relationship, Drug; Drug Interactions | 1997 |
Synthesis of a new homologous series of p-chlorophenyl alcohol amides, their anticonvulsant activity and their testing as potential GABAB receptor antagonists.
Topics: Amides; Animals; Anticonvulsants; Baclofen; Convulsants; GABA-B Receptor Antagonists; Injections, In | 1998 |
Seizure sensitivity and GABAergic modulation of ethanol sensitivity in selectively bred FAST and SLOW mouse lines.
Topics: Animals; Baclofen; Ethanol; GABA Modulators; gamma-Aminobutyric Acid; Genetic Predisposition to Dise | 1998 |
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cl | 1999 |
GABA(B) receptor activation promotes seizure activity in the juvenile rat hippocampus.
Topics: 4-Aminopyridine; Age of Onset; Animals; Baclofen; Convulsants; GABA Agonists; GABA-B Receptor Agonis | 1999 |
Modulation of absence seizures by the GABA(A) receptor: a critical rolefor metabotropic glutamate receptor 4 (mGluR4).
Topics: Animals; Baclofen; Cerebral Cortex; Convulsants; Epilepsy, Absence; Excitatory Amino Acid Antagonist | 2000 |
GABAergic contribution to rat bladder hyperactivity after middle cerebral artery occlusion.
Topics: Animals; Baclofen; Bicuculline; Cerebral Infarction; Cerebral Ventricles; Dose-Response Relationship | 2000 |
Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice.
Topics: Action Potentials; Animals; Baclofen; Behavior, Animal; Central Nervous System; Down-Regulation; Epi | 2001 |
Drug points: Neonatal convulsions after withdrawal of baclofen.
Topics: Baclofen; Female; GABA Agonists; Humans; Infant, Newborn; Maternal-Fetal Exchange; Muscle Relaxants, | 2001 |
Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels.
Topics: 4-Butyrolactone; Animals; Baclofen; Calcium Channels, T-Type; Cerebral Cortex; Electroencephalograph | 2001 |
The biological activity of d- and l-baclofen (Lioresal).
Topics: Aminobutyrates; Animals; Baclofen; Blood Pressure; Cats; Dose-Response Relationship, Drug; Male; Mic | 1978 |
Convulsions induced by hyperbaric oxygen: inhibition by phenobarbital, diazepam and baclofen.
Topics: Aminobutyrates; Animals; Baclofen; Diazepam; Female; gamma-Aminobutyric Acid; Glycine; Hyperbaric Ox | 1977 |
Effects of some GABAergic agents on quinine-induced seizures in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Diazepam; Male; Mice; Mice, Inb | 1992 |
[Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice].
Topics: Animals; Baclofen; Benzodiazepines; Caffeine; Diazepam; Dizocilpine Maleate; Flumazenil; Male; Mice; | 1992 |
Age-dependent changes in substantia nigra GABA-mediated seizure suppression.
Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Dominance, Cerebral; Energy Metabolism; Flu | 1992 |
Prolonged seizure activity after baclofen withdrawal.
Topics: Baclofen; Humans; Male; Middle Aged; Muscle Spasticity; Seizures | 1992 |
Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Chloroquine; Diazepam; gamma-Aminobutyric Ac | 1992 |
Intracerebroventricular administration of kappa-agonists induces convulsions in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1991 |
GABA/BZ-and NMDA-receptor interaction in digoxin-induced convulsions in rats.
Topics: Animals; Baclofen; Diazepam; Digoxin; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Injectio | 1991 |
Pharmacological evidence indicating a role of GABAergic systems in termination of limbic seizures.
Topics: Animals; Baclofen; Bicuculline; Chloride Channels; GABA-A Receptor Antagonists; gamma-Aminobutyric A | 1990 |
Regional and time dependent variations of low Mg2+ induced epileptiform activity in rat temporal cortex slices.
Topics: Animals; Baclofen; Brain Mapping; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Mag | 1991 |
The role of the laterodorsal tegmental nucleus of the rat in experimental seizures.
Topics: Alcian Blue; Animals; Baclofen; Bicuculline; Female; Histocytochemistry; In Vitro Techniques; Microi | 1991 |
Are GABAB receptors involved in the pharmacological effects of ethanol?
Topics: Animals; Baclofen; Cells, Cultured; Chlorine; Diazepam; Ethanol; gamma-Aminobutyric Acid; Male; Mice | 1990 |
Regenerative, all-or-none electrographic seizures in the rat hippocampal slice in Mg-free and physiological medium.
Topics: Action Potentials; Animals; Baclofen; Culture Media; Electric Stimulation; Hippocampus; In Vitro Tec | 1990 |
The central medial nucleus: thalamic site of seizure regulation.
Topics: Animals; Baclofen; Bicuculline; Dose-Response Relationship, Drug; Female; Muscimol; Rats; Rats, Inbr | 1990 |
Effects of potassium channel blockers on baclofen-induced suppression of paroxysmal discharges in rat neo-cortical slices.
Topics: 4-Aminopyridine; Animals; Baclofen; Barium; Cerebral Cortex; Cesium; Magnesium; Potassium Channels; | 1990 |
Evidence for the involvement of nigral GABAA receptors in seizures of adult rats.
Topics: Animals; Baclofen; Bicuculline; Dose-Response Relationship, Drug; Male; Muscimol; Rats; Rats, Inbred | 1989 |
Evidence for the involvement of nigral GABAB receptors in seizures of rat pups.
Topics: Age Factors; Animals; Baclofen; Flurothyl; Rats; Receptors, GABA-A; Seizures; Substantia Nigra | 1989 |
Mechanisms of general anesthesia: brain regional responses to baclofen.
Topics: Anesthesia, General; Animals; Arousal; Baclofen; Brain; Dose-Response Relationship, Drug; Electroenc | 1989 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazole | 1988 |
Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.
Topics: Animals; Anticonvulsants; Baclofen; Barbiturates; Dose-Response Relationship, Drug; Drug Synergism; | 1986 |
GABAergic modulation of inferior colliculus excitability: role in the ethanol withdrawal audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Baclofen; Benzodiazepinones; Bicuculline; Ethanol; Geniculate Bodies; | 1986 |
Baclofen overdose with cardiac conduction abnormalities: case report and review of the literature.
Topics: Adult; Baclofen; Bradycardia; Female; Heart Conduction System; Humans; Myoclonus; Receptors, GABA-A; | 1986 |
Neurobehavioral, neuroendocrine and neurochemical effects of zinc supplementation in rats.
Topics: Adrenocorticotropic Hormone; Animals; Baclofen; Behavior, Animal; beta-Endorphin; Brain; Diazepam; E | 1986 |
Involvement of a GABAergic mechanism in the pharmacologic action of phenytoin.
Topics: Animals; Anticonvulsants; Baclofen; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Phenytoin; Po | 1986 |
First-order elimination kinetics following baclofen overdose.
Topics: Baclofen; Cardiovascular Diseases; Coma; Female; Half-Life; Humans; Kinetics; Middle Aged; Seizures; | 1986 |
Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome.
Topics: Animals; Baclofen; Behavior, Animal; Brain; Electroencephalography; Injections, Intraventricular; Ka | 1986 |
Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Hippocampus; Kainic Acid; Limbic Syste | 1986 |
Overdose with baclofen.
Topics: Adult; Baclofen; Coma; Female; Gastric Lavage; Humans; Seizures | 1986 |