baclofen has been researched along with Schizophrenia in 29 studies
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To substantiate a previously reported disturbance of gamma-aminobutyric acid (GABA) in chronic schizophrenia, plasma growth hormone (GH) response to a direct GABA agonist (baclofen, 10 mg) was assessed in 12 unmedicated chronic schizophrenic males and 10 sex- and age-matched healthy controls." | 9.06 | Baclofen-induced growth hormone secretion is blunted in chronic schizophrenics: neuroendocrine evidence for a GABA disturbance in schizophrenia. ( Forziati, D; Iovino, M; Maj, M; Monteleone, P; Steardo, L; Veltro, F, 1988) |
| " I report a patient who developed the syndrome during treatment for schizophrenia with the antipsychotic agent molindone hydrochloride." | 7.68 | Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen. ( Sandyk, R, 1990) |
| "In early 1975, surprising therapeutic effects of baclofen (Lioresal) in patients suffering from severe, chronic schizophrenia were reported from Sweden." | 7.65 | [Neuroleptic effect of baclofen in chronic schizophrenia (author's transl)]. ( Kuhn, R, 1976) |
| "Baclofen was superior to placebo in the treatment of anxiety, which is of particular interest in view of the recent theories on the mechanism of action of benzodiazepines." | 6.64 | A double-blind trial of baclofen against placebo in the treatment of schizophrenia. ( Andersen, B; Bahr, B; Eliassen, HM; Gulmann, NC, 1976) |
| "To substantiate a previously reported disturbance of gamma-aminobutyric acid (GABA) in chronic schizophrenia, plasma growth hormone (GH) response to a direct GABA agonist (baclofen, 10 mg) was assessed in 12 unmedicated chronic schizophrenic males and 10 sex- and age-matched healthy controls." | 5.06 | Baclofen-induced growth hormone secretion is blunted in chronic schizophrenics: neuroendocrine evidence for a GABA disturbance in schizophrenia. ( Forziati, D; Iovino, M; Maj, M; Monteleone, P; Steardo, L; Veltro, F, 1988) |
| "A role for gamma-aminobutyric acid (GABA) in the pathophysiology of schizophrenia was first suggested by Eugene Roberts in 1972." | 4.76 | The interaction between GABA and dopamine: implications for schizophrenia. ( Garbutt, JC; van Kammen, DP, 1983) |
| " We previously reported that baclofen, the prototypical GABA(B) agonist, elicits antipsychotic-like effects in the rat paradigm of prepulse inhibition (PPI) of the startle, a highly validated animal model of schizophrenia." | 3.74 | Activation of GABA(B) receptors reverses spontaneous gating deficits in juvenile DBA/2J mice. ( Bortolato, M; Castelli, MP; Fà, M; Frau, R; Gessa, GL; Marrosu, F; Mereu, G; Orrù, M; Piras, AP; Puligheddu, M; Tuveri, A, 2007) |
| " I report a patient who developed the syndrome during treatment for schizophrenia with the antipsychotic agent molindone hydrochloride." | 3.68 | Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen. ( Sandyk, R, 1990) |
| "In early 1975, surprising therapeutic effects of baclofen (Lioresal) in patients suffering from severe, chronic schizophrenia were reported from Sweden." | 3.65 | [Neuroleptic effect of baclofen in chronic schizophrenia (author's transl)]. ( Kuhn, R, 1976) |
| "Baclofen was superior to placebo in the treatment of anxiety, which is of particular interest in view of the recent theories on the mechanism of action of benzodiazepines." | 2.64 | A double-blind trial of baclofen against placebo in the treatment of schizophrenia. ( Andersen, B; Bahr, B; Eliassen, HM; Gulmann, NC, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (72.41) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 5 (17.24) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Janz, P | 1 |
| Nicolas, MJ | 1 |
| Redondo, RL | 1 |
| Valencia, M | 1 |
| Arai, S | 1 |
| Takuma, K | 1 |
| Mizoguchi, H | 1 |
| Ibi, D | 1 |
| Nagai, T | 1 |
| Kamei, H | 1 |
| Kim, HC | 1 |
| Yamada, K | 1 |
| Daskalakis, ZJ | 1 |
| George, TP | 1 |
| Gandal, MJ | 1 |
| Sisti, J | 1 |
| Klook, K | 1 |
| Ortinski, PI | 1 |
| Leitman, V | 1 |
| Liang, Y | 1 |
| Thieu, T | 1 |
| Anderson, R | 1 |
| Pierce, RC | 1 |
| Jonak, G | 1 |
| Gur, RE | 1 |
| Carlson, G | 1 |
| Siegel, SJ | 1 |
| Agabio, R | 1 |
| Marras, P | 1 |
| Addolorato, G | 1 |
| Carpiniello, B | 1 |
| Gessa, GL | 2 |
| Bortolato, M | 1 |
| Frau, R | 1 |
| Orrù, M | 1 |
| Piras, AP | 1 |
| Fà, M | 1 |
| Tuveri, A | 1 |
| Puligheddu, M | 1 |
| Castelli, MP | 1 |
| Mereu, G | 1 |
| Marrosu, F | 1 |
| Tegeler, J | 1 |
| Wöller, W | 1 |
| Garbutt, JC | 1 |
| van Kammen, DP | 1 |
| Wolf, ME | 1 |
| Keener, S | 1 |
| Mathis, P | 1 |
| Mosnaim, AD | 1 |
| Nair, NP | 2 |
| Lal, S | 1 |
| Schwartz, G | 2 |
| Thavundayil, JX | 1 |
| Tomitaka, S | 1 |
| Tomitaka, M | 1 |
| Tolliver, BK | 1 |
| Sharp, FR | 1 |
| Carlsson, VA | 1 |
| Yassa, R | 2 |
| Ruiz-Navarro, J | 1 |
| Simpson, GM | 2 |
| Branchey, MH | 2 |
| Shrivastava, RK | 2 |
| Davis, KL | 1 |
| Hollister, LE | 1 |
| Berger, PA | 1 |
| van den Berg, CJ | 1 |
| Bigelow, LB | 2 |
| Nasrallah, H | 1 |
| Carman, J | 1 |
| Gillin, JC | 2 |
| Wyatt, RJ | 2 |
| Beckmann, H | 1 |
| Frische, M | 1 |
| Rüther, E | 1 |
| Zimmer, R | 1 |
| Lee, JH | 1 |
| Schöpf, J | 1 |
| Hucker, H | 1 |
| Potkin, SG | 1 |
| Rogol, A | 1 |
| Nasrallah, HA | 1 |
| Gulmann, NC | 1 |
| Bahr, B | 1 |
| Andersen, B | 1 |
| Eliassen, HM | 1 |
| Walinder, J | 1 |
| Wallin, L | 1 |
| Carlsson, A | 1 |
| Kuhn, R | 1 |
| Sandyk, R | 1 |
| Monteleone, P | 1 |
| Maj, M | 1 |
| Iovino, M | 1 |
| Forziati, D | 1 |
| Veltro, F | 1 |
| Steardo, L | 1 |
| Nair, V | 1 |
| Dimitry, R | 1 |
2 reviews available for baclofen and Schizophrenia
| Article | Year |
|---|---|
Clozapine, GABA(B), and the treatment of resistant schizophrenia.
Topics: Antipsychotic Agents; Baclofen; Clozapine; Drug Resistance; GABA Agonists; GABA Antagonists; gamma-A | 2009 |
The interaction between GABA and dopamine: implications for schizophrenia.
Topics: Animals; Antipsychotic Agents; Baclofen; Brain Chemistry; Catalepsy; Dopamine; gamma-Aminobutyric Ac | 1983 |
8 trials available for baclofen and Schizophrenia
| Article | Year |
|---|---|
Baclofen in the treatment of tardive dyskinesia.
Topics: Adult; Aminobutyrates; Antipsychotic Agents; Baclofen; Clinical Trials as Topic; Double-Blind Method | 1978 |
Baclofen in chronic schizophrenia.
Topics: Adult; Aminobutyrates; Baclofen; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Sc | 1977 |
Baclofen treatment in chronic schizophrenia: a clinical trial.
Topics: Adult; Aminobutyrates; Arousal; Baclofen; Chronic Disease; Clinical Trials as Topic; Depression; Dru | 1977 |
Baclofen (para-chlorphenyl-GABA) in schizophrenia.
Topics: Adult; Aminobutyrates; Animals; Baclofen; Blood-Brain Barrier; Chronic Disease; Clinical Trials as T | 1977 |
Baclofen in the treatment of tardive dyskinesia and schizophrenia.
Topics: Adult; Aminobutyrates; Baclofen; Clinical Trials as Topic; Dyskinesia, Drug-Induced; Female; Humans; | 1978 |
Baclofen in the treatment of schizophrenia: a pilot study.
Topics: Adult; Aminobutyrates; Baclofen; Chronic Disease; Clinical Trials as Topic; Female; Humans; Middle A | 1977 |
A double-blind trial of baclofen against placebo in the treatment of schizophrenia.
Topics: Adult; Aminobutyrates; Anxiety; Baclofen; Chlorpromazine; Clinical Trials as Topic; Drug Evaluation; | 1976 |
Baclofen-induced growth hormone secretion is blunted in chronic schizophrenics: neuroendocrine evidence for a GABA disturbance in schizophrenia.
Topics: Adult; Aged; Baclofen; Brain; Chronic Disease; gamma-Aminobutyric Acid; Growth Hormone; Humans; Male | 1988 |
19 other studies available for baclofen and Schizophrenia
| Article | Year |
|---|---|
GABA
Topics: Animals; Baclofen; Disease Models, Animal; Dizocilpine Maleate; GABA-B Receptor Agonists; Perception | 2022 |
GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice.
Topics: Animals; Baclofen; Cognition Disorders; Dose-Response Relationship, Drug; GABA Agonists; Male; Memor | 2009 |
GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.
Topics: Animals; Autistic Disorder; Baclofen; Disease Models, Animal; Evoked Potentials, Auditory; Explorato | 2012 |
Baclofen suppresses alcohol intake and craving for alcohol in a schizophrenic alcohol-dependent patient: a case report.
Topics: Alcohol Drinking; Alcoholism; Baclofen; Behavior, Addictive; GABA Agonists; Humans; Male; Middle Age | 2007 |
Activation of GABA(B) receptors reverses spontaneous gating deficits in juvenile DBA/2J mice.
Topics: Animals; Antipsychotic Agents; Autoradiography; Baclofen; Brain; Clozapine; Disease Models, Animal; | 2007 |
[Therapeutic measures in tardive dyskinesia].
Topics: Age Factors; Amantadine; Antipsychotic Agents; Baclofen; Benzodiazepines; Bromocriptine; Deanol; Dih | 1983 |
Phenylethylamine-like properties of baclofen.
Topics: Adult; Aged; Baclofen; Chronic Disease; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Humans; | 1983 |
Effect of sodium valproate and baclofen in tardive dyskinesia: clinical and neuroendocrine studies.
Topics: Adult; Baclofen; Chronic Disease; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Halop | 1980 |
Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK-801) injures pyramidal neurons in rat retrosplenial cortex.
Topics: Animals; Anterior Thalamic Nuclei; Baclofen; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; | 2000 |
[The contribution of drug research to the understanding of schizophrenia].
Topics: Adult; Amphetamines; Animals; Antipsychotic Agents; Baclofen; Chlorpromazine; Corpus Striatum; Dopam | 1975 |
Letter: Baclofen in schizophrenia.
Topics: Adult; Aminobutyrates; Baclofen; Drug Evaluation; Female; Humans; Male; Middle Aged; Schizophrenia | 1976 |
Letter: Bacloffen in schizophrenia.
Topics: Aminobutyrates; Baclofen; Drug Evaluation; Humans; Schizophrenia | 1976 |
Gabergic compounds and schizophrenia.
Topics: Baclofen; gamma-Aminobutyric Acid; Humans; Schizophrenia; Valproic Acid | 1976 |
Tardive dyskinesia.
Topics: Antipsychotic Agents; Baclofen; Benzodiazepines; Choline; Dyskinesia, Drug-Induced; Humans; Pimozide | 1979 |
Baclofen: lack of effect on human plasma prolactin.
Topics: Aminobutyrates; Baclofen; Humans; Male; Prolactin; Schizophrenia | 1978 |
Effect of baclofen on cerebrospinal-fluid levels of 5-hydroxyindoleacetic acid and homovanillic acid.
Topics: Adult; Aminobutyrates; Baclofen; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; | 1977 |
[Neuroleptic effect of baclofen in chronic schizophrenia (author's transl)].
Topics: Aminobutyrates; Baclofen; Humans; Schizophrenia | 1976 |
Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen.
Topics: Baclofen; Causalgia; Clonazepam; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Humans; | 1990 |
Prevalence of tardive dystonia.
Topics: Adult; Aged; Antipsychotic Agents; Baclofen; Cross-Sectional Studies; Dementia; Drug Therapy, Combin | 1986 |