baclofen has been researched along with Postoperative Complications in 33 studies
Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with cerebral palsy (CP), we determine the impact of intrathecal baclofen pumps (ITBPs) on scoliosis curve progression before posterior spine fusion (PSF) and its effects on surgical outcome." | 7.96 | Does an intrathecal baclofen pump impact scoliosis progression and complicate posterior spine fusion in patients with cerebral palsy? ( Halanski, MA; Hetzel, SJ; Lins, LAB; Nechyporenko, AV; Noonan, KJ, 2020) |
| "OBJECTIVE Many patients undergoing spinal fusion for neuromuscular scoliosis have preexisting neurosurgical implants, including ventricular shunts (VSs) for hydrocephalus and baclofen pumps (BPs) for spastic cerebral palsy." | 7.88 | Complication rates for preexisting baclofen pumps and ventricular shunts following scoliosis correction: a preliminary study. ( Bonfield, CM; Chotai, S; Dallas, J; Guidry, BS; Sborov, KD, 2018) |
| "Compare a group of individuals with cerebral palsy (CP) who had intrathecal baclofen (ITB) pumps to a group of individuals with CP who did not have ITB pumps in order to determine if there was a difference in the prevalence of new-onset neuromuscular scoliosis, an increased rate of progression of preexisting neuromuscular scoliosis, or an increased rate of posterior spine fusion surgery in skeletally immature individuals with CP who had ITB pumps." | 7.85 | Does Intrathecal Baclofen Therapy Increase Prevalence and/or Progression of Neuromuscular Scoliosis? ( Krach, LE; Novotny, SA; Walker, KR, 2017) |
| "We report the occurrence of delayed postoperative coma in five of nine consecutive children following surgery for insertion of baclofen infusion pumps." | 7.71 | Reversible coma in children after improper baclofen pump insertion. ( Anderson, KJ; Brown, K; Farmer, JP, 2002) |
| "In patients with cerebral palsy (CP), we determine the impact of intrathecal baclofen pumps (ITBPs) on scoliosis curve progression before posterior spine fusion (PSF) and its effects on surgical outcome." | 3.96 | Does an intrathecal baclofen pump impact scoliosis progression and complicate posterior spine fusion in patients with cerebral palsy? ( Halanski, MA; Hetzel, SJ; Lins, LAB; Nechyporenko, AV; Noonan, KJ, 2020) |
| "OBJECTIVE Many patients undergoing spinal fusion for neuromuscular scoliosis have preexisting neurosurgical implants, including ventricular shunts (VSs) for hydrocephalus and baclofen pumps (BPs) for spastic cerebral palsy." | 3.88 | Complication rates for preexisting baclofen pumps and ventricular shunts following scoliosis correction: a preliminary study. ( Bonfield, CM; Chotai, S; Dallas, J; Guidry, BS; Sborov, KD, 2018) |
| "Compare a group of individuals with cerebral palsy (CP) who had intrathecal baclofen (ITB) pumps to a group of individuals with CP who did not have ITB pumps in order to determine if there was a difference in the prevalence of new-onset neuromuscular scoliosis, an increased rate of progression of preexisting neuromuscular scoliosis, or an increased rate of posterior spine fusion surgery in skeletally immature individuals with CP who had ITB pumps." | 3.85 | Does Intrathecal Baclofen Therapy Increase Prevalence and/or Progression of Neuromuscular Scoliosis? ( Krach, LE; Novotny, SA; Walker, KR, 2017) |
| "OBJECTIVE Medically refractory spasticity and dystonia are often alleviated with intrathecal baclofen (ITB) administration through an indwelling catheter inserted in the lumbar spine." | 3.85 | Image-guided intrathecal baclofen pump catheter implantation: a technical note and case series. ( Berde, C; Dasenbrock, HH; O'Brien, CP; Padua, H; Robertson, FC; Robinson, S, 2017) |
| "A male patient with adrenoleukodystrophy and a baclofen pump implant was admitted to the urology department with bladder stones." | 3.75 | Retraction of an intrathecal baclofen infusion catheter following suprapubic cystotomy: a case report. ( Heesakkers, JP; Martens, FM; Somford, DM; van den Burg, MJ; van Kuppevelt, DH, 2009) |
| "A 52-year-old woman with bilateral leg spasticity because of spinal multiple sclerosis underwent baclofen pump implantation, which was subcutaneously placed in the right upper quadrant." | 3.75 | Tangled catheter as a rare cause of baclofen pump malfunction. ( Fukuhara, T; Kuyama, H; Namba, Y; Tanaka, T, 2009) |
| "In this retrospective study, 20 spastic quadriplegic cerebral palsy (CP) patients with baclofen pumps, who underwent spinal fusion and instrumentation for neuromuscular scoliosis, were matched for weight, age, and type of fusion with patients without pumps." | 3.74 | Outcomes of posterior spinal fusion and instrumentation in patients with continuous intrathecal baclofen infusion pumps. ( Ayyangar, RN; Caird, MS; Drongowski, A; Farley, FA; Garton, H; Hensinger, RN; Palanca, AA, 2008) |
| "We report the occurrence of delayed postoperative coma in five of nine consecutive children following surgery for insertion of baclofen infusion pumps." | 3.71 | Reversible coma in children after improper baclofen pump insertion. ( Anderson, KJ; Brown, K; Farmer, JP, 2002) |
| "Trigeminal neuralgia is a paroxysmal and severely disabling facial pain." | 2.39 | The medical and surgical management of trigeminal neuralgia. ( Maxwell, S; Sidebottom, A, 1995) |
| "Patients with a spinal origin of spasticity, a lower modified Rankin Scale and a higher Barthel Index have a higher risk to sustain a complication." | 1.48 | Eleven years' experience with Intrathecal Baclofen - Complications, risk factors. ( Fava, E; Fritz, J; Hitzenberger, G; Laimer, I; Matzak, H; Pucks-Faes, E; Saltuari, L; Verrienti, G, 2018) |
| "To indicate the appropriate baclofen dosage to control severe spasticity of spinal origin and to develop the optimal administration protocol for long-term intrathecal baclofen (ITB) therapy." | 1.48 | The dosage and administration of long-term intrathecal baclofen therapy for severe spasticity of spinal origin. ( Hayashi, T; Kawano, O; Maeda, T; Masuda, M; Morishita, Y; Sakai, H; Takao, T; Ueta, T, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.03) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 14 (42.42) | 29.6817 |
| 2010's | 13 (39.39) | 24.3611 |
| 2020's | 3 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Perez, EA | 1 |
| Ray, E | 1 |
| Gold, CJ | 1 |
| Park, BJ | 1 |
| Piscopo, A | 1 |
| Carnahan, RM | 1 |
| Banks, M | 1 |
| Sanders, RD | 1 |
| Olinger, CR | 1 |
| Mueller, RN | 1 |
| Woodroffe, RW | 1 |
| Benedičič, M | 1 |
| Groleger Sršen, K | 1 |
| Grabljevec, K | 1 |
| Majdič, N | 1 |
| Haber, B | 1 |
| Lins, LAB | 1 |
| Nechyporenko, AV | 1 |
| Halanski, MA | 1 |
| Hetzel, SJ | 1 |
| Noonan, KJ | 1 |
| Thind, M | 1 |
| Cohen, DA | 1 |
| Walker, KR | 1 |
| Novotny, SA | 1 |
| Krach, LE | 1 |
| Lam, SK | 1 |
| Mayer, RR | 1 |
| Vedantam, A | 1 |
| A Staggers, K | 1 |
| Harris, DA | 1 |
| Pan, IW | 1 |
| Buxton, K | 1 |
| Dallas, J | 1 |
| Sborov, KD | 1 |
| Guidry, BS | 1 |
| Chotai, S | 1 |
| Bonfield, CM | 1 |
| Pucks-Faes, E | 1 |
| Hitzenberger, G | 1 |
| Matzak, H | 1 |
| Fava, E | 1 |
| Verrienti, G | 1 |
| Laimer, I | 1 |
| Fritz, J | 1 |
| Saltuari, L | 1 |
| Kawano, O | 1 |
| Masuda, M | 1 |
| Takao, T | 1 |
| Sakai, H | 1 |
| Morishita, Y | 1 |
| Hayashi, T | 1 |
| Ueta, T | 1 |
| Maeda, T | 1 |
| Lee, AR | 1 |
| Cho, YW | 1 |
| Lee, JM | 1 |
| Shin, YJ | 1 |
| Han, IS | 1 |
| Lee, HK | 1 |
| Stroud, J | 1 |
| Scattoloni, J | 1 |
| Blasingim, M | 1 |
| Nafiu, OO | 1 |
| Thakur, SK | 1 |
| Rubin, BA | 1 |
| Harter, DH | 1 |
| Saulino, M | 1 |
| Turner, M | 2 |
| Miesel, K | 1 |
| Cochran, FR | 1 |
| Stromberg, K | 1 |
| Fehrmann, E | 1 |
| Markert, M | 1 |
| Spencer, R | 1 |
| Robinson, S | 1 |
| Robertson, FC | 1 |
| Dasenbrock, HH | 1 |
| O'Brien, CP | 1 |
| Berde, C | 1 |
| Padua, H | 1 |
| Patti, F | 1 |
| Pappalardo, A | 1 |
| Lo Fermo, S | 1 |
| Cimino, V | 1 |
| Castiglione, A | 1 |
| Zappia, M | 1 |
| Borowski, A | 1 |
| Shah, SA | 1 |
| Littleton, AG | 1 |
| Dabney, KW | 1 |
| Miller, F | 1 |
| Martens, FM | 1 |
| Somford, DM | 1 |
| van Kuppevelt, DH | 1 |
| van den Burg, MJ | 1 |
| Heesakkers, JP | 1 |
| Fjelstad, AB | 1 |
| Hommelstad, J | 1 |
| Sorteberg, A | 1 |
| Stetkarova, I | 1 |
| Yablon, SA | 1 |
| Kofler, M | 1 |
| Stokic, DS | 1 |
| Martin, TW | 1 |
| Mayhew, JF | 1 |
| Delhaas, E | 1 |
| Goslinga, S | 1 |
| Atiyeh, BS | 1 |
| Hayek, SN | 1 |
| Skaff, GS | 1 |
| Araj, AM | 1 |
| Chamoun, RB | 1 |
| Albright, AL | 1 |
| Pattisapu, JV | 1 |
| Motta, F | 1 |
| Buonaguro, V | 1 |
| Stignani, C | 1 |
| Caird, MS | 1 |
| Palanca, AA | 1 |
| Garton, H | 1 |
| Hensinger, RN | 1 |
| Ayyangar, RN | 1 |
| Drongowski, A | 1 |
| Farley, FA | 1 |
| Vanhauwaert, DJ | 1 |
| Kalala, JP | 1 |
| Baert, E | 1 |
| Hallaert, G | 1 |
| Crombez, E | 1 |
| Caemaert, J | 1 |
| Van Roost, D | 1 |
| Fukuhara, T | 1 |
| Tanaka, T | 1 |
| Namba, Y | 1 |
| Kuyama, H | 1 |
| Sidebottom, A | 1 |
| Maxwell, S | 1 |
| Marino, RA | 1 |
| Cairns, K | 1 |
| Stein, J | 1 |
| Anderson, KJ | 1 |
| Farmer, JP | 1 |
| Brown, K | 1 |
| Iacono, RP | 1 |
| Linford, J | 1 |
| Tourian, A | 1 |
| Sandyk, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Feasibility of Measuring Cerebrospinal Fluid (CSF) Signatures in Subjects With Intrathecal Catheter-Related Problems[NCT01117090] | 47 participants (Actual) | Observational | 2010-06-30 | Completed | |||
| Intrathecal (IT) Baclofen Drug Distribution Pilot Study[NCT02903823] | Phase 4 | 27 participants (Actual) | Interventional | 2016-04-22 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Collect and characterize, by comparison with the physician's standard trouble-shooting diagnosis, CSF signatures recorded in subjects who have an infusion system who present with signs and/or symptoms of possible catheter-related problems or failure. (NCT01117090)
Timeframe: 1 day
| Intervention | Subjects whose CSF data agree with MD Dx (Number) |
|---|---|
| Subjects With Normal Catheter Function by Physician Diagnosis | 13 |
| Subjects With Catheter Complications by Physician Diagnosis | 16 |
Characterize the relationship between pressure decay-to-baseline time (in seconds) and the physician's standard trouble-shooting diagnosis (NCT01117090)
Timeframe: 1 day
| Intervention | seconds (Mean) |
|---|---|
| Subjects With Normal Catheter Function by Physician Diagnosis | 6.4 |
| Subjects With Catheter Complications by Physician Diagnosis | 19.9 |
Collect and characterize, by comparison with the physician's standard trouble-shooting diagnosis, the mean change in CSF pressure data during the physical task of a cough (NCT01117090)
Timeframe: 1 day
| Intervention | mmHg (Mean) |
|---|---|
| Subjects With Normal Catheter Function by Physician Diagnosis | 21.0 |
| Subjects With Catheter Complications by Physician Diagnosis | 6.6 |
Collect and characterize, by comparison with the physician's standard trouble-shooting diagnosis, the mean change in CSF pressure data during the physical task of a valsalva maneuver (NCT01117090)
Timeframe: 1 day
| Intervention | mmHg (Mean) |
|---|---|
| Subjects With Normal Catheter Function by Physician Diagnosis | 18.7 |
| Subjects With Catheter Complications by Physician Diagnosis | 4.8 |
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of cerebral origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Cervical level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar lever 2 injection site | |
| Subjects With Max MAS Change | 8 | 7 | 3 | 3 |
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of spinal origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Cervical spine level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar level 2 injection site | |
| Subjects With MAS Change - Based on Site of Injection | 4 | 2 | 5 | 3 |
2 reviews available for baclofen and Postoperative Complications
| Article | Year |
|---|---|
Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review.
Topics: Adult; Baclofen; Humans; Infusion Pumps, Implantable; Injections, Spinal; Muscle Hypertonia; Postope | 2010 |
The medical and surgical management of trigeminal neuralgia.
Topics: Baclofen; Carbamazepine; Combined Modality Therapy; Facial Nerve; Humans; Phenytoin; Postoperative C | 1995 |
31 other studies available for baclofen and Postoperative Complications
| Article | Year |
|---|---|
Postoperative Use of the Muscle Relaxants Baclofen and/or Cyclobenzaprine Associated With an Increased Risk of Delirium Following Lumbar Fusion.
Topics: Aged; Baclofen; Cohort Studies; Emergence Delirium; Humans; Muscles; Postoperative Complications; Re | 2023 |
Twenty years of intrathecal baclofen therapy in Slovenia: a retrospective single-center analysis of complications.
Topics: Baclofen; Female; Humans; Infusion Pumps, Implantable; Injections, Spinal; Muscle Relaxants, Central | 2023 |
Does an intrathecal baclofen pump impact scoliosis progression and complicate posterior spine fusion in patients with cerebral palsy?
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Disease Progression; Female; Humans; Infusion Pu | 2020 |
Pulmonary Embolism Presenting as Persistent Hiccups.
Topics: Anticoagulants; Baclofen; Computed Tomography Angiography; Elective Surgical Procedures; Enoxaparin; | 2018 |
Does Intrathecal Baclofen Therapy Increase Prevalence and/or Progression of Neuromuscular Scoliosis?
Topics: Adolescent; Baclofen; Case-Control Studies; Cerebral Palsy; Chi-Square Distribution; Child; Disease | 2017 |
Readmission and complications within 30 days after intrathecal baclofen pump placement.
Topics: Adolescent; Baclofen; Child; Female; Humans; Infusion Pumps, Implantable; Infusions, Spinal; Male; M | 2018 |
Balancing the benefits of intrathecal baclofen pump surgery with potential postoperative complications.
Topics: Baclofen; Humans; Infusion Pumps, Implantable; Injections, Spinal; Muscle Relaxants, Central; Muscle | 2018 |
Complication rates for preexisting baclofen pumps and ventricular shunts following scoliosis correction: a preliminary study.
Topics: Adolescent; Baclofen; Child; Female; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Male; M | 2018 |
Eleven years' experience with Intrathecal Baclofen - Complications, risk factors.
Topics: Adolescent; Adult; Aged; Baclofen; Catheterization; Child; Child, Preschool; Female; Humans; Infusio | 2018 |
The dosage and administration of long-term intrathecal baclofen therapy for severe spasticity of spinal origin.
Topics: Baclofen; Drug Tolerance; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Injections, Spinal | 2018 |
Treatment of persistent postoperative hiccups with stellate ganglion block: Three case reports.
Topics: Adult; Aged; Anesthetics, Local; Autonomic Nerve Block; Baclofen; Hiccup; Humans; Male; Muscle Relax | 2018 |
Intrathecal baclofen toxicity: an unusual cause of paediatric postoperative coma and respiratory depression.
Topics: Adolescent; Baclofen; Cerebral Palsy; Coma; Humans; Injections, Spinal; Male; Muscle Relaxants, Cent | 2014 |
Long-term follow-up for lumbar intrathecal baclofen catheters placed using the paraspinal subfascial technique.
Topics: Adolescent; Adult; Baclofen; Catheterization; Catheters, Indwelling; Child; Child, Preschool; Dyston | 2016 |
Can Cerebrospinal Fluid Pressure Detect Catheter Complications in Patients Who Experience Loss of Effectiveness With Intrathecal Baclofen Therapy?
Topics: Adolescent; Adult; Aged; Algorithms; Baclofen; Catheters, Indwelling; Cerebrospinal Fluid Pressure; | 2017 |
Image-guided intrathecal baclofen pump catheter implantation: a technical note and case series.
Topics: Adolescent; Adult; Anesthesia, General; Baclofen; Catheters, Indwelling; Cerebral Palsy; Cone-Beam C | 2017 |
Life-threatening constipation induced by intrathecal baclofen therapy.
Topics: Adult; Baclofen; Constipation; Female; Humans; Hypoxia, Brain; Ileal Diseases; Infusion Pumps, Impla | 2008 |
Baclofen pump implantation and spinal fusion in children: techniques and complications.
Topics: Adolescent; Adult; Baclofen; Child; Humans; Infusion Pumps, Implantable; Postoperative Complications | 2008 |
Retraction of an intrathecal baclofen infusion catheter following suprapubic cystotomy: a case report.
Topics: Adrenoleukodystrophy; Adult; Baclofen; Cystotomy; Equipment Failure; Humans; Infusion Pumps, Implant | 2009 |
Infections related to intrathecal baclofen therapy in children and adults: frequency and risk factors.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Baclofen; Bacterial Infections; Child; Child, Presch | 2009 |
Baclofen pumps: comment on Anderson et al.
Topics: Anti-Arrhythmia Agents; Atropine; Baclofen; Child; Coma; GABA Agonists; Humans; Infusion Pumps, Impl | 2003 |
Baclofen pumps: comment on Anderson et al.
Topics: Baclofen; Child; Coma; Drug Overdose; GABA Agonists; Humans; Infusion Pumps, Implantable; Medication | 2003 |
Salvage of baclofen pump pocket infection with muscle flap.
Topics: Adult; Astrocytoma; Baclofen; Cerebral Ventricle Neoplasms; Drug Resistance; Humans; Infusion Pumps, | 2004 |
Best-practice surgical techniques for intrathecal baclofen therapy.
Topics: Baclofen; Catheters, Indwelling; Cerebral Palsy; Child; Dystonia; Equipment Design; GABA Agonists; H | 2006 |
The use of intrathecal baclofen pump implants in children and adolescents: safety and complications in 200 consecutive cases.
Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Child, Preschool; Female; Humans; Infusion Pumps, Impla | 2007 |
Outcomes of posterior spinal fusion and instrumentation in patients with continuous intrathecal baclofen infusion pumps.
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Female; Humans; Infusion Pumps, Implantable; Inj | 2008 |
Migration of pump for intrathecal drug delivery into the peritoneal cavity. Case report.
Topics: Abdominal Muscles; Abdominal Wall; Accidents, Traffic; Baclofen; Foreign-Body Migration; Humans; Inf | 2009 |
Tangled catheter as a rare cause of baclofen pump malfunction.
Topics: Baclofen; Catheters, Indwelling; Female; Humans; Infusion Pumps, Implantable; Middle Aged; Multiple | 2009 |
Baclofen therapy for intractable hiccups in pancreatic carcinoma.
Topics: Aged; Baclofen; GABA Agonists; Hiccup; Humans; Male; Pancreatic Neoplasms; Postoperative Complicatio | 1998 |
Motor function improvement following intrathecal baclofen pump placement in a patient with locked-in syndrome.
Topics: Adult; Baclofen; Brain Stem Infarctions; Humans; Infusion Pumps, Implantable; Male; Muscle Relaxants | 2002 |
Reversible coma in children after improper baclofen pump insertion.
Topics: Analgesics, Opioid; Baclofen; Cerebral Palsy; Child; Child, Preschool; Coma; Female; GABA Agonists; | 2002 |
Baclofen in the treatment of post-amputation autonomous stump movements.
Topics: Amputation, Surgical; Baclofen; Humans; Male; Middle Aged; Movement Disorders; Postoperative Complic | 1987 |