baclofen has been researched along with Pain, Intractable in 16 studies
Pain, Intractable: Persistent pain that is refractory to some or all forms of treatment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-eight patients with neuropathic pain of peripheral origin responding poorly to SCS were enrolled in a study with intrathecal baclofen; in a few cases adenosine was also tried." | 2.71 | Intrathecal baclofen as adjuvant therapy to enhance the effect of spinal cord stimulation in neuropathic pain: a pilot study. ( Lind, G; Linderoth, B; Meyerson, BA; Winter, J, 2004) |
| "Phantom pain, a form of neuropathic pain, is caused by damage to somatosensible afferent nerve fibres in the peripheral or central nervous system." | 2.41 | [Pharmacotherapy for neuropathic pain caused by injury to the afferent nerve fibers]. ( Weber, WE, 2001) |
| "For treatment of opioid-induced myoclonus a dose reduction or a change of the opioid should be considered as well as symptomatic treatment with benzodiazepines or baclofen." | 1.30 | [Myoclonus resulting from high-dose epidural and intravenous morphine infusion]. ( Grond, S; Radbruch, L; Zech, D, 1997) |
| "Clonidine was added to baclofen in the pump reservoir and both drugs were administered intrathecally in combination." | 1.29 | Intrathecal clonidine and baclofen in the management of spasticity and neuropathic pain following spinal cord injury: a case study. ( Middleton, JW; Molloy, AR; Rutkowski, SB; Siddall, PJ; Walker, S, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Taira, T | 2 |
| Saulino, M | 1 |
| Harmer, JP | 1 |
| Larson, BS | 1 |
| Lind, G | 1 |
| Meyerson, BA | 1 |
| Winter, J | 1 |
| Linderoth, B | 1 |
| Taha, J | 1 |
| Favre, J | 1 |
| Janszen, M | 1 |
| Galarza, M | 1 |
| Taha, A | 1 |
| Plassat, R | 1 |
| Perrouin Verbe, B | 1 |
| Menei, P | 1 |
| Menegalli, D | 1 |
| Mathé, JF | 1 |
| Richard, I | 1 |
| Shimoyama, N | 1 |
| Akizuki, A | 1 |
| Takahashi, H | 1 |
| Shimoyama, M | 1 |
| Nayak, S | 1 |
| Roberts, S | 1 |
| Cunliffe, M | 1 |
| Kroin, JS | 1 |
| Ali, A | 1 |
| York, M | 1 |
| Penn, RD | 1 |
| Chodakiewitz, JW | 1 |
| Tanikawa, T | 1 |
| Kawamura, H | 1 |
| Iseki, H | 1 |
| Takakura, K | 1 |
| Middleton, JW | 1 |
| Siddall, PJ | 1 |
| Walker, S | 1 |
| Molloy, AR | 1 |
| Rutkowski, SB | 1 |
| Tan, AK | 1 |
| Tan, CB | 1 |
| Radbruch, L | 1 |
| Zech, D | 1 |
| Grond, S | 1 |
| Weber, WE | 1 |
| Lazorthes, Y | 1 |
| Sallerin-Caute, B | 1 |
| Verdie, JC | 1 |
| Bastide, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intrathecal (IT) Baclofen Drug Distribution Pilot Study[NCT02903823] | Phase 4 | 27 participants (Actual) | Interventional | 2016-04-22 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of cerebral origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Cervical level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar lever 2 injection site | |
| Subjects With Max MAS Change | 8 | 7 | 3 | 3 |
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of spinal origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Cervical spine level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar level 2 injection site | |
| Subjects With MAS Change - Based on Site of Injection | 4 | 2 | 5 | 3 |
4 reviews available for baclofen and Pain, Intractable
| Article | Year |
|---|---|
[Chronic intrathecal drug administration for the control of intractable pain].
Topics: Amines; Analgesics, Opioid; Anesthetics, Local; Baclofen; Calcium Channel Blockers; Clonidine; Cyclo | 2008 |
[Palliative medicine for advanced gynecological malignancy].
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Baclofen; Bone Neoplasms; Drug Therapy, | 2004 |
[Pharmacotherapy for neuropathic pain caused by injury to the afferent nerve fibers].
Topics: Amantadine; Analgesics, Non-Narcotic; Anticonvulsants; Antidepressive Agents, Tricyclic; Baclofen; D | 2001 |
Advances in drug delivery systems and applications in neurosurgery.
Topics: Adult; Aged; Aged, 80 and over; Animals; Baclofen; Brain Diseases; Equipment Design; Female; Humans; | 1991 |
2 trials available for baclofen and Pain, Intractable
| Article | Year |
|---|---|
Intrathecal baclofen as adjuvant therapy to enhance the effect of spinal cord stimulation in neuropathic pain: a pilot study.
Topics: Administration, Oral; Adult; Aged; Analgesics; Baclofen; Electric Stimulation Therapy; Female; GABA | 2004 |
Spinal intrathecal baclofen suppresses central pain after a stroke.
Topics: Baclofen; Cerebrovascular Disorders; Female; Humans; Injections, Spinal; Male; Middle Aged; Pain; Pa | 1994 |
10 other studies available for baclofen and Pain, Intractable
| Article | Year |
|---|---|
Simultaneous treatment of intractable pain and spasticity: observations of combined intrathecal baclofen-morphine therapy over a 10-year clinical experience.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Baclofen; Drug Therapy, Combination; Female; Follow-Up | 2012 |
Pain relief from baclofen analgesia in a neuropathic pain patient who failed opioid and pharmacotherapy: case report.
Topics: Analgesics, Opioid; Baclofen; Female; Humans; Injections, Spinal; Middle Aged; Muscle Relaxants, Cen | 2002 |
Correlation between withdrawal symptoms and medication pump residual volume in patients with implantable SynchroMed pumps.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; Baclofen; Bupivacaine; Clon | 2004 |
Treatment of spasticity with intrathecal Baclofen administration: long-term follow-up, review of 40 patients.
Topics: Adult; Baclofen; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Fe | 2004 |
Management of intractable pain from a chronic dislocated hip in an adolescent.
Topics: Baclofen; Catheterization; Child; Chronic Disease; Drug Tolerance; Female; Femoral Nerve; GABA Agoni | 2008 |
The distribution of medication along the spinal canal after chronic intrathecal administration.
Topics: Analgesia, Epidural; Baclofen; Endometrial Neoplasms; Female; Humans; Hydromorphone; Infusion Pumps, | 1993 |
Managing chronic intractable pain.
Topics: Baclofen; Humans; Infusion Pumps, Implantable; Morphine; Pain, Intractable | 1995 |
Intrathecal clonidine and baclofen in the management of spasticity and neuropathic pain following spinal cord injury: a case study.
Topics: Adult; Baclofen; Clonidine; Female; Humans; Infusion Pumps, Implantable; Injections, Spinal; Muscle | 1996 |
The syndrome of painful legs and moving toes--a case report.
Topics: Baclofen; Clonazepam; Female; GABA Agonists; GABA Modulators; Humans; Middle Aged; Neuromuscular Dis | 1996 |
[Myoclonus resulting from high-dose epidural and intravenous morphine infusion].
Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Baclofen; Female; GABA Agonists; Humans; Injections, | 1997 |