baclofen has been researched along with Neuroleptic Malignant Syndrome in 9 studies
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intrathecal baclofen (ITB) is increasingly being used to reduce spasticity among children with cerebral palsy, dystonia, and spinal cord injuries." | 7.74 | Intrathecal baclofen withdrawal resembling serotonin syndrome in an adolescent boy with cerebral palsy. ( Eiland, LS; Salazar, ML, 2008) |
| " Syndromes include adrenergic "fever," anticholinergic "fever," antidopaminergic "fever," serotonin syndrome, malignant hyperthermia, uncoupling of oxidative phosphorylation, and withdrawal from baclofen." | 4.86 | Adverse drug reactions resulting in hyperthermia in the intensive care unit. ( McAllen, KJ; Schwartz, DR, 2010) |
| "Intrathecal baclofen (ITB) is increasingly being used to reduce spasticity among children with cerebral palsy, dystonia, and spinal cord injuries." | 3.74 | Intrathecal baclofen withdrawal resembling serotonin syndrome in an adolescent boy with cerebral palsy. ( Eiland, LS; Salazar, ML, 2008) |
| "We concur with the concept that neuroleptic malignant syndrome represents a spectrum of disorders, and add it to the list of possible sequelae after abrupt withdrawal of baclofen." | 2.41 | Neuroleptic malignant-like syndrome after abrupt withdrawal of baclofen. ( Gainsborough, N; Turner, MR, 2001) |
| "Neuroleptic malignant syndrome is a rare, life-threatening disorder that can occur without the administration of neuroleptic medications." | 1.35 | Neuroleptic malignant syndrome from central nervous system insult: 4 cases and a novel treatment strategy. Clinical article. ( Killory, BD; Ponce, FA; Rekate, HL; Wait, SD; Wallace, D, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hardman, MI | 1 |
| Sprung, J | 1 |
| Weingarten, TN | 1 |
| Salazar, ML | 1 |
| Eiland, LS | 1 |
| Wait, SD | 1 |
| Ponce, FA | 1 |
| Killory, BD | 1 |
| Wallace, D | 1 |
| Rekate, HL | 1 |
| McAllen, KJ | 1 |
| Schwartz, DR | 1 |
| Adeva-Bartolomé, MT | 1 |
| Alonso-Navarro, H | 1 |
| Martín-Prieto, M | 1 |
| Jiménez-Jiménez, FJ | 1 |
| Samson-Fang, L | 1 |
| Gooch, J | 1 |
| Norlin, C | 1 |
| Turner, MR | 1 |
| Gainsborough, N | 1 |
| Coffey, RJ | 1 |
| Edgar, TS | 1 |
| Francisco, GE | 1 |
| Graziani, V | 1 |
| Meythaler, JM | 1 |
| Ridgely, PM | 1 |
| Sadiq, SA | 1 |
| Turner, MS | 1 |
| Rogers, JD | 1 |
| Stoudemire, GA | 1 |
4 reviews available for baclofen and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.
Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor | 2019 |
Adverse drug reactions resulting in hyperthermia in the intensive care unit.
Topics: Baclofen; Critical Care; Drug-Related Side Effects and Adverse Reactions; Fever; Humans; Intensive C | 2010 |
Neuroleptic malignant-like syndrome after abrupt withdrawal of baclofen.
Topics: Adult; Baclofen; Creatine Kinase; Electrocardiography; Humans; Male; Muscle Relaxants, Central; Musc | 2001 |
Abrupt withdrawal from intrathecal baclofen: recognition and management of a potentially life-threatening syndrome.
Topics: Anti-Anxiety Agents; Autonomic Dysreflexia; Baclofen; Benzodiazepines; Diagnosis, Differential; GABA | 2002 |
5 other studies available for baclofen and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Intrathecal baclofen withdrawal resembling serotonin syndrome in an adolescent boy with cerebral palsy.
Topics: Abdominal Pain; Adolescent; Autonomic Dysreflexia; Baclofen; Cerebral Palsy; Diagnosis, Differential | 2008 |
Neuroleptic malignant syndrome from central nervous system insult: 4 cases and a novel treatment strategy. Clinical article.
Topics: Adult; Baclofen; Cerebrospinal Fluid Shunts; Child, Preschool; Equipment Failure; Female; Hemisphere | 2009 |
[Neuroleptic malignant-like syndrome following abrupt withdrawal of baclofen].
Topics: Aged, 80 and over; Baclofen; Humans; Male; Muscle Relaxants, Central; Neuroleptic Malignant Syndrome | 2006 |
Intrathecal baclofen withdrawal simulating neuroleptic malignant syndrome in a child with cerebral palsy.
Topics: Baclofen; Cerebral Palsy; Child; Diagnosis, Differential; Humans; Injections, Spinal; Male; Muscle R | 2000 |
Neuroleptic malignant syndrome in multiple sclerosis. Possible masking effects of antispasmodics.
Topics: Adult; Baclofen; Female; Humans; Multiple Sclerosis; Neuroleptic Malignant Syndrome | 1988 |