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baclofen and Myelopathy

baclofen has been researched along with Myelopathy in 35 studies

Research Excerpts

ExcerptRelevanceReference
") baclofen on chronic, dysesthetic, and spasm-related pain (SRP) among patients with spinal spasticity [i."9.07Intrathecal baclofen suppresses central pain in patients with spinal lesions. A pilot study. ( D'Luzansky, SC; Herman, RM; Ippolito, R, 1992)
"A convenience sample of nine consecutively recruited men with spinal cord injury or multiple sclerosis who were receiving intrathecal baclofen by an implantable pump; average follow-up was 44."5.08Side effects of chronic intrathecal baclofen on erection and ejaculation in patients with spinal cord lesions. ( Azouvi, P; Bussel, B; Chartier-Kastler, E; Denys, P; Mane, M; Thiebaut, JB, 1998)
"A total of 93 patients with intractable spasticity due to either spinal cord injury (59 cases), multiple sclerosis (31 cases), or other spinal pathology (three cases) were entered into a randomized double-blind placebo-controlled screening protocol of intrathecal baclofen test injections."5.07Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study. ( Cahill, D; Coffey, JR; Gill, B; Herman, R; Levy, R; Meythaler, J; Ordia, J; Park, TS; Shetter, AG; Steers, W, 1993)
") baclofen on chronic, dysesthetic, and spasm-related pain (SRP) among patients with spinal spasticity [i."5.07Intrathecal baclofen suppresses central pain in patients with spinal lesions. A pilot study. ( D'Luzansky, SC; Herman, RM; Ippolito, R, 1992)
"A total of 66 consecutive patients with severe spasticity of spinal cord origin were screened with intrathecal baclofen, and all but two responded with a two-point decrease in their Ashworth spasticity scale and/or spasm scale score."3.68Intrathecal baclofen for spasticity of spinal origin: seven years of experience. ( Penn, RD, 1992)
"Adults with CP and chronic pain receiving usual care had stable, persistent pain intensity."3.01Clinical course of pain intensity in individuals with cerebral palsy: A prognostic systematic review. ( Côté, P; Fehlings, DL; Hogg-Johnson, S; Shearer, HM; Verville, L, 2023)
" The dosage for all patients more than doubled (P < 0."2.67Continuous intrathecal baclofen in spinal cord spasticity. A prospective study. ( Cross, LL; Haworth, CS; Meythaler, JM; Steers, WD; Tuel, SM, 1992)
"Twenty patients with spinal spasticity caused by multiple sclerosis or spinal-cord injury who had had no response to treatment with oral baclofen received an intrathecal infusion of baclofen or saline for three days."2.66Intrathecal baclofen for severe spinal spasticity. ( Corcos, D; Gottlieb, G; Kroin, JS; Latash, M; Parke, B; Penn, RD; Savoy, SM, 1989)
"Baclofen is an agonisit at gamma-aminobutyric acid (GABA) receptors, and is, therefore, a neuroinhibitor, and decreases spasticity."2.44[Intrathecal baclofen for severe spasticity]. ( Ueta, T, 2008)
"With the introduction of the antispasticity agent, tizanidine hydrochloride (Zanaflex), physicians have requested information about the optimal way to switch appropriate patients from baclofen to tizanidine."2.40An approach to switching patients from baclofen to tizanidine. ( Brenner, R; Hyman, N; Knobler, R; O'Brien, M; Stephan, T, 1998)
"The pathophysiology of spasticity and the history of posterior rhizotomies are reviewed."2.38Neurosurgical treatment of spasticity: selective posterior rhizotomy and intrathecal baclofen. ( Albright, AL, 1992)
"Propriospinal myoclonus is a subtype of spinal myoclonus characterized by axial flexion or extension jerks, arrhythmic and prolonged muscle bursts with a pattern of activation consistent with a slow conduction within the propriospinal pathways."1.30[Propriospinal myoclonus induced by relaxation and drowsiness]. ( Arné, P; Dousset, V; Henry, P; Paty, J; Tison, F, 1998)
" The following were taken as evaluation criteria: age, sex, performance status, duration and dosage of previous systemic and current spinal morphine therapy, concomitant analgesic and co-analgesic medication, pretreatment of the dorsal column and neurological dysfunction due to damage either of the nerval plexus or of the medulla spinalis."1.29Complications of spinal opioid therapy: myoclonus, spastic muscle tone and spinal jerking. ( Bingel, U; Kloke, M; Seeber, S, 1994)
"However, when the spasticity is severe, the systemic administration has to be increased, often without therapeutic effects but frequently with central side-effects."1.27Intrathecal application of baclofen in the treatment of spasticity. ( Rea, GL; Siegfried, J, 1987)
"We studied a patient with progressive myelopathy, in whom systemic sarcoidosis was discovered."1.26Subacute myelopathy as the presenting manifestation of sarcoidosis. ( Bogousslavsky, J; Graf, HJ; Hungerbühler, JP; Regli, F, 1982)
" Restoration of effective dosage again led to satisfactory voiding function in all patients."1.25Bladder training: its role in evaluating the effect of an antispasticity drug on voiding in patients with neurogenic bladder. ( Abramson, AS; Feibel, A; Levine, SA; Roussan, MS, 1975)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199011 (31.43)18.7374
1990's15 (42.86)18.2507
2000's7 (20.00)29.6817
2010's0 (0.00)24.3611
2020's2 (5.71)2.80

Authors

AuthorsStudies
Perdomo-Pantoja, A1
Zakaria, HM1
Liu, A1
Tsehay, Y1
Weber-Levine, C1
Mao, G1
Theodore, N1
Shearer, HM1
Verville, L1
Côté, P1
Hogg-Johnson, S1
Fehlings, DL1
Patti, F1
Pappalardo, A1
Lo Fermo, S1
Cimino, V1
Castiglione, A1
Zappia, M1
Ueta, T1
Signorelli, CD1
Lavano, A1
Volpentesta, G1
Chirchiglia, D1
Signorelli, F1
Bono, F1
Ferraro, G1
Sibille, M1
Veltri, C1
Aloisi, M1
Piragine, G1
Serra, S1
Scola, P1
Pardatcher, S1
Pardatcher, K1
Santangelo, E1
Ray, BK1
Guha, G1
Misra, AK1
Das, SK1
Dario, A1
Scamoni, C1
Picano, M1
Casagrande, F1
Tomei, G1
Nayak, S1
Roberts, S1
Cunliffe, M1
Young, RR3
Bogousslavsky, J1
Hungerbühler, JP1
Regli, F1
Graf, HJ1
Kloke, M1
Bingel, U1
Seeber, S1
Coffey, JR1
Cahill, D1
Steers, W1
Park, TS2
Ordia, J1
Meythaler, J1
Herman, R1
Shetter, AG1
Levy, R1
Gill, B1
Azouvi, P2
Roby-Brami, A1
Biraben, A1
Thiebaut, JB2
Thurel, C1
Bussel, B2
Denys, P1
Mane, M1
Chartier-Kastler, E1
Tison, F1
Arné, P1
Dousset, V1
Paty, J1
Henry, P1
Brenner, R1
Hyman, N1
Knobler, R1
O'Brien, M1
Stephan, T1
Huch, K1
Kunz, U1
Kluger, P1
Puhl, W1
Huraibi, HA1
Phillips, J1
Rose, RJ1
Pallatroni, H1
Westbrook, H1
Fanciullo, GJ1
Teague, CT1
Merrill, DC1
Duncan, GW1
Shahani, BT1
Gusta, A1
Matwiejko, L1
Pienc, A1
Roussan, MS1
Abramson, AS1
Levine, SA1
Feibel, A1
Kroin, JS2
Steers, WD2
Meythaler, JM2
Haworth, C1
Herrell, D1
Albright, AL1
Tuel, SM1
Cross, LL1
Haworth, CS1
Herman, RM1
D'Luzansky, SC1
Ippolito, R1
Teddy, P1
Jamous, A1
Gardner, B1
Wang, D1
Silver, J1
Penn, RD2
Putty, TK1
Shapiro, SA1
Savoy, SM1
Corcos, D1
Latash, M1
Gottlieb, G1
Parke, B1
Broseta, J1
Morales, F1
García-March, G1
Sánchez-Ledesma, MJ1
Anaya, J1
Gonzalez-Darder, J1
Barberá, J1
Jones, RF1
Anthony, M1
Torda, TA1
Poulos, C1
Siegfried, J1
Rea, GL1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intrathecal (IT) Baclofen Drug Distribution Pilot Study[NCT02903823]Phase 427 participants (Actual)Interventional2016-04-22Completed
The Use of Penile Vibratory Stimulation to Decrease Spasticity Following Spinal Cord Injury[NCT00223873]30 participants Interventional2002-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Subjects Experiencing Maximal MAS Change From Baseline - Spasticity of Cerebral Origin

"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of cerebral origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection

InterventionParticipants (Count of Participants)
Cervical level 4 injection siteThoracic level 3 injection siteThoracic level 10 injection siteLumbar lever 2 injection site
Subjects With Max MAS Change8733

Subjects Experiencing Maximal MAS Change From Baseline - Spasticity of Spinal Origin

"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of spinal origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection

InterventionParticipants (Count of Participants)
Cervical spine level 4 injection siteThoracic level 3 injection siteThoracic level 10 injection siteLumbar level 2 injection site
Subjects With MAS Change - Based on Site of Injection4253

Reviews

6 reviews available for baclofen and Myelopathy

ArticleYear
Clinical course of pain intensity in individuals with cerebral palsy: A prognostic systematic review.
    Developmental medicine and child neurology, 2023, Volume: 65, Issue:1

    Topics: Adult; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Child; Chronic Pain; Humans; Pain Measure

2023
[Intrathecal baclofen for severe spasticity].
    Brain and nerve = Shinkei kenkyu no shinpo, 2008, Volume: 60, Issue:12

    Topics: Adult; Aged; Baclofen; Female; GABA Agonists; Humans; Infusion Pumps, Implantable; Injections, Spina

2008
Pharmacological complications of the chronic baclofen infusion in the severe spinal spasticity. Personal experience and review of the literature.
    Journal of neurosurgical sciences, 2004, Volume: 48, Issue:4

    Topics: Adult; Baclofen; Constipation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug

2004
An approach to switching patients from baclofen to tizanidine.
    Hospital medicine (London, England : 1998), 1998, Volume: 59, Issue:10

    Topics: Baclofen; Clinical Competence; Clonidine; Humans; Multiple Sclerosis; Muscle Relaxants, Central; Mus

1998
Intrathecal drug administration. Present use and future trends.
    Clinical pharmacokinetics, 1992, Volume: 22, Issue:5

    Topics: Analgesics; Baclofen; Brain Diseases; Humans; Injections, Spinal; Neoplasms; Palliative Care; Spasm;

1992
Neurosurgical treatment of spasticity: selective posterior rhizotomy and intrathecal baclofen.
    Stereotactic and functional neurosurgery, 1992, Volume: 58, Issue:1-4

    Topics: Adolescent; Adult; Animals; Baclofen; Cerebral Palsy; Child; Female; Humans; Injections, Spinal; Mal

1992

Trials

9 trials available for baclofen and Myelopathy

ArticleYear
Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study.
    Journal of neurosurgery, 1993, Volume: 78, Issue:2

    Topics: Adult; Aged; Baclofen; Double-Blind Method; Drug Tolerance; Female; Follow-Up Studies; Humans; Infus

1993
Side effects of chronic intrathecal baclofen on erection and ejaculation in patients with spinal cord lesions.
    Archives of physical medicine and rehabilitation, 1998, Volume: 79, Issue:5

    Topics: Adult; Baclofen; Coitus; Ejaculation; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Inject

1998
An evaluation of baclofen treatment for certain symptoms in patients with spinal cord lesions. A double-blind, cross-over study.
    Neurology, 1976, Volume: 26, Issue:5

    Topics: Adult; Aminobutyrates; Baclofen; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Mo

1976
Intrathecal drug administration. Present use and future trends.
    Clinical pharmacokinetics, 1992, Volume: 22, Issue:5

    Topics: Analgesics; Baclofen; Brain Diseases; Humans; Injections, Spinal; Neoplasms; Palliative Care; Spasm;

1992
Effects of acute bolus and chronic continuous intrathecal baclofen on genitourinary dysfunction due to spinal cord pathology.
    The Journal of urology, 1992, Volume: 148, Issue:6

    Topics: Adult; Baclofen; Double-Blind Method; Female; Female Urogenital Diseases; Follow-Up Studies; Humans;

1992
Continuous intrathecal baclofen in spinal cord spasticity. A prospective study.
    American journal of physical medicine & rehabilitation, 1992, Volume: 71, Issue:6

    Topics: Adult; Baclofen; Catheters, Indwelling; Dose-Response Relationship, Drug; Double-Blind Method; Femal

1992
Intrathecal baclofen suppresses central pain in patients with spinal lesions. A pilot study.
    The Clinical journal of pain, 1992, Volume: 8, Issue:4

    Topics: Adult; Baclofen; Double-Blind Method; Female; Humans; Injections, Spinal; Male; Middle Aged; Pain; R

1992
Intrathecal baclofen for severe spinal spasticity.
    The New England journal of medicine, 1989, Jun-08, Volume: 320, Issue:23

    Topics: Adult; Baclofen; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infusion Pumps; Male

1989
Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.
    Acta neurochirurgica. Supplementum, 1989, Volume: 46

    Topics: Adult; Baclofen; Dose-Response Relationship, Drug; Female; Humans; Infusion Pumps; Injections, Spina

1989

Other Studies

21 other studies available for baclofen and Myelopathy

ArticleYear
Vascular Myelopathy Secondary to Compression of the Artery of Adamkiewicz From an Intrathecal Catheter: A Technical Case Report.
    Operative neurosurgery (Hagerstown, Md.), 2022, 08-01, Volume: 23, Issue:2

    Topics: Adult; Arteries; Baclofen; Catheterization; Catheters; Female; Humans; Spinal Cord Diseases

2022
Life-threatening constipation induced by intrathecal baclofen therapy.
    European neurology, 2008, Volume: 60, Issue:2

    Topics: Adult; Baclofen; Constipation; Female; Humans; Hypoxia, Brain; Ileal Diseases; Infusion Pumps, Impla

2008
[Intrathecal baclofen in the treatment of spasticity. Our experience].
    Journal of neurosurgical sciences, 2003, Volume: 47, Issue:1 Suppl 1

    Topics: Baclofen; Brain Diseases; GABA Agonists; Humans; Injections, Spinal; Muscle Spasticity; Spinal Cord

2003
Involuntary jerking of lower half of the body (spinal myoclonus).
    The Journal of the Association of Physicians of India, 2005, Volume: 53

    Topics: Baclofen; Clonazepam; Clonidine; Diagnosis, Differential; Humans; Lower Extremity; Middle Aged; Myoc

2005
Management of intractable pain from a chronic dislocated hip in an adolescent.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:4

    Topics: Baclofen; Catheterization; Child; Chronic Disease; Drug Tolerance; Female; Femoral Nerve; GABA Agoni

2008
The assessment of drug treatment of spastic gait.
    Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:8

    Topics: Baclofen; Gait; Humans; Muscle Spasticity; Spinal Cord Diseases

1982
Subacute myelopathy as the presenting manifestation of sarcoidosis.
    Acta neurochirurgica, 1982, Volume: 65, Issue:3-4

    Topics: Adult; Baclofen; Diagnosis, Differential; Humans; Male; Prednisone; Sarcoidosis; Spinal Cord Disease

1982
Complications of spinal opioid therapy: myoclonus, spastic muscle tone and spinal jerking.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1994, Volume: 2, Issue:4

    Topics: Administration, Oral; Analgesia; Analgesia, Epidural; Baclofen; Clonazepam; Female; Humans; Infusion

1994
Effect of intrathecal baclofen on the monosynaptic reflex in humans: evidence for a postsynaptic action.
    Journal of neurology, neurosurgery, and psychiatry, 1993, Volume: 56, Issue:5

    Topics: Adolescent; Adult; Baclofen; Female; Humans; Injections, Spinal; Leg; Male; Middle Aged; Muscle Spas

1993
[Propriospinal myoclonus induced by relaxation and drowsiness].
    Revue neurologique, 1998, Volume: 154, Issue:5

    Topics: Anticonvulsants; Baclofen; Clonazepam; Electrophysiology; Female; Humans; Middle Aged; Muscle Relaxa

1998
Epidural blood patch under fluoroscopic control: non-surgical treatment of lumbar cerebrospinal fluid fistula following implantation of an intrathecal pump system.
    Spinal cord, 1999, Volume: 37, Issue:9

    Topics: Adult; Baclofen; Blood Patch, Epidural; Cerebrospinal Fluid; Cutaneous Fistula; Fluoroscopy; Humans;

1999
Intrathecal baclofen pump implantation complicated by epidural lipomatosis.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:2

    Topics: Adolescent; Baclofen; Cerebral Palsy; Epidural Space; Humans; Infusion Pumps, Implantable; Injection

2000
Effect of baclofen and dantrolene on bladder stimulator-induced detrusor-sphincter dyssynergia in dogs.
    Urology, 1978, Volume: 11, Issue:5

    Topics: Aminobutyrates; Animals; Baclofen; Dantrolene; Depression, Chemical; Dogs; Electric Stimulation; Fem

1978
[Effect of lioresal on the rehabilitation of spastics].
    Chirurgia narzadow ruchu i ortopedia polska, 1977, Volume: 42, Issue:2

    Topics: Aminobutyrates; Baclofen; Cerebral Palsy; Humans; Muscle Spasticity; Spinal Cord Diseases

1977
Bladder training: its role in evaluating the effect of an antispasticity drug on voiding in patients with neurogenic bladder.
    Archives of physical medicine and rehabilitation, 1975, Volume: 56, Issue:11

    Topics: Adult; Aminobutyrates; Baclofen; Female; Humans; Male; Middle Aged; Parasympatholytics; Spinal Cord

1975
Complications of intrathecal baclofen delivery.
    British journal of neurosurgery, 1992, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Baclofen; Drug Overdose; Female; Follow-Up Studies; Humans; Infusion Pumps, Impla

1992
Intrathecal baclofen for spasticity of spinal origin: seven years of experience.
    Journal of neurosurgery, 1992, Volume: 77, Issue:2

    Topics: Adolescent; Adult; Aged; Baclofen; Catheterization; Child; Equipment Failure; Female; Humans; Infusi

1992
Efficacy of dorsal longitudinal myelotomy in treating spinal spasticity: a review of 20 cases.
    Journal of neurosurgery, 1991, Volume: 75, Issue:3

    Topics: Adult; Aged; Baclofen; Female; Humans; Injections, Spinal; Male; Middle Aged; Paraplegia; Quadripleg

1991
Treatment of spastic paresis.
    The New England journal of medicine, 1989, Jun-08, Volume: 320, Issue:23

    Topics: Baclofen; Humans; Infusion Pumps; Muscle Spasticity; Paralysis; Spinal Cord Diseases; Subarachnoid S

1989
Epidural baclofen for intractable spasticity.
    Lancet (London, England), 1988, Mar-05, Volume: 1, Issue:8584

    Topics: Adult; Baclofen; Female; Humans; Injections, Epidural; Male; Middle Aged; Muscle Spasticity; Spinal

1988
Intrathecal application of baclofen in the treatment of spasticity.
    Acta neurochirurgica. Supplementum, 1987, Volume: 39

    Topics: Adolescent; Adult; Baclofen; Female; gamma-Aminobutyric Acid; Humans; Injections, Spinal; Male; Midd

1987