baclofen has been researched along with Myelopathy in 35 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| ") baclofen on chronic, dysesthetic, and spasm-related pain (SRP) among patients with spinal spasticity [i." | 9.07 | Intrathecal baclofen suppresses central pain in patients with spinal lesions. A pilot study. ( D'Luzansky, SC; Herman, RM; Ippolito, R, 1992) |
| "A convenience sample of nine consecutively recruited men with spinal cord injury or multiple sclerosis who were receiving intrathecal baclofen by an implantable pump; average follow-up was 44." | 5.08 | Side effects of chronic intrathecal baclofen on erection and ejaculation in patients with spinal cord lesions. ( Azouvi, P; Bussel, B; Chartier-Kastler, E; Denys, P; Mane, M; Thiebaut, JB, 1998) |
| "A total of 93 patients with intractable spasticity due to either spinal cord injury (59 cases), multiple sclerosis (31 cases), or other spinal pathology (three cases) were entered into a randomized double-blind placebo-controlled screening protocol of intrathecal baclofen test injections." | 5.07 | Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study. ( Cahill, D; Coffey, JR; Gill, B; Herman, R; Levy, R; Meythaler, J; Ordia, J; Park, TS; Shetter, AG; Steers, W, 1993) |
| ") baclofen on chronic, dysesthetic, and spasm-related pain (SRP) among patients with spinal spasticity [i." | 5.07 | Intrathecal baclofen suppresses central pain in patients with spinal lesions. A pilot study. ( D'Luzansky, SC; Herman, RM; Ippolito, R, 1992) |
| "A total of 66 consecutive patients with severe spasticity of spinal cord origin were screened with intrathecal baclofen, and all but two responded with a two-point decrease in their Ashworth spasticity scale and/or spasm scale score." | 3.68 | Intrathecal baclofen for spasticity of spinal origin: seven years of experience. ( Penn, RD, 1992) |
| "Adults with CP and chronic pain receiving usual care had stable, persistent pain intensity." | 3.01 | Clinical course of pain intensity in individuals with cerebral palsy: A prognostic systematic review. ( Côté, P; Fehlings, DL; Hogg-Johnson, S; Shearer, HM; Verville, L, 2023) |
| " The dosage for all patients more than doubled (P < 0." | 2.67 | Continuous intrathecal baclofen in spinal cord spasticity. A prospective study. ( Cross, LL; Haworth, CS; Meythaler, JM; Steers, WD; Tuel, SM, 1992) |
| "Twenty patients with spinal spasticity caused by multiple sclerosis or spinal-cord injury who had had no response to treatment with oral baclofen received an intrathecal infusion of baclofen or saline for three days." | 2.66 | Intrathecal baclofen for severe spinal spasticity. ( Corcos, D; Gottlieb, G; Kroin, JS; Latash, M; Parke, B; Penn, RD; Savoy, SM, 1989) |
| "Baclofen is an agonisit at gamma-aminobutyric acid (GABA) receptors, and is, therefore, a neuroinhibitor, and decreases spasticity." | 2.44 | [Intrathecal baclofen for severe spasticity]. ( Ueta, T, 2008) |
| "With the introduction of the antispasticity agent, tizanidine hydrochloride (Zanaflex), physicians have requested information about the optimal way to switch appropriate patients from baclofen to tizanidine." | 2.40 | An approach to switching patients from baclofen to tizanidine. ( Brenner, R; Hyman, N; Knobler, R; O'Brien, M; Stephan, T, 1998) |
| "The pathophysiology of spasticity and the history of posterior rhizotomies are reviewed." | 2.38 | Neurosurgical treatment of spasticity: selective posterior rhizotomy and intrathecal baclofen. ( Albright, AL, 1992) |
| "Propriospinal myoclonus is a subtype of spinal myoclonus characterized by axial flexion or extension jerks, arrhythmic and prolonged muscle bursts with a pattern of activation consistent with a slow conduction within the propriospinal pathways." | 1.30 | [Propriospinal myoclonus induced by relaxation and drowsiness]. ( Arné, P; Dousset, V; Henry, P; Paty, J; Tison, F, 1998) |
| " The following were taken as evaluation criteria: age, sex, performance status, duration and dosage of previous systemic and current spinal morphine therapy, concomitant analgesic and co-analgesic medication, pretreatment of the dorsal column and neurological dysfunction due to damage either of the nerval plexus or of the medulla spinalis." | 1.29 | Complications of spinal opioid therapy: myoclonus, spastic muscle tone and spinal jerking. ( Bingel, U; Kloke, M; Seeber, S, 1994) |
| "However, when the spasticity is severe, the systemic administration has to be increased, often without therapeutic effects but frequently with central side-effects." | 1.27 | Intrathecal application of baclofen in the treatment of spasticity. ( Rea, GL; Siegfried, J, 1987) |
| "We studied a patient with progressive myelopathy, in whom systemic sarcoidosis was discovered." | 1.26 | Subacute myelopathy as the presenting manifestation of sarcoidosis. ( Bogousslavsky, J; Graf, HJ; Hungerbühler, JP; Regli, F, 1982) |
| " Restoration of effective dosage again led to satisfactory voiding function in all patients." | 1.25 | Bladder training: its role in evaluating the effect of an antispasticity drug on voiding in patients with neurogenic bladder. ( Abramson, AS; Feibel, A; Levine, SA; Roussan, MS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (31.43) | 18.7374 |
| 1990's | 15 (42.86) | 18.2507 |
| 2000's | 7 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Perdomo-Pantoja, A | 1 |
| Zakaria, HM | 1 |
| Liu, A | 1 |
| Tsehay, Y | 1 |
| Weber-Levine, C | 1 |
| Mao, G | 1 |
| Theodore, N | 1 |
| Shearer, HM | 1 |
| Verville, L | 1 |
| Côté, P | 1 |
| Hogg-Johnson, S | 1 |
| Fehlings, DL | 1 |
| Patti, F | 1 |
| Pappalardo, A | 1 |
| Lo Fermo, S | 1 |
| Cimino, V | 1 |
| Castiglione, A | 1 |
| Zappia, M | 1 |
| Ueta, T | 1 |
| Signorelli, CD | 1 |
| Lavano, A | 1 |
| Volpentesta, G | 1 |
| Chirchiglia, D | 1 |
| Signorelli, F | 1 |
| Bono, F | 1 |
| Ferraro, G | 1 |
| Sibille, M | 1 |
| Veltri, C | 1 |
| Aloisi, M | 1 |
| Piragine, G | 1 |
| Serra, S | 1 |
| Scola, P | 1 |
| Pardatcher, S | 1 |
| Pardatcher, K | 1 |
| Santangelo, E | 1 |
| Ray, BK | 1 |
| Guha, G | 1 |
| Misra, AK | 1 |
| Das, SK | 1 |
| Dario, A | 1 |
| Scamoni, C | 1 |
| Picano, M | 1 |
| Casagrande, F | 1 |
| Tomei, G | 1 |
| Nayak, S | 1 |
| Roberts, S | 1 |
| Cunliffe, M | 1 |
| Young, RR | 3 |
| Bogousslavsky, J | 1 |
| Hungerbühler, JP | 1 |
| Regli, F | 1 |
| Graf, HJ | 1 |
| Kloke, M | 1 |
| Bingel, U | 1 |
| Seeber, S | 1 |
| Coffey, JR | 1 |
| Cahill, D | 1 |
| Steers, W | 1 |
| Park, TS | 2 |
| Ordia, J | 1 |
| Meythaler, J | 1 |
| Herman, R | 1 |
| Shetter, AG | 1 |
| Levy, R | 1 |
| Gill, B | 1 |
| Azouvi, P | 2 |
| Roby-Brami, A | 1 |
| Biraben, A | 1 |
| Thiebaut, JB | 2 |
| Thurel, C | 1 |
| Bussel, B | 2 |
| Denys, P | 1 |
| Mane, M | 1 |
| Chartier-Kastler, E | 1 |
| Tison, F | 1 |
| Arné, P | 1 |
| Dousset, V | 1 |
| Paty, J | 1 |
| Henry, P | 1 |
| Brenner, R | 1 |
| Hyman, N | 1 |
| Knobler, R | 1 |
| O'Brien, M | 1 |
| Stephan, T | 1 |
| Huch, K | 1 |
| Kunz, U | 1 |
| Kluger, P | 1 |
| Puhl, W | 1 |
| Huraibi, HA | 1 |
| Phillips, J | 1 |
| Rose, RJ | 1 |
| Pallatroni, H | 1 |
| Westbrook, H | 1 |
| Fanciullo, GJ | 1 |
| Teague, CT | 1 |
| Merrill, DC | 1 |
| Duncan, GW | 1 |
| Shahani, BT | 1 |
| Gusta, A | 1 |
| Matwiejko, L | 1 |
| Pienc, A | 1 |
| Roussan, MS | 1 |
| Abramson, AS | 1 |
| Levine, SA | 1 |
| Feibel, A | 1 |
| Kroin, JS | 2 |
| Steers, WD | 2 |
| Meythaler, JM | 2 |
| Haworth, C | 1 |
| Herrell, D | 1 |
| Albright, AL | 1 |
| Tuel, SM | 1 |
| Cross, LL | 1 |
| Haworth, CS | 1 |
| Herman, RM | 1 |
| D'Luzansky, SC | 1 |
| Ippolito, R | 1 |
| Teddy, P | 1 |
| Jamous, A | 1 |
| Gardner, B | 1 |
| Wang, D | 1 |
| Silver, J | 1 |
| Penn, RD | 2 |
| Putty, TK | 1 |
| Shapiro, SA | 1 |
| Savoy, SM | 1 |
| Corcos, D | 1 |
| Latash, M | 1 |
| Gottlieb, G | 1 |
| Parke, B | 1 |
| Broseta, J | 1 |
| Morales, F | 1 |
| García-March, G | 1 |
| Sánchez-Ledesma, MJ | 1 |
| Anaya, J | 1 |
| Gonzalez-Darder, J | 1 |
| Barberá, J | 1 |
| Jones, RF | 1 |
| Anthony, M | 1 |
| Torda, TA | 1 |
| Poulos, C | 1 |
| Siegfried, J | 1 |
| Rea, GL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intrathecal (IT) Baclofen Drug Distribution Pilot Study[NCT02903823] | Phase 4 | 27 participants (Actual) | Interventional | 2016-04-22 | Completed | ||
| The Use of Penile Vibratory Stimulation to Decrease Spasticity Following Spinal Cord Injury[NCT00223873] | 30 participants | Interventional | 2002-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of cerebral origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Cervical level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar lever 2 injection site | |
| Subjects With Max MAS Change | 8 | 7 | 3 | 3 |
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of spinal origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Cervical spine level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar level 2 injection site | |
| Subjects With MAS Change - Based on Site of Injection | 4 | 2 | 5 | 3 |
6 reviews available for baclofen and Myelopathy
| Article | Year |
|---|---|
Clinical course of pain intensity in individuals with cerebral palsy: A prognostic systematic review.
Topics: Adult; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Child; Chronic Pain; Humans; Pain Measure | 2023 |
[Intrathecal baclofen for severe spasticity].
Topics: Adult; Aged; Baclofen; Female; GABA Agonists; Humans; Infusion Pumps, Implantable; Injections, Spina | 2008 |
Pharmacological complications of the chronic baclofen infusion in the severe spinal spasticity. Personal experience and review of the literature.
Topics: Adult; Baclofen; Constipation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug | 2004 |
An approach to switching patients from baclofen to tizanidine.
Topics: Baclofen; Clinical Competence; Clonidine; Humans; Multiple Sclerosis; Muscle Relaxants, Central; Mus | 1998 |
Intrathecal drug administration. Present use and future trends.
Topics: Analgesics; Baclofen; Brain Diseases; Humans; Injections, Spinal; Neoplasms; Palliative Care; Spasm; | 1992 |
Neurosurgical treatment of spasticity: selective posterior rhizotomy and intrathecal baclofen.
Topics: Adolescent; Adult; Animals; Baclofen; Cerebral Palsy; Child; Female; Humans; Injections, Spinal; Mal | 1992 |
9 trials available for baclofen and Myelopathy
| Article | Year |
|---|---|
Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study.
Topics: Adult; Aged; Baclofen; Double-Blind Method; Drug Tolerance; Female; Follow-Up Studies; Humans; Infus | 1993 |
Side effects of chronic intrathecal baclofen on erection and ejaculation in patients with spinal cord lesions.
Topics: Adult; Baclofen; Coitus; Ejaculation; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Inject | 1998 |
An evaluation of baclofen treatment for certain symptoms in patients with spinal cord lesions. A double-blind, cross-over study.
Topics: Adult; Aminobutyrates; Baclofen; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Mo | 1976 |
Intrathecal drug administration. Present use and future trends.
Topics: Analgesics; Baclofen; Brain Diseases; Humans; Injections, Spinal; Neoplasms; Palliative Care; Spasm; | 1992 |
Effects of acute bolus and chronic continuous intrathecal baclofen on genitourinary dysfunction due to spinal cord pathology.
Topics: Adult; Baclofen; Double-Blind Method; Female; Female Urogenital Diseases; Follow-Up Studies; Humans; | 1992 |
Continuous intrathecal baclofen in spinal cord spasticity. A prospective study.
Topics: Adult; Baclofen; Catheters, Indwelling; Dose-Response Relationship, Drug; Double-Blind Method; Femal | 1992 |
Intrathecal baclofen suppresses central pain in patients with spinal lesions. A pilot study.
Topics: Adult; Baclofen; Double-Blind Method; Female; Humans; Injections, Spinal; Male; Middle Aged; Pain; R | 1992 |
Intrathecal baclofen for severe spinal spasticity.
Topics: Adult; Baclofen; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infusion Pumps; Male | 1989 |
Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.
Topics: Adult; Baclofen; Dose-Response Relationship, Drug; Female; Humans; Infusion Pumps; Injections, Spina | 1989 |
21 other studies available for baclofen and Myelopathy
| Article | Year |
|---|---|
Vascular Myelopathy Secondary to Compression of the Artery of Adamkiewicz From an Intrathecal Catheter: A Technical Case Report.
Topics: Adult; Arteries; Baclofen; Catheterization; Catheters; Female; Humans; Spinal Cord Diseases | 2022 |
Life-threatening constipation induced by intrathecal baclofen therapy.
Topics: Adult; Baclofen; Constipation; Female; Humans; Hypoxia, Brain; Ileal Diseases; Infusion Pumps, Impla | 2008 |
[Intrathecal baclofen in the treatment of spasticity. Our experience].
Topics: Baclofen; Brain Diseases; GABA Agonists; Humans; Injections, Spinal; Muscle Spasticity; Spinal Cord | 2003 |
Involuntary jerking of lower half of the body (spinal myoclonus).
Topics: Baclofen; Clonazepam; Clonidine; Diagnosis, Differential; Humans; Lower Extremity; Middle Aged; Myoc | 2005 |
Management of intractable pain from a chronic dislocated hip in an adolescent.
Topics: Baclofen; Catheterization; Child; Chronic Disease; Drug Tolerance; Female; Femoral Nerve; GABA Agoni | 2008 |
The assessment of drug treatment of spastic gait.
Topics: Baclofen; Gait; Humans; Muscle Spasticity; Spinal Cord Diseases | 1982 |
Subacute myelopathy as the presenting manifestation of sarcoidosis.
Topics: Adult; Baclofen; Diagnosis, Differential; Humans; Male; Prednisone; Sarcoidosis; Spinal Cord Disease | 1982 |
Complications of spinal opioid therapy: myoclonus, spastic muscle tone and spinal jerking.
Topics: Administration, Oral; Analgesia; Analgesia, Epidural; Baclofen; Clonazepam; Female; Humans; Infusion | 1994 |
Effect of intrathecal baclofen on the monosynaptic reflex in humans: evidence for a postsynaptic action.
Topics: Adolescent; Adult; Baclofen; Female; Humans; Injections, Spinal; Leg; Male; Middle Aged; Muscle Spas | 1993 |
[Propriospinal myoclonus induced by relaxation and drowsiness].
Topics: Anticonvulsants; Baclofen; Clonazepam; Electrophysiology; Female; Humans; Middle Aged; Muscle Relaxa | 1998 |
Epidural blood patch under fluoroscopic control: non-surgical treatment of lumbar cerebrospinal fluid fistula following implantation of an intrathecal pump system.
Topics: Adult; Baclofen; Blood Patch, Epidural; Cerebrospinal Fluid; Cutaneous Fistula; Fluoroscopy; Humans; | 1999 |
Intrathecal baclofen pump implantation complicated by epidural lipomatosis.
Topics: Adolescent; Baclofen; Cerebral Palsy; Epidural Space; Humans; Infusion Pumps, Implantable; Injection | 2000 |
Effect of baclofen and dantrolene on bladder stimulator-induced detrusor-sphincter dyssynergia in dogs.
Topics: Aminobutyrates; Animals; Baclofen; Dantrolene; Depression, Chemical; Dogs; Electric Stimulation; Fem | 1978 |
[Effect of lioresal on the rehabilitation of spastics].
Topics: Aminobutyrates; Baclofen; Cerebral Palsy; Humans; Muscle Spasticity; Spinal Cord Diseases | 1977 |
Bladder training: its role in evaluating the effect of an antispasticity drug on voiding in patients with neurogenic bladder.
Topics: Adult; Aminobutyrates; Baclofen; Female; Humans; Male; Middle Aged; Parasympatholytics; Spinal Cord | 1975 |
Complications of intrathecal baclofen delivery.
Topics: Adolescent; Adult; Baclofen; Drug Overdose; Female; Follow-Up Studies; Humans; Infusion Pumps, Impla | 1992 |
Intrathecal baclofen for spasticity of spinal origin: seven years of experience.
Topics: Adolescent; Adult; Aged; Baclofen; Catheterization; Child; Equipment Failure; Female; Humans; Infusi | 1992 |
Efficacy of dorsal longitudinal myelotomy in treating spinal spasticity: a review of 20 cases.
Topics: Adult; Aged; Baclofen; Female; Humans; Injections, Spinal; Male; Middle Aged; Paraplegia; Quadripleg | 1991 |
Treatment of spastic paresis.
Topics: Baclofen; Humans; Infusion Pumps; Muscle Spasticity; Paralysis; Spinal Cord Diseases; Subarachnoid S | 1989 |
Epidural baclofen for intractable spasticity.
Topics: Adult; Baclofen; Female; Humans; Injections, Epidural; Male; Middle Aged; Muscle Spasticity; Spinal | 1988 |
Intrathecal application of baclofen in the treatment of spasticity.
Topics: Adolescent; Adult; Baclofen; Female; gamma-Aminobutyric Acid; Humans; Injections, Spinal; Male; Midd | 1987 |