baclofen has been researched along with Myelopathy in 35 studies
Excerpt | Relevance | Reference |
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") baclofen on chronic, dysesthetic, and spasm-related pain (SRP) among patients with spinal spasticity [i." | 9.07 | Intrathecal baclofen suppresses central pain in patients with spinal lesions. A pilot study. ( D'Luzansky, SC; Herman, RM; Ippolito, R, 1992) |
"A convenience sample of nine consecutively recruited men with spinal cord injury or multiple sclerosis who were receiving intrathecal baclofen by an implantable pump; average follow-up was 44." | 5.08 | Side effects of chronic intrathecal baclofen on erection and ejaculation in patients with spinal cord lesions. ( Azouvi, P; Bussel, B; Chartier-Kastler, E; Denys, P; Mane, M; Thiebaut, JB, 1998) |
"A total of 93 patients with intractable spasticity due to either spinal cord injury (59 cases), multiple sclerosis (31 cases), or other spinal pathology (three cases) were entered into a randomized double-blind placebo-controlled screening protocol of intrathecal baclofen test injections." | 5.07 | Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study. ( Cahill, D; Coffey, JR; Gill, B; Herman, R; Levy, R; Meythaler, J; Ordia, J; Park, TS; Shetter, AG; Steers, W, 1993) |
") baclofen on chronic, dysesthetic, and spasm-related pain (SRP) among patients with spinal spasticity [i." | 5.07 | Intrathecal baclofen suppresses central pain in patients with spinal lesions. A pilot study. ( D'Luzansky, SC; Herman, RM; Ippolito, R, 1992) |
"A total of 66 consecutive patients with severe spasticity of spinal cord origin were screened with intrathecal baclofen, and all but two responded with a two-point decrease in their Ashworth spasticity scale and/or spasm scale score." | 3.68 | Intrathecal baclofen for spasticity of spinal origin: seven years of experience. ( Penn, RD, 1992) |
"Adults with CP and chronic pain receiving usual care had stable, persistent pain intensity." | 3.01 | Clinical course of pain intensity in individuals with cerebral palsy: A prognostic systematic review. ( Côté, P; Fehlings, DL; Hogg-Johnson, S; Shearer, HM; Verville, L, 2023) |
" The dosage for all patients more than doubled (P < 0." | 2.67 | Continuous intrathecal baclofen in spinal cord spasticity. A prospective study. ( Cross, LL; Haworth, CS; Meythaler, JM; Steers, WD; Tuel, SM, 1992) |
"Twenty patients with spinal spasticity caused by multiple sclerosis or spinal-cord injury who had had no response to treatment with oral baclofen received an intrathecal infusion of baclofen or saline for three days." | 2.66 | Intrathecal baclofen for severe spinal spasticity. ( Corcos, D; Gottlieb, G; Kroin, JS; Latash, M; Parke, B; Penn, RD; Savoy, SM, 1989) |
"Baclofen is an agonisit at gamma-aminobutyric acid (GABA) receptors, and is, therefore, a neuroinhibitor, and decreases spasticity." | 2.44 | [Intrathecal baclofen for severe spasticity]. ( Ueta, T, 2008) |
"With the introduction of the antispasticity agent, tizanidine hydrochloride (Zanaflex), physicians have requested information about the optimal way to switch appropriate patients from baclofen to tizanidine." | 2.40 | An approach to switching patients from baclofen to tizanidine. ( Brenner, R; Hyman, N; Knobler, R; O'Brien, M; Stephan, T, 1998) |
"The pathophysiology of spasticity and the history of posterior rhizotomies are reviewed." | 2.38 | Neurosurgical treatment of spasticity: selective posterior rhizotomy and intrathecal baclofen. ( Albright, AL, 1992) |
"Propriospinal myoclonus is a subtype of spinal myoclonus characterized by axial flexion or extension jerks, arrhythmic and prolonged muscle bursts with a pattern of activation consistent with a slow conduction within the propriospinal pathways." | 1.30 | [Propriospinal myoclonus induced by relaxation and drowsiness]. ( Arné, P; Dousset, V; Henry, P; Paty, J; Tison, F, 1998) |
" The following were taken as evaluation criteria: age, sex, performance status, duration and dosage of previous systemic and current spinal morphine therapy, concomitant analgesic and co-analgesic medication, pretreatment of the dorsal column and neurological dysfunction due to damage either of the nerval plexus or of the medulla spinalis." | 1.29 | Complications of spinal opioid therapy: myoclonus, spastic muscle tone and spinal jerking. ( Bingel, U; Kloke, M; Seeber, S, 1994) |
"However, when the spasticity is severe, the systemic administration has to be increased, often without therapeutic effects but frequently with central side-effects." | 1.27 | Intrathecal application of baclofen in the treatment of spasticity. ( Rea, GL; Siegfried, J, 1987) |
"We studied a patient with progressive myelopathy, in whom systemic sarcoidosis was discovered." | 1.26 | Subacute myelopathy as the presenting manifestation of sarcoidosis. ( Bogousslavsky, J; Graf, HJ; Hungerbühler, JP; Regli, F, 1982) |
" Restoration of effective dosage again led to satisfactory voiding function in all patients." | 1.25 | Bladder training: its role in evaluating the effect of an antispasticity drug on voiding in patients with neurogenic bladder. ( Abramson, AS; Feibel, A; Levine, SA; Roussan, MS, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 11 (31.43) | 18.7374 |
1990's | 15 (42.86) | 18.2507 |
2000's | 7 (20.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 2 (5.71) | 2.80 |
Authors | Studies |
---|---|
Perdomo-Pantoja, A | 1 |
Zakaria, HM | 1 |
Liu, A | 1 |
Tsehay, Y | 1 |
Weber-Levine, C | 1 |
Mao, G | 1 |
Theodore, N | 1 |
Shearer, HM | 1 |
Verville, L | 1 |
Côté, P | 1 |
Hogg-Johnson, S | 1 |
Fehlings, DL | 1 |
Patti, F | 1 |
Pappalardo, A | 1 |
Lo Fermo, S | 1 |
Cimino, V | 1 |
Castiglione, A | 1 |
Zappia, M | 1 |
Ueta, T | 1 |
Signorelli, CD | 1 |
Lavano, A | 1 |
Volpentesta, G | 1 |
Chirchiglia, D | 1 |
Signorelli, F | 1 |
Bono, F | 1 |
Ferraro, G | 1 |
Sibille, M | 1 |
Veltri, C | 1 |
Aloisi, M | 1 |
Piragine, G | 1 |
Serra, S | 1 |
Scola, P | 1 |
Pardatcher, S | 1 |
Pardatcher, K | 1 |
Santangelo, E | 1 |
Ray, BK | 1 |
Guha, G | 1 |
Misra, AK | 1 |
Das, SK | 1 |
Dario, A | 1 |
Scamoni, C | 1 |
Picano, M | 1 |
Casagrande, F | 1 |
Tomei, G | 1 |
Nayak, S | 1 |
Roberts, S | 1 |
Cunliffe, M | 1 |
Young, RR | 3 |
Bogousslavsky, J | 1 |
Hungerbühler, JP | 1 |
Regli, F | 1 |
Graf, HJ | 1 |
Kloke, M | 1 |
Bingel, U | 1 |
Seeber, S | 1 |
Coffey, JR | 1 |
Cahill, D | 1 |
Steers, W | 1 |
Park, TS | 2 |
Ordia, J | 1 |
Meythaler, J | 1 |
Herman, R | 1 |
Shetter, AG | 1 |
Levy, R | 1 |
Gill, B | 1 |
Azouvi, P | 2 |
Roby-Brami, A | 1 |
Biraben, A | 1 |
Thiebaut, JB | 2 |
Thurel, C | 1 |
Bussel, B | 2 |
Denys, P | 1 |
Mane, M | 1 |
Chartier-Kastler, E | 1 |
Tison, F | 1 |
Arné, P | 1 |
Dousset, V | 1 |
Paty, J | 1 |
Henry, P | 1 |
Brenner, R | 1 |
Hyman, N | 1 |
Knobler, R | 1 |
O'Brien, M | 1 |
Stephan, T | 1 |
Huch, K | 1 |
Kunz, U | 1 |
Kluger, P | 1 |
Puhl, W | 1 |
Huraibi, HA | 1 |
Phillips, J | 1 |
Rose, RJ | 1 |
Pallatroni, H | 1 |
Westbrook, H | 1 |
Fanciullo, GJ | 1 |
Teague, CT | 1 |
Merrill, DC | 1 |
Duncan, GW | 1 |
Shahani, BT | 1 |
Gusta, A | 1 |
Matwiejko, L | 1 |
Pienc, A | 1 |
Roussan, MS | 1 |
Abramson, AS | 1 |
Levine, SA | 1 |
Feibel, A | 1 |
Kroin, JS | 2 |
Steers, WD | 2 |
Meythaler, JM | 2 |
Haworth, C | 1 |
Herrell, D | 1 |
Albright, AL | 1 |
Tuel, SM | 1 |
Cross, LL | 1 |
Haworth, CS | 1 |
Herman, RM | 1 |
D'Luzansky, SC | 1 |
Ippolito, R | 1 |
Teddy, P | 1 |
Jamous, A | 1 |
Gardner, B | 1 |
Wang, D | 1 |
Silver, J | 1 |
Penn, RD | 2 |
Putty, TK | 1 |
Shapiro, SA | 1 |
Savoy, SM | 1 |
Corcos, D | 1 |
Latash, M | 1 |
Gottlieb, G | 1 |
Parke, B | 1 |
Broseta, J | 1 |
Morales, F | 1 |
García-March, G | 1 |
Sánchez-Ledesma, MJ | 1 |
Anaya, J | 1 |
Gonzalez-Darder, J | 1 |
Barberá, J | 1 |
Jones, RF | 1 |
Anthony, M | 1 |
Torda, TA | 1 |
Poulos, C | 1 |
Siegfried, J | 1 |
Rea, GL | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Intrathecal (IT) Baclofen Drug Distribution Pilot Study[NCT02903823] | Phase 4 | 27 participants (Actual) | Interventional | 2016-04-22 | Completed | ||
The Use of Penile Vibratory Stimulation to Decrease Spasticity Following Spinal Cord Injury[NCT00223873] | 30 participants | Interventional | 2002-11-30 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of cerebral origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
Intervention | Participants (Count of Participants) | |||
---|---|---|---|---|
Cervical level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar lever 2 injection site | |
Subjects With Max MAS Change | 8 | 7 | 3 | 3 |
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of spinal origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
Intervention | Participants (Count of Participants) | |||
---|---|---|---|---|
Cervical spine level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar level 2 injection site | |
Subjects With MAS Change - Based on Site of Injection | 4 | 2 | 5 | 3 |
6 reviews available for baclofen and Myelopathy
Article | Year |
---|---|
Clinical course of pain intensity in individuals with cerebral palsy: A prognostic systematic review.
Topics: Adult; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Child; Chronic Pain; Humans; Pain Measure | 2023 |
[Intrathecal baclofen for severe spasticity].
Topics: Adult; Aged; Baclofen; Female; GABA Agonists; Humans; Infusion Pumps, Implantable; Injections, Spina | 2008 |
Pharmacological complications of the chronic baclofen infusion in the severe spinal spasticity. Personal experience and review of the literature.
Topics: Adult; Baclofen; Constipation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug | 2004 |
An approach to switching patients from baclofen to tizanidine.
Topics: Baclofen; Clinical Competence; Clonidine; Humans; Multiple Sclerosis; Muscle Relaxants, Central; Mus | 1998 |
Intrathecal drug administration. Present use and future trends.
Topics: Analgesics; Baclofen; Brain Diseases; Humans; Injections, Spinal; Neoplasms; Palliative Care; Spasm; | 1992 |
Neurosurgical treatment of spasticity: selective posterior rhizotomy and intrathecal baclofen.
Topics: Adolescent; Adult; Animals; Baclofen; Cerebral Palsy; Child; Female; Humans; Injections, Spinal; Mal | 1992 |
9 trials available for baclofen and Myelopathy
Article | Year |
---|---|
Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study.
Topics: Adult; Aged; Baclofen; Double-Blind Method; Drug Tolerance; Female; Follow-Up Studies; Humans; Infus | 1993 |
Side effects of chronic intrathecal baclofen on erection and ejaculation in patients with spinal cord lesions.
Topics: Adult; Baclofen; Coitus; Ejaculation; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Inject | 1998 |
An evaluation of baclofen treatment for certain symptoms in patients with spinal cord lesions. A double-blind, cross-over study.
Topics: Adult; Aminobutyrates; Baclofen; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Male; Mo | 1976 |
Intrathecal drug administration. Present use and future trends.
Topics: Analgesics; Baclofen; Brain Diseases; Humans; Injections, Spinal; Neoplasms; Palliative Care; Spasm; | 1992 |
Effects of acute bolus and chronic continuous intrathecal baclofen on genitourinary dysfunction due to spinal cord pathology.
Topics: Adult; Baclofen; Double-Blind Method; Female; Female Urogenital Diseases; Follow-Up Studies; Humans; | 1992 |
Continuous intrathecal baclofen in spinal cord spasticity. A prospective study.
Topics: Adult; Baclofen; Catheters, Indwelling; Dose-Response Relationship, Drug; Double-Blind Method; Femal | 1992 |
Intrathecal baclofen suppresses central pain in patients with spinal lesions. A pilot study.
Topics: Adult; Baclofen; Double-Blind Method; Female; Humans; Injections, Spinal; Male; Middle Aged; Pain; R | 1992 |
Intrathecal baclofen for severe spinal spasticity.
Topics: Adult; Baclofen; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infusion Pumps; Male | 1989 |
Use of intrathecal baclofen administered by programmable infusion pumps in resistent spasticity.
Topics: Adult; Baclofen; Dose-Response Relationship, Drug; Female; Humans; Infusion Pumps; Injections, Spina | 1989 |
21 other studies available for baclofen and Myelopathy
Article | Year |
---|---|
Vascular Myelopathy Secondary to Compression of the Artery of Adamkiewicz From an Intrathecal Catheter: A Technical Case Report.
Topics: Adult; Arteries; Baclofen; Catheterization; Catheters; Female; Humans; Spinal Cord Diseases | 2022 |
Life-threatening constipation induced by intrathecal baclofen therapy.
Topics: Adult; Baclofen; Constipation; Female; Humans; Hypoxia, Brain; Ileal Diseases; Infusion Pumps, Impla | 2008 |
[Intrathecal baclofen in the treatment of spasticity. Our experience].
Topics: Baclofen; Brain Diseases; GABA Agonists; Humans; Injections, Spinal; Muscle Spasticity; Spinal Cord | 2003 |
Involuntary jerking of lower half of the body (spinal myoclonus).
Topics: Baclofen; Clonazepam; Clonidine; Diagnosis, Differential; Humans; Lower Extremity; Middle Aged; Myoc | 2005 |
Management of intractable pain from a chronic dislocated hip in an adolescent.
Topics: Baclofen; Catheterization; Child; Chronic Disease; Drug Tolerance; Female; Femoral Nerve; GABA Agoni | 2008 |
The assessment of drug treatment of spastic gait.
Topics: Baclofen; Gait; Humans; Muscle Spasticity; Spinal Cord Diseases | 1982 |
Subacute myelopathy as the presenting manifestation of sarcoidosis.
Topics: Adult; Baclofen; Diagnosis, Differential; Humans; Male; Prednisone; Sarcoidosis; Spinal Cord Disease | 1982 |
Complications of spinal opioid therapy: myoclonus, spastic muscle tone and spinal jerking.
Topics: Administration, Oral; Analgesia; Analgesia, Epidural; Baclofen; Clonazepam; Female; Humans; Infusion | 1994 |
Effect of intrathecal baclofen on the monosynaptic reflex in humans: evidence for a postsynaptic action.
Topics: Adolescent; Adult; Baclofen; Female; Humans; Injections, Spinal; Leg; Male; Middle Aged; Muscle Spas | 1993 |
[Propriospinal myoclonus induced by relaxation and drowsiness].
Topics: Anticonvulsants; Baclofen; Clonazepam; Electrophysiology; Female; Humans; Middle Aged; Muscle Relaxa | 1998 |
Epidural blood patch under fluoroscopic control: non-surgical treatment of lumbar cerebrospinal fluid fistula following implantation of an intrathecal pump system.
Topics: Adult; Baclofen; Blood Patch, Epidural; Cerebrospinal Fluid; Cutaneous Fistula; Fluoroscopy; Humans; | 1999 |
Intrathecal baclofen pump implantation complicated by epidural lipomatosis.
Topics: Adolescent; Baclofen; Cerebral Palsy; Epidural Space; Humans; Infusion Pumps, Implantable; Injection | 2000 |
Effect of baclofen and dantrolene on bladder stimulator-induced detrusor-sphincter dyssynergia in dogs.
Topics: Aminobutyrates; Animals; Baclofen; Dantrolene; Depression, Chemical; Dogs; Electric Stimulation; Fem | 1978 |
[Effect of lioresal on the rehabilitation of spastics].
Topics: Aminobutyrates; Baclofen; Cerebral Palsy; Humans; Muscle Spasticity; Spinal Cord Diseases | 1977 |
Bladder training: its role in evaluating the effect of an antispasticity drug on voiding in patients with neurogenic bladder.
Topics: Adult; Aminobutyrates; Baclofen; Female; Humans; Male; Middle Aged; Parasympatholytics; Spinal Cord | 1975 |
Complications of intrathecal baclofen delivery.
Topics: Adolescent; Adult; Baclofen; Drug Overdose; Female; Follow-Up Studies; Humans; Infusion Pumps, Impla | 1992 |
Intrathecal baclofen for spasticity of spinal origin: seven years of experience.
Topics: Adolescent; Adult; Aged; Baclofen; Catheterization; Child; Equipment Failure; Female; Humans; Infusi | 1992 |
Efficacy of dorsal longitudinal myelotomy in treating spinal spasticity: a review of 20 cases.
Topics: Adult; Aged; Baclofen; Female; Humans; Injections, Spinal; Male; Middle Aged; Paraplegia; Quadripleg | 1991 |
Treatment of spastic paresis.
Topics: Baclofen; Humans; Infusion Pumps; Muscle Spasticity; Paralysis; Spinal Cord Diseases; Subarachnoid S | 1989 |
Epidural baclofen for intractable spasticity.
Topics: Adult; Baclofen; Female; Humans; Injections, Epidural; Male; Middle Aged; Muscle Spasticity; Spinal | 1988 |
Intrathecal application of baclofen in the treatment of spasticity.
Topics: Adolescent; Adult; Baclofen; Female; gamma-Aminobutyric Acid; Humans; Injections, Spinal; Male; Midd | 1987 |