baclofen has been researched along with Muscle Relaxation in 32 studies
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In mice, AZD3355 produced considerably less central side effects than the prototypical GABA(B) receptor agonist baclofen but evoked hypothermia at very high doses (blocked by a GABA(B) receptor antagonist and absent in GABA(B)-/- mice)." | 3.75 | (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. ( Antonsson, M; Blackshaw, LA; Brändén, L; Bräuner-Osborne, H; Christiansen, B; Dent, J; Elebring, T; Holmberg, AA; Jacobson, BM; Jensen, J; Lehmann, A; Mattsson, JP; Nilsson, K; Oja, SS; Page, AJ; Saransaari, P; von Unge, S, 2009) |
| " A range of GABAB antagonists were tested against baclofen-induced muscle relaxation and hypothermia." | 3.69 | Characterization of GABAB ligands in vivo. ( Humeniuk, RE; Kerr, DI; Ong, J; White, JM, 1995) |
| "Pretreatment with bicuculline (GABAA antagonist) turned them to relaxation." | 2.67 | gamma-Aminobutyric acid enhances the tone of human internal anal sphincter. ( Fujita, S; Kusunoki, M; Sakanoue, Y; Shoji, Y; Utsunomiya, J; Yamamura, T; Yanagi, H, 1991) |
| "Up to 40% of patients report persistent gastroesophageal reflux disease (GERD) symptoms despite proton pump inhibitor (PPI) therapy." | 2.55 | A review of medical therapy for proton pump inhibitor nonresponsive gastroesophageal reflux disease. ( Berendsen, MA; Hillman, L; Pandolfino, JE; Thuluvath, AJ; Yadlapati, R, 2017) |
| " Twice-daily dosing of PPI for inadequate gastric acid suppression and the administration of H2-receptor antagonist before bedtime for nocturnal acid reflux, is effective in most cases." | 2.44 | [Management of gastroesophageal reflux disease (GERD) with refractory to standard dose of proton pump inhibitor]. ( Iwakiri, K; Kawami, N; Kotoyori, M; Sakamoto, C; Sano, H; Tanaka, Y, 2007) |
| "In trials to preserve the pharmacological profile and improve the bioavailability via lipophilicity increment of baclofen 1 and searching for more potent and less toxic muscle relaxants and analgesics, nine substituted cyclic analogues of 1 were designed and synthesized." | 1.35 | 5-(4-Chlorophenyl)-5,6-dihydro-1,3-oxazepin-7(4H)-one derivatives as lipophilic cyclic analogues of baclofen: design, synthesis, and neuropharmacological evaluation. ( Abdel-Hafez, AA; Abdel-Wahab, BA, 2008) |
| " It is concluded that repeated dosing of baclofen leads to mild tolerance development in terms of the effects on transient lower esophageal sphincter relaxation, but that the tolerance is much less pronounced than that previously reported in other animal models." | 1.31 | Effects of repeated administration of baclofen on transient lower esophageal sphincter relaxation in the dog. ( Hansson-Brändén, L; Kärrberg, L; Lehmann, A, 2000) |
| "Baclofen is a potent and efficacious inhibitor of TLESRs and reflux in the dog." | 1.30 | Activation of the GABA(B) receptor inhibits transient lower esophageal sphincter relaxations in dogs. ( Antonsson, M; Bremner-Danielsen, M; Flärdh, M; Hansson-Brändén, L; Kärrberg, L; Lehmann, A, 1999) |
| "CGP 35348 was also studied in mice on (+/-)-baclofen-induced impairment of rota-rod performance." | 1.28 | CGP 35348, a new GABAB antagonist, prevents antinociception and muscle-relaxant effect induced by baclofen. ( Bartolini, A; Ghelardini, C; Giotti, A; Malcangio, M; Malmberg-Aiello, P, 1991) |
| "The baclofen response was antagonized by 5-aminovaleric acid (DAVA, 500 microM), TTX and hyoscine and resistant to GABAA-receptor and adrenoceptor blockade." | 1.28 | An in vitro study of the relationship between GABA receptor function and propulsive motility in the distal colon of the rabbit. ( Candura, SM; Crema, A; Frigo, GM; Manzo, L; Onori, L; Rizzi, CA; Tonini, M, 1989) |
| "tizanidine was antagonized by co-administration of prazosin but not by yohimbine." | 1.28 | Myorelaxant effect after intrathecal injection of antispastic drugs in rats. ( Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Wüllner, U, 1989) |
| "3H-Baclofen was injected i." | 1.27 | [Enhancement of the muscle relaxant action of baclofen by glucocorticoids]. ( Wakayama, K, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (15.63) | 18.7374 |
| 1990's | 10 (31.25) | 18.2507 |
| 2000's | 14 (43.75) | 29.6817 |
| 2010's | 3 (9.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Hafez, AA | 1 |
| Abdel-Wahab, BA | 1 |
| Hillman, L | 1 |
| Yadlapati, R | 1 |
| Thuluvath, AJ | 1 |
| Berendsen, MA | 1 |
| Pandolfino, JE | 1 |
| Boeckxstaens, GE | 3 |
| Lehmann, A | 6 |
| Antonsson, M | 2 |
| Holmberg, AA | 1 |
| Blackshaw, LA | 2 |
| Brändén, L | 2 |
| Bräuner-Osborne, H | 1 |
| Christiansen, B | 1 |
| Dent, J | 2 |
| Elebring, T | 1 |
| Jacobson, BM | 1 |
| Jensen, J | 1 |
| Mattsson, JP | 1 |
| Nilsson, K | 1 |
| Oja, SS | 1 |
| Page, AJ | 1 |
| Saransaari, P | 1 |
| von Unge, S | 1 |
| Rydholm, H | 1 |
| Lei, A | 1 |
| Adler, J | 1 |
| Ruth, M | 2 |
| Denison, H | 1 |
| Jensen, JM | 1 |
| Bremner-Danielsen, M | 2 |
| Kärrberg, L | 3 |
| Balerio, GN | 1 |
| Rubio, MC | 1 |
| Liu, J | 2 |
| Pehlivanov, N | 1 |
| Mittal, RK | 2 |
| Hasler, WL | 1 |
| Bayer, S | 1 |
| Jellali, A | 1 |
| Crenner, F | 1 |
| Aunis, D | 1 |
| Angel, F | 1 |
| Puckett, JL | 1 |
| Takeda, T | 1 |
| Jung, HY | 1 |
| Iwakiri, K | 1 |
| Kawami, N | 1 |
| Tanaka, Y | 1 |
| Sano, H | 1 |
| Kotoyori, M | 1 |
| Sakamoto, C | 1 |
| Szczesniak, MM | 1 |
| Fuentealba, SE | 1 |
| Burnett, A | 1 |
| Cook, IJ | 1 |
| Grossi, L | 1 |
| Spezzaferro, M | 1 |
| Sacco, LF | 1 |
| Marzio, L | 1 |
| Anwar, N | 1 |
| Mason, DF | 1 |
| Humeniuk, RE | 1 |
| Ong, J | 1 |
| Kerr, DI | 1 |
| White, JM | 1 |
| Pencheva, N | 1 |
| Radomirov, R | 1 |
| Staunton, E | 1 |
| Flärdh, M | 1 |
| Hansson-Brändén, L | 2 |
| Schuler, V | 1 |
| Lüscher, C | 1 |
| Blanchet, C | 1 |
| Klix, N | 1 |
| Sansig, G | 1 |
| Klebs, K | 1 |
| Schmutz, M | 1 |
| Heid, J | 1 |
| Gentry, C | 1 |
| Urban, L | 1 |
| Fox, A | 1 |
| Spooren, W | 1 |
| Jaton, AL | 1 |
| Vigouret, J | 1 |
| Pozza, M | 1 |
| Kelly, PH | 1 |
| Mosbacher, J | 1 |
| Froestl, W | 1 |
| Käslin, E | 1 |
| Korn, R | 1 |
| Bischoff, S | 1 |
| Kaupmann, K | 1 |
| van der Putten, H | 1 |
| Bettler, B | 1 |
| Wolfarth, S | 1 |
| Kolasiewicz, W | 1 |
| Ossowska, K | 1 |
| Bober, M | 1 |
| Malcangio, M | 1 |
| Ghelardini, C | 1 |
| Giotti, A | 1 |
| Malmberg-Aiello, P | 1 |
| Bartolini, A | 1 |
| Kusunoki, M | 1 |
| Shoji, Y | 1 |
| Sakanoue, Y | 1 |
| Yanagi, H | 1 |
| Fujita, S | 1 |
| Yamamura, T | 1 |
| Utsunomiya, J | 1 |
| Guo, ZW | 1 |
| Tu, SZ | 1 |
| Li, WH | 1 |
| Chen, J | 1 |
| Stefański, R | 1 |
| Plaznik, A | 1 |
| Pałejko, W | 1 |
| Kostowski, W | 1 |
| Krantis, A | 1 |
| Khalil, A | 1 |
| McKay, A | 1 |
| Dolphin, AC | 1 |
| Scott, RH | 1 |
| Tonini, M | 1 |
| Crema, A | 1 |
| Frigo, GM | 1 |
| Rizzi, CA | 1 |
| Manzo, L | 1 |
| Candura, SM | 1 |
| Onori, L | 1 |
| Klockgether, T | 1 |
| Schwarz, M | 1 |
| Wüllner, U | 1 |
| Turski, L | 1 |
| Sontag, KH | 1 |
| Wakayama, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open, Comparative Study To Evaluate The Performance And Safety Of The Medical Device Marial® In Association With Proton-Pump Inhibitors Versus PPI Alone In Patients Affected By Gastroesophageal Reflux Disease[NCT04130659] | 110 participants (Anticipated) | Interventional | 2019-08-08 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for baclofen and Muscle Relaxation
| Article | Year |
|---|---|
A review of medical therapy for proton pump inhibitor nonresponsive gastroesophageal reflux disease.
Topics: Baclofen; Benzamides; Cytochrome P-450 CYP2C19; Esophageal Sphincter, Lower; Gastroesophageal Reflux | 2017 |
Reflux inhibitors: a new approach for GERD?
Topics: Animals; Baclofen; Esophageal Sphincter, Lower; Esophagitis, Peptic; Gastroesophageal Reflux; Humans | 2008 |
Translational gastrointestinal pharmacology in the 21st century: 'the lesogaberan story'.
Topics: Animals; Baclofen; Dogs; Drug Resistance; Esophageal Sphincter, Lower; GABA-B Receptor Agonists; Gas | 2011 |
[Management of gastroesophageal reflux disease (GERD) with refractory to standard dose of proton pump inhibitor].
Topics: Aryl Hydrocarbon Hydroxylases; Baclofen; Cytochrome P-450 CYP2C19; Diet; Drug Administration Schedul | 2007 |
4 trials available for baclofen and Muscle Relaxation
| Article | Year |
|---|---|
Effect of lesogaberan, a novel GABA(B)-receptor agonist, on transient lower oesophageal sphincter relaxations in male subjects.
Topics: Adolescent; Adult; Baclofen; Cross-Over Studies; Esophageal Sphincter, Lower; GABA Agonists; Gastroe | 2010 |
Differential relaxation and contractile responses of the human upper esophageal sphincter mediated by interplay of mucosal and deep mechanoreceptor activation.
Topics: Administration, Oral; Administration, Topical; Adult; Anesthetics, Local; Baclofen; Catheterization; | 2008 |
Effect of baclofen on oesophageal motility and transient lower oesophageal sphincter relaxations in GORD patients: a 48-h manometric study.
Topics: Adult; Baclofen; Deglutition; Double-Blind Method; Esophageal Sphincter, Lower; Female; Gastroesopha | 2008 |
gamma-Aminobutyric acid enhances the tone of human internal anal sphincter.
Topics: Anal Canal; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Humans; Muscimol; Muscle Contraction; Mu | 1991 |
24 other studies available for baclofen and Muscle Relaxation
| Article | Year |
|---|---|
5-(4-Chlorophenyl)-5,6-dihydro-1,3-oxazepin-7(4H)-one derivatives as lipophilic cyclic analogues of baclofen: design, synthesis, and neuropharmacological evaluation.
Topics: Animals; Baclofen; Cognition Disorders; Cyclization; Dose-Response Relationship, Drug; Drug Design; | 2008 |
(R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action.
Topics: Animals; Autoradiography; Baclofen; Binding, Competitive; Calcium; Dogs; Dose-Response Relationship, | 2009 |
Inhibitory effects of GABA(B) receptor agonists on swallowing in the dog.
Topics: Animals; Baclofen; Deglutition; Dogs; Esophagogastric Junction; GABA-B Receptor Agonists; gamma-Amin | 2002 |
Baclofen analgesia: involvement of the GABAergic system.
Topics: Analgesics; Animals; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; In | 2002 |
Baclofen blocks LES relaxation and crural diaphragm inhibition by esophageal and gastric distension in cats.
Topics: Animals; Baclofen; Catheterization; Cats; Diaphragm; Electromyography; Esophagogastric Junction; Eso | 2002 |
Baclofen effects on esophageal function: a possible therapy for GERD?
Topics: Baclofen; Esophagogastric Junction; Esophagus; GABA Agonists; Gastroesophageal Reflux; Humans; Muscl | 2002 |
Functional evidence for a role of GABA receptors in modulating nerve activities of circular smooth muscle from rat colon in vitro.
Topics: Amino Acid Transport Systems; Animals; Baclofen; Carrier Proteins; Colon; Electric Stimulation; Ente | 2003 |
Crural diaphragm inhibition during esophageal distension correlates with contraction of the esophageal longitudinal muscle in cats.
Topics: Animals; Baclofen; Catheterization; Cats; Diaphragm; Esophageal Sphincter, Lower; Esophagus; Female; | 2005 |
Two actions of gamma-aminobutyric acid on the responses of the isolated basilar artery from the rabbit.
Topics: Animals; Baclofen; Basilar Artery; Drug Interactions; Electric Stimulation; Female; GABA Antagonists | 1982 |
Characterization of GABAB ligands in vivo.
Topics: Animals; Baclofen; beta-Alanine; Drug Interactions; Female; GABA Antagonists; GABA-B Receptor Antago | 1995 |
Biphasic GABA-A receptor-mediated effect on the spontaneous activity of the circular layer in cat terminal ileum.
Topics: Animals; Atropine; Baclofen; Bicuculline; Cats; gamma-Aminobutyric Acid; Ileum; In Vitro Techniques; | 1993 |
Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists.
Topics: Animals; Baclofen; Behavior, Animal; Deglutition; Esophagogastric Junction; Female; Ferrets; GABA Ag | 1999 |
Activation of the GABA(B) receptor inhibits transient lower esophageal sphincter relaxations in dogs.
Topics: Animals; Baclofen; Dogs; Esophagogastric Junction; Female; GABA Agonists; GABA Antagonists; GABA-B R | 1999 |
Effects of repeated administration of baclofen on transient lower esophageal sphincter relaxation in the dog.
Topics: Animals; Baclofen; Dogs; Dose-Response Relationship, Drug; Eating; Esophagogastric Junction; GABA Ag | 2000 |
Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).
Topics: Animals; Animals, Newborn; Avoidance Learning; Baclofen; Body Temperature Regulation; Delta Rhythm; | 2001 |
Direct mechanomyographic measurement of the myorelaxant action of baclofen and diazepam in normal and reserpinized rats.
Topics: Analysis of Variance; Animals; Baclofen; Diazepam; Dose-Response Relationship, Drug; Hindlimb; Male; | 1992 |
CGP 35348, a new GABAB antagonist, prevents antinociception and muscle-relaxant effect induced by baclofen.
Topics: Analgesics; Animals; Baclofen; GABA Antagonists; GABA-A Receptor Antagonists; Injections, Intraventr | 1991 |
[Studies of synthesis and structure-activity relationships of analogs of the muscle relaxant--baclofen].
Topics: Animals; Baclofen; Female; Male; Mice; Muscle Relaxation; Pain; Receptors, GABA-A; Sensory Threshold | 1990 |
Myorelaxant effect of baclofen injected to the nucleus accumbens septi.
Topics: Animals; Baclofen; Behavior, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Halo | 1990 |
Differences in the effects (in vitro) of ethylenediamine on the guinea-pig and rat intestine.
Topics: Animals; Baclofen; Bicuculline; Electric Stimulation; Ethylenediamines; Female; gamma-Aminobutyric A | 1990 |
Inhibition of calcium currents in cultured rat dorsal root ganglion neurones by (-)-baclofen.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Baclofen; Cardiovascular Agents; Cells, Cultured; Ganglia, | 1986 |
An in vitro study of the relationship between GABA receptor function and propulsive motility in the distal colon of the rabbit.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Autonomic Nervous System; Baclofen; Colon; gamma-Aminobu | 1989 |
Myorelaxant effect after intrathecal injection of antispastic drugs in rats.
Topics: Animals; Baclofen; Clonidine; Dose-Response Relationship, Drug; Female; H-Reflex; Injections, Spinal | 1989 |
[Enhancement of the muscle relaxant action of baclofen by glucocorticoids].
Topics: Animals; Baclofen; Drug Synergism; Hydrocortisone; Muscle Contraction; Muscle Relaxants, Central; Mu | 1987 |