baclofen and Low Back Ache studies

Research Excerpts

Excerpt	Relevance	Reference
"Adding baclofen, metaxalone, or tizanidine to ibuprofen does not appear to improve functioning or pain any more than placebo plus ibuprofen by 1 week after an ED visit for acute low back pain."	9.30	A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain. ( Friedman, BW; Gallagher, EJ; Irizarry, E; Jones, MP; Pearlman, S; Shah, PD; Solorzano, C; Wollowitz, A; Zias, E, 2019)
"Adding baclofen, metaxalone, or tizanidine to ibuprofen does not appear to improve functioning or pain any more than placebo plus ibuprofen by 1 week after an ED visit for acute low back pain."	5.30	A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain. ( Friedman, BW; Gallagher, EJ; Irizarry, E; Jones, MP; Pearlman, S; Shah, PD; Solorzano, C; Wollowitz, A; Zias, E, 2019)
"Intrathecal Baclofen and Clonidine may be used as alternatives to provide spinally mediated antinociception when intraspinal opioid fails due to pharmacological side effects such as persistent edema."	3.76	Recurrent cellulitis associated with long-term intrathecal opioid infusion therapy: a case report and review of the literature. ( Chiravuri, S; Couch, JP; Liu, H; Ruan, X; Wang, F, 2010)
"A 40-year-old man had an intrathecal morphine-baclofen pump inserted for the treatment of severe dystonia affecting all limbs and severe low back pain."	3.74	The complications of scar formation associated with intrathecal pump placement. ( Bundock, E; Graham, WA; Nero, C; Nesathurai, S; Protopapas, MG; Westmoreland, S, 2007)
"Although oral baclofen has been used to treat hiccups in various clinical settings, none of the previously reported studies that used baclofen were related to hiccups occurring after spinal injections/procedures."	1.46	Persistent Hiccups After an Epidural Steroid Injection Successfully Treated With Baclofen: A Case Report. ( Colorado, B; Decker, G, 2017)
"We report a 21-yr-old male patient with spondyloepiphyseal dysplasia tarda with progressive arthropathy who developed spastic paraplegia because of spinal stenosis caused by thoracic disk herniations."	1.37	Spondyloepiphyseal dysplasia tarda with progressive arthropathy complicated with paraplegia. ( Gelal, F; Memi, A; Olmez, N; Oz, B; Yoleri, O, 2011)

Research

Studies (8)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Change in Functional Impairment as Measured by the Roland Morris Disability Questionnaire (RMDQ)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (37.50)	29.6817
2010's	4 (50.00)	24.3611
2020's	1 (12.50)	2.80

Authors	Studies
Abril, L	1
Zamora, C	1
Cordero, M	1
Williams, AR	1
Friedman, BW	2
Colorado, B	1
Decker, G	1
Irizarry, E	1
Solorzano, C	1
Zias, E	1
Pearlman, S	1
Wollowitz, A	1
Jones, MP	1
Shah, PD	1
Gallagher, EJ	1
Ruan, X	1
Liu, H	1
Couch, JP	1
Wang, F	1
Chiravuri, S	1
Yoleri, O	1
Oz, B	1
Olmez, N	1
Memi, A	1
Gelal, F	1
Vogels, RL	1
van Orshoven, NP	1
de Koning-Tijssen, MA	1
Wouda, EJ	1
Protopapas, MG	1
Bundock, E	1
Westmoreland, S	1
Nero, C	1
Graham, WA	1
Nesathurai, S	1
Zuniga, RE	1
Schlicht, CR	1
Abram, SE	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain: A Randomized Trial[NCT03068897]	Phase 4	320 participants (Actual)	Interventional	2017-05-03	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"The Roland Morris Disability Questionnaire (RMDQ) is a 24 item instrument that evaluates the impact of low back pain on one's daily life. It is most sensitive for patients with mild to moderate disability due to acute, sub-acute or chronic low back pain. Each question can be answered as either a yes or no. The score ranges from 0 to 24 where a higher score reflects greater impairment and, therefore, worsening in the quality of life. The change in RMDQ is obtained by subtracting the RMDQ score at one week after discharge from the baseline score." (NCT03068897)
Timeframe: Baseline and 7 days

Levels of Disability

Intervention	units on a scale (Mean)
Metaxalone	10.1
Tizanidine	11.2
Baclofen	10.6
Placebo	11.1

Disability will be assessed with the Roland-Morris Disability Questionnaire (RMDQ) where patients are asked to tick a box if they agree with 24 statements regarding their ability to perform certain activities (dressing, housework, walking). If the don't agree with the statement (able to perform those activities) they need to leave the tick-box blank or unchecked. Every agreement (tick) counts as a point and an absolute value is formed (min: 0, max: 24). The higher the value the higher the disability level. (NCT03068897)
Timeframe: 7 days

Number of Participants Who Experience Change in Low Back Pain

Intervention	units on a scale (Median)
Metaxalone	5
Tizanidine	3
Baclofen	6
Placebo	3

Change is assessed by verbal numerical scale of which 0 represents no pain and 10 represents the worst pain imaginable between the baseline ED visit and the one week follow-up (baseline - 1 week ). The baseline questions will refer to the time period immediately prior to ED presentation (Before you came to the ER today, were you able to…..) (NCT03068897)
Timeframe: Baseline and 7 days

Number of Participants With Need for Medication for Low Back Pain

Intervention	Participants (Count of Participants)
Metaxalone	28
Tizanidine	25
Baclofen	26
Placebo	22

Patients will be asked what medications they have used for low back pain (NCT03068897)
Timeframe: 7 days

Article	Year
A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain. Annals of emergency medicine, 2019, Volume: 74, Issue:4 Topics: Acute Pain; Adult; Analgesics, Non-Narcotic; Baclofen; Clonidine; Double-Blind Method; Drug Therapy,	2019
Intrathecal baclofen is analgesic in patients with chronic pain. Anesthesiology, 2000, Volume: 92, Issue:3 Topics: Aged; Amputation, Surgical; Baclofen; Cerebral Palsy; Chronic Disease; Female; GABA Agonists; Hemato	2000

Article	Year
The Relative Efficacy of Seven Skeletal Muscle Relaxants. An Analysis of Data From Randomized Studies. The Journal of emergency medicine, 2022, Volume: 62, Issue:4 Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Baclofen; Diazepam; Humans; Low Back Pain; Meth	2022
Persistent Hiccups After an Epidural Steroid Injection Successfully Treated With Baclofen: A Case Report. PM & R : the journal of injury, function, and rehabilitation, 2017, Volume: 9, Issue:12 Topics: Administration, Oral; Aged; Baclofen; Dexamethasone; GABA-B Receptor Agonists; Glucocorticoids; Hicc	2017
Recurrent cellulitis associated with long-term intrathecal opioid infusion therapy: a case report and review of the literature. Pain medicine (Malden, Mass.), 2010, Volume: 11, Issue:6 Topics: Analgesics, Opioid; Baclofen; Cellulitis; Clonidine; Edema; Female; GABA Agonists; Humans; Hydromorp	2010
Spondyloepiphyseal dysplasia tarda with progressive arthropathy complicated with paraplegia. American journal of physical medicine & rehabilitation, 2011, Volume: 90, Issue:6 Topics: Analgesics; Arthralgia; Baclofen; Disease Progression; Follow-Up Studies; Humans; Low Back Pain; Mal	2011
['Stiff-person'-syndrome]. Nederlands tijdschrift voor geneeskunde, 2003, Jun-21, Volume: 147, Issue:25 Topics: Adrenal Cortex Hormones; Autoantibodies; Baclofen; Diazepam; Electromyography; Female; Glutamate Dec	2003
The complications of scar formation associated with intrathecal pump placement. Archives of physical medicine and rehabilitation, 2007, Volume: 88, Issue:3 Topics: Adult; Analgesics, Opioid; Baclofen; Catheters, Indwelling; Cicatrix; Dystonia; Equipment Failure An	2007

baclofen and Low Back Ache