baclofen has been researched along with Lesch-Nyhan Syndrome in 2 studies
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pozzi, M | 1 |
| Piccinini, L | 1 |
| Gallo, M | 1 |
| Motta, F | 1 |
| Radice, S | 1 |
| Clementi, E | 1 |
| Gedye, A | 1 |
2 other studies available for baclofen and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Treatment of motor and behavioural symptoms in three Lesch-Nyhan patients with intrathecal baclofen.
Topics: Adult; Baclofen; Behavioral Symptoms; Humans; Lesch-Nyhan Syndrome; Male; Motor Skills Disorders; Se | 2014 |
Serotonin-GABA treatment is hypothesized for self-injury in Lesch-Nyhan syndrome.
Topics: Baclofen; Drug Therapy, Combination; gamma-Aminobutyric Acid; Humans; Kynurenine; Lesch-Nyhan Syndro | 1992 |