baclofen and Kidney Failure, Chronic studies

baclofen and Kidney Failure, Chronic

Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.

Research Excerpts

Excerpt	Relevance	Reference
"A 69-year-old woman with a history of hemodialysis-dependent end-stage renal disease presented to the Emergency Department with encephalopathy, ataxia, and dystonia after the addition of a recent baclofen prescription for back pain (10 mg twice daily)."	3.85	Baclofen Toxicity in a Patient with Hemodialysis-Dependent End-Stage Renal Disease. ( Katz, KD; Merrick, SS; Porter, LM, 2017)
"To report the toxic effects of baclofen in patients with severely impaired renal function."	2.40	Baclofen toxicity in patients with severely impaired renal function. ( Bullard, MJ; Chen, KS; Chien, YY; Lee, SY, 1997)
"Baclofen is a centrally acting gamma-aminobutyric acid agonist used for the symptomatic relief of skeletal muscle spasm and spasticity in traumatic spinal cord lesions, multiple sclerosis, cerebral palsy, and stroke."	1.42	Encephalopathy and hypotonia due to baclofen toxicity in a patient with end-stage renal disease. ( Ijaz, M; Kashif, M; Marquez, JG; Tariq, H, 2015)
"Baclofen was detected in the blood sampled on admission at a level above the therapeutic range."	1.33	Prolonged unconsciousness in a patient on automated peritoneal dialysis. ( de Tourtchaninoff, M; Goffin, E; Hantson, P; Laterre, PF; Lois, F; Vanbinst, R; Wallemacq, P, 2006)
" In the course of Baclofen's therapy, toxic effects of the drug like weakness, nausea, vomiting and fears appeared during the second day of treatment."	1.31	[Toxic effects of baclofen in a patient with chronic renal insufficiency]. ( Kroczak, M; Rakus, A, 2001)

Research

Studies (23)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (8.70)	18.7374
1990's	2 (8.70)	18.2507
2000's	8 (34.78)	29.6817
2010's	9 (39.13)	24.3611
2020's	2 (8.70)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

2 (8.70)

18.7374

1990's

2 (8.70)

18.2507

2000's

8 (34.78)

29.6817

2010's

9 (39.13)

24.3611

2020's

2 (8.70)

2.80

Authors

Authors	Studies
Grech, E	1
Attard, SC	1
Attard, A	1
Farrugia, E	1
Norouzi, S	1
Farouk, SS	1
Sparks, MA	1
Khazneh, E	1
Shamlawi, A	1
Jebrin, K	1
Hamdan, Z	1
Sawalmeh, O	1
Lee, J	1
Shin, HS	1
Jung, YS	1
Rim, H	1
Justo-Ávila, P	1
Fernández-Antuña, L	1
Compte-Jove, MT	1
Gállego-Gil, C	1
Ijaz, M	1
Tariq, H	1
Kashif, M	1
Marquez, JG	1
Radhakrishnan, H	1
Porter, LM	1
Merrick, SS	1
Katz, KD	1
Su, W	1
Yegappan, C	1
Carlisle, EJ	1
Clase, CM	1
Quiñones Ortiz, L	1
Suárez Laurés, A	1
Pobes Martínez, A	1
de la Torre, M	1
Torres Lacalle, A	1
Forascepi Roza, R	1
El-Husseini, A	1
Sabucedo, A	1
Lamarche, J	1
Courville, C	1
Peguero, A	1
Ruiz-Roso, G	1
Gomis, A	1
Fernández-Lucas, M	1
Díaz-Domínguez, M	1
Teruel-Briones, JL	1
Quereda, C	1
Chen, YC	1
Chang, CT	1
Fang, JT	1
Huang, CC	1
Sanjay, S	1
Manoharan, B	1
Arun, KN	1
Sundar, S	1
Wu, VC	1
Lin, SL	1
Lin, SM	1
Fang, CC	1
Lois, F	1
Wallemacq, P	1
de Tourtchaninoff, M	1
Vanbinst, R	1
Laterre, PF	1
Goffin, E	1
Hantson, P	1
Chou, CL	1
Chen, CA	1
Lin, SH	1
Huang, HH	1
Seyfert, S	1
Kraft, D	1
Wagner, K	1
Chen, KS	1
Bullard, MJ	1
Chien, YY	1
Lee, SY	1
Peces, R	1
Navascués, RA	1
Baltar, J	1
Laurés, AS	1
Alvarez-Grande, J	1
Bassilios, N	1
Launay-Vacher, V	1
Mercadal, L	1
Deray, G	1
Kroczak, M	1
Rakus, A	1
Méry, JP	1
Kenouch, S	1

Studies

Grech, E

Attard, SC

Attard, A

Farrugia, E

Norouzi, S

Farouk, SS

Sparks, MA

Khazneh, E

Shamlawi, A

Jebrin, K

Hamdan, Z

Sawalmeh, O

Lee, J

Shin, HS

Jung, YS

Rim, H

Justo-Ávila, P

Fernández-Antuña, L

Compte-Jove, MT

Gállego-Gil, C

Ijaz, M

Tariq, H

Kashif, M

Marquez, JG

Radhakrishnan, H

Porter, LM

Merrick, SS

Katz, KD

Su, W

Yegappan, C

Carlisle, EJ

Clase, CM

Quiñones Ortiz, L

Suárez Laurés, A

Pobes Martínez, A

de la Torre, M

Torres Lacalle, A

Forascepi Roza, R

El-Husseini, A

Sabucedo, A

Lamarche, J

Courville, C

Peguero, A

Ruiz-Roso, G

Gomis, A

Fernández-Lucas, M

Díaz-Domínguez, M

Teruel-Briones, JL

Quereda, C

Chen, YC

Chang, CT

Fang, JT

Huang, CC

Sanjay, S

Manoharan, B

Arun, KN

Sundar, S

Wu, VC

Lin, SL

Lin, SM

Fang, CC

Lois, F

Wallemacq, P

de Tourtchaninoff, M

Vanbinst, R

Laterre, PF

Goffin, E

Hantson, P

Chou, CL

Chen, CA

Lin, SH

Huang, HH

Seyfert, S

Kraft, D

Wagner, K

Chen, KS

Bullard, MJ

Chien, YY

Lee, SY

Peces, R

Navascués, RA

Baltar, J

Laurés, AS

Alvarez-Grande, J

Bassilios, N

Launay-Vacher, V

Mercadal, L

Deray, G

Kroczak, M

Rakus, A

Méry, JP

Kenouch, S

Reviews

3 reviews available for baclofen and Kidney Failure, Chronic

Article	Year
Reduced level of consciousness from baclofen in people with low kidney function. BMJ (Clinical research ed.), 2009, Dec-31, Volume: 339 Topics: Back Pain; Baclofen; Coma; Female; Humans; Kidney Failure, Chronic; Middle Aged; Muscle Relaxants, C	2009
Baclofen-induced neurotoxicity in chronic renal failure patients with intractable hiccups. Southern medical journal, 2006, Volume: 99, Issue:11 Topics: Aged; Baclofen; Comorbidity; GABA Agonists; Hiccup; Humans; Kidney Failure, Chronic; Male; Neurotoxi	2006
Baclofen toxicity in patients with severely impaired renal function. The Annals of pharmacotherapy, 1997, Volume: 31, Issue:11 Topics: Adult; Aged; Baclofen; Central Nervous System Diseases; Contraindications; Female; Humans; Kidney Fa	1997

Article

Year

Reduced level of consciousness from baclofen in people with low kidney function.

BMJ (Clinical research ed.), 2009, Dec-31, Volume: 339

Topics: Back Pain; Baclofen; Coma; Female; Humans; Kidney Failure, Chronic; Middle Aged; Muscle Relaxants, C

2009

Baclofen-induced neurotoxicity in chronic renal failure patients with intractable hiccups.

Southern medical journal, 2006, Volume: 99, Issue:11

Topics: Aged; Baclofen; Comorbidity; GABA Agonists; Hiccup; Humans; Kidney Failure, Chronic; Male; Neurotoxi

2006

Baclofen toxicity in patients with severely impaired renal function.

The Annals of pharmacotherapy, 1997, Volume: 31, Issue:11

Topics: Adult; Aged; Baclofen; Central Nervous System Diseases; Contraindications; Female; Humans; Kidney Fa

1997

Other Studies

20 other studies available for baclofen and Kidney Failure, Chronic

Article	Year
Baclofen toxicity in a patient with advanced chronic kidney disease. British journal of hospital medicine (London, England : 2005), 2023, 09-02, Volume: 84, Issue:9 Topics: Baclofen; Chronic Disease; Humans; Kidney Failure, Chronic; Renal Insufficiency, Chronic	2023
Back off baclofen when the kidneys don't work. Kidney international, 2020, Volume: 98, Issue:4 Topics: Baclofen; Humans; Kidney; Kidney Failure, Chronic; Renal Insufficiency; Retrospective Studies	2020
Single-dose baclofen-induced neurotoxicity in a patient with end stage renal disease: case report. BMC nephrology, 2018, 12-11, Volume: 19, Issue:1 Topics: Baclofen; Female; GABA-B Receptor Agonists; Humans; Kidney Failure, Chronic; Middle Aged; Neurotoxic	2018
Two cases of baclofen-induced encephalopathy in hemodialysis and peritoneal dialysis patients. Renal failure, 2013, Volume: 35, Issue:6 Topics: Adult; Aged; Baclofen; Female; GABA-B Receptor Agonists; Humans; Kidney Failure, Chronic; Male; Neur	2013
Baclofen neurotoxicity in a patient with end-stage chronic renal failure. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2014, Volume: 34, Issue:4 Topics: Adult; Baclofen; Humans; Kidney Failure, Chronic; Male; Muscle Relaxants, Central; Neurotoxicity Syn	2014
Encephalopathy and hypotonia due to baclofen toxicity in a patient with end-stage renal disease. The American journal of case reports, 2015, Apr-20, Volume: 16 Topics: Baclofen; Brain Diseases; Female; Humans; Kidney Failure, Chronic; Middle Aged; Muscle Hypotonia; Mu	2015
Baclofen-induced neurotoxicity in a patient with end-stage renal disease. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2016, Volume: 27, Issue:3 Topics: Acute Kidney Injury; Baclofen; Humans; Kidney Failure, Chronic; Renal Dialysis	2016
Baclofen Toxicity in a Patient with Hemodialysis-Dependent End-Stage Renal Disease. The Journal of emergency medicine, 2017, Volume: 52, Issue:4 Topics: Aged; Ataxia; Back Pain; Baclofen; Brain Diseases; Confusion; Dystonia; Emergency Service, Hospital;	2017
Warning against unexpected medication in haemodialysis. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2011, Volume: 31, Issue:5 Topics: Acyclovir; Aged; Akathisia, Drug-Induced; Alcoholic Intoxication; Baclofen; Continuity of Patient Ca	2011
Baclofen toxicity in patients with advanced nephropathy: proposal for new labeling. American journal of nephrology, 2011, Volume: 34, Issue:6 Topics: Administration, Oral; Aged; Baclofen; Drug Labeling; Drug-Related Side Effects and Adverse Reactions	2011
Aciclovir and valaciclovir neurotoxicity in patients with renal failure. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2012, Volume: 32, Issue:1 Topics: Acyclovir; Akathisia, Drug-Induced; Baclofen; Continuity of Patient Care; Humans; Kidney Failure, Ch	2012
Baclofen neurotoxicity in uremic patients: is continuous ambulatory peritoneal dialysis less effective than intermittent hemodialysis? Renal failure, 2003, Volume: 25, Issue:2 Topics: Aged; Baclofen; Humans; Kidney Failure, Chronic; Male; Middle Aged; Neurotoxicity Syndromes; Outcome	2003
Baclofen in the treatment of intractable hiccups. The Journal of the Association of Physicians of India, 2003, Volume: 51 Topics: Baclofen; Contraindications; Hiccup; Humans; Kidney Failure, Chronic; Muscle Relaxants, Central	2003
Treatment of baclofen overdose by haemodialysis: a pharmacokinetic study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, Volume: 20, Issue:2 Topics: Aged; Baclofen; Drug Overdose; Female; Humans; Kidney Failure, Chronic; Muscle Relaxants, Central; R	2005
Prolonged unconsciousness in a patient on automated peritoneal dialysis. European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2006, Volume: 13, Issue:6 Topics: Aged; Antidotes; Automation; Baclofen; Chromatography, High Pressure Liquid; Critical Care; Electroe	2006
[Baclofen toxicity during intermittent renal dialysis (author's transl)]. Der Nervenarzt, 1981, Volume: 52, Issue:10 Topics: Adult; Baclofen; Electroencephalography; Female; Humans; Kidney Failure, Chronic; Middle Aged; Renal	1981
Baclofen neurotoxicity in chronic haemodialysis patients with hiccups. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1998, Volume: 13, Issue:7 Topics: Aged; Baclofen; Central Nervous System; Coma; Confusion; GABA Agonists; Hiccup; Humans; Kidney Failu	1998
Baclofen neurotoxicity [correction of unerotoxicity] in a chronic haemodialysis patient. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2000, Volume: 15, Issue:5 Topics: Aged; Baclofen; Brain Diseases; Humans; Kidney Failure, Chronic; Male; Neurotoxins; Recovery of Func	2000
[Toxic effects of baclofen in a patient with chronic renal insufficiency]. Przeglad lekarski, 2001, Volume: 58, Issue:4 Topics: Adult; Baclofen; Female; Humans; Kidney Failure, Chronic; Muscle Hypertonia; Muscle Relaxants, Centr	2001
Oral baclofen may be effective in patients with spasticity due to spinal cord injury or disease. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1987, Volume: 10, Issue:4 Topics: Baclofen; Humans; Kidney Failure, Chronic; Urinary Bladder, Neurogenic	1987

Article

Year

Baclofen toxicity in a patient with advanced chronic kidney disease.

British journal of hospital medicine (London, England : 2005), 2023, 09-02, Volume: 84, Issue:9

Topics: Baclofen; Chronic Disease; Humans; Kidney Failure, Chronic; Renal Insufficiency, Chronic

2023

Back off baclofen when the kidneys don't work.

Kidney international, 2020, Volume: 98, Issue:4

Topics: Baclofen; Humans; Kidney; Kidney Failure, Chronic; Renal Insufficiency; Retrospective Studies

2020

Single-dose baclofen-induced neurotoxicity in a patient with end stage renal disease: case report.

BMC nephrology, 2018, 12-11, Volume: 19, Issue:1

Topics: Baclofen; Female; GABA-B Receptor Agonists; Humans; Kidney Failure, Chronic; Middle Aged; Neurotoxic

2018

Two cases of baclofen-induced encephalopathy in hemodialysis and peritoneal dialysis patients.

Renal failure, 2013, Volume: 35, Issue:6

Topics: Adult; Aged; Baclofen; Female; GABA-B Receptor Agonists; Humans; Kidney Failure, Chronic; Male; Neur

2013

Baclofen neurotoxicity in a patient with end-stage chronic renal failure.

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2014, Volume: 34, Issue:4

Topics: Adult; Baclofen; Humans; Kidney Failure, Chronic; Male; Muscle Relaxants, Central; Neurotoxicity Syn

2014

Encephalopathy and hypotonia due to baclofen toxicity in a patient with end-stage renal disease.

The American journal of case reports, 2015, Apr-20, Volume: 16

Topics: Baclofen; Brain Diseases; Female; Humans; Kidney Failure, Chronic; Middle Aged; Muscle Hypotonia; Mu

2015

Baclofen-induced neurotoxicity in a patient with end-stage renal disease.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2016, Volume: 27, Issue:3

Topics: Acute Kidney Injury; Baclofen; Humans; Kidney Failure, Chronic; Renal Dialysis

2016

Baclofen Toxicity in a Patient with Hemodialysis-Dependent End-Stage Renal Disease.

The Journal of emergency medicine, 2017, Volume: 52, Issue:4

Topics: Aged; Ataxia; Back Pain; Baclofen; Brain Diseases; Confusion; Dystonia; Emergency Service, Hospital;

2017

Warning against unexpected medication in haemodialysis.

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2011, Volume: 31, Issue:5

Topics: Acyclovir; Aged; Akathisia, Drug-Induced; Alcoholic Intoxication; Baclofen; Continuity of Patient Ca

2011

Baclofen toxicity in patients with advanced nephropathy: proposal for new labeling.

American journal of nephrology, 2011, Volume: 34, Issue:6

Topics: Administration, Oral; Aged; Baclofen; Drug Labeling; Drug-Related Side Effects and Adverse Reactions

2011

Aciclovir and valaciclovir neurotoxicity in patients with renal failure.

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2012, Volume: 32, Issue:1

Topics: Acyclovir; Akathisia, Drug-Induced; Baclofen; Continuity of Patient Care; Humans; Kidney Failure, Ch

2012

Baclofen neurotoxicity in uremic patients: is continuous ambulatory peritoneal dialysis less effective than intermittent hemodialysis?

Renal failure, 2003, Volume: 25, Issue:2

Topics: Aged; Baclofen; Humans; Kidney Failure, Chronic; Male; Middle Aged; Neurotoxicity Syndromes; Outcome

2003

Baclofen in the treatment of intractable hiccups.

The Journal of the Association of Physicians of India, 2003, Volume: 51

Topics: Baclofen; Contraindications; Hiccup; Humans; Kidney Failure, Chronic; Muscle Relaxants, Central

2003

Treatment of baclofen overdose by haemodialysis: a pharmacokinetic study.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, Volume: 20, Issue:2

Topics: Aged; Baclofen; Drug Overdose; Female; Humans; Kidney Failure, Chronic; Muscle Relaxants, Central; R

2005

Prolonged unconsciousness in a patient on automated peritoneal dialysis.

European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2006, Volume: 13, Issue:6

Topics: Aged; Antidotes; Automation; Baclofen; Chromatography, High Pressure Liquid; Critical Care; Electroe

2006

[Baclofen toxicity during intermittent renal dialysis (author's transl)].

Der Nervenarzt, 1981, Volume: 52, Issue:10

Topics: Adult; Baclofen; Electroencephalography; Female; Humans; Kidney Failure, Chronic; Middle Aged; Renal

1981

Baclofen neurotoxicity in chronic haemodialysis patients with hiccups.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1998, Volume: 13, Issue:7

Topics: Aged; Baclofen; Central Nervous System; Coma; Confusion; GABA Agonists; Hiccup; Humans; Kidney Failu

1998

Baclofen neurotoxicity [correction of unerotoxicity] in a chronic haemodialysis patient.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2000, Volume: 15, Issue:5

Topics: Aged; Baclofen; Brain Diseases; Humans; Kidney Failure, Chronic; Male; Neurotoxins; Recovery of Func

2000

[Toxic effects of baclofen in a patient with chronic renal insufficiency].

Przeglad lekarski, 2001, Volume: 58, Issue:4

Topics: Adult; Baclofen; Female; Humans; Kidney Failure, Chronic; Muscle Hypertonia; Muscle Relaxants, Centr

2001

Oral baclofen may be effective in patients with spasticity due to spinal cord injury or disease.

American journal of kidney diseases : the official journal of the National Kidney Foundation, 1987, Volume: 10, Issue:4

Topics: Baclofen; Humans; Kidney Failure, Chronic; Urinary Bladder, Neurogenic

1987