baclofen has been researched along with Hypothermia in 13 studies
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our laboratory recently demonstrated that a drug combination of baclofen and L-NAME, a nonspecific nitric oxide synthase (NOS) inhibitor, evokes synergistic hypothermia in rats." | 7.73 | Baclofen and NOS inhibitors interact to evoke synergistic hypothermia in rats. ( Jacobs, K; Rawls, SM; Tallarida, RJ, 2006) |
| ") significantly attenuated MSO-induced hypothermia, but pretreatment with ketanserin (0." | 7.68 | Hypothermia induced by infusion of methionine sulfoximine into the dorsal raphe nucleus of the rat: involvement of 5-HT1A and GABAB receptors. ( Gayet, J; Ginefri-Gayet, M, 1993) |
| " However, the highest dose abolished the hypothermia induced by the GABAB agonist baclofen (10 mg/kg i." | 7.68 | Inhibition of baclofen-induced hypothermia in mice by the novel GABAB antagonist CGP 35348. ( Jackson, HC; Nutt, DJ, 1991) |
| "Duodenal ulcers were also observed in about 80% of the hypothermic animals treated with the highest dose of baclofen." | 5.28 | [Ulcerogenic effect of a GABA derivative, baclofen, in the rat: effect of hypothermia]. ( Goto, Y; Hara, N; Hara, Y; Natsume, Y, 1990) |
| " In mice, AZD3355 produced considerably less central side effects than the prototypical GABA(B) receptor agonist baclofen but evoked hypothermia at very high doses (blocked by a GABA(B) receptor antagonist and absent in GABA(B)-/- mice)." | 3.75 | (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. ( Antonsson, M; Blackshaw, LA; Brändén, L; Bräuner-Osborne, H; Christiansen, B; Dent, J; Elebring, T; Holmberg, AA; Jacobson, BM; Jensen, J; Lehmann, A; Mattsson, JP; Nilsson, K; Oja, SS; Page, AJ; Saransaari, P; von Unge, S, 2009) |
| "L: -Baclofen produced a significant dose-dependent hypothermia and ataxia in most, but not all, mouse strains examined." | 3.73 | Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains. ( Cryan, JF; Jacobson, LH, 2005) |
| "Our laboratory recently demonstrated that a drug combination of baclofen and L-NAME, a nonspecific nitric oxide synthase (NOS) inhibitor, evokes synergistic hypothermia in rats." | 3.73 | Baclofen and NOS inhibitors interact to evoke synergistic hypothermia in rats. ( Jacobs, K; Rawls, SM; Tallarida, RJ, 2006) |
| ") significantly attenuated MSO-induced hypothermia, but pretreatment with ketanserin (0." | 3.68 | Hypothermia induced by infusion of methionine sulfoximine into the dorsal raphe nucleus of the rat: involvement of 5-HT1A and GABAB receptors. ( Gayet, J; Ginefri-Gayet, M, 1993) |
| " However, the highest dose abolished the hypothermia induced by the GABAB agonist baclofen (10 mg/kg i." | 3.68 | Inhibition of baclofen-induced hypothermia in mice by the novel GABAB antagonist CGP 35348. ( Jackson, HC; Nutt, DJ, 1991) |
| " GHB is frequently combined with other recreational drugs although these interactions are not well characterised." | 1.35 | Sedative and hypothermic effects of gamma-hydroxybutyrate (GHB) in rats alone and in combination with other drugs: assessment using biotelemetry. ( McGregor, IS; van Nieuwenhuijzen, PS, 2009) |
| "Baclofen was administered to rats systemically (intraperitoneal, i." | 1.32 | Pronounced hypothermic synergy between systemic baclofen and NOS inhibitor. ( Baron, DA; Gomez, T; Jacobs, K; Rawls, SM; Tallarida, RJ, 2004) |
| "Duodenal ulcers were also observed in about 80% of the hypothermic animals treated with the highest dose of baclofen." | 1.28 | [Ulcerogenic effect of a GABA derivative, baclofen, in the rat: effect of hypothermia]. ( Goto, Y; Hara, N; Hara, Y; Natsume, Y, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 9 (69.23) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Nieuwenhuijzen, PS | 1 |
| McGregor, IS | 1 |
| Lehmann, A | 2 |
| Antonsson, M | 1 |
| Holmberg, AA | 1 |
| Blackshaw, LA | 1 |
| Brändén, L | 1 |
| Bräuner-Osborne, H | 1 |
| Christiansen, B | 1 |
| Dent, J | 1 |
| Elebring, T | 1 |
| Jacobson, BM | 1 |
| Jensen, J | 1 |
| Mattsson, JP | 2 |
| Nilsson, K | 1 |
| Oja, SS | 1 |
| Page, AJ | 1 |
| Saransaari, P | 1 |
| von Unge, S | 1 |
| Koek, W | 1 |
| France, CP | 1 |
| Cheng, K | 1 |
| Rice, KC | 1 |
| Quéva, C | 1 |
| Bremner-Danielsen, M | 1 |
| Edlund, A | 1 |
| Ekstrand, AJ | 1 |
| Elg, S | 1 |
| Erickson, S | 1 |
| Johansson, T | 1 |
| Rawls, SM | 2 |
| Baron, DA | 1 |
| Gomez, T | 1 |
| Jacobs, K | 2 |
| Tallarida, RJ | 2 |
| Haller, C | 1 |
| Casanova, E | 1 |
| Müller, M | 1 |
| Vacher, CM | 1 |
| Vigot, R | 1 |
| Doll, T | 1 |
| Barbieri, S | 1 |
| Gassmann, M | 1 |
| Bettler, B | 2 |
| Jacobson, LH | 2 |
| Cryan, JF | 2 |
| Kaupmann, K | 1 |
| Hetzler, BE | 1 |
| Ondracek, JM | 1 |
| Ginefri-Gayet, M | 1 |
| Gayet, J | 1 |
| Jackson, HC | 1 |
| Nutt, DJ | 1 |
| Hara, N | 1 |
| Hara, Y | 1 |
| Natsume, Y | 1 |
| Goto, Y | 1 |
13 other studies available for baclofen and Hypothermia
| Article | Year |
|---|---|
Sedative and hypothermic effects of gamma-hydroxybutyrate (GHB) in rats alone and in combination with other drugs: assessment using biotelemetry.
Topics: Animals; Baclofen; Benzazepines; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance | 2009 |
(R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action.
Topics: Animals; Autoradiography; Baclofen; Binding, Competitive; Calcium; Dogs; Dose-Response Relationship, | 2009 |
GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo.
Topics: Animals; Baclofen; Benzofurans; Body Temperature; Dose-Response Relationship, Drug; Enzyme Inhibitor | 2010 |
Effects of GABA agonists on body temperature regulation in GABA(B(1))-/- mice.
Topics: Animals; Baclofen; Behavior, Animal; Body Temperature Regulation; Brain; Cloning, Molecular; GABA Ag | 2003 |
Pronounced hypothermic synergy between systemic baclofen and NOS inhibitor.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Hypothermia; | 2004 |
Floxed allele for conditional inactivation of the GABAB(1) gene.
Topics: Alleles; Animals; Baclofen; Behavior, Animal; Body Temperature Regulation; Crosses, Genetic; Female; | 2004 |
Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains.
Topics: Animals; Baclofen; Body Temperature; GABA Agonists; GABA-B Receptor Agonists; Hypothermia; Male; Mic | 2005 |
Baclofen and NOS inhibitors interact to evoke synergistic hypothermia in rats.
Topics: Animals; Area Under Curve; Baclofen; Body Temperature; Dose-Response Relationship, Drug; Drug Synerg | 2006 |
GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice.
Topics: Animals; Ataxia; Baclofen; Body Temperature; Darkness; Female; GABA Agonists; GABA-B Receptor Agonis | 2006 |
Baclofen alters flash-evoked potentials in Long-Evans rats.
Topics: Animals; Baclofen; Body Temperature; Dose-Response Relationship, Drug; Evoked Potentials, Visual; GA | 2007 |
Hypothermia induced by infusion of methionine sulfoximine into the dorsal raphe nucleus of the rat: involvement of 5-HT1A and GABAB receptors.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Baclofen; Bicuculline; Body Temperature Regul | 1993 |
Inhibition of baclofen-induced hypothermia in mice by the novel GABAB antagonist CGP 35348.
Topics: Animals; Baclofen; Body Temperature; GABA-A Receptor Antagonists; Hypothermia; Male; Mice; Organopho | 1991 |
[Ulcerogenic effect of a GABA derivative, baclofen, in the rat: effect of hypothermia].
Topics: Animals; Baclofen; Duodenal Ulcer; gamma-Aminobutyric Acid; Gastric Acid; Gastric Mucosa; Hypothermi | 1990 |