Page last updated: 2024-10-23

baclofen and Hypotension

baclofen has been researched along with Hypotension in 10 studies

Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Research Excerpts

ExcerptRelevanceReference
"We investigated the effects of bilateral injections of the GABA receptor agonists muscimol (GABA A) and baclofen (GABA B) into the nucleus tractus solitarius (NTS) on the bradycardia and hypotension induced by iv serotonin injections (5-HT, 2 microg/rat) in awake male Holtzman rats."3.73The bradycardic and hypotensive responses to serotonin are reduced by activation of GABAA receptors in the nucleus tractus solitarius of awake rats. ( Callera, JC; Colombari, E; De Luca, LA; Menani, JV, 2005)
"Baclofen is a centrally acting skeletal muscle relaxant approved by the US Food and Drug Administration (FDA) for the treatment of muscle spasticity, but the immediate release mode of administration and rapid absorption has been associated with adverse effects."1.56Design, characterization and in vivo evaluation of modified release baclofen floating coated beads. ( Abdelkader, H; Ibrahim, M; Naguib, YW; Sarhan, HA, 2020)
"Baclofen is a lipophilic analogue of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in central nervous system."1.33Selected clinical aspects of acute intoxication with baclofen. ( Burda, P; Chodorowski, Z; Sein Anand, J, 2005)
"There was no correlation between the dosage of baclofen and the clinical outcome."1.32[Acute intoxication with baclofen]. ( Chodorowski, Z; Sein Anand, J; Wiśniewski, M, 2004)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19902 (20.00)18.7374
1990's2 (20.00)18.2507
2000's5 (50.00)29.6817
2010's0 (0.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Ibrahim, M1
Sarhan, HA1
Naguib, YW1
Abdelkader, H1
Chodorowski, Z2
Sein Anand, J2
Wiśniewski, M1
Lew, SM1
Psaty, EL1
Abbott, R1
Callera, JC1
Colombari, E1
De Luca, LA1
Menani, JV1
Burda, P1
Grande, LA1
Loeser, JD1
Samii, A1
Brodkey, JA1
Feler, CA1
Green, LB1
Nelson, VS1
Sill, JC1
Schumacher, K1
Southorn, PA1
Reuter, J1
Yaksh, TL1
Cohen, MB1
Gailey, RA1
McCoy, GC1

Reviews

1 review available for baclofen and Hypotension

ArticleYear
Death after acute withdrawal of intrathecal baclofen: case report and literature review.
    Archives of physical medicine and rehabilitation, 1999, Volume: 80, Issue:12

    Topics: Administration, Oral; Adult; Baclofen; Brain Death; Cervical Vertebrae; Equipment Failure; Fatal Out

1999

Trials

1 trial available for baclofen and Hypotension

ArticleYear
Bradycardia and hypotension associated with baclofen used during general anesthesia.
    Anesthesiology, 1986, Volume: 64, Issue:2

    Topics: Adult; Aged; Anesthesia, General; Baclofen; Bradycardia; Clinical Trials as Topic; Double-Blind Meth

1986

Other Studies

8 other studies available for baclofen and Hypotension

ArticleYear
Design, characterization and in vivo evaluation of modified release baclofen floating coated beads.
    International journal of pharmaceutics, 2020, May-30, Volume: 582

    Topics: Acrylic Resins; Administration, Oral; Animals; Baclofen; Biological Availability; Blood Pressure; De

2020
[Acute intoxication with baclofen].
    Przeglad lekarski, 2004, Volume: 61, Issue:4

    Topics: Acute Disease; Adolescent; Adult; Baclofen; Bradycardia; Coma; Creatine Kinase; Female; GABA Agonist

2004
An unusual cause of overdose after baclofen pump implantation: case report.
    Neurosurgery, 2005, Volume: 56, Issue:3

    Topics: Adolescent; Baclofen; Cerebral Palsy; Consciousness Disorders; Contrast Media; Drug Overdose; Dyston

2005
The bradycardic and hypotensive responses to serotonin are reduced by activation of GABAA receptors in the nucleus tractus solitarius of awake rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2005, Volume: 38, Issue:7

    Topics: Animals; Baclofen; Blood Pressure; Bradycardia; GABA Agonists; Heart Rate; Hypotension; Male; Muscim

2005
Selected clinical aspects of acute intoxication with baclofen.
    Przeglad lekarski, 2005, Volume: 62, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Baclofen; Bradycardia; Coma; Creatine Kinase; Drug Overdose; Femal

2005
Recurrent transient global amnesia with intrathecal baclofen.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:4

    Topics: Amnesia, Anterograde; Baclofen; Female; Humans; Hypotension; Injections, Spinal; Isosorbide Dinitrat

2008
Hypotension following a trial intrathecal dose of baclofen.
    Journal of the Tennessee Medical Association, 1993, Volume: 86, Issue:7

    Topics: Adult; Baclofen; Humans; Hypotension; Injections, Spinal; Male; Morphine; Spasm

1993
Atropine in the treatment of baclofen overdose.
    The American journal of emergency medicine, 1986, Volume: 4, Issue:6

    Topics: Adolescent; Atropine; Baclofen; Bradycardia; Humans; Hypotension; Male

1986