baclofen and Hypermyotonia studies

Research Excerpts

Excerpt	Relevance	Reference
"To evaluate the impact of intrathecal baclofen (ITB) on function and quality of life (QOL) and to obtain efficacy and safety data in poststroke spastic hypertonia."	9.12	Intrathecal baclofen management of poststroke spastic hypertonia: implications for function and quality of life. ( Francisco, GE; Grissom, SP; Ivanhoe, CB; McGuire, JR; Subramanian, T, 2006)
"We sought to determine whether continuous intrathecal delivery of baclofen can effectively decrease spastic hypertonia due to stroke."	9.09	Intrathecal baclofen for spastic hypertonia from stroke. ( Brunner, RC; Guin-Renfroe, S; Hadley, MN; Meythaler, JM, 2001)
"This chapter will review the application of intrathecal baclofen (ITB) in the management of post-stroke hypertonia, a major complication that results in deformity and discomfort, and limits mobility and performance of activities of daily living (ADL)."	8.84	Intrathecal baclofen in the management of post-stroke hypertonia: current applications and future directions. ( Francisco, GE, 2007)
"Implantation of an intrathecal baclofen pump is recommended for children with cerebral palsy as a means to improve care and comfort when other options fail to control severe hypertonia."	7.80	Improvements in children with cerebral palsy following intrathecal baclofen: use of the Rehabilitation Institute of Chicago Care and Comfort Caregiver Questionnaire (RIC CareQ). ( Baker, KW; Gaebler-Spira, D; Mutlu, A; Tann, B, 2014)
"To compare the long-term outcome of patients with severe traumatic brain injury and patients with hypoxic brain injury with dysautonomia and hypertonia treated with intrathecal baclofen therapy."	7.78	Comparison of long-term outcomes of patients with severe traumatic or hypoxic brain injuries treated with intrathecal baclofen therapy for dysautonomia. ( Cuny, E; Dehail, P; Hoarau, X; Richer, E, 2012)
"To determine whether intrathecal baclofen (ITB) changes mortality risk in persons with cerebral palsy (CP)."	7.76	Survival of individuals with cerebral palsy receiving continuous intrathecal baclofen treatment: a matched-cohort study. ( Day, SM; Krach, LE; Kriel, RL; Strauss, DJ, 2010)
"To determine if the continuous intrathecal delivery of baclofen will control spastic hypertonia caused by long-standing cerebral palsy (CP)."	7.71	Continuously infused intrathecal baclofen over 12 months for spastic hypertonia in adolescents and adults with cerebral palsy. ( Grabb, P; Guin-Renfroe, S; Hadley, MN; Law, C; Meythaler, JM, 2001)
"Although excessive weight gain is not a common problem in children with cerebral origin spasticity, increased weight-gain velocity is prevalent in children receiving ITB therapy."	5.33	Weight gain in children with hypertonia of cerebral origin receiving intrathecal baclofen therapy. ( Ayyangar, RN; Fox, MA; McCoy, AA; Schaubel, DE, 2006)
"To evaluate the impact of intrathecal baclofen (ITB) on function and quality of life (QOL) and to obtain efficacy and safety data in poststroke spastic hypertonia."	5.12	Intrathecal baclofen management of poststroke spastic hypertonia: implications for function and quality of life. ( Francisco, GE; Grissom, SP; Ivanhoe, CB; McGuire, JR; Subramanian, T, 2006)
"We sought to determine whether continuous intrathecal delivery of baclofen can effectively decrease spastic hypertonia due to stroke."	5.09	Intrathecal baclofen for spastic hypertonia from stroke. ( Brunner, RC; Guin-Renfroe, S; Hadley, MN; Meythaler, JM, 2001)
"This chapter will review the application of intrathecal baclofen (ITB) in the management of post-stroke hypertonia, a major complication that results in deformity and discomfort, and limits mobility and performance of activities of daily living (ADL)."	4.84	Intrathecal baclofen in the management of post-stroke hypertonia: current applications and future directions. ( Francisco, GE, 2007)
"Implantation of an intrathecal baclofen pump is recommended for children with cerebral palsy as a means to improve care and comfort when other options fail to control severe hypertonia."	3.80	Improvements in children with cerebral palsy following intrathecal baclofen: use of the Rehabilitation Institute of Chicago Care and Comfort Caregiver Questionnaire (RIC CareQ). ( Baker, KW; Gaebler-Spira, D; Mutlu, A; Tann, B, 2014)
"To compare the long-term outcome of patients with severe traumatic brain injury and patients with hypoxic brain injury with dysautonomia and hypertonia treated with intrathecal baclofen therapy."	3.78	Comparison of long-term outcomes of patients with severe traumatic or hypoxic brain injuries treated with intrathecal baclofen therapy for dysautonomia. ( Cuny, E; Dehail, P; Hoarau, X; Richer, E, 2012)
"To determine whether intrathecal baclofen (ITB) changes mortality risk in persons with cerebral palsy (CP)."	3.76	Survival of individuals with cerebral palsy receiving continuous intrathecal baclofen treatment: a matched-cohort study. ( Day, SM; Krach, LE; Kriel, RL; Strauss, DJ, 2010)
"To determine if the continuous intrathecal delivery of baclofen will control spastic hypertonia caused by long-standing cerebral palsy (CP)."	3.71	Continuously infused intrathecal baclofen over 12 months for spastic hypertonia in adolescents and adults with cerebral palsy. ( Grabb, P; Guin-Renfroe, S; Hadley, MN; Law, C; Meythaler, JM, 2001)
"Adults (N=28) with muscle hypertonia due to stroke, trauma, or anoxia."	2.75	Effect of intrathecal baclofen bolus injection on lower extremity joint range of motion during gait in patients with acquired brain injury. ( Chow, JW; Horn, TS; Lee, JE; Stokic, DS; Yablon, SA, 2010)
"When excessive spasticity is not sufficiently controlled by physical therapy and pharmacological treatment, patients can have recourse to neurosurgery: neurostimulation, intrathecal baclofen or selective ablative procedures."	2.41	Neurosurgery for spasticity. ( Mertens, P; Sindou, MP, 2000)
" The most commonly used ITB dosing modes were continuous (73%) and flexible (23%)."	1.62	Intrathecal baclofen pumps in the management of hypertonia in childhood: a UK and Ireland wide survey. ( Amin, S; Ammar, A; Bellis, L; Brink, P; Calisto, A; Crimmins, D; Eunson, P; Forsyth, RJ; Goodden, J; Kaminska, M; Kehoe, J; Kirkpatrick, M; Kumar, R; Leonard, J; Lodh, R; Lording, A; Lumsden, DE; Martin, K; Miller, R; Mordekar, SR; Pettorini, B; Smith, M; Smith, R; Sneade, C; Vloeberghs, M; Whitney, A; Zaki, H, 2021)
"Baclofen was started at a postnatal age of 86."	1.38	Is oral baclofen effective in neonatal hypertonia? ( Mathew, OP; Schulz, E, 2012)
"Although excessive weight gain is not a common problem in children with cerebral origin spasticity, increased weight-gain velocity is prevalent in children receiving ITB therapy."	1.33	Weight gain in children with hypertonia of cerebral origin receiving intrathecal baclofen therapy. ( Ayyangar, RN; Fox, MA; McCoy, AA; Schaubel, DE, 2006)
" In the course of Baclofen's therapy, toxic effects of the drug like weakness, nausea, vomiting and fears appeared during the second day of treatment."	1.31	[Toxic effects of baclofen in a patient with chronic renal insufficiency]. ( Kroczak, M; Rakus, A, 2001)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (3.13)	18.7374
1990's	0 (0.00)	18.2507
2000's	12 (37.50)	29.6817
2010's	15 (46.88)	24.3611
2020's	4 (12.50)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS): A Randomized, Controlled, Multi-center, Prospective Study Evaluating Dose Reduction in ITB Patients.[NCT04530955]				92 participants (Anticipated)	Interventional	2020-09-24	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Hypertonia. Current problems in pediatric and adolescent health care, 2017, Volume: 47, Issue:7 Topics: Baclofen; Dystonia; Humans; Muscle Hypertonia; Muscle Relaxants, Central; Muscle Spasticity	2017
Intrathecal baclofen therapy: an update. PM & R : the journal of injury, function, and rehabilitation, 2009, Volume: 1, Issue:9 Topics: Baclofen; GABA Agonists; Humans; Infusion Pumps, Implantable; Injections, Spinal; Muscle Hypertonia;	2009
Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review. Neurorehabilitation and neural repair, 2010, Volume: 24, Issue:7 Topics: Adult; Baclofen; Humans; Infusion Pumps, Implantable; Injections, Spinal; Muscle Hypertonia; Postope	2010
Effect of spinal cord injury and of intrathecal baclofen on brainstem reflexes. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2012, Volume: 123, Issue:1 Topics: Acoustic Stimulation; Animals; Baclofen; Blinking; Brain Stem; GABA-B Receptor Agonists; Humans; Inj	2012
Neurosurgical management of abnormal muscle tone in childhood. Pediatric clinics of North America, 2004, Volume: 51, Issue:2 Topics: Baclofen; Child; Dystonia; Electrodes, Implanted; Humans; Infusion Pumps, Implantable; Muscle Hypert	2004
Intrathecal baclofen for childhood hypertonia. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2007, Volume: 23, Issue:9 Topics: Baclofen; Drug Administration Routes; Infusion Pumps, Implantable; Muscle Hypertonia; Muscle Relaxan	2007
Intrathecal baclofen in the management of post-stroke hypertonia: current applications and future directions. Acta neurochirurgica. Supplement, 2007, Volume: 97, Issue:Pt 1 Topics: Baclofen; Humans; Injections, Spinal; Muscle Hypertonia; Muscle Relaxants, Central; Stroke	2007
Neurosurgery for spasticity. Stereotactic and functional neurosurgery, 2000, Volume: 74, Issue:3-4 Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Combined Modality Therapy; Gai	2000
Intrathecal application of drugs for muscle hypertonia. Scandinavian journal of rehabilitation medicine. Supplement, 1988, Volume: 17 Topics: Baclofen; Humans; Injections, Spinal; Midazolam; Morphine; Muscle Hypertonia	1988

Article	Year
Effect of intrathecal baclofen bolus injection on lower extremity joint range of motion during gait in patients with acquired brain injury. Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:1 Topics: Adult; Ankle Joint; Baclofen; Brain Injuries; Female; Gait; Hip Joint; Humans; Injections, Spinal; J	2010
Effect of concentration and mode of intrathecal baclofen administration on soleus H-reflex in patients with muscle hypertonia. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2012, Volume: 123, Issue:11 Topics: Adult; Baclofen; Dose-Response Relationship, Drug; Female; H-Reflex; Humans; Infusion Pumps; Infusio	2012
Intrathecal baclofen management of poststroke spastic hypertonia: implications for function and quality of life. Archives of physical medicine and rehabilitation, 2006, Volume: 87, Issue:11 Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Baclofen; Female; Humans; Infusion Pumps	2006
Intrathecal baclofen for spastic hypertonia from stroke. Stroke, 2001, Volume: 32, Issue:9 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Baclofen; Cross-Over Studies; Dose-Response Relationship	2001

Article	Year
Pendulum test parameters are useful for detecting knee muscle hypertonia and quantifying response to an intrathecal baclofen bolus injection. International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, 2023, Sep-01, Volume: 46, Issue:3 Topics: Baclofen; Humans; Lower Extremity; Muscle Hypertonia; Muscle Relaxants, Central; Muscle Spasticity;	2023
Knee Muscle Stretch Reflex Responses After an Intrathecal Baclofen Bolus in Neurological Patients With Moderate-to-Severe Hypertonia. Neuromodulation : journal of the International Neuromodulation Society, 2020, Volume: 23, Issue:7 Topics: Baclofen; Electromyography; Humans; Injections, Spinal; Knee; Muscle Hypertonia; Muscle Spasticity;	2020
The Impact of Intrathecal Baclofen Therapy on Health-related Quality of Life for Children with Marked Hypertonia. Developmental neurorehabilitation, 2020, Volume: 23, Issue:8 Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Child, Preschool; Cohort Studies; Disabled Children; Fe	2020
Intrathecal baclofen pumps in the management of hypertonia in childhood: a UK and Ireland wide survey. Archives of disease in childhood, 2021, Volume: 106, Issue:12 Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Child, Preschool; Cross-Sectional Studies; Humans; Inje	2021
Intrathecal baclofen therapy in children: an analysis of individualized goals. Developmental medicine and child neurology, 2018, Volume: 60, Issue:4 Topics: Adolescent; Australia; Baclofen; Cerebral Palsy; Child; Cohort Studies; Female; Goals; Humans; Injec	2018
Improvements in children with cerebral palsy following intrathecal baclofen: use of the Rehabilitation Institute of Chicago Care and Comfort Caregiver Questionnaire (RIC CareQ). Journal of child neurology, 2014, Volume: 29, Issue:3 Topics: Activities of Daily Living; Adolescent; Adult; Baclofen; Caregivers; Cerebral Palsy; Child; Child, P	2014
Effect of intrathecal baclofen bolus injection on ankle muscle activation during gait in patients with acquired brain injury. Neurorehabilitation and neural repair, 2015, Volume: 29, Issue:2 Topics: Adolescent; Adult; Ankle; Baclofen; Biomechanical Phenomena; Brain Injuries; Electromyography; Femal	2015
Orexin-a system neuromodulation by intrathecal baclofen. Journal of clinical psychopharmacology, 2014, Volume: 34, Issue:4 Topics: Adult; Baclofen; Biomarkers; Female; Humans; Injections, Spinal; Intracellular Signaling Peptides an	2014
Mobility and gait outcomes following intensive rehabilitation, onabotulinumtoxin A, and baclofen treatment chronic post-stroke: a case report. Journal of allied health, 2014,Winter, Volume: 43, Issue:4 Topics: Baclofen; Botulinum Toxins, Type A; Combined Modality Therapy; Exercise Therapy; Gait; Humans; Male;	2014
Survival of individuals with cerebral palsy receiving continuous intrathecal baclofen treatment: a matched-cohort study. Developmental medicine and child neurology, 2010, Volume: 52, Issue:7 Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Cohort Studies; Epilepsy; Fema	2010
Intrathecal baclofen. Developmental medicine and child neurology, 2010, Volume: 52, Issue:7 Topics: Baclofen; Cerebral Palsy; Humans; Infusion Pumps, Implantable; Injections, Spinal; Muscle Hypertonia	2010
Is oral baclofen effective in neonatal hypertonia? Journal of child neurology, 2012, Volume: 27, Issue:2 Topics: Baclofen; Female; Humans; Infant, Newborn; Infant, Premature; Male; Muscle Hypertonia; Muscle Relaxa	2012
Comparison of long-term outcomes of patients with severe traumatic or hypoxic brain injuries treated with intrathecal baclofen therapy for dysautonomia. Brain injury, 2012, Volume: 26, Issue:12 Topics: Adolescent; Adult; Baclofen; Brain Injuries; Child; Drug Administration Schedule; Female; Follow-Up	2012
Baclofen in community paediatric management of hypertonia. Archives of disease in childhood, 2013, Volume: 98, Issue:2 Topics: Baclofen; Child; Community Health Services; England; Humans; Muscle Hypertonia; Muscle Relaxants, Ce	2013
Cyproheptadine for intrathecal baclofen withdrawal. Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:5 Topics: Acute Disease; Adult; Baclofen; Cerebral Palsy; Cyproheptadine; Diagnosis, Differential; Female; Fev	2003
The use of baclofen in full-term neonates with hypertonia. Journal of perinatology : official journal of the California Perinatal Association, 2005, Volume: 25, Issue:1 Topics: Baclofen; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Male; Muscle Hypertonia	2005
Weight gain in children with hypertonia of cerebral origin receiving intrathecal baclofen therapy. Archives of physical medicine and rehabilitation, 2006, Volume: 87, Issue:11 Topics: Adolescent; Baclofen; Brain Injuries; Cerebral Palsy; Child; Child, Preschool; Female; Hospitals, Pe	2006
Continuously infused intrathecal baclofen over 12 months for spastic hypertonia in adolescents and adults with cerebral palsy. Archives of physical medicine and rehabilitation, 2001, Volume: 82, Issue:2 Topics: Adolescent; Adult; Analysis of Variance; Baclofen; Cerebral Palsy; Female; Humans; Infusion Pumps; I	2001
[Toxic effects of baclofen in a patient with chronic renal insufficiency]. Przeglad lekarski, 2001, Volume: 58, Issue:4 Topics: Adult; Baclofen; Female; Humans; Kidney Failure, Chronic; Muscle Hypertonia; Muscle Relaxants, Centr	2001

baclofen and Hypermyotonia

Research Excerpts

Research

Studies (32)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Chow, JW	4
Stokic, DS	6
Yablon, SA	6
Stewart, K	2
Copeland, L	1
Lewis, J	1
Lodh, R	1
Amin, S	1
Ammar, A	1
Bellis, L	1
Brink, P	1
Calisto, A	1
Crimmins, D	1
Eunson, P	1
Forsyth, RJ	1
Goodden, J	1
Kaminska, M	1
Kehoe, J	1
Kirkpatrick, M	1
Kumar, R	2
Leonard, J	1
Lording, A	1
Martin, K	1
Miller, R	1
Mordekar, SR	1
Pettorini, B	1
Smith, M	1
Smith, R	1
Sneade, C	1
Whitney, A	1
Vloeberghs, M	1
Zaki, H	1
Lumsden, DE	1
Evans, SH	1
Cameron, MW	1
Burton, JM	1
Liew, PY	1
Khan, D	1
Arnup, SJ	1
Scheinberg, A	1
Baker, KW	1
Tann, B	1
Mutlu, A	1
Gaebler-Spira, D	1
Margetis, K	1
Markianos, M	1
Gatzonis, S	1
Kalamatianos, T	1
Sakas, D	1
Barakatt, E	1
Coleman-Salgado, B	1
McKeough, M	1
Mandeville, D	1
Gong, J	1
Mintz, E	1
Thatch, J	1
Vourakis, A	1
Thakur, N	1
Francisco, GE	3
Saulino, MF	1
Turner, M	1
Krach, LE	1
Kriel, RL	1
Day, SM	1
Strauss, DJ	1
Russman, BS	1
Horn, TS	1
Lee, JE	1
Stetkarova, I	1
Kofler, M	2
Schulz, E	1
Mathew, OP	1
Kumru, H	1
Hoarau, X	1
Richer, E	1
Dehail, P	1
Cuny, E	1
George, B	1
Meythaler, JM	3
Roper, JF	1
Brunner, RC	2
Abbott, R	1
Moran, LR	1
Cincotta, T	1
Krishnamoorthy, K	1
Insoft, RM	1
McCoy, AA	1
Fox, MA	1
Schaubel, DE	1
Ayyangar, RN	1
Ivanhoe, CB	1
McGuire, JR	1
Subramanian, T	1
Grissom, SP	1
Albright, AL	1
Guin-Renfroe, S	2
Law, C	1
Grabb, P	1
Hadley, MN	2
Sindou, MP	1
Mertens, P	1
Kroczak, M	1
Rakus, A	1
Siegfried, J	1
Rea, GL	1