baclofen has been researched along with Huntington Disease in 10 studies
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quinolinic acid (QA) is an endogenous excitotoxin present in mammalian brain that reproduces many of the histologic and neurochemical features of Huntington's disease (HD)." | 1.27 | Systemic approaches to modifying quinolinic acid striatal lesions in rats. ( Beal, MF; Ferrante, RJ; Kowall, NW; Martin, JB; Swartz, KJ, 1988) |
| "A 29-year-old woman with known Huntington's disease took from 900 to 970 mg of Lioresal, a cogener of gamma amino butyric acid (GABA) used experimentally to treat muscle spasm." | 1.26 | Overdose of lioresal. ( Paulson, GW, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (80.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, W | 1 |
| Seo, H | 1 |
| Roccatagliata, G | 2 |
| Albano, C | 2 |
| Marsden, CD | 1 |
| Sheehy, MP | 1 |
| Fisher, RH | 1 |
| Norris, JW | 1 |
| DeManuele, F | 1 |
| Ridgley, B | 1 |
| Malyon, C | 1 |
| Rubin, AJ | 1 |
| King, WM | 1 |
| Reinbold, KA | 1 |
| Shoulson, I | 2 |
| Paulson, GW | 2 |
| Besio, G | 1 |
| Ivaldi, EM | 1 |
| Beal, MF | 1 |
| Kowall, NW | 1 |
| Swartz, KJ | 1 |
| Ferrante, RJ | 1 |
| Martin, JB | 1 |
| Odoroff, C | 1 |
| Oakes, D | 1 |
| Behr, J | 1 |
| Goldblatt, D | 1 |
| Caine, E | 1 |
| Kennedy, J | 1 |
| Miller, C | 1 |
| Bamford, K | 1 |
| Rubin, A | 1 |
3 trials available for baclofen and Huntington Disease
| Article | Year |
|---|---|
GABA and movement disorders.
Topics: Anticonvulsants; Baclofen; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; | 1981 |
Quantitative longitudinal assessment of saccades in Huntington's disease.
Topics: Adult; Aged; Baclofen; Biomarkers; Eye Movements; Humans; Huntington Disease; Longitudinal Studies; | 1993 |
A controlled clinical trial of baclofen as protective therapy in early Huntington's disease.
Topics: Adolescent; Adult; Baclofen; Clinical Trials as Topic; Female; Humans; Huntington Disease; Male; Mid | 1989 |
7 other studies available for baclofen and Huntington Disease
| Article | Year |
|---|---|
Baclofen, a GABAB receptor agonist, enhances ubiquitin-proteasome system functioning and neuronal survival in Huntington's disease model mice.
Topics: Animals; Baclofen; Cell Survival; Corpus Striatum; Disease Models, Animal; GABA-B Receptor Agonists; | 2014 |
[Therapy of Huntington's chorea: a pharmacological and clinical approach to the organization of the basal ganglia].
Topics: Adult; Aged; Baclofen; Basal Ganglia; Behavior; Biperiden; Bromocriptine; Female; Fluphenazine; Homo | 1980 |
Huntington's chorea.
Topics: Baclofen; Canada; gamma-Aminobutyric Acid; Health Facilities; Humans; Huntington Disease; Hydroxybut | 1982 |
Lioresal in Huntington's disease.
Topics: Aminobutyrates; Baclofen; Dantrolene; Diazepam; Drug Evaluation; Gait; gamma-Aminobutyric Acid; Grow | 1976 |
Overdose of lioresal.
Topics: Adult; Aminobutyrates; Baclofen; Female; Humans; Huntington Disease; Suicide, Attempted | 1976 |
[Choreic dyskinesia and GABA - pharmaco-clinical approach. Preliminary note].
Topics: Adult; Aminobutyrates; Baclofen; Extrapyramidal Tracts; Female; Homovanillic Acid; Humans; Huntingto | 1978 |
Systemic approaches to modifying quinolinic acid striatal lesions in rats.
Topics: 2-Amino-5-phosphonovalerate; Allopurinol; Amino Acids; Animals; Antioxidants; Baclofen; Corpus Stria | 1988 |