Page last updated: 2024-10-23

baclofen and Huntington Disease

baclofen has been researched along with Huntington Disease in 10 studies

Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Research Excerpts

ExcerptRelevanceReference
"Quinolinic acid (QA) is an endogenous excitotoxin present in mammalian brain that reproduces many of the histologic and neurochemical features of Huntington's disease (HD)."1.27Systemic approaches to modifying quinolinic acid striatal lesions in rats. ( Beal, MF; Ferrante, RJ; Kowall, NW; Martin, JB; Swartz, KJ, 1988)
"A 29-year-old woman with known Huntington's disease took from 900 to 970 mg of Lioresal, a cogener of gamma amino butyric acid (GABA) used experimentally to treat muscle spasm."1.26Overdose of lioresal. ( Paulson, GW, 1976)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19908 (80.00)18.7374
1990's1 (10.00)18.2507
2000's0 (0.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kim, W1
Seo, H1
Roccatagliata, G2
Albano, C2
Marsden, CD1
Sheehy, MP1
Fisher, RH1
Norris, JW1
DeManuele, F1
Ridgley, B1
Malyon, C1
Rubin, AJ1
King, WM1
Reinbold, KA1
Shoulson, I2
Paulson, GW2
Besio, G1
Ivaldi, EM1
Beal, MF1
Kowall, NW1
Swartz, KJ1
Ferrante, RJ1
Martin, JB1
Odoroff, C1
Oakes, D1
Behr, J1
Goldblatt, D1
Caine, E1
Kennedy, J1
Miller, C1
Bamford, K1
Rubin, A1

Trials

3 trials available for baclofen and Huntington Disease

ArticleYear
GABA and movement disorders.
    Advances in biochemical psychopharmacology, 1981, Volume: 30

    Topics: Anticonvulsants; Baclofen; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced;

1981
Quantitative longitudinal assessment of saccades in Huntington's disease.
    Journal of clinical neuro-ophthalmology, 1993, Volume: 13, Issue:1

    Topics: Adult; Aged; Baclofen; Biomarkers; Eye Movements; Humans; Huntington Disease; Longitudinal Studies;

1993
A controlled clinical trial of baclofen as protective therapy in early Huntington's disease.
    Annals of neurology, 1989, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Baclofen; Clinical Trials as Topic; Female; Humans; Huntington Disease; Male; Mid

1989

Other Studies

7 other studies available for baclofen and Huntington Disease

ArticleYear
Baclofen, a GABAB receptor agonist, enhances ubiquitin-proteasome system functioning and neuronal survival in Huntington's disease model mice.
    Biochemical and biophysical research communications, 2014, Jan-10, Volume: 443, Issue:2

    Topics: Animals; Baclofen; Cell Survival; Corpus Striatum; Disease Models, Animal; GABA-B Receptor Agonists;

2014
[Therapy of Huntington's chorea: a pharmacological and clinical approach to the organization of the basal ganglia].
    La Clinica terapeutica, 1980, Aug-15, Volume: 94, Issue:3

    Topics: Adult; Aged; Baclofen; Basal Ganglia; Behavior; Biperiden; Bromocriptine; Female; Fluphenazine; Homo

1980
Huntington's chorea.
    Canadian Medical Association journal, 1982, Mar-15, Volume: 126, Issue:6

    Topics: Baclofen; Canada; gamma-Aminobutyric Acid; Health Facilities; Humans; Huntington Disease; Hydroxybut

1982
Lioresal in Huntington's disease.
    Diseases of the nervous system, 1976, Volume: 37, Issue:8

    Topics: Aminobutyrates; Baclofen; Dantrolene; Diazepam; Drug Evaluation; Gait; gamma-Aminobutyric Acid; Grow

1976
Overdose of lioresal.
    Neurology, 1976, Volume: 26, Issue:11

    Topics: Adult; Aminobutyrates; Baclofen; Female; Humans; Huntington Disease; Suicide, Attempted

1976
[Choreic dyskinesia and GABA - pharmaco-clinical approach. Preliminary note].
    Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie, 1978, Volume: 123, Issue:1

    Topics: Adult; Aminobutyrates; Baclofen; Extrapyramidal Tracts; Female; Homovanillic Acid; Humans; Huntingto

1978
Systemic approaches to modifying quinolinic acid striatal lesions in rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1988, Volume: 8, Issue:10

    Topics: 2-Amino-5-phosphonovalerate; Allopurinol; Amino Acids; Animals; Antioxidants; Baclofen; Corpus Stria

1988