baclofen has been researched along with Friedreich Ataxia in 3 studies
Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report on the case of a patient suffering from Friedreich's ataxia (FA) with very painful and disabling spasms that were improved markedly by intrathecal baclofen infusion." | 7.73 | Intrathecal baclofen in the treatment of painful, disabling spasms in Friedreich's ataxia. ( Ben Smail, D; Bussel, B; Denys, P; Jacq, C, 2005) |
| "We report on the case of a patient suffering from Friedreich's ataxia (FA) with very painful and disabling spasms that were improved markedly by intrathecal baclofen infusion." | 3.73 | Intrathecal baclofen in the treatment of painful, disabling spasms in Friedreich's ataxia. ( Ben Smail, D; Bussel, B; Denys, P; Jacq, C, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kalyvas, AV | 1 |
| Drosos, E | 1 |
| Korfias, S | 1 |
| Gatzonis, S | 1 |
| Themistocleous, M | 1 |
| Sakas, DE | 1 |
| Berntsson, SG | 1 |
| Gauffin, H | 1 |
| Melberg, A | 1 |
| Holtz, A | 1 |
| Landtblom, AM | 1 |
| Ben Smail, D | 1 |
| Jacq, C | 1 |
| Denys, P | 1 |
| Bussel, B | 1 |
3 other studies available for baclofen and Friedreich Ataxia
| Article | Year |
|---|---|
Intrathecal Baclofen Therapy for Painful Muscle Spasms in a Patient with Friedreich's Ataxia.
Topics: Aged; Baclofen; Female; Follow-Up Studies; Friedreich Ataxia; Humans; Injections, Spinal; Muscle Rel | 2018 |
Inherited Ataxia and Intrathecal Baclofen for the Treatment of Spasticity and Painful Spasms.
Topics: Adult; Aged; Baclofen; Female; Friedreich Ataxia; Humans; Injections, Spinal; Male; Middle Aged; Mus | 2019 |
Intrathecal baclofen in the treatment of painful, disabling spasms in Friedreich's ataxia.
Topics: Adult; Baclofen; Electromyography; Friedreich Ataxia; Humans; Male; Muscle Relaxants, Central; Pain; | 2005 |