Page last updated: 2024-10-23

baclofen and Flaccid Quadriplegia

baclofen has been researched along with Flaccid Quadriplegia in 74 studies

Research Excerpts

ExcerptRelevanceReference
"To compare scoliosis progression in quadriplegic spastic cerebral palsy with and without intrathecal baclofen (ITB) pumps."7.85Intrathecal baclofen pumps do not accelerate progression of scoliosis in quadriplegic spastic cerebral palsy. ( Ammar, A; Aujla, RK; Grevitt, MP; Nasto, LA; Rushton, PRP; Vloeberghs, MH, 2017)
"We describe a 6 year-old girl with hydranencephaly who underwent an intrathecal baclofen test dose and developed severe bradycardia."7.81Profound Bradycardia After Intrathecal Baclofen Injection in a Patient With Hydranencephaly. ( Cain, N; Kinsman, S; Sechrist, C, 2015)
"Medical and radiographic review of 19 consecutive patients with spastic quadriplegia before and after intrathecal baclofen pump insertion with special attention paid to progression of scoliosis."7.74Progression of scoliosis in patients with spastic quadriplegia after the insertion of an intrathecal baclofen pump. ( Ginsburg, GM; Lauder, AJ, 2007)
"To present our preliminary experience and complications with posterior spine fusion in patients with cerebral palsy and continuous intrathecal baclofen infusion and provide a literature review."7.73Potential complications of posterior spine fusion and instrumentation in patients with cerebral palsy treated with intrathecal baclofen infusion. ( Kanev, PM; Segal, LS; Wallach, DM, 2005)
"Continuous intrathecal baclofen was effective in treating severe spasticity and dystonia of cerebral origin with major effect on muscles of the lower extremities, pelvis, and back and in particular opisthotonus was relieved."7.72[Intrathecal baclofen in the treatment of severe spastic tetraplegia and dystonia in children and adolescents]. ( Fischer, C; Hansen, FJ; Illum, NO; Nielsen, OA; Uldall, PV, 2003)
"Intrathecal baclofen infusion (IBI) is an effective treatment for spasticity secondary to cerebral palsy (CP)."7.70Intrathecal baclofen infusion and subsequent orthopedic surgery in patients with spastic cerebral palsy. ( Albright, AL; Gerszten, PC; Johnstone, GF, 1998)
"A 29-year-old man with C6 tetraplegia (ASIA A) using an implanted baclofen pump and intrathecal catheter infusion system for spasticity control developed severe spasticity, hyperthermia, hypotension, rhabdomyolysis, and disseminated intravascular coagulation after catheter disconnection."7.70Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure. ( Christopherson, MW; Reeves, RK; Stolp-Smith, KA, 1998)
"The purpose of the study was to analyze the relative cost of selective functional posterior rhizotomy (SFPR) and continuous intrathecal baclofen in the treatment of children with severe spastic quadriplegia related to cerebral palsy."7.69Cost analysis of continuous intrathecal baclofen versus selective functional posterior rhizotomy in the treatment of spastic quadriplegia associated with cerebral palsy. ( Daneshvar, H; Evans, D; Kestle, JR; Steinbok, P, 1995)
"A report on pregnancy in a quadriplegic patient treated with a high dose of 1000 mcg/24 h continuous intrathecal baclofen infusion using an implanted drug delivery system (Synchromed, Medtronic, USA)."7.68Pregnancy in a quadriplegic patient treated with continuous intrathecal baclofen infusion to manage her severe spasticity. Case report. ( Delhaas, EM; Verhagen, J, 1992)
"Baclofen overdose is treated with supportive care and antiepileptic medications as indicated."5.40An unusual cause of flaccid paralysis and coma: baclofen overdose. ( Caron, E; Morgan, R; Wheless, JW, 2014)
"Baclofen (Lioresal) is a drug of choice to treat spasticity and is increasingly being administered intrathecally via an implantable pump in cases refractory to oral therapy."5.32Intrathecal baclofen withdrawal mimicking sepsis. ( Amin, Y; Kao, LW; Kirk, MA; Turner, MS, 2003)
"To compare scoliosis progression in quadriplegic spastic cerebral palsy with and without intrathecal baclofen (ITB) pumps."3.85Intrathecal baclofen pumps do not accelerate progression of scoliosis in quadriplegic spastic cerebral palsy. ( Ammar, A; Aujla, RK; Grevitt, MP; Nasto, LA; Rushton, PRP; Vloeberghs, MH, 2017)
"A 15-year-old patient with spastic quadriparesis and cerebral palsy underwent unexpected removal of his baclofen pump due to an infection that was encountered during a planned pump revision."3.81Dexmedetomidine for acute baclofen withdrawal. ( Heard, CM; Li, V; Morr, S; Reynolds, RM, 2015)
"We describe a 6 year-old girl with hydranencephaly who underwent an intrathecal baclofen test dose and developed severe bradycardia."3.81Profound Bradycardia After Intrathecal Baclofen Injection in a Patient With Hydranencephaly. ( Cain, N; Kinsman, S; Sechrist, C, 2015)
"Intrathecal baclofen (ITB) is a reversible treatment that reduces muscle tone to ameliorate spasticity and dystonia in patients with cerebral palsy (CP)."3.80Indwelling intrathecal catheter with subcutaneous abdominal reservoir: a viable baclofen delivery system in severely cachectic patients. ( Ellenbogen, JR; Kumar, R; Pettorini, BL; Sneade, C; Waqar, M; Williams, D; Zebian, B, 2014)
" After the first admission of 5 mg of oral Baclofen, he collapsed in bed with extreme bradycardia, hypotension, hyperventilation and decreased oxygen saturation."3.74Heart conduction problems in a tetraplegic patient caused by a single therapeutic dosage of Baclofen. ( Slim, EJ; Smit, CA, 2008)
"Medical and radiographic review of 19 consecutive patients with spastic quadriplegia before and after intrathecal baclofen pump insertion with special attention paid to progression of scoliosis."3.74Progression of scoliosis in patients with spastic quadriplegia after the insertion of an intrathecal baclofen pump. ( Ginsburg, GM; Lauder, AJ, 2007)
"To present our preliminary experience and complications with posterior spine fusion in patients with cerebral palsy and continuous intrathecal baclofen infusion and provide a literature review."3.73Potential complications of posterior spine fusion and instrumentation in patients with cerebral palsy treated with intrathecal baclofen infusion. ( Kanev, PM; Segal, LS; Wallach, DM, 2005)
"Continuous intrathecal baclofen was effective in treating severe spasticity and dystonia of cerebral origin with major effect on muscles of the lower extremities, pelvis, and back and in particular opisthotonus was relieved."3.72[Intrathecal baclofen in the treatment of severe spastic tetraplegia and dystonia in children and adolescents]. ( Fischer, C; Hansen, FJ; Illum, NO; Nielsen, OA; Uldall, PV, 2003)
" He developed perinephric haematoma while he was taking warfarin as prophylactic for deep vein thrombosis."3.71How should an infected perinephric haematoma be drained in a tetraplegic patient with baclofen pump implanted in the abdominal wall? - A case report. ( Hughes, PL; Oo, T; Sett, P; Singh, G; Soni, BM; Vaidyanathan, S; Watt, JW, 2002)
"Intrathecal baclofen (ITB) can reduce spasticity in adults and children with cerebral palsy."3.71Improvement of sleep apnea in a patient with cerebral palsy. ( Gaebler-Spira, D; Harvey, RL; McCarty, SF, 2001)
"A 29-year-old man with C6 tetraplegia (ASIA A) using an implanted baclofen pump and intrathecal catheter infusion system for spasticity control developed severe spasticity, hyperthermia, hypotension, rhabdomyolysis, and disseminated intravascular coagulation after catheter disconnection."3.70Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure. ( Christopherson, MW; Reeves, RK; Stolp-Smith, KA, 1998)
"Intrathecal baclofen infusion (IBI) is an effective treatment for spasticity secondary to cerebral palsy (CP)."3.70Intrathecal baclofen infusion and subsequent orthopedic surgery in patients with spastic cerebral palsy. ( Albright, AL; Gerszten, PC; Johnstone, GF, 1998)
"The purpose of the study was to analyze the relative cost of selective functional posterior rhizotomy (SFPR) and continuous intrathecal baclofen in the treatment of children with severe spastic quadriplegia related to cerebral palsy."3.69Cost analysis of continuous intrathecal baclofen versus selective functional posterior rhizotomy in the treatment of spastic quadriplegia associated with cerebral palsy. ( Daneshvar, H; Evans, D; Kestle, JR; Steinbok, P, 1995)
"Rapid baclofen withdrawal is known to cause markedly increased spasticity, but high fever associated with this complication has not been reported."3.68Hyperthermia associated with baclofen withdrawal and increased spasticity. ( Hurvitz, EA; Mandac, BR; Nelson, VS, 1993)
"A report on pregnancy in a quadriplegic patient treated with a high dose of 1000 mcg/24 h continuous intrathecal baclofen infusion using an implanted drug delivery system (Synchromed, Medtronic, USA)."3.68Pregnancy in a quadriplegic patient treated with continuous intrathecal baclofen infusion to manage her severe spasticity. Case report. ( Delhaas, EM; Verhagen, J, 1992)
"Sudden withdrawal of baclofen has been shown to provoke hallucinations."3.67Baclofen pseudopsychosis: case report. ( Roy, CW; Wakefield, IR, 1986)
"This report summarizes experience with baclofen (Lioresal) in the management of spasticity and muscle spasms in 113 patients treated for up to six years."3.65Bacloffen (Lioresal) in the long-term management of spasticity. ( Jones, RF; Lance, JW, 1976)
"Baclofen was not effective at sustaining plasma IGF-1 concentrations in the physiological range in men with chronic SCI."2.78Low-dose baclofen therapy raised plasma insulin-like growth factor-1 concentrations, but not into the normal range in a predictable and sustained manner in men with chronic spinal cord injury. ( Bauman, WA; Cirnigliaro, CM; Kirshblum, SC; La Fountaine, MF; Spungen, AM, 2013)
"In a group of 17 patients with spastic hemiparesis, with a different etiology, 2 groups were separated."2.73[Assessment of spasticity therapy with baclofen pump in children]. ( Swierczyńska, A, 2007)
"0001) increase in intrathecal baclofen dosage requirements during the 1-year follow-up period to maintain the reductions in spasm frequency, reflexes and tone."2.70Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia. ( Burns, AS; Meythaler, JM, 2001)
"When excessive spasticity is not sufficiently controlled by physical therapy and pharmacological treatment, patients can have recourse to neurosurgery: neurostimulation, intrathecal baclofen or selective ablative procedures."2.41Neurosurgery for spasticity. ( Mertens, P; Sindou, MP, 2000)
"Six of these 23 patients, who had spastic tetraplegia and were able to undergo spirometric testing, were included this study."1.43Respiratory Function Under Intrathecal Baclofen Therapy in Patients With Spastic Tetraplegia. ( Goto, Y; Hirata, M; Hosomi, K; Khoo, HM; Kishima, H; Maruo, T; Oshino, S; Tani, N; Yanagisawa, T; Yoshimine, T, 2016)
"Baclofen overdose is treated with supportive care and antiepileptic medications as indicated."1.40An unusual cause of flaccid paralysis and coma: baclofen overdose. ( Caron, E; Morgan, R; Wheless, JW, 2014)
"Baclofen is a GABAB receptor agonist commonly used to relief spasticity related to motor disorders."1.39Selective effects of baclofen on use-dependent modulation of GABAB inhibition after tetraplegia. ( Barry, MD; Bunday, KL; Chen, R; Perez, MA, 2013)
"Recurrent respiratory tract infections and occasional decubitus required periodic hospitalizations."1.35[Comprehensive management of a child with a post-traumatic brain stem and spinal cord injury. A case study and presentation of current therapeutic modalities]. ( Inglot, B; Kobylarz, K; Kwiatkowski, S; Mróz, A, 2008)
" There are few published guidelines for dosing efficacy and no studies looking at the effect of concentration of ITB on spasticity management."1.35Effect of intrathecal baclofen concentration on spasticity control: case series. ( Chiodo, AE; Saval, A, 2008)
" We report such an experience where a patient in a long-term care facility received multi-day, excessive dosing of glipizide rather than her anti-spasticity medication, baclofen."1.34Look-alike medications: a formula for possible morbidity and mortality in the long-term care facility. ( Grossberg, R; Reed, MD; Walliser, G, 2007)
"Treatment of spasticity with intrathecal baclofen pump implantation is a chance for clinical improvement in patients with severe spasticity."1.34[The parents expectations after baclofen pump implantation in child with severe spasticity in physical rehabilitation and psychological aspects]. ( Fafara, A; Grzegorzewski, P; Kawecka, J; Kawecki, Z; Kwiatkowski, S, 2007)
"Central pontine and extrapontine myelinolysis (CPEM) are rare conditions usually associated with rapid correction of hyponatremia."1.34Psychotic disorder in a patient with central and extrapontine myelinolysis. ( Krystal, A; Lim, L, 2007)
"Severe spasticity likely contributed to respiratory compromise in this patient."1.33Baclofen pump intervention for spasticity affecting pulmonary function. ( Britton, D; Esselman, P; Goldstein, B; Jones-Redmond, J, 2005)
"Consecutive sample with acute tetraplegia."1.33A longitudinal evaluation of sleep and breathing in the first year after cervical spinal cord injury. ( Berlowitz, DJ; Brown, DJ; Campbell, DA; Pierce, RJ, 2005)
"The baclofen pump has been utilized in children with refractory spasticity."1.33Placement of baclofen pumps through the foramen magnum and upper cervical spine. ( Dziurzynski, K; Iskandar, BJ; Mcleish, D; Ward, M, 2006)
"Baclofen (Lioresal) is a drug of choice to treat spasticity and is increasingly being administered intrathecally via an implantable pump in cases refractory to oral therapy."1.32Intrathecal baclofen withdrawal mimicking sepsis. ( Amin, Y; Kao, LW; Kirk, MA; Turner, MS, 2003)
"To ascertain the prevalence of spasticity among adults living in a developmental center and to document the development of spasticity treatment plans for this population."1.32Spasticity in adults living in a developmental center. ( Charles, PD; Damian, MM; Noel-Spaudling, S; Pfister, AA; Roberts, AG; Taylor, HM, 2003)
"The lower-extremity reduction in spasticity of 1."1.30Midthoracic catheter tip placement for intrathecal baclofen administration in children with quadriparetic spasticity. ( Grabb, PA; Guin-Renfroe, S; Meythaler, JM, 1999)
"Oral treatment with baclofen and sodium valproate was partially successful in one patient, but ineffective in the other."1.29Propriospinal myoclonus in tetraplegic patients: clinical, electrophysiological and therapeutic aspects. ( Alaoui, P; Arné, P; Barat, M; Fouillet, N; Petit, H; Wiart, L, 1995)
"Baclofen was identified in urine by gas chromatography/mass spectrometry."1.28Toxicological analysis of a fatal baclofen (Lioresal) ingestion. ( Fraser, AD; Isner, AF; MacNeil, W, 1991)
"Since 1986 21 patients with severe spasticity mainly in multiple sclerosis were treated with an implantable pump system to administrate continuously Baclofen intrathecally."1.28[Continuous intrathecal baclofen therapy using an implantable pump system in severe spasticity]. ( Behrens, C; Braunsdorf, WE; Kleiter, K; Kuhlendahl, HD; Volkheimer, A, 1990)
"When clonidine therapy was initiated, the patient responded rapidly with both subjective and objective improvements in her spasticity."1.28Clonidine in the treatment of brainstem spasticity. Case report. ( Sandford, PR; Sawasky, KB; Spengler, SE, 1992)
"We present the case of a spastic quadriplegic who developed mental symptoms which resolved when his Baclofen was discontinued."1.27Reversible electroencephalogram changes associated with administration of baclofen in a quadriplegic patient: case report. ( Lee, L; Riley, TL; Wainapel, SF, 1986)

Research

Studies (74)

TimeframeStudies, this research(%)All Research%
pre-19904 (5.41)18.7374
1990's16 (21.62)18.2507
2000's35 (47.30)29.6817
2010's18 (24.32)24.3611
2020's1 (1.35)2.80

Authors

AuthorsStudies
Meher, RK1
Aghoram, R1
Nair, PP1
Aljuboori, Z1
Archer, J1
Huff, W1
Moreno, A1
Jea, A1
Caron, E1
Morgan, R1
Wheless, JW1
Barry, MD1
Bunday, KL1
Chen, R1
Perez, MA1
Bauman, WA3
La Fountaine, MF1
Cirnigliaro, CM2
Kirshblum, SC2
Spungen, AM3
Abrous-Anane, S1
Benhassine, S1
Lopez, S1
Cristina, K1
Mazeron, JJ1
Stroud, J1
Scattoloni, J1
Blasingim, M1
Nafiu, OO1
Cardoso, AL1
Quintaneiro, C1
Seabra, H1
Teixeira, C1
Reynolds, RM2
Morton, RP1
Walker, ML1
Massagli, TL1
Browd, SR1
Waqar, M1
Ellenbogen, JR1
Kumar, R1
Sneade, C1
Zebian, B1
Williams, D1
Pettorini, BL1
Morr, S1
Heard, CM1
Li, V1
Pistoia, F1
Sacco, S1
Sarà, M1
Franceschini, M1
Carolei, A1
Marvulli, R1
Chiumarulo, P1
Nisi, M1
Barulli, L1
Megna, G1
Pietro, F1
Ianieri, G1
Megna, M1
Sechrist, C1
Kinsman, S1
Cain, N1
Kishima, H1
Yanagisawa, T1
Goto, Y1
Oshino, S1
Maruo, T1
Tani, N1
Khoo, HM1
Hosomi, K1
Hirata, M1
Yoshimine, T1
Rushton, PRP1
Nasto, LA1
Aujla, RK1
Ammar, A1
Grevitt, MP1
Vloeberghs, MH1
Awuor, SO1
Kitei, PM1
Nawaz, Y1
Ahnert, AM1
Kobylarz, K1
Kwiatkowski, S2
Inglot, B1
Mróz, A1
Saval, A1
Chiodo, AE1
Sauneuf, B1
Totouom, HK1
Savary, B1
Varin, L1
Dupeyrat, J1
Ramakers, S1
Hanouz, JL1
Yang, TF1
Wang, JC1
Chiu, JW1
Lai, CJ1
Chan, RC1
Lee, SS1
Vaidyanathan, S2
Soni, BM2
Hughes, PL2
Singh, G2
Watt, JW2
Oo, T2
Sett, P2
Greenberg, MI1
Hendrickson, RG1
Kao, LW1
Amin, Y1
Kirk, MA1
Turner, MS1
Illum, NO1
Hansen, FJ1
Fischer, C1
Uldall, PV1
Nielsen, OA1
Pfister, AA1
Roberts, AG1
Taylor, HM1
Noel-Spaudling, S1
Damian, MM1
Charles, PD1
Selmi, F1
Bottanelli, M1
Rubini, G1
Venturelli, V1
Cosentino, A1
Rossato, G1
Vicentini, S1
Romito, S1
Rizzuto, N1
Bertolasi, L1
Segal, LS1
Wallach, DM1
Kanev, PM1
Tubbs, RS1
Law, C1
Oakes, WJ1
Grabb, PA2
Dziurzynski, K1
Mcleish, D1
Ward, M1
Iskandar, BJ1
Berlowitz, DJ1
Brown, DJ1
Campbell, DA1
Pierce, RJ1
Britton, D1
Goldstein, B1
Jones-Redmond, J1
Esselman, P1
Morrison, NG1
Zhang, RL1
Albright, AL2
Turner, M1
Pattisapu, JV1
Cooper, JA1
Ridley, B1
Lim, L1
Krystal, A1
Ceulemans, B1
van Rhijn, J1
Kenis, S1
Krols, R1
Laridon, A1
Van Havenbergh, T1
Smit, CA1
Slim, EJ1
Walliser, G1
Grossberg, R1
Reed, MD1
Swierczyńska, A1
Fafara, A1
Kawecka, J1
Grzegorzewski, P1
Kawecki, Z1
Hansen, CR1
Gooch, JL1
Such-Neibar, T1
Ginsburg, GM1
Lauder, AJ1
Saveika, JA1
Shelton, JE1
Vanhauwaert, DJ1
Kalala, JP1
Baert, E1
Hallaert, G1
Crombez, E1
Caemaert, J1
Van Roost, D1
Steinbok, P1
Daneshvar, H1
Evans, D1
Kestle, JR1
Dicpinigaitis, PV1
Absgarten, A1
Almenoff, PL1
Mandac, BR1
Hurvitz, EA1
Nelson, VS1
Fouillet, N1
Wiart, L1
Arné, P1
Alaoui, P1
Petit, H1
Barat, M1
Donovan, WH1
Reeves, RK1
Stolp-Smith, KA1
Christopherson, MW1
Gerszten, PC1
Johnstone, GF1
Sampathkumar, P1
Scanlon, PD1
Plevak, DJ1
Guin-Renfroe, S1
Meythaler, JM2
Ridgeway, B1
Wallace, M1
Gerayli, A1
Samson-Fang, L1
Gooch, J1
Norlin, C1
Sindou, MP1
Mertens, P1
Hemingway, C1
McGrogan, J1
Freeman, JM1
McCarty, SF1
Gaebler-Spira, D1
Harvey, RL1
Burns, AS1
Cairns, K1
Stein, J1
Mooney, JF1
Jones, RF1
Lance, JW1
Sandford, PR1
Spengler, SE1
Sawasky, KB1
Siegfried, RN1
Jacobson, L1
Chabal, C1
Delhaas, EM1
Verhagen, J1
Fodstad, H1
Ljunggren, BC1
Putty, TK1
Shapiro, SA1
Fraser, AD1
MacNeil, W1
Isner, AF1
Braunsdorf, WE1
Kuhlendahl, HD1
Volkheimer, A1
Behrens, C1
Kleiter, K1
Wainapel, SF1
Lee, L1
Riley, TL1
Roy, CW1
Wakefield, IR1
Frances, A1
Thomas, MR1
Thompson, TL1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Using Telemedicine to Improve Spasticity Diagnosis Rates[NCT03211390]60 participants (Actual)Observational2018-01-30Completed
Prevalence of Comorbid Spasticity and Urinary Incontinence in Residents of a Long-Term Care Facility[NCT03250988]60 participants (Actual)Observational2018-01-30Completed
Validity and Inter-Rater Reliability of a Novel Bedside Referral Tool for Spasticity[NCT03209960]60 participants (Actual)Observational2018-01-30Completed
Inter-Rater Reliability of a Spasticity Diagnosis Algorithm[NCT01644123]72 participants (Actual)Observational2013-04-30Completed
Intrathecal (IT) Baclofen Drug Distribution Pilot Study[NCT02903823]Phase 427 participants (Actual)Interventional2016-04-22Completed
Energy Costs of Spasticity in Spinal Cord Injury: A Pilot Investigation[NCT00572845]20 participants (Actual)Interventional2008-01-31Terminated (stopped due to Unable to recruit enough participants.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Subjects Experiencing Maximal MAS Change From Baseline - Spasticity of Cerebral Origin

"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of cerebral origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection

InterventionParticipants (Count of Participants)
Cervical level 4 injection siteThoracic level 3 injection siteThoracic level 10 injection siteLumbar lever 2 injection site
Subjects With Max MAS Change8733

Subjects Experiencing Maximal MAS Change From Baseline - Spasticity of Spinal Origin

"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of spinal origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection

InterventionParticipants (Count of Participants)
Cervical spine level 4 injection siteThoracic level 3 injection siteThoracic level 10 injection siteLumbar level 2 injection site
Subjects With MAS Change - Based on Site of Injection4253

Reviews

2 reviews available for baclofen and Flaccid Quadriplegia

ArticleYear
Intrathecal baclofen: effects on spasticity, pain, and consciousness in disorders of consciousness and locked-in syndrome.
    Current pain and headache reports, 2015, Volume: 19, Issue:1

    Topics: Baclofen; Consciousness; Consciousness Disorders; Drug Administration Schedule; Humans; Injections,

2015
Neurosurgery for spasticity.
    Stereotactic and functional neurosurgery, 2000, Volume: 74, Issue:3-4

    Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Combined Modality Therapy; Gai

2000

Trials

4 trials available for baclofen and Flaccid Quadriplegia

ArticleYear
Low-dose baclofen therapy raised plasma insulin-like growth factor-1 concentrations, but not into the normal range in a predictable and sustained manner in men with chronic spinal cord injury.
    The journal of spinal cord medicine, 2013, Volume: 36, Issue:5

    Topics: Adult; Baclofen; Chronic Disease; Dose-Response Relationship, Drug; Humans; Insulin-Like Growth Fact

2013
Effect of low-dose baclofen administration on plasma insulin-like growth factor-I in persons with spinal cord injury.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:4

    Topics: Adult; Baclofen; Chronic Disease; Dose-Response Relationship, Drug; Humans; Insulin-Like Growth Fact

2006
[Assessment of spasticity therapy with baclofen pump in children].
    Przeglad lekarski, 2007, Volume: 64 Suppl 2

    Topics: Adolescent; Adult; Baclofen; Child; Feasibility Studies; Follow-Up Studies; GABA Agonists; Hemiplegi

2007
Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia.
    Spinal cord, 2001, Volume: 39, Issue:8

    Topics: Adult; Arm; Baclofen; Female; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Leg; Male; Mid

2001

Other Studies

68 other studies available for baclofen and Flaccid Quadriplegia

ArticleYear
Adrenoleukodystrophy presenting as glue sniffing.
    BMJ case reports, 2020, Mar-12, Volume: 13, Issue:3

    Topics: Adrenocorticotropic Hormone; Adrenoleukodystrophy; Aftercare; Baclofen; Child; Cognitive Dysfunction

2020
Placement of baclofen pump catheter through a C1-2 puncture: technical note.
    Journal of neurosurgery. Pediatrics, 2018, Volume: 21, Issue:4

    Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Child, Preschool; Epilepsy; Female; Humans; Infusion Pu

2018
An unusual cause of flaccid paralysis and coma: baclofen overdose.
    Journal of child neurology, 2014, Volume: 29, Issue:4

    Topics: Adolescent; Baclofen; Central Nervous System; Coma; Drug Overdose; Epilepsy, Generalized; Female; Hu

2014
Selective effects of baclofen on use-dependent modulation of GABAB inhibition after tetraplegia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jul-31, Volume: 33, Issue:31

    Topics: Adult; Analysis of Variance; Antimanic Agents; Baclofen; Case-Control Studies; Cortical Spreading De

2013
[Radiotherapy and implantable medical device: example of infusion pumps].
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2013, Volume: 17, Issue:8

    Topics: Baclofen; Carcinoma, Squamous Cell; Dose Fractionation, Radiation; Female; Humans; Infusion Pumps, I

2013
Intrathecal baclofen toxicity: an unusual cause of paediatric postoperative coma and respiratory depression.
    European journal of anaesthesiology, 2014, Volume: 31, Issue:6

    Topics: Adolescent; Baclofen; Cerebral Palsy; Coma; Humans; Injections, Spinal; Male; Muscle Relaxants, Cent

2014
Cardiac arrest due to baclofen withdrawal syndrome.
    BMJ case reports, 2014, May-14, Volume: 2014

    Topics: Adult; Baclofen; Equipment Failure; Heart Arrest; Humans; Injections, Spinal; Male; Muscle Relaxants

2014
Role of dorsal rhizotomy in spinal cord injury-induced spasticity.
    Journal of neurosurgery. Pediatrics, 2014, Volume: 14, Issue:3

    Topics: Accidental Falls; Adolescent; Baclofen; Cervical Vertebrae; Child; Dose-Response Relationship, Drug;

2014
Indwelling intrathecal catheter with subcutaneous abdominal reservoir: a viable baclofen delivery system in severely cachectic patients.
    Journal of neurosurgery. Pediatrics, 2014, Volume: 14, Issue:4

    Topics: Baclofen; Cachexia; Catheters, Indwelling; Cerebral Palsy; Child; Dystonia; Humans; Infusion Pumps,

2014
Dexmedetomidine for acute baclofen withdrawal.
    Neurocritical care, 2015, Volume: 22, Issue:2

    Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Baclofen; Cerebral Palsy; Dexmedetomidine; GABA-B

2015
Use Of External Intrathecal Infusion Pumps In The Management Of Septic Complications: A Case Report.
    Endocrine, metabolic & immune disorders drug targets, 2015, Volume: 15, Issue:4

    Topics: Abdomen; Administration, Oral; Adolescent; Anti-Bacterial Agents; Baclofen; Catheter-Related Infecti

2015
Profound Bradycardia After Intrathecal Baclofen Injection in a Patient With Hydranencephaly.
    Pediatric neurology, 2015, Volume: 53, Issue:6

    Topics: Baclofen; Bradycardia; Cerebral Palsy; Child; Female; Humans; Hydranencephaly; Injections, Spinal; M

2015
Respiratory Function Under Intrathecal Baclofen Therapy in Patients With Spastic Tetraplegia.
    Neuromodulation : journal of the International Neuromodulation Society, 2016, Volume: 19, Issue:6

    Topics: Adult; Baclofen; Female; Humans; Injections, Spinal; Male; Middle Aged; Muscle Relaxants, Central; Q

2016
Intrathecal baclofen pumps do not accelerate progression of scoliosis in quadriplegic spastic cerebral palsy.
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2017, Volume: 26, Issue:6

    Topics: Baclofen; Case-Control Studies; Cerebral Palsy; Child; Cohort Studies; Disease Progression; Female;

2017
Intrathecal baclofen withdrawal: A rare cause of reversible cardiomyopathy.
    Acute cardiac care, 2016, Volume: 18, Issue:1

    Topics: Adult; Baclofen; Cardiomyopathies; Catheterization, Swan-Ganz; Coronary Angiography; Echocardiograph

2016
[Comprehensive management of a child with a post-traumatic brain stem and spinal cord injury. A case study and presentation of current therapeutic modalities].
    Przeglad lekarski, 2008, Volume: 65, Issue:2

    Topics: Baclofen; Brain Injuries; Brain Stem; Cervical Vertebrae; Child; Drug Resistance; Humans; Infusion P

2008
Effect of intrathecal baclofen concentration on spasticity control: case series.
    The journal of spinal cord medicine, 2008, Volume: 31, Issue:4

    Topics: Adult; Baclofen; Brain Injuries; Cerebral Palsy; Female; GABA Agonists; Humans; Infusion Pumps; Inje

2008
Clinical and EEG features of acute intrathecal baclofen overdose.
    Clinical neurology and neurosurgery, 2012, Volume: 114, Issue:1

    Topics: Baclofen; Drug Overdose; Electroencephalography; Ependymoma; Equipment Failure; GABA Agonists; Glasg

2012
Ultrasound-guided refilling of an intrathecal baclofen pump--a case report.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2013, Volume: 29, Issue:2

    Topics: Baclofen; Child; Female; Humans; Infusion Pumps, Implantable; Infusions, Spinal; Quadriplegia; Ultra

2013
How should an infected perinephric haematoma be drained in a tetraplegic patient with baclofen pump implanted in the abdominal wall? - A case report.
    BMC urology, 2002, Sep-10, Volume: 2

    Topics: Abdominal Wall; Anesthetics, Intravenous; Baclofen; Drainage; Hematoma; Humans; Infusion Pumps, Impl

2002
Baclofen withdrawal following removal of an intrathecal baclofen pump despite oral baclofen replacement.
    Journal of toxicology. Clinical toxicology, 2003, Volume: 41, Issue:1

    Topics: Adult; Baclofen; GABA Agonists; GABA-A Receptor Agonists; Hemodynamics; Humans; Injections, Spinal;

2003
Intrathecal baclofen withdrawal mimicking sepsis.
    The Journal of emergency medicine, 2003, Volume: 24, Issue:4

    Topics: Baclofen; Child, Preschool; Clinical Protocols; Decerebrate State; Diagnosis, Differential; Emergenc

2003
[Intrathecal baclofen in the treatment of severe spastic tetraplegia and dystonia in children and adolescents].
    Ugeskrift for laeger, 2003, Apr-21, Volume: 165, Issue:17

    Topics: Adolescent; Baclofen; Child; Child, Preschool; Dystonia; GABA Agonists; Humans; Infusion Pumps; Inje

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Spasticity in adults living in a developmental center.
    Archives of physical medicine and rehabilitation, 2003, Volume: 84, Issue:12

    Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi

2003
Management of recurrent priapism in a cervical spinal cord injury patient with oral baclofen therapy.
    Spinal cord, 2004, Volume: 42, Issue:2

    Topics: Administration, Oral; Baclofen; Catheters, Indwelling; Cervical Vertebrae; Dose-Response Relationshi

2004
Weight and height gain after intrathecal baclofen pump implantation in children with spastic tetraparesis.
    Developmental medicine and child neurology, 2004, Volume: 46, Issue:11

    Topics: Anthropometry; Baclofen; Body Height; Child; Female; Humans; Infusion Pumps, Implantable; Male; Musc

2004
Potential complications of posterior spine fusion and instrumentation in patients with cerebral palsy treated with intrathecal baclofen infusion.
    Spine, 2005, Apr-15, Volume: 30, Issue:8

    Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Drug Delivery Systems; Headache; Humans; Injections, Sp

2005
Acquired Chiari I malformation following baclofen pump placement in a child. Case report.
    Journal of neurosurgery, 2004, Volume: 101, Issue:2 Suppl

    Topics: Adolescent; Arnold-Chiari Malformation; Baclofen; Decompression, Surgical; Humans; Hydrocephalus; In

2004
Placement of baclofen pumps through the foramen magnum and upper cervical spine.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2006, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Baclofen; Catheters, Indwelling; Cerebral Palsy; Cervical Vertebrae; Child; Femal

2006
A longitudinal evaluation of sleep and breathing in the first year after cervical spinal cord injury.
    Archives of physical medicine and rehabilitation, 2005, Volume: 86, Issue:6

    Topics: Abdomen; Adolescent; Adult; Aged; Anti-Anxiety Agents; Antidepressive Agents; Baclofen; Cervical Ver

2005
Baclofen pump intervention for spasticity affecting pulmonary function.
    The journal of spinal cord medicine, 2005, Volume: 28, Issue:4

    Topics: Baclofen; Humans; Infusion Pumps, Implantable; Injections, Spinal; Lung; Male; Middle Aged; Muscle R

2005
Best-practice surgical techniques for intrathecal baclofen therapy.
    Journal of neurosurgery, 2006, Volume: 104, Issue:4 Suppl

    Topics: Baclofen; Catheters, Indwelling; Cerebral Palsy; Child; Dystonia; Equipment Design; GABA Agonists; H

2006
Response of intrathecal baclofen resistance to dose reduction.
    Neurology, 2006, Oct-24, Volume: 67, Issue:8

    Topics: Adult; Analgesics; Anticonvulsants; Baclofen; Dose-Response Relationship, Drug; Drug Resistance; Dru

2006
Psychotic disorder in a patient with central and extrapontine myelinolysis.
    Psychiatry and clinical neurosciences, 2007, Volume: 61, Issue:3

    Topics: Antidepressive Agents, Second-Generation; Antiparkinson Agents; Antipsychotic Agents; Baclofen; Fema

2007
Opisthotonus and intrathecal treatment with baclofen (ITB) in children.
    European journal of pediatrics, 2008, Volume: 167, Issue:6

    Topics: Adolescent; Adult; Baclofen; Belgium; Child; Child, Preschool; Dystonia; Epilepsy; Female; Follow-Up

2008
Heart conduction problems in a tetraplegic patient caused by a single therapeutic dosage of Baclofen.
    Spinal cord, 2008, Volume: 46, Issue:4

    Topics: Adult; Baclofen; Bradycardia; Cervical Vertebrae; GABA Agonists; Heart Conduction System; Humans; Ma

2008
Look-alike medications: a formula for possible morbidity and mortality in the long-term care facility.
    Journal of the American Medical Directors Association, 2007, Volume: 8, Issue:8

    Topics: Baclofen; Dosage Forms; Female; Glipizide; Homes for the Aged; Humans; Hypoglycemic Agents; Long-Ter

2007
[The parents expectations after baclofen pump implantation in child with severe spasticity in physical rehabilitation and psychological aspects].
    Przeglad lekarski, 2007, Volume: 64 Suppl 2

    Topics: Activities of Daily Living; Adult; Baclofen; Cerebral Palsy; Child; Female; Follow-Up Studies; Hemip

2007
Prolonged, severe intrathecal baclofen withdrawal syndrome: a case report.
    Archives of physical medicine and rehabilitation, 2007, Volume: 88, Issue:11

    Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Critical Care; Cross Infection; Device Removal; Dose-Re

2007
Progression of scoliosis in patients with spastic quadriplegia after the insertion of an intrathecal baclofen pump.
    Spine, 2007, Nov-15, Volume: 32, Issue:24

    Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Disease Progression; Female; H

2007
Cyproheptadine for pediatric intrathecal baclofen withdrawal: a case report.
    American journal of physical medicine & rehabilitation, 2007, Volume: 86, Issue:12

    Topics: Adolescent; Age Factors; Baclofen; Cerebral Palsy; Child; Cyproheptadine; Equipment Failure; Female;

2007
Migration of pump for intrathecal drug delivery into the peritoneal cavity. Case report.
    Surgical neurology, 2009, Volume: 71, Issue:5

    Topics: Abdominal Muscles; Abdominal Wall; Accidents, Traffic; Baclofen; Foreign-Body Migration; Humans; Inf

2009
Cost analysis of continuous intrathecal baclofen versus selective functional posterior rhizotomy in the treatment of spastic quadriplegia associated with cerebral palsy.
    Pediatric neurosurgery, 1995, Volume: 22, Issue:5

    Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Costs and Cost Analysis; Hospitalization; Humans; Injec

1995
Inhibition of bronchial hyperresponsiveness by the GABA-agonist baclofen.
    Chest, 1994, Volume: 106, Issue:3

    Topics: Adult; Baclofen; Bronchial Hyperreactivity; Bronchial Provocation Tests; Drug Evaluation; Forced Exp

1994
Hyperthermia associated with baclofen withdrawal and increased spasticity.
    Archives of physical medicine and rehabilitation, 1993, Volume: 74, Issue:1

    Topics: Adolescent; Baclofen; Fever; Humans; Male; Muscle Spasticity; Quadriplegia; Substance Withdrawal Syn

1993
Propriospinal myoclonus in tetraplegic patients: clinical, electrophysiological and therapeutic aspects.
    Paraplegia, 1995, Volume: 33, Issue:11

    Topics: Adult; Baclofen; Electromyography; Humans; Injections, Spinal; Male; Muscle Relaxants, Central; Myoc

1995
Profile of the Institute for Rehabilitation and Research.
    Spinal cord, 1997, Volume: 35, Issue:9

    Topics: Automobile Driving; Baclofen; GABA Agonists; Humans; Patient Education as Topic; Quadriplegia; Rehab

1997
Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure.
    Archives of physical medicine and rehabilitation, 1998, Volume: 79, Issue:3

    Topics: Adult; Baclofen; Catheters, Indwelling; Dantrolene; Disseminated Intravascular Coagulation; Equipmen

1998
Intrathecal baclofen infusion and subsequent orthopedic surgery in patients with spastic cerebral palsy.
    Journal of neurosurgery, 1998, Volume: 88, Issue:6

    Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Contracture; Femur; Follow-Up

1998
Baclofen withdrawal presenting as multiorgan system failure.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:3

    Topics: Adult; Baclofen; Humans; Male; Multiple Organ Failure; Muscle Relaxants, Central; Muscle Spasticity;

1998
Midthoracic catheter tip placement for intrathecal baclofen administration in children with quadriparetic spasticity.
    Neurosurgery, 1999, Volume: 45, Issue:4

    Topics: Baclofen; Catheters, Indwelling; Child; Dose-Response Relationship, Drug; Female; Follow-Up Studies;

1999
Ziconotide for the treatment of severe spasticity after spinal cord injury.
    Pain, 2000, Volume: 85, Issue:1-2

    Topics: Adult; Analgesics, Opioid; Baclofen; Calcium Channel Blockers; Drug Resistance; Humans; Male; Morphi

2000
Intrathecal baclofen withdrawal simulating neuroleptic malignant syndrome in a child with cerebral palsy.
    Developmental medicine and child neurology, 2000, Volume: 42, Issue:8

    Topics: Baclofen; Cerebral Palsy; Child; Diagnosis, Differential; Humans; Injections, Spinal; Male; Muscle R

2000
Energy requirements of spasticity.
    Developmental medicine and child neurology, 2001, Volume: 43, Issue:4

    Topics: Adolescent; Baclofen; Combined Modality Therapy; Energy Intake; Energy Metabolism; Humans; Male; Qua

2001
Improvement of sleep apnea in a patient with cerebral palsy.
    American journal of physical medicine & rehabilitation, 2001, Volume: 80, Issue:7

    Topics: Adult; Baclofen; Cerebral Palsy; Dystonia; Female; Humans; Injections, Spinal; Muscle Spasticity; Po

2001
Motor function improvement following intrathecal baclofen pump placement in a patient with locked-in syndrome.
    American journal of physical medicine & rehabilitation, 2002, Volume: 81, Issue:4

    Topics: Adult; Baclofen; Brain Stem Infarctions; Humans; Infusion Pumps, Implantable; Male; Muscle Relaxants

2002
Selective posterior rhizotomy and intrathecal baclofen for the treatment of spasticity.
    Pediatric neurosurgery, 2002, Volume: 36, Issue:4

    Topics: Baclofen; Cerebral Palsy; Humans; Injections, Spinal; Muscle Relaxants, Central; Quadriplegia; Rhizo

2002
Bacloffen (Lioresal) in the long-term management of spasticity.
    The Medical journal of Australia, 1976, May-01, Volume: 1, Issue:18

    Topics: Adolescent; Adult; Aged; Aminobutyrates; Baclofen; Cerebral Palsy; Child; Female; Humans; Long-Term

1976
Clonidine in the treatment of brainstem spasticity. Case report.
    American journal of physical medicine & rehabilitation, 1992, Volume: 71, Issue:5

    Topics: Adult; Baclofen; Cerebral Infarction; Clonidine; Female; Humans; Medulla Oblongata; Muscle Spasticit

1992
Development of an acute withdrawal syndrome following the cessation of intrathecal baclofen in a patient with spasticity.
    Anesthesiology, 1992, Volume: 77, Issue:5

    Topics: Adult; Baclofen; Humans; Infusion Pumps, Implantable; Injections, Spinal; Male; Muscle Spasticity; Q

1992
Pregnancy in a quadriplegic patient treated with continuous intrathecal baclofen infusion to manage her severe spasticity. Case report.
    Paraplegia, 1992, Volume: 30, Issue:7

    Topics: Adult; Baclofen; Cesarean Section; Drug Implants; Female; Humans; Injections, Spinal; Muscle Spastic

1992
Baclofen and carbamazepine in supraspinal spasticity.
    Journal of the Royal Society of Medicine, 1991, Volume: 84, Issue:12

    Topics: Administration, Oral; Adult; Baclofen; Brain Injuries; Carbamazepine; Drug Therapy, Combination; Fem

1991
Efficacy of dorsal longitudinal myelotomy in treating spinal spasticity: a review of 20 cases.
    Journal of neurosurgery, 1991, Volume: 75, Issue:3

    Topics: Adult; Aged; Baclofen; Female; Humans; Injections, Spinal; Male; Middle Aged; Paraplegia; Quadripleg

1991
Toxicological analysis of a fatal baclofen (Lioresal) ingestion.
    Journal of forensic sciences, 1991, Volume: 36, Issue:5

    Topics: Adult; Baclofen; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Drug Overdose; Ga

1991
[Continuous intrathecal baclofen therapy using an implantable pump system in severe spasticity].
    Neurochirurgia, 1990, Volume: 33 Suppl 1

    Topics: Baclofen; Dose-Response Relationship, Drug; Humans; Infusion Pumps, Implantable; Motor Neurons; Musc

1990
Reversible electroencephalogram changes associated with administration of baclofen in a quadriplegic patient: case report.
    Paraplegia, 1986, Volume: 24, Issue:2

    Topics: Adult; Baclofen; Cervical Vertebrae; Delta Rhythm; Electroencephalography; Fractures, Bone; Humans;

1986
Baclofen pseudopsychosis: case report.
    Paraplegia, 1986, Volume: 24, Issue:5

    Topics: Adult; Baclofen; Diagnosis, Differential; Hallucinations; Humans; Male; Muscle Spasticity; Psychotic

1986
A quadriplegic patient with borderline personality disorder.
    Hospital & community psychiatry, 1985, Volume: 36, Issue:5

    Topics: Adult; Baclofen; Borderline Personality Disorder; Humans; Male; Personality Disorders; Psychoses, Su

1985