baclofen has been researched along with Flaccid Quadriplegia in 74 studies
Excerpt | Relevance | Reference |
---|---|---|
"To compare scoliosis progression in quadriplegic spastic cerebral palsy with and without intrathecal baclofen (ITB) pumps." | 7.85 | Intrathecal baclofen pumps do not accelerate progression of scoliosis in quadriplegic spastic cerebral palsy. ( Ammar, A; Aujla, RK; Grevitt, MP; Nasto, LA; Rushton, PRP; Vloeberghs, MH, 2017) |
"We describe a 6 year-old girl with hydranencephaly who underwent an intrathecal baclofen test dose and developed severe bradycardia." | 7.81 | Profound Bradycardia After Intrathecal Baclofen Injection in a Patient With Hydranencephaly. ( Cain, N; Kinsman, S; Sechrist, C, 2015) |
"Medical and radiographic review of 19 consecutive patients with spastic quadriplegia before and after intrathecal baclofen pump insertion with special attention paid to progression of scoliosis." | 7.74 | Progression of scoliosis in patients with spastic quadriplegia after the insertion of an intrathecal baclofen pump. ( Ginsburg, GM; Lauder, AJ, 2007) |
"To present our preliminary experience and complications with posterior spine fusion in patients with cerebral palsy and continuous intrathecal baclofen infusion and provide a literature review." | 7.73 | Potential complications of posterior spine fusion and instrumentation in patients with cerebral palsy treated with intrathecal baclofen infusion. ( Kanev, PM; Segal, LS; Wallach, DM, 2005) |
"Continuous intrathecal baclofen was effective in treating severe spasticity and dystonia of cerebral origin with major effect on muscles of the lower extremities, pelvis, and back and in particular opisthotonus was relieved." | 7.72 | [Intrathecal baclofen in the treatment of severe spastic tetraplegia and dystonia in children and adolescents]. ( Fischer, C; Hansen, FJ; Illum, NO; Nielsen, OA; Uldall, PV, 2003) |
"Intrathecal baclofen infusion (IBI) is an effective treatment for spasticity secondary to cerebral palsy (CP)." | 7.70 | Intrathecal baclofen infusion and subsequent orthopedic surgery in patients with spastic cerebral palsy. ( Albright, AL; Gerszten, PC; Johnstone, GF, 1998) |
"A 29-year-old man with C6 tetraplegia (ASIA A) using an implanted baclofen pump and intrathecal catheter infusion system for spasticity control developed severe spasticity, hyperthermia, hypotension, rhabdomyolysis, and disseminated intravascular coagulation after catheter disconnection." | 7.70 | Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure. ( Christopherson, MW; Reeves, RK; Stolp-Smith, KA, 1998) |
"The purpose of the study was to analyze the relative cost of selective functional posterior rhizotomy (SFPR) and continuous intrathecal baclofen in the treatment of children with severe spastic quadriplegia related to cerebral palsy." | 7.69 | Cost analysis of continuous intrathecal baclofen versus selective functional posterior rhizotomy in the treatment of spastic quadriplegia associated with cerebral palsy. ( Daneshvar, H; Evans, D; Kestle, JR; Steinbok, P, 1995) |
"A report on pregnancy in a quadriplegic patient treated with a high dose of 1000 mcg/24 h continuous intrathecal baclofen infusion using an implanted drug delivery system (Synchromed, Medtronic, USA)." | 7.68 | Pregnancy in a quadriplegic patient treated with continuous intrathecal baclofen infusion to manage her severe spasticity. Case report. ( Delhaas, EM; Verhagen, J, 1992) |
"Baclofen overdose is treated with supportive care and antiepileptic medications as indicated." | 5.40 | An unusual cause of flaccid paralysis and coma: baclofen overdose. ( Caron, E; Morgan, R; Wheless, JW, 2014) |
"Baclofen (Lioresal) is a drug of choice to treat spasticity and is increasingly being administered intrathecally via an implantable pump in cases refractory to oral therapy." | 5.32 | Intrathecal baclofen withdrawal mimicking sepsis. ( Amin, Y; Kao, LW; Kirk, MA; Turner, MS, 2003) |
"To compare scoliosis progression in quadriplegic spastic cerebral palsy with and without intrathecal baclofen (ITB) pumps." | 3.85 | Intrathecal baclofen pumps do not accelerate progression of scoliosis in quadriplegic spastic cerebral palsy. ( Ammar, A; Aujla, RK; Grevitt, MP; Nasto, LA; Rushton, PRP; Vloeberghs, MH, 2017) |
"A 15-year-old patient with spastic quadriparesis and cerebral palsy underwent unexpected removal of his baclofen pump due to an infection that was encountered during a planned pump revision." | 3.81 | Dexmedetomidine for acute baclofen withdrawal. ( Heard, CM; Li, V; Morr, S; Reynolds, RM, 2015) |
"We describe a 6 year-old girl with hydranencephaly who underwent an intrathecal baclofen test dose and developed severe bradycardia." | 3.81 | Profound Bradycardia After Intrathecal Baclofen Injection in a Patient With Hydranencephaly. ( Cain, N; Kinsman, S; Sechrist, C, 2015) |
"Intrathecal baclofen (ITB) is a reversible treatment that reduces muscle tone to ameliorate spasticity and dystonia in patients with cerebral palsy (CP)." | 3.80 | Indwelling intrathecal catheter with subcutaneous abdominal reservoir: a viable baclofen delivery system in severely cachectic patients. ( Ellenbogen, JR; Kumar, R; Pettorini, BL; Sneade, C; Waqar, M; Williams, D; Zebian, B, 2014) |
" After the first admission of 5 mg of oral Baclofen, he collapsed in bed with extreme bradycardia, hypotension, hyperventilation and decreased oxygen saturation." | 3.74 | Heart conduction problems in a tetraplegic patient caused by a single therapeutic dosage of Baclofen. ( Slim, EJ; Smit, CA, 2008) |
"Medical and radiographic review of 19 consecutive patients with spastic quadriplegia before and after intrathecal baclofen pump insertion with special attention paid to progression of scoliosis." | 3.74 | Progression of scoliosis in patients with spastic quadriplegia after the insertion of an intrathecal baclofen pump. ( Ginsburg, GM; Lauder, AJ, 2007) |
"To present our preliminary experience and complications with posterior spine fusion in patients with cerebral palsy and continuous intrathecal baclofen infusion and provide a literature review." | 3.73 | Potential complications of posterior spine fusion and instrumentation in patients with cerebral palsy treated with intrathecal baclofen infusion. ( Kanev, PM; Segal, LS; Wallach, DM, 2005) |
"Continuous intrathecal baclofen was effective in treating severe spasticity and dystonia of cerebral origin with major effect on muscles of the lower extremities, pelvis, and back and in particular opisthotonus was relieved." | 3.72 | [Intrathecal baclofen in the treatment of severe spastic tetraplegia and dystonia in children and adolescents]. ( Fischer, C; Hansen, FJ; Illum, NO; Nielsen, OA; Uldall, PV, 2003) |
" He developed perinephric haematoma while he was taking warfarin as prophylactic for deep vein thrombosis." | 3.71 | How should an infected perinephric haematoma be drained in a tetraplegic patient with baclofen pump implanted in the abdominal wall? - A case report. ( Hughes, PL; Oo, T; Sett, P; Singh, G; Soni, BM; Vaidyanathan, S; Watt, JW, 2002) |
"Intrathecal baclofen (ITB) can reduce spasticity in adults and children with cerebral palsy." | 3.71 | Improvement of sleep apnea in a patient with cerebral palsy. ( Gaebler-Spira, D; Harvey, RL; McCarty, SF, 2001) |
"A 29-year-old man with C6 tetraplegia (ASIA A) using an implanted baclofen pump and intrathecal catheter infusion system for spasticity control developed severe spasticity, hyperthermia, hypotension, rhabdomyolysis, and disseminated intravascular coagulation after catheter disconnection." | 3.70 | Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure. ( Christopherson, MW; Reeves, RK; Stolp-Smith, KA, 1998) |
"Intrathecal baclofen infusion (IBI) is an effective treatment for spasticity secondary to cerebral palsy (CP)." | 3.70 | Intrathecal baclofen infusion and subsequent orthopedic surgery in patients with spastic cerebral palsy. ( Albright, AL; Gerszten, PC; Johnstone, GF, 1998) |
"The purpose of the study was to analyze the relative cost of selective functional posterior rhizotomy (SFPR) and continuous intrathecal baclofen in the treatment of children with severe spastic quadriplegia related to cerebral palsy." | 3.69 | Cost analysis of continuous intrathecal baclofen versus selective functional posterior rhizotomy in the treatment of spastic quadriplegia associated with cerebral palsy. ( Daneshvar, H; Evans, D; Kestle, JR; Steinbok, P, 1995) |
"Rapid baclofen withdrawal is known to cause markedly increased spasticity, but high fever associated with this complication has not been reported." | 3.68 | Hyperthermia associated with baclofen withdrawal and increased spasticity. ( Hurvitz, EA; Mandac, BR; Nelson, VS, 1993) |
"A report on pregnancy in a quadriplegic patient treated with a high dose of 1000 mcg/24 h continuous intrathecal baclofen infusion using an implanted drug delivery system (Synchromed, Medtronic, USA)." | 3.68 | Pregnancy in a quadriplegic patient treated with continuous intrathecal baclofen infusion to manage her severe spasticity. Case report. ( Delhaas, EM; Verhagen, J, 1992) |
"Sudden withdrawal of baclofen has been shown to provoke hallucinations." | 3.67 | Baclofen pseudopsychosis: case report. ( Roy, CW; Wakefield, IR, 1986) |
"This report summarizes experience with baclofen (Lioresal) in the management of spasticity and muscle spasms in 113 patients treated for up to six years." | 3.65 | Bacloffen (Lioresal) in the long-term management of spasticity. ( Jones, RF; Lance, JW, 1976) |
"Baclofen was not effective at sustaining plasma IGF-1 concentrations in the physiological range in men with chronic SCI." | 2.78 | Low-dose baclofen therapy raised plasma insulin-like growth factor-1 concentrations, but not into the normal range in a predictable and sustained manner in men with chronic spinal cord injury. ( Bauman, WA; Cirnigliaro, CM; Kirshblum, SC; La Fountaine, MF; Spungen, AM, 2013) |
"In a group of 17 patients with spastic hemiparesis, with a different etiology, 2 groups were separated." | 2.73 | [Assessment of spasticity therapy with baclofen pump in children]. ( Swierczyńska, A, 2007) |
"0001) increase in intrathecal baclofen dosage requirements during the 1-year follow-up period to maintain the reductions in spasm frequency, reflexes and tone." | 2.70 | Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia. ( Burns, AS; Meythaler, JM, 2001) |
"When excessive spasticity is not sufficiently controlled by physical therapy and pharmacological treatment, patients can have recourse to neurosurgery: neurostimulation, intrathecal baclofen or selective ablative procedures." | 2.41 | Neurosurgery for spasticity. ( Mertens, P; Sindou, MP, 2000) |
"Six of these 23 patients, who had spastic tetraplegia and were able to undergo spirometric testing, were included this study." | 1.43 | Respiratory Function Under Intrathecal Baclofen Therapy in Patients With Spastic Tetraplegia. ( Goto, Y; Hirata, M; Hosomi, K; Khoo, HM; Kishima, H; Maruo, T; Oshino, S; Tani, N; Yanagisawa, T; Yoshimine, T, 2016) |
"Baclofen overdose is treated with supportive care and antiepileptic medications as indicated." | 1.40 | An unusual cause of flaccid paralysis and coma: baclofen overdose. ( Caron, E; Morgan, R; Wheless, JW, 2014) |
"Baclofen is a GABAB receptor agonist commonly used to relief spasticity related to motor disorders." | 1.39 | Selective effects of baclofen on use-dependent modulation of GABAB inhibition after tetraplegia. ( Barry, MD; Bunday, KL; Chen, R; Perez, MA, 2013) |
"Recurrent respiratory tract infections and occasional decubitus required periodic hospitalizations." | 1.35 | [Comprehensive management of a child with a post-traumatic brain stem and spinal cord injury. A case study and presentation of current therapeutic modalities]. ( Inglot, B; Kobylarz, K; Kwiatkowski, S; Mróz, A, 2008) |
" There are few published guidelines for dosing efficacy and no studies looking at the effect of concentration of ITB on spasticity management." | 1.35 | Effect of intrathecal baclofen concentration on spasticity control: case series. ( Chiodo, AE; Saval, A, 2008) |
" We report such an experience where a patient in a long-term care facility received multi-day, excessive dosing of glipizide rather than her anti-spasticity medication, baclofen." | 1.34 | Look-alike medications: a formula for possible morbidity and mortality in the long-term care facility. ( Grossberg, R; Reed, MD; Walliser, G, 2007) |
"Treatment of spasticity with intrathecal baclofen pump implantation is a chance for clinical improvement in patients with severe spasticity." | 1.34 | [The parents expectations after baclofen pump implantation in child with severe spasticity in physical rehabilitation and psychological aspects]. ( Fafara, A; Grzegorzewski, P; Kawecka, J; Kawecki, Z; Kwiatkowski, S, 2007) |
"Central pontine and extrapontine myelinolysis (CPEM) are rare conditions usually associated with rapid correction of hyponatremia." | 1.34 | Psychotic disorder in a patient with central and extrapontine myelinolysis. ( Krystal, A; Lim, L, 2007) |
"Severe spasticity likely contributed to respiratory compromise in this patient." | 1.33 | Baclofen pump intervention for spasticity affecting pulmonary function. ( Britton, D; Esselman, P; Goldstein, B; Jones-Redmond, J, 2005) |
"Consecutive sample with acute tetraplegia." | 1.33 | A longitudinal evaluation of sleep and breathing in the first year after cervical spinal cord injury. ( Berlowitz, DJ; Brown, DJ; Campbell, DA; Pierce, RJ, 2005) |
"The baclofen pump has been utilized in children with refractory spasticity." | 1.33 | Placement of baclofen pumps through the foramen magnum and upper cervical spine. ( Dziurzynski, K; Iskandar, BJ; Mcleish, D; Ward, M, 2006) |
"Baclofen (Lioresal) is a drug of choice to treat spasticity and is increasingly being administered intrathecally via an implantable pump in cases refractory to oral therapy." | 1.32 | Intrathecal baclofen withdrawal mimicking sepsis. ( Amin, Y; Kao, LW; Kirk, MA; Turner, MS, 2003) |
"To ascertain the prevalence of spasticity among adults living in a developmental center and to document the development of spasticity treatment plans for this population." | 1.32 | Spasticity in adults living in a developmental center. ( Charles, PD; Damian, MM; Noel-Spaudling, S; Pfister, AA; Roberts, AG; Taylor, HM, 2003) |
"The lower-extremity reduction in spasticity of 1." | 1.30 | Midthoracic catheter tip placement for intrathecal baclofen administration in children with quadriparetic spasticity. ( Grabb, PA; Guin-Renfroe, S; Meythaler, JM, 1999) |
"Oral treatment with baclofen and sodium valproate was partially successful in one patient, but ineffective in the other." | 1.29 | Propriospinal myoclonus in tetraplegic patients: clinical, electrophysiological and therapeutic aspects. ( Alaoui, P; Arné, P; Barat, M; Fouillet, N; Petit, H; Wiart, L, 1995) |
"Baclofen was identified in urine by gas chromatography/mass spectrometry." | 1.28 | Toxicological analysis of a fatal baclofen (Lioresal) ingestion. ( Fraser, AD; Isner, AF; MacNeil, W, 1991) |
"Since 1986 21 patients with severe spasticity mainly in multiple sclerosis were treated with an implantable pump system to administrate continuously Baclofen intrathecally." | 1.28 | [Continuous intrathecal baclofen therapy using an implantable pump system in severe spasticity]. ( Behrens, C; Braunsdorf, WE; Kleiter, K; Kuhlendahl, HD; Volkheimer, A, 1990) |
"When clonidine therapy was initiated, the patient responded rapidly with both subjective and objective improvements in her spasticity." | 1.28 | Clonidine in the treatment of brainstem spasticity. Case report. ( Sandford, PR; Sawasky, KB; Spengler, SE, 1992) |
"We present the case of a spastic quadriplegic who developed mental symptoms which resolved when his Baclofen was discontinued." | 1.27 | Reversible electroencephalogram changes associated with administration of baclofen in a quadriplegic patient: case report. ( Lee, L; Riley, TL; Wainapel, SF, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (5.41) | 18.7374 |
1990's | 16 (21.62) | 18.2507 |
2000's | 35 (47.30) | 29.6817 |
2010's | 18 (24.32) | 24.3611 |
2020's | 1 (1.35) | 2.80 |
Authors | Studies |
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Meher, RK | 1 |
Aghoram, R | 1 |
Nair, PP | 1 |
Aljuboori, Z | 1 |
Archer, J | 1 |
Huff, W | 1 |
Moreno, A | 1 |
Jea, A | 1 |
Caron, E | 1 |
Morgan, R | 1 |
Wheless, JW | 1 |
Barry, MD | 1 |
Bunday, KL | 1 |
Chen, R | 1 |
Perez, MA | 1 |
Bauman, WA | 3 |
La Fountaine, MF | 1 |
Cirnigliaro, CM | 2 |
Kirshblum, SC | 2 |
Spungen, AM | 3 |
Abrous-Anane, S | 1 |
Benhassine, S | 1 |
Lopez, S | 1 |
Cristina, K | 1 |
Mazeron, JJ | 1 |
Stroud, J | 1 |
Scattoloni, J | 1 |
Blasingim, M | 1 |
Nafiu, OO | 1 |
Cardoso, AL | 1 |
Quintaneiro, C | 1 |
Seabra, H | 1 |
Teixeira, C | 1 |
Reynolds, RM | 2 |
Morton, RP | 1 |
Walker, ML | 1 |
Massagli, TL | 1 |
Browd, SR | 1 |
Waqar, M | 1 |
Ellenbogen, JR | 1 |
Kumar, R | 1 |
Sneade, C | 1 |
Zebian, B | 1 |
Williams, D | 1 |
Pettorini, BL | 1 |
Morr, S | 1 |
Heard, CM | 1 |
Li, V | 1 |
Pistoia, F | 1 |
Sacco, S | 1 |
Sarà, M | 1 |
Franceschini, M | 1 |
Carolei, A | 1 |
Marvulli, R | 1 |
Chiumarulo, P | 1 |
Nisi, M | 1 |
Barulli, L | 1 |
Megna, G | 1 |
Pietro, F | 1 |
Ianieri, G | 1 |
Megna, M | 1 |
Sechrist, C | 1 |
Kinsman, S | 1 |
Cain, N | 1 |
Kishima, H | 1 |
Yanagisawa, T | 1 |
Goto, Y | 1 |
Oshino, S | 1 |
Maruo, T | 1 |
Tani, N | 1 |
Khoo, HM | 1 |
Hosomi, K | 1 |
Hirata, M | 1 |
Yoshimine, T | 1 |
Rushton, PRP | 1 |
Nasto, LA | 1 |
Aujla, RK | 1 |
Ammar, A | 1 |
Grevitt, MP | 1 |
Vloeberghs, MH | 1 |
Awuor, SO | 1 |
Kitei, PM | 1 |
Nawaz, Y | 1 |
Ahnert, AM | 1 |
Kobylarz, K | 1 |
Kwiatkowski, S | 2 |
Inglot, B | 1 |
Mróz, A | 1 |
Saval, A | 1 |
Chiodo, AE | 1 |
Sauneuf, B | 1 |
Totouom, HK | 1 |
Savary, B | 1 |
Varin, L | 1 |
Dupeyrat, J | 1 |
Ramakers, S | 1 |
Hanouz, JL | 1 |
Yang, TF | 1 |
Wang, JC | 1 |
Chiu, JW | 1 |
Lai, CJ | 1 |
Chan, RC | 1 |
Lee, SS | 1 |
Vaidyanathan, S | 2 |
Soni, BM | 2 |
Hughes, PL | 2 |
Singh, G | 2 |
Watt, JW | 2 |
Oo, T | 2 |
Sett, P | 2 |
Greenberg, MI | 1 |
Hendrickson, RG | 1 |
Kao, LW | 1 |
Amin, Y | 1 |
Kirk, MA | 1 |
Turner, MS | 1 |
Illum, NO | 1 |
Hansen, FJ | 1 |
Fischer, C | 1 |
Uldall, PV | 1 |
Nielsen, OA | 1 |
Pfister, AA | 1 |
Roberts, AG | 1 |
Taylor, HM | 1 |
Noel-Spaudling, S | 1 |
Damian, MM | 1 |
Charles, PD | 1 |
Selmi, F | 1 |
Bottanelli, M | 1 |
Rubini, G | 1 |
Venturelli, V | 1 |
Cosentino, A | 1 |
Rossato, G | 1 |
Vicentini, S | 1 |
Romito, S | 1 |
Rizzuto, N | 1 |
Bertolasi, L | 1 |
Segal, LS | 1 |
Wallach, DM | 1 |
Kanev, PM | 1 |
Tubbs, RS | 1 |
Law, C | 1 |
Oakes, WJ | 1 |
Grabb, PA | 2 |
Dziurzynski, K | 1 |
Mcleish, D | 1 |
Ward, M | 1 |
Iskandar, BJ | 1 |
Berlowitz, DJ | 1 |
Brown, DJ | 1 |
Campbell, DA | 1 |
Pierce, RJ | 1 |
Britton, D | 1 |
Goldstein, B | 1 |
Jones-Redmond, J | 1 |
Esselman, P | 1 |
Morrison, NG | 1 |
Zhang, RL | 1 |
Albright, AL | 2 |
Turner, M | 1 |
Pattisapu, JV | 1 |
Cooper, JA | 1 |
Ridley, B | 1 |
Lim, L | 1 |
Krystal, A | 1 |
Ceulemans, B | 1 |
van Rhijn, J | 1 |
Kenis, S | 1 |
Krols, R | 1 |
Laridon, A | 1 |
Van Havenbergh, T | 1 |
Smit, CA | 1 |
Slim, EJ | 1 |
Walliser, G | 1 |
Grossberg, R | 1 |
Reed, MD | 1 |
Swierczyńska, A | 1 |
Fafara, A | 1 |
Kawecka, J | 1 |
Grzegorzewski, P | 1 |
Kawecki, Z | 1 |
Hansen, CR | 1 |
Gooch, JL | 1 |
Such-Neibar, T | 1 |
Ginsburg, GM | 1 |
Lauder, AJ | 1 |
Saveika, JA | 1 |
Shelton, JE | 1 |
Vanhauwaert, DJ | 1 |
Kalala, JP | 1 |
Baert, E | 1 |
Hallaert, G | 1 |
Crombez, E | 1 |
Caemaert, J | 1 |
Van Roost, D | 1 |
Steinbok, P | 1 |
Daneshvar, H | 1 |
Evans, D | 1 |
Kestle, JR | 1 |
Dicpinigaitis, PV | 1 |
Absgarten, A | 1 |
Almenoff, PL | 1 |
Mandac, BR | 1 |
Hurvitz, EA | 1 |
Nelson, VS | 1 |
Fouillet, N | 1 |
Wiart, L | 1 |
Arné, P | 1 |
Alaoui, P | 1 |
Petit, H | 1 |
Barat, M | 1 |
Donovan, WH | 1 |
Reeves, RK | 1 |
Stolp-Smith, KA | 1 |
Christopherson, MW | 1 |
Gerszten, PC | 1 |
Johnstone, GF | 1 |
Sampathkumar, P | 1 |
Scanlon, PD | 1 |
Plevak, DJ | 1 |
Guin-Renfroe, S | 1 |
Meythaler, JM | 2 |
Ridgeway, B | 1 |
Wallace, M | 1 |
Gerayli, A | 1 |
Samson-Fang, L | 1 |
Gooch, J | 1 |
Norlin, C | 1 |
Sindou, MP | 1 |
Mertens, P | 1 |
Hemingway, C | 1 |
McGrogan, J | 1 |
Freeman, JM | 1 |
McCarty, SF | 1 |
Gaebler-Spira, D | 1 |
Harvey, RL | 1 |
Burns, AS | 1 |
Cairns, K | 1 |
Stein, J | 1 |
Mooney, JF | 1 |
Jones, RF | 1 |
Lance, JW | 1 |
Sandford, PR | 1 |
Spengler, SE | 1 |
Sawasky, KB | 1 |
Siegfried, RN | 1 |
Jacobson, L | 1 |
Chabal, C | 1 |
Delhaas, EM | 1 |
Verhagen, J | 1 |
Fodstad, H | 1 |
Ljunggren, BC | 1 |
Putty, TK | 1 |
Shapiro, SA | 1 |
Fraser, AD | 1 |
MacNeil, W | 1 |
Isner, AF | 1 |
Braunsdorf, WE | 1 |
Kuhlendahl, HD | 1 |
Volkheimer, A | 1 |
Behrens, C | 1 |
Kleiter, K | 1 |
Wainapel, SF | 1 |
Lee, L | 1 |
Riley, TL | 1 |
Roy, CW | 1 |
Wakefield, IR | 1 |
Frances, A | 1 |
Thomas, MR | 1 |
Thompson, TL | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Using Telemedicine to Improve Spasticity Diagnosis Rates[NCT03211390] | 60 participants (Actual) | Observational | 2018-01-30 | Completed | |||
Prevalence of Comorbid Spasticity and Urinary Incontinence in Residents of a Long-Term Care Facility[NCT03250988] | 60 participants (Actual) | Observational | 2018-01-30 | Completed | |||
Validity and Inter-Rater Reliability of a Novel Bedside Referral Tool for Spasticity[NCT03209960] | 60 participants (Actual) | Observational | 2018-01-30 | Completed | |||
Inter-Rater Reliability of a Spasticity Diagnosis Algorithm[NCT01644123] | 72 participants (Actual) | Observational | 2013-04-30 | Completed | |||
Intrathecal (IT) Baclofen Drug Distribution Pilot Study[NCT02903823] | Phase 4 | 27 participants (Actual) | Interventional | 2016-04-22 | Completed | ||
Energy Costs of Spasticity in Spinal Cord Injury: A Pilot Investigation[NCT00572845] | 20 participants (Actual) | Interventional | 2008-01-31 | Terminated (stopped due to Unable to recruit enough participants.) | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of cerebral origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
Intervention | Participants (Count of Participants) | |||
---|---|---|---|---|
Cervical level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar lever 2 injection site | |
Subjects With Max MAS Change | 8 | 7 | 3 | 3 |
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of spinal origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
Intervention | Participants (Count of Participants) | |||
---|---|---|---|---|
Cervical spine level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar level 2 injection site | |
Subjects With MAS Change - Based on Site of Injection | 4 | 2 | 5 | 3 |
2 reviews available for baclofen and Flaccid Quadriplegia
Article | Year |
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Intrathecal baclofen: effects on spasticity, pain, and consciousness in disorders of consciousness and locked-in syndrome.
Topics: Baclofen; Consciousness; Consciousness Disorders; Drug Administration Schedule; Humans; Injections, | 2015 |
Neurosurgery for spasticity.
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Combined Modality Therapy; Gai | 2000 |
4 trials available for baclofen and Flaccid Quadriplegia
Article | Year |
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Low-dose baclofen therapy raised plasma insulin-like growth factor-1 concentrations, but not into the normal range in a predictable and sustained manner in men with chronic spinal cord injury.
Topics: Adult; Baclofen; Chronic Disease; Dose-Response Relationship, Drug; Humans; Insulin-Like Growth Fact | 2013 |
Effect of low-dose baclofen administration on plasma insulin-like growth factor-I in persons with spinal cord injury.
Topics: Adult; Baclofen; Chronic Disease; Dose-Response Relationship, Drug; Humans; Insulin-Like Growth Fact | 2006 |
[Assessment of spasticity therapy with baclofen pump in children].
Topics: Adolescent; Adult; Baclofen; Child; Feasibility Studies; Follow-Up Studies; GABA Agonists; Hemiplegi | 2007 |
Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia.
Topics: Adult; Arm; Baclofen; Female; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Leg; Male; Mid | 2001 |
68 other studies available for baclofen and Flaccid Quadriplegia
Article | Year |
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Adrenoleukodystrophy presenting as glue sniffing.
Topics: Adrenocorticotropic Hormone; Adrenoleukodystrophy; Aftercare; Baclofen; Child; Cognitive Dysfunction | 2020 |
Placement of baclofen pump catheter through a C1-2 puncture: technical note.
Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Child, Preschool; Epilepsy; Female; Humans; Infusion Pu | 2018 |
An unusual cause of flaccid paralysis and coma: baclofen overdose.
Topics: Adolescent; Baclofen; Central Nervous System; Coma; Drug Overdose; Epilepsy, Generalized; Female; Hu | 2014 |
Selective effects of baclofen on use-dependent modulation of GABAB inhibition after tetraplegia.
Topics: Adult; Analysis of Variance; Antimanic Agents; Baclofen; Case-Control Studies; Cortical Spreading De | 2013 |
[Radiotherapy and implantable medical device: example of infusion pumps].
Topics: Baclofen; Carcinoma, Squamous Cell; Dose Fractionation, Radiation; Female; Humans; Infusion Pumps, I | 2013 |
Intrathecal baclofen toxicity: an unusual cause of paediatric postoperative coma and respiratory depression.
Topics: Adolescent; Baclofen; Cerebral Palsy; Coma; Humans; Injections, Spinal; Male; Muscle Relaxants, Cent | 2014 |
Cardiac arrest due to baclofen withdrawal syndrome.
Topics: Adult; Baclofen; Equipment Failure; Heart Arrest; Humans; Injections, Spinal; Male; Muscle Relaxants | 2014 |
Role of dorsal rhizotomy in spinal cord injury-induced spasticity.
Topics: Accidental Falls; Adolescent; Baclofen; Cervical Vertebrae; Child; Dose-Response Relationship, Drug; | 2014 |
Indwelling intrathecal catheter with subcutaneous abdominal reservoir: a viable baclofen delivery system in severely cachectic patients.
Topics: Baclofen; Cachexia; Catheters, Indwelling; Cerebral Palsy; Child; Dystonia; Humans; Infusion Pumps, | 2014 |
Dexmedetomidine for acute baclofen withdrawal.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Baclofen; Cerebral Palsy; Dexmedetomidine; GABA-B | 2015 |
Use Of External Intrathecal Infusion Pumps In The Management Of Septic Complications: A Case Report.
Topics: Abdomen; Administration, Oral; Adolescent; Anti-Bacterial Agents; Baclofen; Catheter-Related Infecti | 2015 |
Profound Bradycardia After Intrathecal Baclofen Injection in a Patient With Hydranencephaly.
Topics: Baclofen; Bradycardia; Cerebral Palsy; Child; Female; Humans; Hydranencephaly; Injections, Spinal; M | 2015 |
Respiratory Function Under Intrathecal Baclofen Therapy in Patients With Spastic Tetraplegia.
Topics: Adult; Baclofen; Female; Humans; Injections, Spinal; Male; Middle Aged; Muscle Relaxants, Central; Q | 2016 |
Intrathecal baclofen pumps do not accelerate progression of scoliosis in quadriplegic spastic cerebral palsy.
Topics: Baclofen; Case-Control Studies; Cerebral Palsy; Child; Cohort Studies; Disease Progression; Female; | 2017 |
Intrathecal baclofen withdrawal: A rare cause of reversible cardiomyopathy.
Topics: Adult; Baclofen; Cardiomyopathies; Catheterization, Swan-Ganz; Coronary Angiography; Echocardiograph | 2016 |
[Comprehensive management of a child with a post-traumatic brain stem and spinal cord injury. A case study and presentation of current therapeutic modalities].
Topics: Baclofen; Brain Injuries; Brain Stem; Cervical Vertebrae; Child; Drug Resistance; Humans; Infusion P | 2008 |
Effect of intrathecal baclofen concentration on spasticity control: case series.
Topics: Adult; Baclofen; Brain Injuries; Cerebral Palsy; Female; GABA Agonists; Humans; Infusion Pumps; Inje | 2008 |
Clinical and EEG features of acute intrathecal baclofen overdose.
Topics: Baclofen; Drug Overdose; Electroencephalography; Ependymoma; Equipment Failure; GABA Agonists; Glasg | 2012 |
Ultrasound-guided refilling of an intrathecal baclofen pump--a case report.
Topics: Baclofen; Child; Female; Humans; Infusion Pumps, Implantable; Infusions, Spinal; Quadriplegia; Ultra | 2013 |
How should an infected perinephric haematoma be drained in a tetraplegic patient with baclofen pump implanted in the abdominal wall? - A case report.
Topics: Abdominal Wall; Anesthetics, Intravenous; Baclofen; Drainage; Hematoma; Humans; Infusion Pumps, Impl | 2002 |
Baclofen withdrawal following removal of an intrathecal baclofen pump despite oral baclofen replacement.
Topics: Adult; Baclofen; GABA Agonists; GABA-A Receptor Agonists; Hemodynamics; Humans; Injections, Spinal; | 2003 |
Intrathecal baclofen withdrawal mimicking sepsis.
Topics: Baclofen; Child, Preschool; Clinical Protocols; Decerebrate State; Diagnosis, Differential; Emergenc | 2003 |
[Intrathecal baclofen in the treatment of severe spastic tetraplegia and dystonia in children and adolescents].
Topics: Adolescent; Baclofen; Child; Child, Preschool; Dystonia; GABA Agonists; Humans; Infusion Pumps; Inje | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Management of recurrent priapism in a cervical spinal cord injury patient with oral baclofen therapy.
Topics: Administration, Oral; Baclofen; Catheters, Indwelling; Cervical Vertebrae; Dose-Response Relationshi | 2004 |
Weight and height gain after intrathecal baclofen pump implantation in children with spastic tetraparesis.
Topics: Anthropometry; Baclofen; Body Height; Child; Female; Humans; Infusion Pumps, Implantable; Male; Musc | 2004 |
Potential complications of posterior spine fusion and instrumentation in patients with cerebral palsy treated with intrathecal baclofen infusion.
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Drug Delivery Systems; Headache; Humans; Injections, Sp | 2005 |
Acquired Chiari I malformation following baclofen pump placement in a child. Case report.
Topics: Adolescent; Arnold-Chiari Malformation; Baclofen; Decompression, Surgical; Humans; Hydrocephalus; In | 2004 |
Placement of baclofen pumps through the foramen magnum and upper cervical spine.
Topics: Adolescent; Adult; Baclofen; Catheters, Indwelling; Cerebral Palsy; Cervical Vertebrae; Child; Femal | 2006 |
A longitudinal evaluation of sleep and breathing in the first year after cervical spinal cord injury.
Topics: Abdomen; Adolescent; Adult; Aged; Anti-Anxiety Agents; Antidepressive Agents; Baclofen; Cervical Ver | 2005 |
Baclofen pump intervention for spasticity affecting pulmonary function.
Topics: Baclofen; Humans; Infusion Pumps, Implantable; Injections, Spinal; Lung; Male; Middle Aged; Muscle R | 2005 |
Best-practice surgical techniques for intrathecal baclofen therapy.
Topics: Baclofen; Catheters, Indwelling; Cerebral Palsy; Child; Dystonia; Equipment Design; GABA Agonists; H | 2006 |
Response of intrathecal baclofen resistance to dose reduction.
Topics: Adult; Analgesics; Anticonvulsants; Baclofen; Dose-Response Relationship, Drug; Drug Resistance; Dru | 2006 |
Psychotic disorder in a patient with central and extrapontine myelinolysis.
Topics: Antidepressive Agents, Second-Generation; Antiparkinson Agents; Antipsychotic Agents; Baclofen; Fema | 2007 |
Opisthotonus and intrathecal treatment with baclofen (ITB) in children.
Topics: Adolescent; Adult; Baclofen; Belgium; Child; Child, Preschool; Dystonia; Epilepsy; Female; Follow-Up | 2008 |
Heart conduction problems in a tetraplegic patient caused by a single therapeutic dosage of Baclofen.
Topics: Adult; Baclofen; Bradycardia; Cervical Vertebrae; GABA Agonists; Heart Conduction System; Humans; Ma | 2008 |
Look-alike medications: a formula for possible morbidity and mortality in the long-term care facility.
Topics: Baclofen; Dosage Forms; Female; Glipizide; Homes for the Aged; Humans; Hypoglycemic Agents; Long-Ter | 2007 |
[The parents expectations after baclofen pump implantation in child with severe spasticity in physical rehabilitation and psychological aspects].
Topics: Activities of Daily Living; Adult; Baclofen; Cerebral Palsy; Child; Female; Follow-Up Studies; Hemip | 2007 |
Prolonged, severe intrathecal baclofen withdrawal syndrome: a case report.
Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Critical Care; Cross Infection; Device Removal; Dose-Re | 2007 |
Progression of scoliosis in patients with spastic quadriplegia after the insertion of an intrathecal baclofen pump.
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Disease Progression; Female; H | 2007 |
Cyproheptadine for pediatric intrathecal baclofen withdrawal: a case report.
Topics: Adolescent; Age Factors; Baclofen; Cerebral Palsy; Child; Cyproheptadine; Equipment Failure; Female; | 2007 |
Migration of pump for intrathecal drug delivery into the peritoneal cavity. Case report.
Topics: Abdominal Muscles; Abdominal Wall; Accidents, Traffic; Baclofen; Foreign-Body Migration; Humans; Inf | 2009 |
Cost analysis of continuous intrathecal baclofen versus selective functional posterior rhizotomy in the treatment of spastic quadriplegia associated with cerebral palsy.
Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Costs and Cost Analysis; Hospitalization; Humans; Injec | 1995 |
Inhibition of bronchial hyperresponsiveness by the GABA-agonist baclofen.
Topics: Adult; Baclofen; Bronchial Hyperreactivity; Bronchial Provocation Tests; Drug Evaluation; Forced Exp | 1994 |
Hyperthermia associated with baclofen withdrawal and increased spasticity.
Topics: Adolescent; Baclofen; Fever; Humans; Male; Muscle Spasticity; Quadriplegia; Substance Withdrawal Syn | 1993 |
Propriospinal myoclonus in tetraplegic patients: clinical, electrophysiological and therapeutic aspects.
Topics: Adult; Baclofen; Electromyography; Humans; Injections, Spinal; Male; Muscle Relaxants, Central; Myoc | 1995 |
Profile of the Institute for Rehabilitation and Research.
Topics: Automobile Driving; Baclofen; GABA Agonists; Humans; Patient Education as Topic; Quadriplegia; Rehab | 1997 |
Hyperthermia, rhabdomyolysis, and disseminated intravascular coagulation associated with baclofen pump catheter failure.
Topics: Adult; Baclofen; Catheters, Indwelling; Dantrolene; Disseminated Intravascular Coagulation; Equipmen | 1998 |
Intrathecal baclofen infusion and subsequent orthopedic surgery in patients with spastic cerebral palsy.
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Contracture; Femur; Follow-Up | 1998 |
Baclofen withdrawal presenting as multiorgan system failure.
Topics: Adult; Baclofen; Humans; Male; Multiple Organ Failure; Muscle Relaxants, Central; Muscle Spasticity; | 1998 |
Midthoracic catheter tip placement for intrathecal baclofen administration in children with quadriparetic spasticity.
Topics: Baclofen; Catheters, Indwelling; Child; Dose-Response Relationship, Drug; Female; Follow-Up Studies; | 1999 |
Ziconotide for the treatment of severe spasticity after spinal cord injury.
Topics: Adult; Analgesics, Opioid; Baclofen; Calcium Channel Blockers; Drug Resistance; Humans; Male; Morphi | 2000 |
Intrathecal baclofen withdrawal simulating neuroleptic malignant syndrome in a child with cerebral palsy.
Topics: Baclofen; Cerebral Palsy; Child; Diagnosis, Differential; Humans; Injections, Spinal; Male; Muscle R | 2000 |
Energy requirements of spasticity.
Topics: Adolescent; Baclofen; Combined Modality Therapy; Energy Intake; Energy Metabolism; Humans; Male; Qua | 2001 |
Improvement of sleep apnea in a patient with cerebral palsy.
Topics: Adult; Baclofen; Cerebral Palsy; Dystonia; Female; Humans; Injections, Spinal; Muscle Spasticity; Po | 2001 |
Motor function improvement following intrathecal baclofen pump placement in a patient with locked-in syndrome.
Topics: Adult; Baclofen; Brain Stem Infarctions; Humans; Infusion Pumps, Implantable; Male; Muscle Relaxants | 2002 |
Selective posterior rhizotomy and intrathecal baclofen for the treatment of spasticity.
Topics: Baclofen; Cerebral Palsy; Humans; Injections, Spinal; Muscle Relaxants, Central; Quadriplegia; Rhizo | 2002 |
Bacloffen (Lioresal) in the long-term management of spasticity.
Topics: Adolescent; Adult; Aged; Aminobutyrates; Baclofen; Cerebral Palsy; Child; Female; Humans; Long-Term | 1976 |
Clonidine in the treatment of brainstem spasticity. Case report.
Topics: Adult; Baclofen; Cerebral Infarction; Clonidine; Female; Humans; Medulla Oblongata; Muscle Spasticit | 1992 |
Development of an acute withdrawal syndrome following the cessation of intrathecal baclofen in a patient with spasticity.
Topics: Adult; Baclofen; Humans; Infusion Pumps, Implantable; Injections, Spinal; Male; Muscle Spasticity; Q | 1992 |
Pregnancy in a quadriplegic patient treated with continuous intrathecal baclofen infusion to manage her severe spasticity. Case report.
Topics: Adult; Baclofen; Cesarean Section; Drug Implants; Female; Humans; Injections, Spinal; Muscle Spastic | 1992 |
Baclofen and carbamazepine in supraspinal spasticity.
Topics: Administration, Oral; Adult; Baclofen; Brain Injuries; Carbamazepine; Drug Therapy, Combination; Fem | 1991 |
Efficacy of dorsal longitudinal myelotomy in treating spinal spasticity: a review of 20 cases.
Topics: Adult; Aged; Baclofen; Female; Humans; Injections, Spinal; Male; Middle Aged; Paraplegia; Quadripleg | 1991 |
Toxicological analysis of a fatal baclofen (Lioresal) ingestion.
Topics: Adult; Baclofen; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Drug Overdose; Ga | 1991 |
[Continuous intrathecal baclofen therapy using an implantable pump system in severe spasticity].
Topics: Baclofen; Dose-Response Relationship, Drug; Humans; Infusion Pumps, Implantable; Motor Neurons; Musc | 1990 |
Reversible electroencephalogram changes associated with administration of baclofen in a quadriplegic patient: case report.
Topics: Adult; Baclofen; Cervical Vertebrae; Delta Rhythm; Electroencephalography; Fractures, Bone; Humans; | 1986 |
Baclofen pseudopsychosis: case report.
Topics: Adult; Baclofen; Diagnosis, Differential; Hallucinations; Humans; Male; Muscle Spasticity; Psychotic | 1986 |
A quadriplegic patient with borderline personality disorder.
Topics: Adult; Baclofen; Borderline Personality Disorder; Humans; Male; Personality Disorders; Psychoses, Su | 1985 |