baclofen and Epileptiform Neuralgia studies

Research Excerpts

Excerpt	Relevance	Reference
"L-Baclofen was compared with racemic baclofen (Lioresal) in a double-blind crossover trial in 15 patients with typical trigeminal neuralgia."	9.06	Comparison of L-baclofen and racemic baclofen in trigeminal neuralgia. ( Fromm, GH; Terrence, CF, 1987)
"A double-blind crossover study of the effects of baclofen was conducted on 10 patients with typical trigeminal neuralgia."	9.05	Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up. ( Chattha, AS; Fromm, GH; Terrence, CF, 1984)
"Baclofen has significantly exhibited analgesic efficacy: all groups, as a whole, were improved by 68."	6.65	Efficacy of baclofen in trigeminal neuralgia and some other painful conditions. A clinical trial. ( Leo, A; Marano, E; Steardo, L, 1984)
" A reduction in the dosage of baclofen in six of these patients resulted in a recurrence of painful paroxysms in five patients."	5.26	Baclofen in trigeminal neuralgia: its effect on the spinal trigeminal nucleus: a pilot study. ( Chattha, AS; Fromm, GH; Glass, JD; Terrence, CF, 1980)
"L-Baclofen was compared with racemic baclofen (Lioresal) in a double-blind crossover trial in 15 patients with typical trigeminal neuralgia."	5.06	Comparison of L-baclofen and racemic baclofen in trigeminal neuralgia. ( Fromm, GH; Terrence, CF, 1987)
"A double-blind crossover study of the effects of baclofen was conducted on 10 patients with typical trigeminal neuralgia."	5.05	Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up. ( Chattha, AS; Fromm, GH; Terrence, CF, 1984)
"There is low-quality evidence that the effect of tizanidine is not significantly different than that of carbamazepine in treating trigeminal neuralgia."	4.89	Non-antiepileptic drugs for trigeminal neuralgia. ( Chen, N; He, L; Yang, M; Zakrzewska, JM; Zhang, J; Zhou, M, 2013)
"Carbamazepine continues to be the most useful drug in the treatment of trigeminal neuralgia."	3.67	[Treatment of typical trigeminus neuralgias. Overview of the current state of drug and surgical therapy]. ( Leopold, HC; Möbius, E; Paulus, WM, 1984)
"Baclofen has significantly exhibited analgesic efficacy: all groups, as a whole, were improved by 68."	2.65	Efficacy of baclofen in trigeminal neuralgia and some other painful conditions. A clinical trial. ( Leo, A; Marano, E; Steardo, L, 1984)
" When sodium channel blockers cannot reach full dosage because of side effects, an add-on treatment with lamotrigine or baclofen should be considered."	2.58	Current and Innovative Pharmacological Options to Treat Typical and Atypical Trigeminal Neuralgia. ( Cruccu, G; Di Stefano, G; Truini, A, 2018)
"Tizanidine was investigated in two trials."	2.43	Non-antiepileptic drugs for trigeminal neuralgia. ( He, L; Wu, B; Zhou, M, 2006)
"Trigeminal neuralgia and glossopharyngeal neuralgia are extremely painful conditions that typically afflict an older population."	2.42	Trigeminal neuralgia and glossopharyngeal neuralgia. ( Rozen, TD, 2004)
"Trigeminal neuralgia is a unique neuropathic pain disorder with a specific therapy."	2.42	Management issues of neuropathic trigeminal pain from a medical perspective. ( Watson, CP, 2004)
"Among the more common symptoms is spasticity."	2.41	Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis. ( Schapiro, RT, 2001)
"Trigeminal neuralgia is the most frequent cranial neuralgia, the incidence being 1 per 1,000,00 persons per year."	2.41	Trigeminal neuralgia: current concepts and management. ( Das, B; Saha, SP, 2001)
"Trigeminal neuralgia is a sudden, severe, brief, recurrent, stabbing pain in the distribution of the trigeminal nerve."	2.40	Trigeminal neuralgia. ( Zakrzewska, JM, 1997)
"Trigeminal neuralgia is a paroxysmal and severely disabling facial pain."	2.39	The medical and surgical management of trigeminal neuralgia. ( Maxwell, S; Sidebottom, A, 1995)
"Baclofen is a gamma-aminobutyric acid (GABA) agonist approved for the treatment of spasticity and commonly used in the management of many types of neuropathic pain."	2.39	Baclofen as an adjuvant analgesic. ( Fromm, GH, 1994)
" On the basis of these considerations and clinical reports describing the use of these drugs, we make dosage recommendations to enable the practitioner to individualize therapeutic regimens."	2.38	Drugs used in the management of trigeminal neuralgia. ( Patsalos, PN; Zakrzewska, JM, 1992)
"The mechanism of action of pimozide for treating trigeminal neuralgia is not known."	2.38	Review article: the medical management of trigeminal neuralgia. ( Green, MW; Selman, JE, 1991)
" This article reviews the indications, dosing regimens, and potential side effects of the drugs used for the treatment of trigeminal and glossopharyngeal neuralgia, posttherapeutic neuralgia, temporal arteritis, and migraine based on the clinical pharmacology of these drugs, so that the most appropriate treatment for each patient can be chosen on a sound, rational basis."	2.38	Clinical pharmacology of drugs used to treat head and face pain. ( Fromm, GH, 1990)
"Trigeminal neuralgia is probably the most excruciatingly painful disorder to afflict mankind and is refractory to all conventional analgesic agents."	2.38	Trigeminal neuralgia and related disorders. ( Fromm, GH, 1989)
"Carbamazepine was effective only after doses (> or =10 mg/kg s."	1.30	Pharmacological studies on a rat model of trigeminal neuropathic pain: baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuates the allodynia-like behaviour. ( Guilbaud, G; Idänpään-Heikkilä, JJ, 1999)
"Trigeminal neuralgia is not common, but is a debilitating pain syndrome."	1.29	Trigeminal neuralgia (tic douloureux). ( Mauskop, A, 1993)
"Carbamazepine was used on all patients."	1.28	[Pharmacotherapy of trigeminal neuralgia]. ( Martinez, C; Montini, C; Oliva, J; Ramirez, H, 1989)
"Drugs that are effective in the treatment of trigeminal neuralgia facilitate segmental inhibition in the trigeminal nucleus, as well as depressing excitatory transmission."	1.27	Trigeminal neuralgia. Current concepts regarding etiology and pathogenesis. ( Fromm, GH; Maroon, JC; Terrence, CF, 1984)
" A reduction in the dosage of baclofen in six of these patients resulted in a recurrence of painful paroxysms in five patients."	1.26	Baclofen in trigeminal neuralgia: its effect on the spinal trigeminal nucleus: a pilot study. ( Chattha, AS; Fromm, GH; Glass, JD; Terrence, CF, 1980)

Timeframe	Studies, this research(%)	All Research%
pre-1990	20 (46.51)	18.7374
1990's	9 (20.93)	18.2507
2000's	9 (20.93)	29.6817
2010's	5 (11.63)	24.3611
2020's	0 (0.00)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662]	Phase 4	50 participants (Anticipated)	Interventional	2015-02-28	Recruiting
Examining the Efficacy of Low Intensity Low Frequency Surface Acoustic Wave Ultrasound(LILF/SAWU) in Trigeminal Neuralgia Pain[NCT01447108]	Phase 4	16 participants (Actual)	Interventional	2011-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Current and Innovative Pharmacological Options to Treat Typical and Atypical Trigeminal Neuralgia. Drugs, 2018, Volume: 78, Issue:14 Topics: Anticonvulsants; Antidepressive Agents; Baclofen; Carbamazepine; Drug Therapy, Combination; Gabapent	2018
Non-antiepileptic drugs for trigeminal neuralgia. The Cochrane database of systematic reviews, 2013, Dec-03, Issue:12 Topics: Amitriptyline; Analgesics; Anticonvulsants; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans	2013
Non-antiepileptic drugs for trigeminal neuralgia. The Cochrane database of systematic reviews, 2011, Jan-19, Issue:1 Topics: Amitriptyline; Analgesics; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans; Pimozide; Propo	2011
Trigeminal neuralgia and glossopharyngeal neuralgia. Neurologic clinics, 2004, Volume: 22, Issue:1 Topics: Analgesics, Non-Narcotic; Anticonvulsants; Baclofen; Carbamazepine; GABA Agonists; Glossopharyngeal	2004
Management issues of neuropathic trigeminal pain from a medical perspective. Journal of orofacial pain, 2004,Fall, Volume: 18, Issue:4 Topics: Amines; Analgesics, Non-Narcotic; Anticonvulsants; Antidepressive Agents; Baclofen; Carbamazepine; C	2004
Non-antiepileptic drugs for trigeminal neuralgia. The Cochrane database of systematic reviews, 2006, Jul-19, Issue:3 Topics: Amitriptyline; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans; Pimozide; Propoxycaine; Ran	2006
Evidence-based approach to the medical management of trigeminal neuralgia. British journal of neurosurgery, 2007, Volume: 21, Issue:3 Topics: Analgesics; Baclofen; Carbamazepine; Drug Therapy, Combination; Evidence-Based Medicine; Female; GAB	2007
The medical and surgical management of trigeminal neuralgia. Journal of clinical pharmacy and therapeutics, 1995, Volume: 20, Issue:1 Topics: Baclofen; Carbamazepine; Combined Modality Therapy; Facial Nerve; Humans; Phenytoin; Postoperative C	1995
Baclofen as an adjuvant analgesic. Journal of pain and symptom management, 1994, Volume: 9, Issue:8 Topics: Adjuvants, Pharmaceutic; Analgesics; Baclofen; Clinical Trials as Topic; Drug Administration Schedul	1994
Trigeminal neuralgia. Primary dental care : journal of the Faculty of General Dental Practitioners (UK), 1997, Volume: 4, Issue:1 Topics: Anticonvulsants; Baclofen; Carbamazepine; Diagnosis, Differential; Humans; Incidence; Muscle Relaxan	1997
Trigeminal neuralgia--an update. Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2000, Volume: 21, Issue:4 Topics: Acupuncture Analgesia; Anticonvulsants; Baclofen; Carbamazepine; Facial Pain; GABA Agonists; Homeopa	2000
Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis. Current neurology and neuroscience reports, 2001, Volume: 1, Issue:3 Topics: Acetates; Amines; Autoimmune Diseases; Baclofen; Benzodiazepines; Botulinum Toxins, Type A; Cannabin	2001
Trigeminal neuralgia: current concepts and management. Journal of the Indian Medical Association, 2001, Volume: 99, Issue:12 Topics: Analgesics, Non-Narcotic; Baclofen; Carbamazepine; Humans; Phenytoin; Pimozide; Radiosurgery; Trigem	2001
Drugs used in the management of trigeminal neuralgia. Oral surgery, oral medicine, and oral pathology, 1992, Volume: 74, Issue:4 Topics: Anticonvulsants; Baclofen; Carbamazepine; Clonazepam; Humans; Oxcarbazepine; Phenytoin; Trigeminal N	1992
[The current treatment of trigeminal neuralgia. Experience in 162 thermorhizotomies]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1992, Dec-22, Volume: 81, Issue:52 Topics: Aged; Baclofen; Carbamazepine; Diagnosis, Differential; Electrocoagulation; Facial Neuralgia; Humans	1992
Review article: the medical management of trigeminal neuralgia. Headache, 1991, Volume: 31, Issue:9 Topics: Anticonvulsants; Baclofen; Humans; Pimozide; Trigeminal Neuralgia	1991
Clinical pharmacology of drugs used to treat head and face pain. Neurologic clinics, 1990, Volume: 8, Issue:1 Topics: Baclofen; Carbamazepine; Facial Pain; Humans; Migraine Disorders; Phenytoin; Trigeminal Neuralgia	1990
Trigeminal neuralgia and related disorders. Neurologic clinics, 1989, Volume: 7, Issue:2 Topics: Baclofen; Carbamazepine; Chronic Disease; Humans; Trigeminal Neuralgia	1989
The pharmacology of trigeminal neuralgia. Clinical neuropharmacology, 1989, Volume: 12, Issue:3 Topics: Baclofen; Carbamazepine; Humans; Phenytoin; Trigeminal Neuralgia; Trigeminal Nuclei	1989
Medical treatment of the major neuralgias. Seminars in neurology, 1988, Volume: 8, Issue:4 Topics: Baclofen; Carbamazepine; Chlorphenesin; Combined Modality Therapy; Facial Neuralgia; Glossopharyngea	1988
[Facial pain]. Revue medicale de Liege, 1986, May-01, Volume: 41, Issue:9 Topics: Acyclovir; Adrenal Cortex Hormones; Adult; Baclofen; Calcium Channel Blockers; Carbamazepine; Cervic	1986
[Trigeminal neuralgia. Treatment]. Revista clinica espanola, 1985, Volume: 176, Issue:8 Topics: Baclofen; Carbamazepine; Glycerol; Humans; Nerve Block; Nerve Compression Syndromes; Phenytoin; Trig	1985

Article	Year
Efficacy of baclofen in trigeminal neuralgia and some other painful conditions. A clinical trial. European neurology, 1984, Volume: 23, Issue:1 Topics: Adult; Amputation Stumps; Baclofen; Carbamazepine; Clinical Trials as Topic; Female; Humans; Male; M	1984
Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up. Annals of neurology, 1984, Volume: 15, Issue:3 Topics: Adult; Aged; Baclofen; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Drug Synergism;	1984
Comparison of L-baclofen and racemic baclofen in trigeminal neuralgia. Neurology, 1987, Volume: 37, Issue:11 Topics: Adult; Aged; Baclofen; Clinical Trials as Topic; Double-Blind Method; Humans; Isomerism; Middle Aged	1987

Article	Year
Phenytoin in topical formulations augments pain reduction of other topically applied analgesics in the treatment of trigeminal neuralgia. Journal of clinical anesthesia, 2017, Volume: 38 Topics: Administration, Cutaneous; Aged; Analgesics; Baclofen; Drug Synergism; Humans; Hyperalgesia; Ketamin	2017
Painful traumatic trigeminal neuropathy: an open study on the pharmacotherapeutic response to stepped treatment. Journal of oral & facial pain and headache, 2014,Winter, Volume: 28, Issue:1 Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Baclofen; Carbamazepine; Clinical Proto	2014
The 5-HT(1A) receptor agonist F 13640 attenuates mechanical allodynia in a rat model of trigeminal neuropathic pain. European journal of pharmacology, 2002, Dec-05, Volume: 456, Issue:1-3 Topics: Aminopyridines; Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Dose-Response Relations	2002
Trigeminal neuralgia and glossopharyngeal neuralgia: two orofacial pain syndromes encountered by dentists. Journal of the American Dental Association (1939), 2004, Volume: 135, Issue:10 Topics: Anticonvulsants; Baclofen; Decompression, Surgical; Facial Pain; GABA Agonists; Glossopharyngeal Ner	2004
Neurotransmitter-blocking agents influence antinociceptive effects of carbamazepine, baclofen, pentazocine and morphine on bradykinin-induced trigeminal pain. Neuropharmacology, 1984, Volume: 23, Issue:6 Topics: Analgesics; Animals; Atropine; Baclofen; Bicuculline; Bradykinin; Carbamazepine; Haloperidol; Male;	1984
[Treatment of typical trigeminus neuralgias. Overview of the current state of drug and surgical therapy]. Fortschritte der Medizin, 1984, Oct-11, Volume: 102, Issue:38 Topics: Adult; Antipsychotic Agents; Baclofen; Carbamazepine; Chlorphenesin; Electrocoagulation; Female; Hum	1984
Baclofen in trigeminal neuralgia: its effect on the spinal trigeminal nucleus: a pilot study. Archives of neurology, 1980, Volume: 37, Issue:12 Topics: Adult; Aged; Animals; Baclofen; Cats; Female; Humans; Male; Middle Aged; Pilot Projects; Synaptic Tr	1980
Role of inhibitory mechanisms in trigeminal neuralgia. Neurology, 1981, Volume: 31, Issue:6 Topics: Animals; Baclofen; Carbamazepine; Cats; Electric Stimulation; Maxillary Nerve; Neural Inhibition; Ph	1981
Cluster headache with trigeminal neuralgia. An uncommon association that may be more than coincidental. Postgraduate medicine, 1984, Feb-01, Volume: 75, Issue:2 Topics: Adrenal Cortex Hormones; Adult; Baclofen; Carbamazepine; Chlorphenesin; Cluster Headache; Drug Thera	1984
Trigeminal neuralgia. Current concepts regarding etiology and pathogenesis. Archives of neurology, 1984, Volume: 41, Issue:11 Topics: Baclofen; Carbamazepine; Humans; Phenytoin; Trigeminal Neuralgia	1984
Baclofen in the treatment of neuralgia. Annals of internal medicine, 1984, Volume: 100, Issue:6 Topics: Baclofen; Carbamazepine; Humans; Phenytoin; Trigeminal Neuralgia	1984
[Baclofen in trigeminal neuritis]. Harefuah, 1982, Jan-15, Volume: 102, Issue:2 Topics: Baclofen; Female; Humans; Middle Aged; Multiple Sclerosis; Trigeminal Neuralgia	1982
Trigeminal neuralgia. A practical approach to treatment. Drugs, 1982, Volume: 24, Issue:3 Topics: Baclofen; Carbamazepine; Chlorphenesin; Humans; Microsurgery; Phenytoin; Trigeminal Neuralgia	1982
Trigeminal neuralgia (tic douloureux). Journal of pain and symptom management, 1993, Volume: 8, Issue:3 Topics: Baclofen; Carbamazepine; Diagnosis, Differential; Humans; Phenytoin; Trigeminal Neuralgia	1993
Pharmacological studies on a rat model of trigeminal neuropathic pain: baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuates the allodynia-like behaviour. Pain, 1999, Volume: 79, Issue:2-3 Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Baclofen; B	1999
[Pharmacotherapy of trigeminal neuralgia]. Odontologia chilena, 1989, Volume: 37, Issue:2 Topics: Amphetamines; Baclofen; Carbamazepine; Female; Humans; Imipramine; Male; Phenytoin; Trigeminal Neura	1989
Trigeminal neuralgia. Middle East journal of anaesthesiology, 1989, Volume: 10, Issue:1 Topics: Adult; Anesthesia, General; Baclofen; Carbamazepine; Chlorphenesin; Female; Hematologic Tests; Human	1989
Baclofen-induced memory impairment. Clinical neuropharmacology, 1985, Volume: 8, Issue:3 Topics: Adult; Baclofen; Female; Humans; Memory, Short-Term; Middle Aged; Multiple Sclerosis; Spasm; Trigemi	1985

baclofen and Epileptiform Neuralgia

Research Excerpts

Research

Studies (43)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Kopsky, DJ	1
Keppel Hesselink, JM	1
Di Stefano, G	1
Truini, A	1
Cruccu, G	1
Zhang, J	1
Yang, M	2
Zhou, M	3
He, L	3
Chen, N	2
Zakrzewska, JM	5
Haviv, Y	1
Zadik, Y	1
Sharav, Y	1
Benoliel, R	1
Deseure, K	1
Koek, W	1
Colpaert, FC	1
Adriaensen, H	1
Rozen, TD	1
Horowitz, M	2
Ochs, M	1
Carrau, R	1
Kassam, A	1
Watson, CP	1
Wu, B	1
Jorns, TP	1
Foong, FW	1
Satoh, M	1
Möbius, E	1
Leopold, HC	1
Paulus, WM	1
Steardo, L	1
Leo, A	1
Marano, E	1
Fromm, GH	9
Terrence, CF	5
Chattha, AS	3
Glass, JD	2
Diamond, S	1
Freitag, FG	1
Cohen, JS	1
Maroon, JC	1
Hershey, LA	1
Hering, R	1
Kuritzki, A	1
Bechar, M	1
Dalessio, DJ	2
Sidebottom, A	1
Maxwell, S	1
Mauskop, A	1
Idänpään-Heikkilä, JJ	1
Guilbaud, G	1
Türp, JC	1
Gobetti, JP	1
Schapiro, RT	1
Das, B	1
Saha, SP	1
Patsalos, PN	1
Reber, M	1
Husag, L	1
Green, MW	1
Selman, JE	1
Ramirez, H	1
Martinez, C	1
Oliva, J	1
Montini, C	1
Aurellano-Hoh, ZR	1
Maertens de Noordhout, A	1
Schoenen, J	1
Arias, MJ	1
Sandyk, R	1
Gillman, MA	1