baclofen has been researched along with Epilepsy, Absence in 27 studies
Epilepsy, Absence: A seizure disorder usually occurring in childhood characterized by rhythmic electrical brain discharges of generalized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the SEIZURES. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Baclofen is a central nervous system agent that is commonly used for the treatment of muscle spasticity in spinal cord injury patients." | 3.68 | Neurological manifestations of baclofen withdrawal. ( Chancellor, MB; Freedman, MK; Hill, K; Rivas, DA, 1993) |
| "Experimental absence seizures are associated with perturbations in the presynaptic release of GABA and glutamate within thalamocortical circuitry." | 1.31 | Modulation of absence seizures by the GABA(A) receptor: a critical rolefor metabotropic glutamate receptor 4 (mGluR4). ( Banerjee, PK; Burnham, M; Hampson, D; Snead, OC, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 17 (62.96) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Inaba, Y | 1 |
| D'Antuono, M | 1 |
| Bertazzoni, G | 1 |
| Biagini, G | 1 |
| Avoli, M | 1 |
| Bortolato, M | 1 |
| Frau, R | 2 |
| Orrù, M | 1 |
| Fà, M | 2 |
| Dessì, C | 1 |
| Puligheddu, M | 2 |
| Barberini, L | 2 |
| Pillolla, G | 1 |
| Polizzi, L | 1 |
| Santoni, F | 2 |
| Mereu, G | 2 |
| Marrosu, F | 2 |
| Ngomba, RT | 1 |
| Biagioni, F | 1 |
| Casciato, S | 1 |
| Willems-van Bree, E | 1 |
| Battaglia, G | 1 |
| Bruno, V | 1 |
| Nicoletti, F | 1 |
| van Luijtelaar, EL | 1 |
| Bowery, NG | 3 |
| Genugu, F | 1 |
| Manunta, M | 1 |
| Bessaïh, T | 1 |
| Bourgeais, L | 1 |
| Badiu, CI | 1 |
| Carter, DA | 1 |
| Toth, TI | 1 |
| Ruano, D | 1 |
| Lambolez, B | 1 |
| Crunelli, V | 2 |
| Leresche, N | 2 |
| Vergnes, M | 5 |
| Marescaux, C | 5 |
| Micheletti, G | 1 |
| Depaulis, A | 3 |
| Rumbach, L | 1 |
| Warter, JM | 1 |
| Hosford, DA | 4 |
| Lin, FH | 3 |
| Kraemer, DL | 1 |
| Cao, Z | 3 |
| Wang, Y | 1 |
| Wilson, JT | 1 |
| Richards, DA | 2 |
| Lemos, T | 1 |
| Whitton, PS | 1 |
| Banerjee, PK | 2 |
| Snead, OC | 4 |
| Rivas, DA | 1 |
| Chancellor, MB | 1 |
| Hill, K | 1 |
| Freedman, MK | 1 |
| von Krosigk, M | 1 |
| Bal, T | 1 |
| McCormick, DA | 1 |
| Caddick, SJ | 1 |
| Aizawa, M | 1 |
| Ito, Y | 1 |
| Fukuda, H | 1 |
| Parri, HR | 1 |
| Erdemli, G | 1 |
| Guyon, A | 1 |
| Turner, JP | 1 |
| Williams, SR | 1 |
| Asprodini, E | 1 |
| Matejovská, I | 1 |
| Velísková, J | 1 |
| Velísek, L | 1 |
| Burnham, M | 1 |
| Hampson, D | 1 |
| Morrone, LA | 1 |
| Kim, D | 1 |
| Song, I | 1 |
| Keum, S | 1 |
| Lee, T | 1 |
| Jeong, MJ | 1 |
| Kim, SS | 1 |
| McEnery, MW | 1 |
| Shin, HS | 1 |
| Liu, Z | 2 |
| Clark, S | 1 |
| Wilson, WA | 1 |
| Morrisett, RA | 1 |
| Huin, A | 1 |
| Bernasconi, R | 3 |
| Lauber, J | 1 |
| Martin, P | 1 |
| Rubio, V | 1 |
| Leonhardt, T | 1 |
| Reymann, N | 1 |
| Bittiger, H | 1 |
1 review available for baclofen and Epilepsy, Absence
| Article | Year |
|---|---|
GABAB receptor: a site of therapeutic benefit.
Topics: Animals; Baclofen; Brain; Clinical Trials as Topic; Cognition; Drug Evaluation, Preclinical; Epileps | 2006 |
26 other studies available for baclofen and Epilepsy, Absence
| Article | Year |
|---|---|
Diminished presynaptic GABA(B) receptor function in the neocortex of a genetic model of absence epilepsy.
Topics: 4-Aminopyridine; Animals; Baclofen; Cell Membrane; Disease Models, Animal; Dose-Response Relationshi | 2009 |
GABAB receptor activation exacerbates spontaneous spike-and-wave discharges in DBA/2J mice.
Topics: Animals; Baclofen; Electroencephalography; Epilepsy, Absence; GABA Agonists; Male; Mice; Mice, Inbre | 2010 |
The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy.
Topics: Age Factors; Amino Acids; Analysis of Variance; Animals; Baclofen; Behavior, Animal; Blotting, Weste | 2005 |
Beta and gamma range EEG power-spectrum correlation with spiking discharges in DBA/2J mice absence model: role of GABA receptors.
Topics: Alpha Rhythm; Animals; Baclofen; Beta Rhythm; Cerebral Cortex; Cognition; Cortical Synchronization; | 2006 |
Nucleus-specific abnormalities of GABAergic synaptic transmission in a genetic model of absence seizures.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Epilepsy, Absence; Excitatory Postsynaptic | 2006 |
Enhancement of spike and wave discharges by GABAmimetic drugs in rats with spontaneous petit-mal-like epilepsy.
Topics: Action Potentials; Aminocaproates; Animals; Baclofen; Epilepsy, Absence; gamma-Aminobutyric Acid; Is | 1984 |
Neural network of structures in which GABAB receptors regulate absence seizures in the lethargic (lh/lh) mouse model.
Topics: Animals; Autoradiography; Baclofen; Electroencephalography; Epilepsy, Absence; GABA Antagonists; GAB | 1995 |
Extracellular GABA in the ventrolateral thalamus of rats exhibiting spontaneous absence epilepsy: a microdialysis study.
Topics: Animals; Baclofen; Electroencephalography; Epilepsy, Absence; Extracellular Space; GABA Antagonists; | 1995 |
Presynaptic gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB (GABAB) receptor-mediated release of GABA and glutamate (GLU) in rat thalamic ventrobasal nucleus (VB): a possible mechanism for the generation of absence-like seizures induced by GH
Topics: Action Potentials; Animals; Baclofen; Epilepsy, Absence; Extracellular Space; GABA-B Receptor Antago | 1995 |
Neurological manifestations of baclofen withdrawal.
Topics: Adult; Baclofen; Diplopia; Epilepsy, Absence; Female; Humans; Male; Muscle Spasticity; Psychoses, Su | 1993 |
Increased number of GABAB receptors in the lethargic (lh/lh) mouse model of absence epilepsy.
Topics: Animals; Baclofen; Biomarkers; Disease Models, Animal; Epilepsy, Absence; Male; Mice; Mice, Neurolog | 1993 |
Cellular mechanisms of a synchronized oscillation in the thalamus.
Topics: Animals; Baclofen; Bicuculline; Calcium; Epilepsy, Absence; Ferrets; Geniculate Bodies; In Vitro Tec | 1993 |
Antiabsence seizure activity of specific GABAB and gamma-Hydroxybutyric acid receptor antagonists.
Topics: Animals; Anticonvulsants; Baclofen; Benzocycloheptenes; Electroencephalography; Epilepsy, Absence; G | 1996 |
GABAB-activated gK+ in thalamic neurons in the lethargic (lh/lh) mouse model of generalized absence seizures.
Topics: Animals; Baclofen; Disease Models, Animal; Epilepsy, Absence; Mice; Mice, Inbred Strains; Potassium | 1996 |
Roles of gamma-aminobutyric acidB (GABA B) and gamma-hydroxybutyric acid receptors in hippocampal long-term potentiation and pathogenesis of absence seizures.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Baclofen; Benzocycloheptenes; Electroencephalography; Epi | 1997 |
On the action of the anti-absence drug ethosuximide in the rat and cat thalamus.
Topics: Action Potentials; Animals; Anticonvulsants; Baclofen; Calcium Channels; Cats; Epilepsy, Absence; Et | 1998 |
Bicuculline-induced rhythmic EEG episodes: gender differences and the effects of ethosuximide and baclofen treatment.
Topics: Animals; Baclofen; Bicuculline; Epilepsy; Epilepsy, Absence; Estradiol; Ethosuximide; Female; Incide | 1998 |
Modulation of absence seizures by the GABA(A) receptor: a critical rolefor metabotropic glutamate receptor 4 (mGluR4).
Topics: Animals; Baclofen; Cerebral Cortex; Convulsants; Epilepsy, Absence; Excitatory Amino Acid Antagonist | 2000 |
Hippocampal extracellular amino acids and EEG spectral analysis in a genetic rat model of absence epilepsy.
Topics: Amino Acids; Animals; Baclofen; Electroencephalography; Epilepsy, Absence; Extracellular Space; Fema | 2000 |
Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels.
Topics: 4-Butyrolactone; Animals; Baclofen; Calcium Channels, T-Type; Cerebral Cortex; Electroencephalograph | 2001 |
Involvement of intrathalamic GABAB neurotransmission in the control of absence seizures in the rat.
Topics: Animals; Baclofen; Electroencephalography; Epilepsy, Absence; GABA-A Receptor Antagonists; gamma-Ami | 1992 |
Evidence for GABAB-mediated mechanisms in experimental generalized absence seizures.
Topics: Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy, Absen | 1992 |
The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice.
Topics: Animals; Anticonvulsants; Baclofen; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 1992 |
Experimental absence seizures: potential role of gamma-hydroxybutyric acid and GABAB receptors.
Topics: 4-Butyrolactone; Animals; Baclofen; Brain; Cyclic GMP; Disease Models, Animal; Epilepsy, Absence; GA | 1992 |
GABAB receptor antagonists: potential new anti-absence drugs.
Topics: Action Potentials; Administration, Oral; Animals; Baclofen; Blood-Brain Barrier; Disease Models, Ani | 1992 |
GABAB receptor involvement in the control of genetic absence seizures in rats.
Topics: Animals; Baclofen; Brain Mapping; Cerebral Cortex; Epilepsy, Absence; Evoked Potentials; GABA-A Rece | 1992 |