baclofen has been researched along with Down Syndrome in 2 studies
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Children with Down syndrome are highly susceptible to infantile spasms." | 1.35 | Infantile spasms and Down syndrome: a new animal model. ( Aleem, IS; Ashraf, A; Cortez, MA; Kanawaty, A; Liu, CC; Sadeghnia, HR; Shen, L; Snead, OC; Stewart, L; Trepanier, CH; Wu, Y, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cortez, MA | 1 |
| Shen, L | 1 |
| Wu, Y | 1 |
| Aleem, IS | 1 |
| Trepanier, CH | 1 |
| Sadeghnia, HR | 1 |
| Ashraf, A | 1 |
| Kanawaty, A | 1 |
| Liu, CC | 1 |
| Stewart, L | 1 |
| Snead, OC | 1 |
| Best, TK | 1 |
| Siarey, RJ | 1 |
| Galdzicki, Z | 1 |
2 other studies available for baclofen and Down Syndrome
| Article | Year |
|---|---|
Infantile spasms and Down syndrome: a new animal model.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Baclofen; Brain; Disease Models, Animal; Down Syndrome; E | 2009 |
Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current.
Topics: Animals; Animals, Newborn; Baclofen; Brain; Cell Membrane; Cells, Cultured; Disease Models, Animal; | 2007 |