baclofen has been researched along with Diabetic Neuropathies in 8 studies
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| " To date, only the antidepressants and the anticonvulsants have shown any effectiveness, albeit incomplete and inconsistent, and many questions remain unanswered: What are the exact indications for the antidepressants? What component of neuropathic pain do they relieve, and through which mechanisms? Which type of antidepressants should be prescribed? A first-generation tricyclic? Or a new compound with a selective action on serotonin reuptake? What are the effective dosage and duration of the treatment? What is it mechanism of action? What other antalgic effects do carbamazepine and baclofen possess apart from their action on trigeminal neuralgia? The opiates are generally considered to be without effect, but recent clinical and experimental findings seem to point otherwise." | 4.78 | [Pharmacological treatment of neuropathic pain]. ( Ollat, H, 1992) |
| "Phantom pain, a form of neuropathic pain, is caused by damage to somatosensible afferent nerve fibres in the peripheral or central nervous system." | 2.41 | [Pharmacotherapy for neuropathic pain caused by injury to the afferent nerve fibers]. ( Weber, WE, 2001) |
| "Baclofen treatment significantly suppressed their expression, bringing it close to the levels of controls." | 1.40 | Intrathecal baclofen, a GABAB receptor agonist, inhibits the expression of p-CREB and NR2B in the spinal dorsal horn in rats with diabetic neuropathic pain. ( Bai, HP; Guo, WY; Liu, P; Wang, Q; Wang, XL; Zhang, YZ; Zhao, XN, 2014) |
| "Diabetic animals displayed marked mechanical hyperalgesia, and some thermal hypoalgesia." | 1.30 | Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat. ( Eastwood, C; Fox, A; Gentry, C; Manning, D; Urban, L, 1999) |
| "Baclofen has shown analgesic properties in a number of animal studies but has failed as a conventional analgesic in the human postoperative dental pain model." | 1.27 | Baclofen as an analgesic in chronic peripheral nerve disease. ( Fromm, GH; Tenicela, R; Terrence, CF, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, HP | 2 |
| Liu, P | 2 |
| Wu, YM | 1 |
| Guo, WY | 2 |
| Guo, YX | 1 |
| Wang, XL | 3 |
| Zhao, XN | 1 |
| Wang, Q | 1 |
| Zhang, YZ | 1 |
| Zhang, HM | 1 |
| Chen, SR | 1 |
| Pan, HL | 1 |
| Anghinah, R | 1 |
| Oliveira, AS | 1 |
| Gabbai, AA | 1 |
| Fox, A | 1 |
| Eastwood, C | 1 |
| Gentry, C | 1 |
| Manning, D | 1 |
| Urban, L | 1 |
| Weber, WE | 1 |
| Ollat, H | 1 |
| Terrence, CF | 1 |
| Fromm, GH | 1 |
| Tenicela, R | 1 |
2 reviews available for baclofen and Diabetic Neuropathies
| Article | Year |
|---|---|
[Pharmacotherapy for neuropathic pain caused by injury to the afferent nerve fibers].
Topics: Amantadine; Analgesics, Non-Narcotic; Anticonvulsants; Antidepressive Agents, Tricyclic; Baclofen; D | 2001 |
[Pharmacological treatment of neuropathic pain].
Topics: Anesthetics, Local; Anticonvulsants; Antidepressive Agents; Baclofen; Capsaicin; Chronic Disease; Di | 1992 |
6 other studies available for baclofen and Diabetic Neuropathies
| Article | Year |
|---|---|
Activation of spinal GABAB receptors normalizes N-methyl-D-aspartate receptor in diabetic neuropathy.
Topics: Analysis of Variance; Animals; Antibiotics, Antineoplastic; Baclofen; CREB-Binding Protein; Diabetic | 2014 |
Intrathecal baclofen, a GABAB receptor agonist, inhibits the expression of p-CREB and NR2B in the spinal dorsal horn in rats with diabetic neuropathic pain.
Topics: Animals; Baclofen; CREB-Binding Protein; Diabetic Neuropathies; GABA-B Receptor Agonists; GABA-B Rec | 2014 |
Altered synaptic input and GABAB receptor function in spinal superficial dorsal horn neurons in rats with diabetic neuropathy.
Topics: Animals; Baclofen; Bicuculline; Diabetic Neuropathies; Disease Models, Animal; Excitatory Postsynapt | 2007 |
Effect of baclofen on pain in diabetic neuropathy.
Topics: Adult; Baclofen; Diabetic Neuropathies; Humans; Male; Middle Aged; Pain | 1994 |
Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat.
Topics: Animals; Baclofen; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; H | 1999 |
Baclofen as an analgesic in chronic peripheral nerve disease.
Topics: Adult; Aged; Analgesia; Baclofen; Diabetic Neuropathies; Female; Herpes Simplex; Humans; Male; Middl | 1985 |