baclofen has been researched along with Depression in 20 studies
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Baclofen did not lead to a differential change in cognitive biases compared with placebo, and trait anxiety levels did not moderate this." | 9.27 | Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein? ( Beraha, EM; Krediet, E; Salemink, E; Wiers, RW, 2018) |
| "In order to establish whether alterations in the GABAergic control of GH secretion occur in male patients with major depression, the GH response to the GABAergic-B agonist baclofen (10 mg PO at 0830h) or to placebo was tested in 9 depressed men and in 10 age- and weight-matched male normal controls." | 9.07 | Reduction of GH response to the GABA-B agonist baclofen in patients with major depression. ( Chiodera, P; Coiro, V; Dassó, L; De Ferri, A; De Risio, C; Marchesi, C; Menozzi, P; Volpi, R, 1991) |
| "Baclofen did not lead to a differential change in cognitive biases compared with placebo, and trait anxiety levels did not moderate this." | 5.27 | Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein? ( Beraha, EM; Krediet, E; Salemink, E; Wiers, RW, 2018) |
| "Effects of the N-methyl-D-aspartate (NMDA) agonist (D-cycloserine) and GABA(B) agonist (baclofen) on the fear memory extinction as manifested in the passive avoidance reaction in C57Bl/6J mice with "behavioral despair" (model of depression) and without previously developed stress have been studied." | 3.78 | [Fear memory extinction accelerated by simultaneous activation of GABA(B) and NMDA receptors]. ( Dubrovina, NI, 2012) |
| " Activation of GABA(B) receptors with baclofen accelerated extinction of the memory of fear in mice with the depression-like state." | 3.74 | Contribution of GABA receptors to extinction of memory traces in normal conditions and in a depression-like state. ( Dubrovina, NI; Zinov'ev, DR, 2008) |
| "Depression was assessed with Montgomery-Ashberg scale." | 2.80 | [Double blind placebo controlled randomized pilot clinical trial of baclofen (Baclosan®) for alcohol dependence]. ( Alexeeva, YV; Berntsev, VA; Chekhlaty, EI; Kiselev, AS; Krupitsky, EM; Neznanov, NG; Popov, YV; Rybakova, KV; Zubova, EY, 2015) |
| "Baclofen has shown promise in treating substance use disorders and also reduced binge frequency in an open-label trial." | 2.77 | Baclofen reduces binge eating in a double-blind, placebo-controlled, crossover study. ( Boan, J; Corwin, RL; Peters, KF; Ulbrecht, JS, 2012) |
| "Baclofen was associated with a significant reduction in state anxiety (F(1,73)= 5." | 2.75 | Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial. ( Flannery, BA; Gallop, R; Garbutt, JC; Kalka-Juhl, L; Kampov-Polevoy, AB, 2010) |
| "Baclofen is a γ-aminobutyric acid B (GABA-B) agonist which is used increasingly as an off-label treatment." | 2.58 | Baclofen: its effectiveness in reducing harmful drinking, craving, and negative mood. A meta-analysis. ( Jones, A; Rose, AK, 2018) |
| "Participants had a diagnosis of alcohol dependence according the Diagnostic and Statistical Manual of Mental Disorders (DSM) IV or the International Classification of Diseases (ICD)-10 criteria who were currently drinking." | 2.58 | Baclofen for alcohol use disorder. ( Minozzi, S; Rösner, S; Saulle, R, 2018) |
| " The mean dosage of baclofen at the onset of the first adverse effect was 83 ± 57 mg/day." | 1.42 | Tolerability of High-dose Baclofen in the Treatment of Patients with Alcohol Disorders: A Retrospective Study. ( Alexandre-Dubroeucq, C; Jaury, P; Le Jeunne, C; Legay Hoang, L; Pinot, J; Rigal, L, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 11 (55.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gawlińska, K | 1 |
| Jastrzębska, J | 1 |
| Gamberini, S | 1 |
| Gawliński, D | 1 |
| Pieniążek, R | 1 |
| Suder, A | 1 |
| Wydra, K | 1 |
| Frankowska, M | 1 |
| Rose, AK | 1 |
| Jones, A | 1 |
| Beraha, EM | 1 |
| Salemink, E | 1 |
| Krediet, E | 1 |
| Wiers, RW | 1 |
| Minozzi, S | 1 |
| Saulle, R | 1 |
| Rösner, S | 1 |
| Stratton, MS | 1 |
| Staros, M | 1 |
| Budefeld, T | 1 |
| Searcy, BT | 1 |
| Nash, C | 1 |
| Eitel, C | 1 |
| Carbone, D | 1 |
| Handa, RJ | 1 |
| Majdic, G | 1 |
| Tobet, SA | 1 |
| Rigal, L | 1 |
| Legay Hoang, L | 1 |
| Alexandre-Dubroeucq, C | 1 |
| Pinot, J | 1 |
| Le Jeunne, C | 1 |
| Jaury, P | 1 |
| Krupitsky, EM | 1 |
| Rybakova, KV | 1 |
| Kiselev, AS | 1 |
| Alexeeva, YV | 1 |
| Berntsev, VA | 1 |
| Chekhlaty, EI | 1 |
| Zubova, EY | 1 |
| Popov, YV | 1 |
| Neznanov, NG | 1 |
| Nazari, SK | 1 |
| Nikoui, V | 1 |
| Ostadhadi, S | 1 |
| Chegini, ZH | 1 |
| Oryan, S | 1 |
| Bakhtiarian, A | 1 |
| Dubrovina, NI | 3 |
| Zinov'ev, DR | 2 |
| Kheifez, IA | 1 |
| Molodavkin, GM | 1 |
| Voronina, TA | 1 |
| Dugina, YL | 1 |
| Sergeeva, SA | 1 |
| Epstein, OI | 1 |
| Garbutt, JC | 1 |
| Kampov-Polevoy, AB | 1 |
| Gallop, R | 1 |
| Kalka-Juhl, L | 1 |
| Flannery, BA | 1 |
| Pangilinan, PH | 1 |
| Giacoletti-Argento, A | 1 |
| Shellhaas, R | 1 |
| Hurvitz, EA | 1 |
| Hornyak, JE | 1 |
| Corwin, RL | 1 |
| Boan, J | 1 |
| Peters, KF | 1 |
| Ulbrecht, JS | 1 |
| Marshall, FH | 1 |
| Badr, GG | 1 |
| Matousek, M | 1 |
| Frederiksen, PK | 1 |
| Nakagawa, Y | 1 |
| Ishima, T | 1 |
| Ishibashi, Y | 1 |
| Tsuji, M | 1 |
| Takashima, T | 1 |
| Bigelow, LB | 1 |
| Nasrallah, H | 1 |
| Carman, J | 1 |
| Gillin, JC | 1 |
| Wyatt, RJ | 1 |
| Marchesi, C | 1 |
| Chiodera, P | 1 |
| De Ferri, A | 1 |
| De Risio, C | 1 |
| Dassó, L | 1 |
| Menozzi, P | 1 |
| Volpi, R | 1 |
| Coiro, V | 1 |
4 reviews available for baclofen and Depression
| Article | Year |
|---|---|
Baclofen: its effectiveness in reducing harmful drinking, craving, and negative mood. A meta-analysis.
Topics: Affect; Alcohol Abstinence; Alcohol Drinking; Alcoholism; Anxiety; Baclofen; Craving; Depression; GA | 2018 |
Baclofen for alcohol use disorder.
Topics: Acamprosate; Alcohol Deterrents; Alcohol Drinking; Alcoholism; Baclofen; Craving; Depression; Female | 2018 |
Neuropharmacology in pediatric brain injury: a review.
Topics: Adolescent; Adrenergic beta-Antagonists; Anticonvulsants; Antidepressive Agents; Antipsychotic Agent | 2010 |
Is the GABA B heterodimer a good drug target?
Topics: Animals; Baclofen; Brain; Cognition Disorders; Depression; Dimerization; GABA Agonists; GABA Antagon | 2005 |
6 trials available for baclofen and Depression
| Article | Year |
|---|---|
Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein?
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Anxiety; Anxiety Disorders; Attentional Bias; | 2018 |
[Double blind placebo controlled randomized pilot clinical trial of baclofen (Baclosan®) for alcohol dependence].
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Anxiety; Baclofen; Depression; Double-Blind M | 2015 |
Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Alcohol Drinking; Alcoholism; Anxiety; Baclofen; Depression; Double-Blind Method; | 2010 |
Baclofen reduces binge eating in a double-blind, placebo-controlled, crossover study.
Topics: Adult; Anxiety; Baclofen; Binge-Eating Disorder; Cross-Over Studies; Depression; Double-Blind Method | 2012 |
Baclofen treatment in chronic schizophrenia: a clinical trial.
Topics: Adult; Aminobutyrates; Arousal; Baclofen; Chronic Disease; Clinical Trials as Topic; Depression; Dru | 1977 |
Reduction of GH response to the GABA-B agonist baclofen in patients with major depression.
Topics: Adult; Aged; Baclofen; Depression; Growth Hormone; Humans; Male; Middle Aged; Radioimmunoassay; Rece | 1991 |
10 other studies available for baclofen and Depression
| Article | Year |
|---|---|
The impact of GABA
Topics: Animals; Baclofen; Behavior, Addictive; Behavior, Animal; Brain; Central Nervous System Stimulants; | 2020 |
Embryonic GABA(B) receptor blockade alters cell migration, adult hypothalamic structure, and anxiety- and depression-like behaviors sex specifically in mice.
Topics: Animals; Anxiety; Baclofen; Cell Movement; Depression; Embryo, Mammalian; Female; GABA-B Receptor An | 2014 |
Tolerability of High-dose Baclofen in the Treatment of Patients with Alcohol Disorders: A Retrospective Study.
Topics: Adult; Alcoholism; Baclofen; Depression; Dose-Response Relationship, Drug; Female; GABA-B Receptor A | 2015 |
Possible involvement of ATP-sensitive potassium channels in the antidepressant-like effect of baclofen in mouse forced swimming test.
Topics: Animals; Antidepressive Agents; Baclofen; Depression; Dose-Response Relationship, Drug; GABA-B Recep | 2016 |
Contribution of GABA receptors to extinction of memory traces in normal conditions and in a depression-like state.
Topics: Animals; Avoidance Learning; Baclofen; Bicuculline; Depression; Dose-Response Relationship, Drug; Ex | 2008 |
Involvement of the GABA-B system in the mechanism of action of ultralow-dose antibodies to S-100 protein.
Topics: Animals; Anti-Anxiety Agents; Antibodies; Antidepressive Agents; Anxiety; Baclofen; Depression; Diaz | 2008 |
[Fear memory extinction accelerated by simultaneous activation of GABA(B) and NMDA receptors].
Topics: Animals; Antimetabolites; Avoidance Learning; Baclofen; Cycloserine; Depression; Extinction, Psychol | 2012 |
[Contribution of GABA receptors in extinction of memory trace in norm and depressive-like state].
Topics: Animals; Baclofen; Behavior, Animal; Bicuculline; Depression; Fear; GABA Agonists; GABA Antagonists; | 2007 |
A quantitative EEG analysis of the effects of baclofen on man.
Topics: Adult; Aged; Baclofen; Brain; Computers; Depression; Electroencephalography; Humans; Male; Middle Ag | 1983 |
Involvement of GABAB receptor systems in experimental depression: baclofen but not bicuculline exacerbates helplessness in rats.
Topics: Animals; Baclofen; Bicuculline; Depression; Electroshock; GABA Agonists; GABA Antagonists; Helplessn | 1996 |