baclofen and Conjugate Nystagmus studies

Research Excerpts

Excerpt	Relevance	Reference
"To determine the exact role of GAD-Ab and gamma-aminobutyric acid (GABA)-ergic neurotransmission in the pathogenesis of cerebellar ataxia."	3.73	Anti-GAD antibodies and periodic alternating nystagmus. ( Honnorat, J; Tilikete, C; Trouillas, P; Vighetto, A, 2005)
"Acquired brain injury can cause eye movement disorders which may include: strabismus, gaze deficits and nystagmus, causing visual symptoms of double, blurred or 'juddery' vision and reading difficulties."	2.58	Interventions for eye movement disorders due to acquired brain injury. ( Dodridge, CS; Evans, JR; Garcia-Finana, M; Hanna, K; Howard, C; Jarvis, KA; Maan, T; MacDiarmid, SL; Noonan, CP; North, L; Rodgers, H; Rowe, FJ, 2018)
"Acquired pendular nystagmus may respond to gabapentin or memantine; downbeat and upbeat nystagmus to aminopyridines; and periodic alternating nystagmus to baclofen."	2.48	The pharmacological treatment of acquired nystagmus. ( Kennard, C; Mehta, AR, 2012)
"This, in turn, leads to several eye movement disorders, including spontaneous downbeat (DBN) and periodic alternating nystagmus."	1.48	Disabling Central Paroxysmal Positioning Upbeat Nystagmus and Vertigo Associated With the Presence of Anti-Glutamic Acid Decarboxylase Antibodies. ( Amorim, AM; Carvalho, JN; Eggenberger, E; Geraldo, A; Lemos, J; Martins, AI, 2018)
"Acquired pendular nystagmus (APN) occurs with multiple sclerosis (MS) and oculopalatal tremor (OPT); distinct features of the nystagmus have led to the development of separate models for their pathogenesis."	1.37	Pharmacological tests of hypotheses for acquired pendular nystagmus. ( Leigh, RJ; Optican, LM; Shaikh, AG; Thurtell, MJ, 2011)
"A case of Wernicke's encephalopathy due to proven thiamine deficiency suffering from upbeat nystagmus (UN) changing to downbeat nystagmus (DN) after a latency of 1 year is presented."	1.32	Presumed pharmacologically induced change from upbeat- to downbeat nystagmus in a patient with Wernicke's encephalopathy. ( Diener, HC; Kastrup, O; Keidel, M; Maschke, M, 2004)
"Periodic alternating nystagmus is a rare central nervous system disorder in which the eyes undergo a horizontal jerk nystagmus that periodically reverses direction."	1.31	Periodic alternating nystagmus provoked by an attack of Ménière's disease. ( Chiu, B; Hain, TC, 2002)
"Acquired Pendular Nystagmus (APN) may cause distressing visual symptoms in patients who are already suffering a severe general disease."	1.31	Improvement of acquired pendular nystagmus by gabapentin: case report. ( Fabre, K; Smet-Dieleman, H; Zeyen, T, 2001)
"Baclofen treatment was unsuccessful."	1.30	Congenital periodic alternating nystagmus. Diagnosis and Management. ( Goldstein, HP; Gradstein, L; Reinecke, RD; Wizov, SS, 1997)
"Macro square wave jerks and pendular nystagmus were mildly suppressed after the intramuscular injection of 100 mg of phenobarbital, the oral intake of sodium valproate of 600 mg/day or baclofen of 60 mg/day."	1.28	[Multiple system atrophy with macro square wave jerks and pendular nystagmus]. ( Fukusako, T; Morimatsu, M; Nogaki, H; Yamamoto, K, 1992)
"Horizontal jerk nystagmus is indicative of a disorder involving the vestibular system."	1.27	Periodic alternating nystagmus. ( DiBartolomeo, JR; Yee, RD, 1988)
"We report two cases of non periodic alternating nystagmus, one of vascular origin (ischemia of the vertebrobasilar territory) and a second of traumatic origin (whiplash injury) with otoneurological signs, typical of lesions in posterior cranial fossa and in particular of vestibulum-cerebellum and brainstem: gaze paretic nystagmus, rebound nystagmus, saccadic dysmetria, vestibular hyperreflexia and impaired visual suppression test."	1.27	Aperiodic alternating nystagmus: report of two cases and treatment by baclofen. ( Ciacci, G; Federico, A; Giannini, F; Nuti, D; Rossi, A, 1986)
"A case of periodic alternating nystagmus (PAN), probably of congenital type, was reported."	1.27	A case of periodic alternating nystagmus: with a special reference to the efficacy of baclofen treatment. ( Isago, H; Kataura, A; Tsuboya, R, 1985)
"Two patients with longstanding acquired periodic alternating nystagmus (PAN) were treated with baclofen, 30 mg/day."	1.26	Treatment of periodic alternating nystagmus. ( Gresty, MA; Halmagyi, GM; Leigh, RJ; Rudge, P; Zee, DS, 1980)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (26.47)	18.7374
1990's	7 (20.59)	18.2507
2000's	12 (35.29)	29.6817
2010's	6 (17.65)	24.3611
2020's	0 (0.00)	2.80

Trial	Enrollment	Study Type	Start Date	Status
Examining the Effect of Eye Gaze Technology on Children With Cortical Visual Impairment and Its Impact on Occupational Performance[NCT06067607]	10 participants (Anticipated)	Interventional	2023-02-01	Recruiting
Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187]	8 participants (Actual)	Interventional	2009-11-30	Terminated (stopped due to PI left institution)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Interventions for eye movement disorders due to acquired brain injury. The Cochrane database of systematic reviews, 2018, 03-05, Volume: 3 Topics: 4-Aminopyridine; Abducens Nerve Diseases; Amifampridine; Amines; Baclofen; Botulinum Toxins; Brain I	2018
[Pharmacotherapy of central oculomotor disorders]. Der Nervenarzt, 2008, Volume: 79, Issue:12 Topics: 4-Aminopyridine; Amifampridine; Amines; Baclofen; Cyclohexanecarboxylic Acids; Diagnosis, Differenti	2008
[Nystagmus in ophthalmology]. La Clinica terapeutica, 2009, Volume: 160, Issue:2 Topics: Amines; Baclofen; Cyclohexanecarboxylic Acids; Diagnostic Techniques, Ophthalmological; Eye Diseases	2009
The pharmacological treatment of nystagmus: a review. Expert opinion on pharmacotherapy, 2009, Volume: 10, Issue:11 Topics: Amines; Animals; Baclofen; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans;	2009
The pharmacological treatment of acquired nystagmus. Practical neurology, 2012, Volume: 12, Issue:3 Topics: Amines; Aminopyridines; Baclofen; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid;	2012
Medical treatment of acquired nystagmus. Current opinion in ophthalmology, 2012, Volume: 23, Issue:6 Topics: 4-Aminopyridine; Baclofen; GABA-B Receptor Agonists; Humans; Nystagmus, Pathologic; Potassium Channe	2012

Article	Year
Disabling Central Paroxysmal Positioning Upbeat Nystagmus and Vertigo Associated With the Presence of Anti-Glutamic Acid Decarboxylase Antibodies. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2018, Volume: 38, Issue:1 Topics: Aged; Autoantibodies; Baclofen; Diabetes Mellitus, Type 1; Female; GABA-B Receptor Agonists; Glutama	2018
[Pharmacological treatment of nystagmus]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2011, Volume: 108, Issue:2 Topics: 4-Aminopyridine; Amines; Anticonvulsants; Baclofen; Cyclohexanecarboxylic Acids; Dopamine Agents; Ga	2011
Pharmacological tests of hypotheses for acquired pendular nystagmus. Annals of the New York Academy of Sciences, 2011, Volume: 1233 Topics: Amines; Baclofen; Cerebellar Cortex; Cyclohexanecarboxylic Acids; Eye Movements; Gabapentin; gamma-A	2011
Periodic alternating nystagmus provoked by an attack of Ménière's disease. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2002, Volume: 22, Issue:2 Topics: Baclofen; Electronystagmography; GABA Agonists; Humans; Magnetic Resonance Imaging; Male; Meniere Di	2002
Improvement of acquired pendular nystagmus by gabapentin: case report. Bulletin de la Societe belge d'ophtalmologie, 2001, Issue:282 Topics: Acetates; Administration, Oral; Amines; Baclofen; Cyclohexanecarboxylic Acids; Female; Gabapentin; g	2001
Lithium-induced periodic alternating nystagmus. Neurology, 2003, Jan-28, Volume: 60, Issue:2 Topics: Antidepressive Agents, Second-Generation; Antimanic Agents; Baclofen; Bipolar Disorder; Female; Fluo	2003
Presumed pharmacologically induced change from upbeat- to downbeat nystagmus in a patient with Wernicke's encephalopathy. Clinical neurology and neurosurgery, 2004, Volume: 107, Issue:1 Topics: Adult; Baclofen; Electronystagmography; Female; GABA Agonists; Humans; Nystagmus, Pathologic; Reflex	2004
Anti-GAD antibodies and periodic alternating nystagmus. Archives of neurology, 2005, Volume: 62, Issue:8 Topics: Aged; Autoantibodies; Baclofen; Cerebellar Ataxia; Cerebellum; Female; GABA Agonists; gamma-Aminobut	2005
Survey of management of acquired nystagmus in the United Kingdom. Eye (London, England), 2007, Volume: 21, Issue:9 Topics: Amines; Baclofen; Cyclohexanecarboxylic Acids; Drug Utilization; Excitatory Amino Acid Antagonists;	2007
Periodic alternating nystagmus with circumscribed nodular lesion. Neurology, 2006, Aug-08, Volume: 67, Issue:3 Topics: Adult; Baclofen; Dizziness; Ependymoma; Fourth Ventricle; Humans; Male; Nystagmus, Pathologic; Surgi	2006
Head-shaking nystagmus and new technology. Neurology, 2007, Apr-24, Volume: 68, Issue:17 Topics: Baclofen; Brain Stem Infarctions; Diagnosis, Differential; Dominance, Cerebral; GABA Agonists; Head	2007
Head-shaking nystagmus in lateral medullary infarction: patterns and possible mechanisms. Neurology, 2007, Apr-24, Volume: 68, Issue:17 Topics: Adult; Afferent Pathways; Aged; Baclofen; Brain Stem Infarctions; Caloric Tests; Diagnosis, Differen	2007
Baclofen as a treatment for nystagmus. Annals of neurology, 1982, Volume: 11, Issue:2 Topics: Aged; Baclofen; Humans; Male; Nystagmus, Pathologic	1982
Periodic alternating nystagmus in a case of hereditary ataxia and its treatment with baclofen. Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:10 Topics: Adult; Baclofen; Cerebellar Ataxia; Humans; Male; Nystagmus, Pathologic; Periodicity	1982
Periodic alternating nystagmus in a case of hereditary ataxia and its treatment with baclofen. Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:12 Topics: Adult; Baclofen; Cerebellar Ataxia; Genes, Dominant; Humans; Male; Nystagmus, Pathologic	1982
[The action of baclofen on periodic alternating nystagmus. Current perspectives in the treatment of certain forms of nystagmus]. Bulletins et memoires de la Societe francaise d'ophtalmologie, 1982, Volume: 94 Topics: Baclofen; Eye Movements; Humans; Male; Middle Aged; Multiple Sclerosis; Nystagmus, Pathologic	1982
Treatment of periodic alternating nystagmus. Annals of neurology, 1980, Volume: 8, Issue:6 Topics: Adult; Baclofen; Female; Humans; Male; Nystagmus, Pathologic	1980
Congenital periodic alternating nystagmus. Diagnosis and Management. Ophthalmology, 1997, Volume: 104, Issue:6 Topics: Adolescent; Adult; Aged; Albinism, Ocular; Albinism, Oculocutaneous; Baclofen; Child; Child, Prescho	1997
Effects of the GABA agonists baclofen and THIP on long-term compensation in hemilabyrinthectomised rats. Brain research, 1998, Jun-08, Volume: 795, Issue:1-2 Topics: Animals; Baclofen; Ear, Inner; Eye Movements; Functional Laterality; GABA Agonists; Isoxazoles; Magn	1998
[Multiple system atrophy with macro square wave jerks and pendular nystagmus]. Rinsho shinkeigaku = Clinical neurology, 1992, Volume: 32, Issue:11 Topics: Atrophy; Baclofen; Brain Diseases; Diazepam; Electrooculography; Eye Movements; Female; Humans; Midd	1992
Treatment of acquired intermittent horizontal jerk nystagmus with baclofen. American journal of ophthalmology, 1992, Sep-15, Volume: 114, Issue:3 Topics: Baclofen; Child; Eye Movements; Humans; Male; Nystagmus, Pathologic	1992
The effects of baclofen and cholinergic drugs on upbeat and downbeat nystagmus. Journal of neurology, neurosurgery, and psychiatry, 1991, Volume: 54, Issue:7 Topics: Adult; Aged; Baclofen; Biperiden; Cerebellum; Electrooculography; Female; Humans; Male; Middle Aged;	1991
Periodic alternating oscillopsia: a symptom of alternating nystagmus abolished by baclofen. Journal of clinical neuro-ophthalmology, 1990, Volume: 10, Issue:4 Topics: Baclofen; Eye Movements; Female; Humans; Middle Aged; Nystagmus, Pathologic; Posture; Vision Disorde	1990
Periodic alternating nystagmus. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1988, Volume: 99, Issue:6 Topics: Baclofen; Electronystagmography; Humans; Labyrinth Diseases; Magnetic Resonance Imaging; Male; Middl	1988
The effects of baclofen on periodic alternating nystagmus and experimentally induced nystagmus. Advances in oto-rhino-laryngology, 1988, Volume: 42 Topics: Baclofen; Electrooculography; Female; Humans; Middle Aged; Nystagmus, Pathologic; Nystagmus, Physiol	1988
Aperiodic alternating nystagmus: report of two cases and treatment by baclofen. Italian journal of neurological sciences, 1986, Volume: 7, Issue:4 Topics: Aged; Baclofen; Electroencephalography; Electronystagmography; Humans; Male; Middle Aged; Nystagmus,	1986
A case of periodic alternating nystagmus: with a special reference to the efficacy of baclofen treatment. Auris, nasus, larynx, 1985, Volume: 12, Issue:1 Topics: Adult; Baclofen; Electronystagmography; Female; Humans; Nystagmus, Pathologic; Pursuit, Smooth; Sacc	1985

baclofen and Conjugate Nystagmus

Research Excerpts

Research

Studies (34)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Martins, AI	1
Carvalho, JN	1
Amorim, AM	1
Geraldo, A	1
Eggenberger, E	2
Lemos, J	1
Rowe, FJ	1
Hanna, K	1
Evans, JR	1
Noonan, CP	1
Garcia-Finana, M	1
Dodridge, CS	1
Howard, C	1
Jarvis, KA	1
MacDiarmid, SL	1
Maan, T	1
North, L	1
Rodgers, H	1
Kalla, R	1
Spiegel, R	1
Wagner, J	1
Rettinger, N	1
Jahn, K	1
Strupp, M	1
Nebbioso, M	1
D'Innocenzo, D	1
Rapone, S	1
Di Benedetto, G	1
Grenga, R	1
McLean, RJ	1
Gottlob, I	2
Pieh-Beisse, C	1
Lagrèze, WA	1
Shaikh, AG	1
Thurtell, MJ	1
Optican, LM	1
Leigh, RJ	3
Mehta, AR	1
Kennard, C	1
Ehrhardt, D	1
Chiu, B	1
Hain, TC	2
Fabre, K	1
Smet-Dieleman, H	1
Zeyen, T	1
Lee, MS	1
Lessell, S	1
Kastrup, O	1
Maschke, M	1
Keidel, M	1
Diener, HC	1
Tilikete, C	1
Vighetto, A	1
Trouillas, P	1
Honnorat, J	1
Choudhuri, I	1
Sarvananthan, N	1
Oh, YM	1
Choi, KD	2
Oh, SY	2
Kim, JS	2
Park, SH	1
Kim, JH	1
Koo, JW	1
Larmande, P	2
Plant, GT	2
Larmande, A	1
Halmagyi, GM	1
Rudge, P	1
Gresty, MA	1
Zee, DS	1
Gradstein, L	1
Reinecke, RD	1
Wizov, SS	1
Goldstein, HP	1
Averbuch-Heller, L	1
Tusa, RJ	1
Fuhry, L	1
Rottach, KG	1
Ganser, GL	1
Heide, W	1
Büttner, U	2
Magnusson, AK	1
Eriksson, B	1
Tham, R	1
Yamamoto, K	1
Fukusako, T	1
Nogaki, H	1
Morimatsu, M	1
Miller, BA	1
Younger, DA	1
Friendly, DS	1
Dieterich, M	1
Straube, A	1
Brandt, T	1
Paulus, W	1
Troost, BT	1
Janton, F	1
Weaver, R	1
DiBartolomeo, JR	1
Yee, RD	1
Uemura, T	1
Inoue, H	1
Hirano, T	1
Nuti, D	1
Ciacci, G	1
Giannini, F	1
Rossi, A	1
Federico, A	1
Isago, H	1
Tsuboya, R	1
Kataura, A	1