baclofen has been researched along with Chemical Dependence in 38 studies
Excerpt | Relevance | Reference |
---|---|---|
"Baclofen has been shown to decrease self-administration of GHB in mice and reduce relapse in a case series of GHB-dependent patients." | 2.87 | Baclofen to Prevent Relapse in Gamma-Hydroxybutyrate (GHB)-Dependent Patients: A Multicentre, Open-Label, Non-Randomized, Controlled Trial. ( Beurmanjer, H; de Jong, CAJ; Dijkstra, BAG; Kamal, RM; Schellekens, AFA, 2018) |
"Baclofen was well tolerated; patients reported mild side effects such as fatigue, nausea, dry mouth, excessive sweating, and depressive feelings." | 2.80 | Baclofen as relapse prevention in the treatment of gamma-hydroxybutyrate dependence: a case series. ( De Jong, CA; Dijkstra, BA; Kamal, RM; Loonen, AJ, 2015) |
"Baclofen is a psychotropic drug and its recreational use among adolescents and young adults represent a serious problem and should be considered by healthcare professionals." | 2.66 | Baclofen overdose following recreational use in adolescents and young adults: A case report and review of the literature. ( Abbara, C; Beloncle, F; Briet, M; Drevin, G; Ghamrawi, S, 2020) |
"The primary analysis quantified opioid overdose risk across 7 prescription opioid-skeletal muscle relaxant therapies and a negative control outcome (sepsis) to assess potential confounding by unmeasured illicit opioid use." | 1.72 | Comparative Risk of Opioid Overdose With Concomitant Use of Prescription Opioids and Skeletal Muscle Relaxants. ( Barnett, ML; Bykov, K; Gagne, JJ; Glynn, RJ; Khan, NF; Vine, SM, 2022) |
"Baclofen (BLF) has been prescribed in the UK since 1972 for the alleviation of spasticity." | 1.62 | Baclofen: To Screen or Not to Screen in Postmortem Blood? ( Murphy, KG; Nahar, LK; Paterson, S, 2021) |
" At 100 mg/kg, CGP35348 shifted the dose-response curves of baclofen and SKF97541 to the right but not those of GHB and GBL; at 320 mg/kg, CGP35348 shifted the curves of all four compounds to the right." | 1.34 | Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348. ( Coop, A; Koek, W; Mercer, SL, 2007) |
"Pretreatment with baclofen (1." | 1.32 | Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat. ( Collu, M; Fadda, P; Fratta, W; Fresu, A; Scherma, M, 2003) |
" In contrast to earlier reports, no increase in the plasma half-life of elimination of baclofen could be observed (t1/2 = 4." | 1.27 | Pharmacokinetics in baclofen overdose. ( Anderson, P; Nohér, H; Swahn, CG, 1984) |
"We present the case of a spastic quadriplegic who developed mental symptoms which resolved when his Baclofen was discontinued." | 1.27 | Reversible electroencephalogram changes associated with administration of baclofen in a quadriplegic patient: case report. ( Lee, L; Riley, TL; Wainapel, SF, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (21.05) | 18.7374 |
1990's | 1 (2.63) | 18.2507 |
2000's | 11 (28.95) | 29.6817 |
2010's | 13 (34.21) | 24.3611 |
2020's | 5 (13.16) | 2.80 |
Authors | Studies |
---|---|
Khan, NF | 1 |
Bykov, K | 1 |
Barnett, ML | 1 |
Glynn, RJ | 1 |
Vine, SM | 1 |
Gagne, JJ | 1 |
Reynoard, J | 1 |
Schmitt, C | 1 |
Torrents, R | 1 |
Simon, N | 1 |
Nahar, LK | 1 |
Murphy, KG | 1 |
Paterson, S | 1 |
Drevin, G | 1 |
Briet, M | 1 |
Ghamrawi, S | 1 |
Beloncle, F | 1 |
Abbara, C | 1 |
Joshi, YB | 1 |
Friend, SF | 1 |
Jimenez, B | 1 |
Steiger, LR | 1 |
Hamel Sénécal, L | 1 |
Chrétien, B | 1 |
Jean-Jacques, PY | 1 |
Lelong Boulouard, V | 1 |
Cohen, D | 1 |
Le Boisselier, R | 1 |
Beurmanjer, H | 1 |
Kamal, RM | 3 |
de Jong, CAJ | 1 |
Dijkstra, BAG | 1 |
Schellekens, AFA | 1 |
Hardman, MI | 1 |
Sprung, J | 1 |
Weingarten, TN | 1 |
Paino, M | 1 |
Aletraris, L | 1 |
Roman, PM | 1 |
Agabio, R | 1 |
Preti, A | 1 |
Gessa, GL | 1 |
Masi, G | 1 |
Mucci, M | 1 |
Liboni, F | 1 |
Ferrari, A | 1 |
Sicca, F | 1 |
Phillips, TJ | 1 |
Reed, C | 1 |
Besson, J | 1 |
Khazaal, Y | 1 |
Tomei, A | 1 |
Grivel, J | 1 |
Zullino, D | 1 |
Loonen, AJ | 1 |
Dijkstra, BA | 2 |
De Jong, CA | 2 |
Schellekens, A | 1 |
Miranda, F | 1 |
Jiménez, JC | 1 |
Cedillo, LN | 1 |
Sandoval-Sánchez, A | 1 |
Millán-Mejía, P | 1 |
Sánchez-Castillo, H | 1 |
Velázquez-Martínez, DN | 1 |
Bell, J | 1 |
Collins, R | 1 |
Lile, JA | 1 |
Kelly, TH | 1 |
Hays, LR | 1 |
Samokhvalov, AV | 1 |
Paton-Gay, CL | 1 |
Balchand, K | 1 |
Rehm, J | 1 |
Fadda, P | 1 |
Scherma, M | 1 |
Fresu, A | 1 |
Collu, M | 1 |
Fratta, W | 1 |
Bartoletti, M | 2 |
Gubellini, C | 1 |
Ricci, F | 2 |
Gaiardi, M | 2 |
Bowery, NG | 1 |
Heinzerling, KG | 1 |
Shoptaw, S | 2 |
Peck, JA | 1 |
Yang, X | 1 |
Liu, J | 1 |
Roll, J | 1 |
Ling, W | 3 |
Rawson, R | 1 |
Koek, W | 1 |
Mercer, SL | 1 |
Coop, A | 1 |
Ameisen, O | 1 |
Abramson, SI | 1 |
Holmes, AA | 1 |
Hagberg, CA | 1 |
DeFeudis, FV | 1 |
Anderson, P | 1 |
Nohér, H | 1 |
Swahn, CG | 1 |
Seyfert, S | 2 |
Straschill, M | 1 |
May, CR | 1 |
Haubenstock, A | 1 |
Hruby, K | 1 |
Jäger, U | 1 |
Lenz, K | 1 |
Kraft, D | 1 |
Wagner, K | 1 |
Xi, ZX | 1 |
Stein, EA | 1 |
Cousins, MS | 1 |
Roberts, DC | 1 |
de Wit, H | 1 |
Hulinder, B | 1 |
Ostman, O | 1 |
Wainapel, SF | 1 |
Lee, L | 1 |
Riley, TL | 1 |
8 reviews available for baclofen and Chemical Dependence
Article | Year |
---|---|
Toxicological considerations in the prescription of baclofen for the treatment of substance use disorders.
Topics: Alcoholism; Baclofen; Dose-Response Relationship, Drug; GABA-B Receptor Agonists; Humans; Off-Label | 2020 |
Baclofen overdose following recreational use in adolescents and young adults: A case report and review of the literature.
Topics: Adolescent; Baclofen; Chromatography, Liquid; Drug Overdose; GABA-B Receptor Agonists; Humans; Male; | 2020 |
Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.
Topics: Akathisia, Drug-Induced; Baclofen; Cyproheptadine; Dexmedetomidine; Diphenhydramine; GABA-A Receptor | 2019 |
Efficacy and tolerability of baclofen in substance use disorders: a systematic review.
Topics: Baclofen; GABA-B Receptor Agonists; Humans; Randomized Controlled Trials as Topic; Substance Withdra | 2013 |
Targeting GABAB receptors for anti-abuse drug discovery.
Topics: Animals; Baclofen; Drug Discovery; Humans; Receptors, GABA-B; Substance-Related Disorders | 2014 |
GABAB receptor: a site of therapeutic benefit.
Topics: Animals; Baclofen; Brain; Clinical Trials as Topic; Cognition; Drug Evaluation, Preclinical; Epileps | 2006 |
Management of methamphetamine abuse and dependence.
Topics: Baclofen; Benzhydryl Compounds; Brain; Bupropion; Cognition Disorders; Cognitive Behavioral Therapy; | 2006 |
GABA(B) receptor agonists for the treatment of drug addiction: a review of recent findings.
Topics: Animals; Baclofen; Brain; Dopamine; GABA Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid | 2002 |
4 trials available for baclofen and Chemical Dependence
Article | Year |
---|---|
Baclofen to Prevent Relapse in Gamma-Hydroxybutyrate (GHB)-Dependent Patients: A Multicentre, Open-Label, Non-Randomized, Controlled Trial.
Topics: Adult; Ambulatory Care; Baclofen; Female; GABA-B Receptor Agonists; Humans; Male; Secondary Preventi | 2018 |
Baclofen as relapse prevention in the treatment of gamma-hydroxybutyrate dependence: a case series.
Topics: Adult; Anesthetics; Baclofen; Drug Administration Schedule; Female; GABA-B Receptor Agonists; Humans | 2015 |
Baclofen as relapse prevention in the treatment of Gamma- Hydroxybutyrate (GHB) dependence: an open label study.
Topics: Adult; Baclofen; Clinical Protocols; Craving; Female; GABA Agonists; Humans; Male; Quality of Life; | 2015 |
Randomized, placebo-controlled trial of baclofen and gabapentin for the treatment of methamphetamine dependence.
Topics: Adult; Amines; Anti-Anxiety Agents; Baclofen; Central Nervous System Stimulants; Cyclohexanecarboxyl | 2006 |
26 other studies available for baclofen and Chemical Dependence
Article | Year |
---|---|
Comparative Risk of Opioid Overdose With Concomitant Use of Prescription Opioids and Skeletal Muscle Relaxants.
Topics: Amitriptyline; Analgesics, Opioid; Baclofen; Benzodiazepines; Carisoprodol; Chlorzoxazone; Cohort St | 2022 |
Baclofen: To Screen or Not to Screen in Postmortem Blood?
Topics: Autopsy; Baclofen; Gabapentin; Humans; Pregabalin; Substance-Related Disorders | 2021 |
Dissociative Intoxication and Prolonged Withdrawal Associated With Phenibut: A Case Report.
Topics: Adult; Baclofen; Delirium; GABA Agonists; gamma-Aminobutyric Acid; Humans; Male; Substance Withdrawa | 2017 |
A Case of Drug Dependence Syndrome to Baclofen Following High-Dose Therapy.
Topics: Baclofen; Female; GABA-B Receptor Agonists; Humans; Middle Aged; Substance Withdrawal Syndrome; Subs | 2018 |
The use of off-label medications in substance abuse treatment programs.
Topics: Accreditation; Adrenergic alpha-2 Receptor Agonists; Anticonvulsants; Antiemetics; Baclofen; Clonidi | 2020 |
Self-induced multiple comas with recreational baclofen overdoses in an adolescent girl.
Topics: Adolescent; Baclofen; Coma; Diagnostic Errors; Drug Overdose; Female; Humans; Muscle Relaxants, Cent | 2013 |
[Addiction].
Topics: Alcoholism; Baclofen; Cell Phone; Empathy; GABA-B Receptor Agonists; Humans; Substance-Related Disor | 2015 |
The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure.
Topics: Animals; Baclofen; Central Nervous System Stimulants; Conditioning, Psychological; Dextroamphetamine | 2009 |
Gamma-butyrolactone (GBL) dependence and withdrawal.
Topics: 4-Butyrolactone; Adult; Ambulatory Care; Baclofen; Delirium; Diazepam; Dose-Response Relationship, D | 2011 |
Separate and combined effects of the GABA(B) agonist baclofen and Δ9-THC in humans discriminating Δ9-THC.
Topics: Adolescent; Adult; Baclofen; Blood Pressure; Body Temperature; Body Temperature Regulation; Demograp | 2012 |
Phenibut dependence.
Topics: Adult; Baclofen; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; | 2013 |
Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat.
Topics: Animals; Baclofen; Cocaine; Dopamine; Dose-Response Relationship, Drug; Extracellular Fluid; GABA Ag | 2003 |
The GABAB agonist baclofen blocks the expression of sensitisation to the locomotor stimulant effect of amphetamine.
Topics: Amphetamine; Animals; Baclofen; Central Nervous System Stimulants; GABA Agonists; Male; Motor Activi | 2004 |
A GABA(B) agonist reverses the behavioral sensitization to morphine in rats.
Topics: Animals; Baclofen; Behavior, Animal; Drug Administration Schedule; Drug Delivery Systems; GABA Agoni | 2007 |
Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348.
Topics: 4-Butyrolactone; Animals; Baclofen; Catalepsy; Dose-Response Relationship, Drug; GABA Agonists; GABA | 2007 |
Baclofen as a craving-suppressing agent.
Topics: Baclofen; GABA Agonists; Humans; Substance-Related Disorders | 2007 |
Awake insertion of the Bonfils Retromolar Intubation Fiberscope in five patients with anticipated difficult airways.
Topics: Accidents, Traffic; Adult; Aged; Baclofen; Body Size; Cervical Vertebrae; Equipment Design; Fiber Op | 2008 |
gamma-Aminobutyric acid-ergic analgesia: implications for gamma-aminobutyric acid-ergic therapy for drug addictions.
Topics: Animals; Baclofen; Brain; Drug Tolerance; Endorphins; GABA Antagonists; gamma-Aminobutyric Acid; Hum | 1984 |
Pharmacokinetics in baclofen overdose.
Topics: Absorption; Administration, Oral; Adult; Baclofen; Blood Gas Analysis; Female; Gas Chromatography-Ma | 1984 |
[Electroencephalographic changes induced by baclofen].
Topics: Adult; Aged; Baclofen; Electroencephalography; Evoked Potentials; Female; Humans; Male; Middle Aged; | 1982 |
Baclofen overdose.
Topics: Adult; Baclofen; Female; Humans; Substance-Related Disorders | 1983 |
Baclofen (Lioresal) intoxication report of 4 cases and review of the literature.
Topics: Adult; Aged; Baclofen; Female; Humans; Male; Middle Aged; Substance-Related Disorders | 1983 |
[Baclofen toxicity during intermittent renal dialysis (author's transl)].
Topics: Adult; Baclofen; Electroencephalography; Female; Humans; Kidney Failure, Chronic; Middle Aged; Renal | 1981 |
Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release.
Topics: Animals; Baclofen; Behavior, Animal; Dopamine; Electrodes; GABA Agonists; Heroin; Limbic System; Mal | 1999 |
[Baclofen--a new agent used by addicts].
Topics: Adult; Baclofen; Humans; Male; Middle Aged; Substance-Related Disorders | 1987 |
Reversible electroencephalogram changes associated with administration of baclofen in a quadriplegic patient: case report.
Topics: Adult; Baclofen; Cervical Vertebrae; Delta Rhythm; Electroencephalography; Fractures, Bone; Humans; | 1986 |