baclofen has been researched along with Cerebral Ischemia in 16 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 7.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "We investigated the neuroprotective effects of vinconate (a vinca alkaloid derivative), baclofen (a GABAB receptor agonist), or pentobarbital (a GABAA receptor-effector) on neuronal damage following repeated brief cerebral ischemia in the gerbils." | 7.68 | Comparative protective effects of vinconate, baclofen, and pentobarbital against neuronal damage following repeated brief cerebral ischemia in the gerbil brain. ( Araki, T; Kato, H; Kogure, K, 1991) |
| " We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, on mortality, working memory, and light microscopic hippocampal and cortical damage in the four-vessel occlusion model of cerebral ischemia using 64 male Wistar rats." | 7.68 | Baclofen does not protect against cerebral ischemia in rats. ( Grotta, AT; Grotta, JC; Ostrow, P; Pettigrew, LC; Picone, CM; Rhoades, H; Rosenbaum, DM; Strong, R, 1990) |
| " This study compared the neuroprotective efficacies of muscimol, a GABA A receptor agonist, and a GABA B receptor agonist baclofen in rat brain ischemia." | 3.74 | Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade. ( Li, C; Xu, J; Yin, XH; Zhang, GY, 2008) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 3.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "We investigated the neuroprotective effects of vinconate (a vinca alkaloid derivative), baclofen (a GABAB receptor agonist), or pentobarbital (a GABAA receptor-effector) on neuronal damage following repeated brief cerebral ischemia in the gerbils." | 3.68 | Comparative protective effects of vinconate, baclofen, and pentobarbital against neuronal damage following repeated brief cerebral ischemia in the gerbil brain. ( Araki, T; Kato, H; Kogure, K, 1991) |
| " We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, on mortality, working memory, and light microscopic hippocampal and cortical damage in the four-vessel occlusion model of cerebral ischemia using 64 male Wistar rats." | 3.68 | Baclofen does not protect against cerebral ischemia in rats. ( Grotta, AT; Grotta, JC; Ostrow, P; Pettigrew, LC; Picone, CM; Rhoades, H; Rosenbaum, DM; Strong, R, 1990) |
| " Chronic administration of GABAB receptors agonist baclofen significantly alleviated neuronal damage." | 1.42 | Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion. ( Guo, LJ; Li, CJ; Liu, L; Lu, Y; Luo, C; Sun, J; Zong, XG, 2015) |
| "In global cerebral ischemia, focal cerebral ischemia and oxygen-glucose deprivation, application of muscimol and baclofen, agonists of GABA(A) receptor and GABA(B) receptor, exerted neuroprotection." | 1.35 | Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion. ( Han, D; Li, C; Wang, W; Yan, JZ; Yu, CZ; Zhang, GY; Zhang, QG; Zong, YY, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, L | 1 |
| Li, CJ | 1 |
| Lu, Y | 1 |
| Zong, XG | 1 |
| Luo, C | 1 |
| Sun, J | 1 |
| Guo, LJ | 1 |
| Zhou, C | 2 |
| Li, C | 4 |
| Yu, HM | 2 |
| Zhang, F | 2 |
| Han, D | 3 |
| Zhang, GY | 4 |
| Cimarosti, H | 1 |
| Kantamneni, S | 1 |
| Henley, JM | 1 |
| Wang, R | 1 |
| Zhang, QG | 2 |
| Zong, YY | 1 |
| Yu, CZ | 1 |
| Wang, W | 1 |
| Yan, JZ | 1 |
| Xu, J | 1 |
| Yin, XH | 1 |
| Kawajiri, S | 1 |
| Kojima, H | 1 |
| Akashi, A | 1 |
| Kulinskiĭ, VI | 2 |
| Mikhel'son, GV | 2 |
| Ito, H | 1 |
| Watanabe, Y | 1 |
| Isshiki, A | 1 |
| Uchino, H | 1 |
| Babcock, AM | 1 |
| Everingham, A | 1 |
| Paden, CM | 1 |
| Kimura, M | 1 |
| Fowler, JC | 1 |
| Araki, T | 1 |
| Kato, H | 1 |
| Kogure, K | 1 |
| Rosenbaum, DM | 1 |
| Grotta, JC | 1 |
| Pettigrew, LC | 1 |
| Ostrow, P | 1 |
| Strong, R | 1 |
| Rhoades, H | 1 |
| Picone, CM | 1 |
| Grotta, AT | 1 |
| Rothman, SM | 1 |
| Olney, JW | 1 |
| Rossignol, P | 1 |
| Claperon, N | 1 |
| Durussel, JJ | 1 |
1 review available for baclofen and Cerebral Ischemia
| Article | Year |
|---|---|
Glutamate and the pathophysiology of hypoxic--ischemic brain damage.
Topics: Animals; Baclofen; Brain; Brain Ischemia; Calcium Channel Blockers; Cats; Cells, Cultured; Cerebral | 1986 |
15 other studies available for baclofen and Cerebral Ischemia
| Article | Year |
|---|---|
Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion.
Topics: Animals; Apoptosis; Autophagy; Baclofen; Biomarkers; Brain Ischemia; CA1 Region, Hippocampal; Caspas | 2015 |
Neuroprotection of gamma-aminobutyric acid receptor agonists via enhancing neuronal nitric oxide synthase (Ser847) phosphorylation through increased neuronal nitric oxide synthase and PSD95 interaction and inhibited protein phosphatase activity in cerebra
Topics: Animals; Baclofen; Blotting, Western; Brain Ischemia; Disks Large Homolog 4 Protein; Dizocilpine Mal | 2008 |
Ischaemia differentially regulates GABA(B) receptor subunits in organotypic hippocampal slice cultures.
Topics: Animals; Baclofen; Brain Ischemia; Cell Death; Cell Hypoxia; Drug Evaluation, Preclinical; GABA Agon | 2009 |
Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion.
Topics: Analysis of Variance; Animals; Apoptosis; Baclofen; Brain Ischemia; Cerebral Infarction; Disease Mod | 2007 |
Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion.
Topics: Animals; Apoptosis; Baclofen; Brain Ischemia; Disks Large Homolog 4 Protein; GABA Agonists; GluK2 Ka | 2008 |
Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade.
Topics: Analysis of Variance; Animals; Baclofen; Brain Ischemia; Disease Models, Animal; Dose-Response Relat | 2008 |
[A comparison of the effects of baclofen and some other muscle relaxants on alpha-rigidity in rats].
Topics: Animals; Baclofen; Brain Ischemia; Chlordiazepoxide; Dantrolene; Decerebrate State; Diazepam; Male; | 1984 |
[Receptor mechanism of the neuroprotective effect of GABAergic agents].
Topics: Animals; Baclofen; Brain Ischemia; Female; GABA Agonists; GABA Antagonists; Injections, Intraventric | 1998 |
Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Baclofen; Brain Ischemia; Dose-Response Relationship, Drug; GABA | 1999 |
Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia.
Topics: Animals; Baclofen; Bicuculline; Brain Ischemia; Drug Interactions; Female; GABA Agonists; GABA Antag | 2000 |
Baclofen is neuroprotective and prevents loss of calcium/calmodulin-dependent protein kinase II immunoreactivity in the ischemic gerbil hippocampus.
Topics: Animals; Antibodies; Baclofen; Blotting, Western; Brain Ischemia; Calcium-Calmodulin-Dependent Prote | 2002 |
Escape from inhibition of synaptic transmission during in vitro hypoxia and hypoglycemia in the hippocampus.
Topics: Adenosine; Animals; Baclofen; Brain Ischemia; Cell Hypoxia; Electric Stimulation; Electrophysiology; | 1992 |
Comparative protective effects of vinconate, baclofen, and pentobarbital against neuronal damage following repeated brief cerebral ischemia in the gerbil brain.
Topics: Animals; Baclofen; Behavior, Animal; Body Temperature; Brain Ischemia; Gerbillinae; Male; Neurons; P | 1991 |
Baclofen does not protect against cerebral ischemia in rats.
Topics: Animals; Baclofen; Brain Ischemia; Dose-Response Relationship, Drug; Male; Motor Activity; Rats; Rat | 1990 |
Stereoselectivity of the inhibiting effects of baclofen on the electrogenesis of the rat cortex under ischemia.
Topics: Animals; Baclofen; Brain; Brain Ischemia; Cerebral Cortex; Electrocardiography; Male; Rats; Rats, In | 1987 |