baclofen has been researched along with Brain Ischemia in 16 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 7.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "We investigated the neuroprotective effects of vinconate (a vinca alkaloid derivative), baclofen (a GABAB receptor agonist), or pentobarbital (a GABAA receptor-effector) on neuronal damage following repeated brief cerebral ischemia in the gerbils." | 7.68 | Comparative protective effects of vinconate, baclofen, and pentobarbital against neuronal damage following repeated brief cerebral ischemia in the gerbil brain. ( Araki, T; Kato, H; Kogure, K, 1991) |
| " We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, on mortality, working memory, and light microscopic hippocampal and cortical damage in the four-vessel occlusion model of cerebral ischemia using 64 male Wistar rats." | 7.68 | Baclofen does not protect against cerebral ischemia in rats. ( Grotta, AT; Grotta, JC; Ostrow, P; Pettigrew, LC; Picone, CM; Rhoades, H; Rosenbaum, DM; Strong, R, 1990) |
| " This study compared the neuroprotective efficacies of muscimol, a GABA A receptor agonist, and a GABA B receptor agonist baclofen in rat brain ischemia." | 3.74 | Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade. ( Li, C; Xu, J; Yin, XH; Zhang, GY, 2008) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 3.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "We investigated the neuroprotective effects of vinconate (a vinca alkaloid derivative), baclofen (a GABAB receptor agonist), or pentobarbital (a GABAA receptor-effector) on neuronal damage following repeated brief cerebral ischemia in the gerbils." | 3.68 | Comparative protective effects of vinconate, baclofen, and pentobarbital against neuronal damage following repeated brief cerebral ischemia in the gerbil brain. ( Araki, T; Kato, H; Kogure, K, 1991) |
| " We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, on mortality, working memory, and light microscopic hippocampal and cortical damage in the four-vessel occlusion model of cerebral ischemia using 64 male Wistar rats." | 3.68 | Baclofen does not protect against cerebral ischemia in rats. ( Grotta, AT; Grotta, JC; Ostrow, P; Pettigrew, LC; Picone, CM; Rhoades, H; Rosenbaum, DM; Strong, R, 1990) |
| " Chronic administration of GABAB receptors agonist baclofen significantly alleviated neuronal damage." | 1.42 | Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion. ( Guo, LJ; Li, CJ; Liu, L; Lu, Y; Luo, C; Sun, J; Zong, XG, 2015) |
| "In global cerebral ischemia, focal cerebral ischemia and oxygen-glucose deprivation, application of muscimol and baclofen, agonists of GABA(A) receptor and GABA(B) receptor, exerted neuroprotection." | 1.35 | Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion. ( Han, D; Li, C; Wang, W; Yan, JZ; Yu, CZ; Zhang, GY; Zhang, QG; Zong, YY, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, L | 1 |
| Li, CJ | 1 |
| Lu, Y | 1 |
| Zong, XG | 1 |
| Luo, C | 1 |
| Sun, J | 1 |
| Guo, LJ | 1 |
| Zhou, C | 2 |
| Li, C | 4 |
| Yu, HM | 2 |
| Zhang, F | 2 |
| Han, D | 3 |
| Zhang, GY | 4 |
| Cimarosti, H | 1 |
| Kantamneni, S | 1 |
| Henley, JM | 1 |
| Wang, R | 1 |
| Zhang, QG | 2 |
| Zong, YY | 1 |
| Yu, CZ | 1 |
| Wang, W | 1 |
| Yan, JZ | 1 |
| Xu, J | 1 |
| Yin, XH | 1 |
| Kawajiri, S | 1 |
| Kojima, H | 1 |
| Akashi, A | 1 |
| Kulinskiĭ, VI | 2 |
| Mikhel'son, GV | 2 |
| Ito, H | 1 |
| Watanabe, Y | 1 |
| Isshiki, A | 1 |
| Uchino, H | 1 |
| Babcock, AM | 1 |
| Everingham, A | 1 |
| Paden, CM | 1 |
| Kimura, M | 1 |
| Fowler, JC | 1 |
| Araki, T | 1 |
| Kato, H | 1 |
| Kogure, K | 1 |
| Rosenbaum, DM | 1 |
| Grotta, JC | 1 |
| Pettigrew, LC | 1 |
| Ostrow, P | 1 |
| Strong, R | 1 |
| Rhoades, H | 1 |
| Picone, CM | 1 |
| Grotta, AT | 1 |
| Rothman, SM | 1 |
| Olney, JW | 1 |
| Rossignol, P | 1 |
| Claperon, N | 1 |
| Durussel, JJ | 1 |
1 review available for baclofen and Brain Ischemia
| Article | Year |
|---|---|
Glutamate and the pathophysiology of hypoxic--ischemic brain damage.
Topics: Animals; Baclofen; Brain; Brain Ischemia; Calcium Channel Blockers; Cats; Cells, Cultured; Cerebral | 1986 |
15 other studies available for baclofen and Brain Ischemia
| Article | Year |
|---|---|
Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion.
Topics: Animals; Apoptosis; Autophagy; Baclofen; Biomarkers; Brain Ischemia; CA1 Region, Hippocampal; Caspas | 2015 |
Neuroprotection of gamma-aminobutyric acid receptor agonists via enhancing neuronal nitric oxide synthase (Ser847) phosphorylation through increased neuronal nitric oxide synthase and PSD95 interaction and inhibited protein phosphatase activity in cerebra
Topics: Animals; Baclofen; Blotting, Western; Brain Ischemia; Disks Large Homolog 4 Protein; Dizocilpine Mal | 2008 |
Ischaemia differentially regulates GABA(B) receptor subunits in organotypic hippocampal slice cultures.
Topics: Animals; Baclofen; Brain Ischemia; Cell Death; Cell Hypoxia; Drug Evaluation, Preclinical; GABA Agon | 2009 |
Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion.
Topics: Analysis of Variance; Animals; Apoptosis; Baclofen; Brain Ischemia; Cerebral Infarction; Disease Mod | 2007 |
Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion.
Topics: Animals; Apoptosis; Baclofen; Brain Ischemia; Disks Large Homolog 4 Protein; GABA Agonists; GluK2 Ka | 2008 |
Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade.
Topics: Analysis of Variance; Animals; Baclofen; Brain Ischemia; Disease Models, Animal; Dose-Response Relat | 2008 |
[A comparison of the effects of baclofen and some other muscle relaxants on alpha-rigidity in rats].
Topics: Animals; Baclofen; Brain Ischemia; Chlordiazepoxide; Dantrolene; Decerebrate State; Diazepam; Male; | 1984 |
[Receptor mechanism of the neuroprotective effect of GABAergic agents].
Topics: Animals; Baclofen; Brain Ischemia; Female; GABA Agonists; GABA Antagonists; Injections, Intraventric | 1998 |
Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Baclofen; Brain Ischemia; Dose-Response Relationship, Drug; GABA | 1999 |
Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia.
Topics: Animals; Baclofen; Bicuculline; Brain Ischemia; Drug Interactions; Female; GABA Agonists; GABA Antag | 2000 |
Baclofen is neuroprotective and prevents loss of calcium/calmodulin-dependent protein kinase II immunoreactivity in the ischemic gerbil hippocampus.
Topics: Animals; Antibodies; Baclofen; Blotting, Western; Brain Ischemia; Calcium-Calmodulin-Dependent Prote | 2002 |
Escape from inhibition of synaptic transmission during in vitro hypoxia and hypoglycemia in the hippocampus.
Topics: Adenosine; Animals; Baclofen; Brain Ischemia; Cell Hypoxia; Electric Stimulation; Electrophysiology; | 1992 |
Comparative protective effects of vinconate, baclofen, and pentobarbital against neuronal damage following repeated brief cerebral ischemia in the gerbil brain.
Topics: Animals; Baclofen; Behavior, Animal; Body Temperature; Brain Ischemia; Gerbillinae; Male; Neurons; P | 1991 |
Baclofen does not protect against cerebral ischemia in rats.
Topics: Animals; Baclofen; Brain Ischemia; Dose-Response Relationship, Drug; Male; Motor Activity; Rats; Rat | 1990 |
Stereoselectivity of the inhibiting effects of baclofen on the electrogenesis of the rat cortex under ischemia.
Topics: Animals; Baclofen; Brain; Brain Ischemia; Cerebral Cortex; Electrocardiography; Male; Rats; Rats, In | 1987 |