baclofen and Brain Disorders studies

Research Excerpts

Excerpt	Relevance	Reference
" He developed acute kidney injury at hospital secondary to vancomycin use, and mental status declined."	5.05	Encephalopathy of Unknown Origin in a Baclofen Patient: Case Report and Review of the Literature. ( Abraham, M; Behmer Hansen, R; Gold, J; Lad, M; Mammis, A; Zhao, K, 2020)
"A 69-year-old woman with a history of hemodialysis-dependent end-stage renal disease presented to the Emergency Department with encephalopathy, ataxia, and dystonia after the addition of a recent baclofen prescription for back pain (10 mg twice daily)."	3.85	Baclofen Toxicity in a Patient with Hemodialysis-Dependent End-Stage Renal Disease. ( Katz, KD; Merrick, SS; Porter, LM, 2017)
"Intrathecal baclofen therapy is increasingly used to alleviate medically intractable spasticity in children with cerebral palsy, spinal cord injuries, and generalized dystonia."	3.73	Intrathecal baclofen overdose followed by withdrawal: clinical and EEG features. ( Adirim, TA; Darbari, FP; Kothare, SV; Melvin, JJ; Piatt, JH, 2005)
" The dosage of ITB increased from a mean of 157 microg/day 3 months after pump insertion to 300 microg/day at 2 years postimplantation, and remained relatively stable thereafter."	2.71	Long-term intrathecal baclofen therapy for severe spasticity of cerebral origin. ( Albright, AL; Gilmartin, R; Ivanhoe, CB; Krach, LE; McLaughlin, JF; Swift, D, 2003)
"Improvement was reported in spasticity, spasms, pain, gait, activities of daily life and providing care."	2.48	Intrathecal baclofen for progressive neurological disease in childhood: a systematic review of literature. ( Becher, JG; Bonouvrié, LA; van Ouwerkerk, WJ; van Schie, PE; Vermeulen, RJ, 2012)
"The term cerebral palsy is restricted to non-progressive disorders of motor function, already observed at an early age and due to cerebral lesions."	2.37	[Functional neurosurgery of cerebral palsy]. ( Alexandre, F; Angelini, L; Benezech, J; Broggi, G; Claverie, P; Deonna, T; Frerebeau, P; Lazorthes, Y; Siegfried, J; Verdie, JC, 1985)
"To quantify the risk of encephalopathy associated with oral baclofen compared with other muscle relaxants-tizanidine or cyclobenzaprine."	1.91	Baclofen and the Risk of Encephalopathy: A Real-World, Active-Comparator Cohort Study. ( Brotman, DJ; Chang, AR; Grams, ME; Hwang, YJ; Inker, LA; Shin, JI, 2023)
"Hospitalization with encephalopathy occurred in 26 of 360 baclofen users (7."	1.56	Baclofen has a risk of encephalopathy in older adults receiving dialysis. ( Bathini, L; Blake, PG; Chauvin, KJ; Dixon, SN; Garg, AX; Kim, RB; McArthur, E; Moist, L; Muanda, FT; Sontrop, JM; Weir, MA, 2020)
"Baclofen is a centrally acting gamma-aminobutyric acid agonist used for the symptomatic relief of skeletal muscle spasm and spasticity in traumatic spinal cord lesions, multiple sclerosis, cerebral palsy, and stroke."	1.42	Encephalopathy and hypotonia due to baclofen toxicity in a patient with end-stage renal disease. ( Ijaz, M; Kashif, M; Marquez, JG; Tariq, H, 2015)
"05), while baclofen dosage increased (p = 0."	1.40	Intrathecal baclofen therapy in children with severe spasticity: Outcome and complications. ( Altermatt, S; Furrer, C; Meyer-Heim, A; Walter, M, 2014)
"Baclofen is a centrally acting gamma-ammino butyric acid agonist that is used like muscular relaxant in disorders with spasticity and intractable hiccups."	1.33	[Baclofen-associated encephalopathy in a hemodialysis patient with hiccups]. ( Butjosa, M; Lladó, A; Poch, E; Quintana, LF; Santamaría, J; Torras, A, 2006)
"In addition, the lowering of tonic seizure threshold observed with thalamic lesions was reversed by these (-)baclofen injections."	1.29	An ascending seizure-controlling pathway in the medial brainstem and thalamus. ( Bardgett, ME; Gray, BC; Miller, JW; Turner, GM, 1993)
"Macro square wave jerks and pendular nystagmus were mildly suppressed after the intramuscular injection of 100 mg of phenobarbital, the oral intake of sodium valproate of 600 mg/day or baclofen of 60 mg/day."	1.28	[Multiple system atrophy with macro square wave jerks and pendular nystagmus]. ( Fukusako, T; Morimatsu, M; Nogaki, H; Yamamoto, K, 1992)
"We report a case of acute transient encephalopathy with confusion, drowsiness, myoclonic jerks, periodic triphasic sharp wave EEG patterns induced by low doses of baclofen."	1.28	Acute transient cerebral intoxication induced by low doses of baclofen. ( Lazzarino, LG; Nicolai, A; Valassi, F, 1991)
"Acute encephalopathy and an abnormal electroencephalogram with a periodic sharp wave pattern developed in a 58-year-old woman shortly after she received a few doses of baclofen."	1.27	Periodic sharp waves in baclofen-induced encephalopathy. ( Benarroch, EE; Hormes, JT; Klass, DW; Rodriguez, M, 1988)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (23.33)	18.7374
1990's	6 (20.00)	18.2507
2000's	6 (20.00)	29.6817
2010's	6 (20.00)	24.3611
2020's	5 (16.67)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS): A Randomized, Controlled, Multi-center, Prospective Study Evaluating Dose Reduction in ITB Patients.[NCT04530955]				92 participants (Anticipated)	Interventional	2020-09-24	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Encephalopathy of Unknown Origin in a Baclofen Patient: Case Report and Review of the Literature. World neurosurgery, 2020, Volume: 136 Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Baclofen; Brain Diseases; Electroencephalography;	2020
Intrathecal baclofen for progressive neurological disease in childhood: a systematic review of literature. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2012, Volume: 16, Issue:3 Topics: Adolescent; Adult; Baclofen; Brain Diseases; Child; Child, Preschool; Female; Humans; Injections, Sp	2012
Intrathecal drug administration. Present use and future trends. Clinical pharmacokinetics, 1992, Volume: 22, Issue:5 Topics: Analgesics; Baclofen; Brain Diseases; Humans; Injections, Spinal; Neoplasms; Palliative Care; Spasm;	1992
Advances in drug delivery systems and applications in neurosurgery. Advances and technical standards in neurosurgery, 1991, Volume: 18 Topics: Adult; Aged; Aged, 80 and over; Animals; Baclofen; Brain Diseases; Equipment Design; Female; Humans;	1991
[Functional neurosurgery of cerebral palsy]. Neuro-Chirurgie, 1985, Volume: 31 Suppl 1 Topics: Adolescent; Adult; Animals; Baclofen; Benzodiazepines; Brain; Brain Diseases; Cerebellar Cortex; Cer	1985

Article	Year
Long-term intrathecal baclofen therapy for severe spasticity of cerebral origin. Journal of neurosurgery, 2003, Volume: 98, Issue:2 Topics: Adolescent; Baclofen; Brain Diseases; Cerebral Cortex; Child; Dose-Response Relationship, Drug; Foll	2003
Time course of the effect of a bolus dose of intrathecal baclofen on severe cerebral spasticity. Journal of neurology, 2003, Volume: 250, Issue:10 Topics: Adult; Baclofen; Brain Diseases; Female; Humans; Infusion Pumps, Implantable; Injections, Spinal; Kn	2003
Intrathecal drug administration. Present use and future trends. Clinical pharmacokinetics, 1992, Volume: 22, Issue:5 Topics: Analgesics; Baclofen; Brain Diseases; Humans; Injections, Spinal; Neoplasms; Palliative Care; Spasm;	1992

Article	Year
Baclofen and the Risk of Encephalopathy: A Real-World, Active-Comparator Cohort Study. Mayo Clinic proceedings, 2023, Volume: 98, Issue:5 Topics: Adolescent; Adult; Baclofen; Brain Diseases; Cohort Studies; Humans; Muscle Relaxants, Central; Musc	2023
Reviewing the Evidence of the Association Between Baclofen and Encephalopathy. Mayo Clinic proceedings, 2023, Volume: 98, Issue:5 Topics: Baclofen; Brain Diseases; Electroencephalography; Humans	2023
Baclofen encephalopathy: uncommon side effect of a common drug. Postgraduate medical journal, 2020, Volume: 96, Issue:1142 Topics: Aged; Baclofen; Biomarkers; Brain Diseases; Diagnosis, Differential; Electroencephalography; Female;	2020
Baclofen has a risk of encephalopathy in older adults receiving dialysis. Kidney international, 2020, Volume: 98, Issue:4 Topics: Aged; Baclofen; Brain Diseases; Cohort Studies; Female; Hospitalization; Humans; Ontario; Renal Dial	2020
Baclofen-induced encephalopathy in overdose - Modeling of the electroencephalographic effect/concentration relationships and contribution of tolerance in the rat. Progress in neuro-psychopharmacology & biological psychiatry, 2018, 08-30, Volume: 86 Topics: Animals; Baclofen; Brain; Brain Diseases; Dose-Response Relationship, Drug; Drug Overdose; Drug Tole	2018
Intrathecal baclofen therapy in children with severe spasticity: Outcome and complications. Developmental neurorehabilitation, 2014, Volume: 17, Issue:6 Topics: Adolescent; Baclofen; Brain Diseases; Brain Injuries; Child; Child, Preschool; Female; Follow-Up Stu	2014
Encephalopathy and hypotonia due to baclofen toxicity in a patient with end-stage renal disease. The American journal of case reports, 2015, Apr-20, Volume: 16 Topics: Baclofen; Brain Diseases; Female; Humans; Kidney Failure, Chronic; Middle Aged; Muscle Hypotonia; Mu	2015
Baclofen Toxicity in a Patient with Hemodialysis-Dependent End-Stage Renal Disease. The Journal of emergency medicine, 2017, Volume: 52, Issue:4 Topics: Aged; Ataxia; Back Pain; Baclofen; Brain Diseases; Confusion; Dystonia; Emergency Service, Hospital;	2017
Spasticity in children and young people with non-progressive brain disorders: summary of NICE guidance. BMJ (Clinical research ed.), 2012, Jul-26, Volume: 345 Topics: Adolescent; Baclofen; Botulinum Toxins, Type A; Brain Diseases; Cerebral Palsy; Child; Humans; Injec	2012
[Intrathecal baclofen in the treatment of spasticity. Our experience]. Journal of neurosurgical sciences, 2003, Volume: 47, Issue:1 Suppl 1 Topics: Baclofen; Brain Diseases; GABA Agonists; Humans; Injections, Spinal; Muscle Spasticity; Spinal Cord	2003
Intrathecal baclofen overdose followed by withdrawal: clinical and EEG features. Pediatric neurology, 2005, Volume: 33, Issue:5 Topics: Baclofen; Brain Diseases; Cerebral Palsy; Child; Drug Overdose; Electroencephalography; Humans; Inje	2005
[Baclofen-associated encephalopathy in a hemodialysis patient with hiccups]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2006, Volume: 26, Issue:4 Topics: Aged; Baclofen; Brain Diseases; Hiccup; Humans; Male; Muscle Relaxants, Central; Renal Dialysis	2006
The pharmacology of olivopontocerebellar atrophy. Advances in neurology, 1984, Volume: 41 Topics: Adult; Amantadine; Atrophy; Baclofen; Brain Diseases; Carbidopa; Cerebellar Ataxia; Female; Humans;	1984
[Periodic triphasic EEG waves]. Harefuah, 1982, Nov-15, Volume: 103, Issue:10 Topics: Baclofen; Brain Diseases; Coma; Electroencephalography; Humans; Hypernatremia; Periodicity; Phenothi	1982
An ascending seizure-controlling pathway in the medial brainstem and thalamus. Experimental neurology, 1993, Volume: 121, Issue:1 Topics: Animals; Arousal; Baclofen; Brain Diseases; Female; Neural Pathways; Rats; Seizures; Sleep; Tegmentu	1993
Baclofen neurotoxicity [correction of unerotoxicity] in a chronic haemodialysis patient. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2000, Volume: 15, Issue:5 Topics: Aged; Baclofen; Brain Diseases; Humans; Kidney Failure, Chronic; Male; Neurotoxins; Recovery of Func	2000
An approach to the treatment of spasticity. Drugs, 1975, Volume: 10, Issue:2 Topics: Adrenergic alpha-Antagonists; Baclofen; Brain Diseases; Dantrolene; Diazepam; Humans; Mephenesin; Mu	1975
[Multiple system atrophy with macro square wave jerks and pendular nystagmus]. Rinsho shinkeigaku = Clinical neurology, 1992, Volume: 32, Issue:11 Topics: Atrophy; Baclofen; Brain Diseases; Diazepam; Electrooculography; Eye Movements; Female; Humans; Midd	1992
Baclofen-induced frontal lobe syndrome: case report. Paraplegia, 1991, Volume: 29, Issue:8 Topics: Aged; Aged, 80 and over; Baclofen; Behavior; Brain Diseases; Confusion; Electroencephalography; Fron	1991
Acute transient cerebral intoxication induced by low doses of baclofen. Italian journal of neurological sciences, 1991, Volume: 12, Issue:3 Topics: Acute Disease; Aged; Baclofen; Brain Diseases; Electroencephalography; Evoked Potentials, Auditory,	1991
Periodic sharp waves in baclofen-induced encephalopathy. Archives of neurology, 1988, Volume: 45, Issue:7 Topics: Baclofen; Brain Diseases; Electroencephalography; Female; Humans; Middle Aged; Muscular Diseases; Pa	1988
Encephalopathy associated with baclofen. Annals of neurology, 1985, Volume: 17, Issue:6 Topics: Aged; Baclofen; Brain Diseases; Electroencephalography; Female; Humans; Male	1985
Olivopontocerebellar atrophy with dementia, blindness, and chorea. Response to baclofen. Archives of neurology, 1985, Volume: 42, Issue:8 Topics: Adolescent; Adult; Atrophy; Baclofen; Blindness; Brain Diseases; Cerebellar Diseases; Chorea; Dement	1985

baclofen and Brain Disorders

Research Excerpts

Research

Studies (30)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Hwang, YJ	1
Chang, AR	1
Brotman, DJ	1
Inker, LA	1
Grams, ME	1
Shin, JI	1
Muanda, FT	2
Sontrop, JM	2
Garg, AX	2
Gold, J	1
Zhao, K	1
Abraham, M	1
Behmer Hansen, R	1
Lad, M	1
Mammis, A	1
Sachan, A	1
Singh, VK	1
Kalita, J	1
Misra, UK	1
Chauvin, KJ	1
Blake, PG	1
Weir, MA	1
Bathini, L	1
Dixon, SN	1
McArthur, E	1
Moist, L	1
Kim, RB	1
Chartier, M	1
Malissin, I	1
Tannous, S	1
Labat, L	1
Risède, P	1
Mégarbane, B	1
Chevillard, L	1
Walter, M	1
Altermatt, S	1
Furrer, C	1
Meyer-Heim, A	1
Ijaz, M	1
Tariq, H	1
Kashif, M	1
Marquez, JG	1
Porter, LM	1
Merrick, SS	1
Katz, KD	1
Bonouvrié, LA	1
van Schie, PE	1
Becher, JG	1
van Ouwerkerk, WJ	1
Vermeulen, RJ	1
Mugglestone, MA	1
Eunson, P	1
Murphy, MS	1
Albright, AL	1
Gilmartin, R	1
Swift, D	1
Krach, LE	1
Ivanhoe, CB	1
McLaughlin, JF	1
Pohl, M	1
Rockstroh, G	1
Rückriem, S	1
Mehrholz, J	1
Pause, M	1
Koch, R	1
Strik, H	1
Signorelli, CD	1
Lavano, A	1
Volpentesta, G	1
Chirchiglia, D	1
Signorelli, F	1
Bono, F	1
Ferraro, G	1
Sibille, M	1
Veltri, C	1
Aloisi, M	1
Piragine, G	1
Serra, S	1
Scola, P	1
Pardatcher, S	1
Pardatcher, K	1
Santangelo, E	1
Darbari, FP	1
Melvin, JJ	1
Piatt, JH	1
Adirim, TA	1
Kothare, SV	1
Quintana, LF	1
Lladó, A	1
Butjosa, M	1
Santamaría, J	1
Torras, A	1
Poch, E	1
Goetz, CG	1
Tanner, CM	1
Klawans, HL	1
Abarbanel, J	2
Herishanu, Y	2
Miller, JW	1
Gray, BC	1
Turner, GM	1
Bardgett, ME	1
Bassilios, N	1
Launay-Vacher, V	1
Mercadal, L	1
Deray, G	1
Burke, DJ	1
Yamamoto, K	1
Fukusako, T	1
Nogaki, H	1
Morimatsu, M	1
Kroin, JS	1
Liu, HC	1
Tsai, SC	1
Liu, TY	1
Chi, CW	1
Lazzarino, LG	1
Nicolai, A	1
Valassi, F	1
Lazorthes, Y	2
Sallerin-Caute, B	1
Verdie, JC	2
Bastide, R	1
Hormes, JT	1
Benarroch, EE	1
Rodriguez, M	1
Klass, DW	1
Siegfried, J	1
Broggi, G	1
Claverie, P	1
Deonna, T	1
Frerebeau, P	1
Alexandre, F	1
Angelini, L	1
Benezech, J	1
Frisher, S	1
Trauner, DA	1