baclofen has been researched along with Body Weight in 25 studies
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To characterize the population pharmacokinetics (PK) of oral baclofen and assess impact of patient-specific covariates in children with cerebral palsy (CP) in order to support its clinical use." | 9.19 | Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy. ( Brunstrom-Hernandez, JE; Butler, M; Christensen, A; Dai, H; Dosa, NP; Gaebler-Spira, D; Gaedigk, A; He, Y; Hoon, AH; Jusko, WJ; Kennedy, D; Krach, LE; Kuroda, MM; Lackey, S; Leeder, JS; Lewandowski, A; Lopez, C; Lowenhaupt, S; McLaughlin, JF; Roge, D; Schwabe, A; Stashinko, E; Stevenson, RD; Thio, LL; Tilton, A; Vargus-Adams, J, 2014) |
| "To determine whether leg muscle stiffness is measurably reduced after intrathecal baclofen (ITB) in subjects with spastic hemiplegia." | 7.72 | Intrathecal baclofen in subjects with spastic hemiplegia: assessment of the antispastic effect during gait. ( Bouilland, S; Bussel, B; Rémy-Néris, O; Tiffreau, V, 2003) |
| "The aim of the study was to identify oral baclofen dosing variability at steady state based on weight and Gross Motor Function Classification System level using a retrospective cross-sectional study design." | 5.56 | Variability of Steady State Oral Baclofen Prescribing Practices in Pediatric Patients With Cerebral Palsy. ( McGhee, E; McLaughlin, MJ; Ratnasingam, D, 2020) |
| " The observations that chronic administration of baclofen (4mg/kg) stimulates short-term food intake without affecting long term (24h) feeding, but decreases body weight gain, suggest that baclofen may act through different mechanisms to influence food intake and body weight." | 5.36 | Effects of chronic systemic administration of the GABA(B) receptor agonist baclofen on food intake and body weight in rats. ( Ebenezer, IS; Patel, SM, 2010) |
| " In an open-label single-dose pharmacokinetic study, eight children with the diagnosis of GER made on clinical grounds received an oral dose of baclofen, 2." | 5.32 | Pharmacokinetics of a single oral dose of baclofen in pediatric patients with gastroesophageal reflux disease. ( Benninga, MA; Butter, JJ; Omari, T; van Aalderen, WM; van Boxtel, CJ; Wiersma, HE, 2003) |
| "To characterize the population pharmacokinetics (PK) of oral baclofen and assess impact of patient-specific covariates in children with cerebral palsy (CP) in order to support its clinical use." | 5.19 | Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy. ( Brunstrom-Hernandez, JE; Butler, M; Christensen, A; Dai, H; Dosa, NP; Gaebler-Spira, D; Gaedigk, A; He, Y; Hoon, AH; Jusko, WJ; Kennedy, D; Krach, LE; Kuroda, MM; Lackey, S; Leeder, JS; Lewandowski, A; Lopez, C; Lowenhaupt, S; McLaughlin, JF; Roge, D; Schwabe, A; Stashinko, E; Stevenson, RD; Thio, LL; Tilton, A; Vargus-Adams, J, 2014) |
| "To assess changes in body composition, body weight and resting metabolic rate in patients who received intrathecal baclofen therapy for spasticity." | 3.85 | Changes in body composition after spasticity treatment with intrathecal baclofen. ( Ertzgaard, P; Levi, R; Samuelsson, K; Skogberg, O, 2017) |
| "To determine whether leg muscle stiffness is measurably reduced after intrathecal baclofen (ITB) in subjects with spastic hemiplegia." | 3.72 | Intrathecal baclofen in subjects with spastic hemiplegia: assessment of the antispastic effect during gait. ( Bouilland, S; Bussel, B; Rémy-Néris, O; Tiffreau, V, 2003) |
| "The aim of the study was to identify oral baclofen dosing variability at steady state based on weight and Gross Motor Function Classification System level using a retrospective cross-sectional study design." | 1.56 | Variability of Steady State Oral Baclofen Prescribing Practices in Pediatric Patients With Cerebral Palsy. ( McGhee, E; McLaughlin, MJ; Ratnasingam, D, 2020) |
| " In the 2nd Experiment, the effects of acute and chronic administration of baclofen (2 mg/kg) were investigated on 24 h food intake in rats." | 1.35 | The effects of chronic intraperitoneal administration of the GABA B receptor agonist baclofen on food intake in rats. ( Ebenezer, IS; Patel, SM, 2008) |
| "Baclofen is a GABA-B agonist that may be useful in the treatment of substance use disorders, and also reduces 'binge-like' eating in rodents." | 1.34 | Baclofen for binge eating: an open-label trial. ( Attia, E; Broft, AI; Corwin, RL; Devlin, MJ; Mayer, L; Spanos, A; Steinglass, J; Walsh, BT, 2007) |
| " In an open-label single-dose pharmacokinetic study, eight children with the diagnosis of GER made on clinical grounds received an oral dose of baclofen, 2." | 1.32 | Pharmacokinetics of a single oral dose of baclofen in pediatric patients with gastroesophageal reflux disease. ( Benninga, MA; Butter, JJ; Omari, T; van Aalderen, WM; van Boxtel, CJ; Wiersma, HE, 2003) |
| "Rats developed mechanical hyperalgesia as soon as 2 weeks after STZ injection." | 1.30 | A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats. ( Malcangio, M; Tomlinson, DR, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 11 (44.00) | 29.6817 |
| 2010's | 9 (36.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| McLaughlin, MJ | 1 |
| Ratnasingam, D | 1 |
| McGhee, E | 1 |
| Mitsuboshi, S | 1 |
| Wojnicki, FH | 2 |
| Brown, SD | 1 |
| Corwin, RL | 3 |
| He, Y | 1 |
| Brunstrom-Hernandez, JE | 1 |
| Thio, LL | 1 |
| Lackey, S | 1 |
| Gaebler-Spira, D | 1 |
| Kuroda, MM | 1 |
| Stashinko, E | 1 |
| Hoon, AH | 1 |
| Vargus-Adams, J | 1 |
| Stevenson, RD | 1 |
| Lowenhaupt, S | 1 |
| McLaughlin, JF | 1 |
| Christensen, A | 1 |
| Dosa, NP | 1 |
| Butler, M | 1 |
| Schwabe, A | 1 |
| Lopez, C | 1 |
| Roge, D | 1 |
| Kennedy, D | 1 |
| Tilton, A | 1 |
| Krach, LE | 1 |
| Lewandowski, A | 1 |
| Dai, H | 1 |
| Gaedigk, A | 1 |
| Leeder, JS | 1 |
| Jusko, WJ | 1 |
| Bolton, MM | 1 |
| Heaney, CF | 1 |
| Murtishaw, AS | 1 |
| Sabbagh, JJ | 1 |
| Magcalas, CM | 1 |
| Kinney, JW | 1 |
| Vickers, SP | 1 |
| Hackett, D | 1 |
| Murray, F | 1 |
| Hutson, PH | 1 |
| Heal, DJ | 1 |
| Skogberg, O | 1 |
| Samuelsson, K | 1 |
| Ertzgaard, P | 1 |
| Levi, R | 1 |
| Patel, SM | 2 |
| Ebenezer, IS | 2 |
| Czyzyk, TA | 1 |
| Sahr, AE | 1 |
| Statnick, MA | 1 |
| Bonaventura, MM | 1 |
| Crivello, M | 1 |
| Ferreira, ML | 1 |
| Repetto, M | 1 |
| Cymeryng, C | 1 |
| Libertun, C | 1 |
| Lux-Lantos, VA | 1 |
| Villas Boas, GR | 1 |
| Zamboni, CG | 1 |
| Peretti, MC | 1 |
| Correia, D | 1 |
| Rueda, AV | 1 |
| Camarini, R | 1 |
| Brunialti-Godard, AL | 1 |
| Boerngen-Lacerda, R | 1 |
| Wiersma, HE | 1 |
| van Boxtel, CJ | 1 |
| Butter, JJ | 1 |
| van Aalderen, WM | 1 |
| Omari, T | 1 |
| Benninga, MA | 1 |
| Rémy-Néris, O | 1 |
| Tiffreau, V | 1 |
| Bouilland, S | 1 |
| Bussel, B | 1 |
| Kaupmann, K | 1 |
| Cryan, JF | 1 |
| Wellendorph, P | 1 |
| Mombereau, C | 1 |
| Sansig, G | 1 |
| Klebs, K | 1 |
| Schmutz, M | 1 |
| Froestl, W | 1 |
| van der Putten, H | 1 |
| Mosbacher, J | 1 |
| Bräuner-Osborne, H | 1 |
| Waldmeier, P | 1 |
| Bettler, B | 1 |
| Królczyk, G | 1 |
| Laskiewicz, J | 1 |
| Sobocki, J | 1 |
| Matyja, A | 1 |
| Kolasińska-Kloch, W | 1 |
| Thor, PJ | 1 |
| Buda-Levin, A | 1 |
| Kandov, Y | 1 |
| Israel, Y | 1 |
| Kest, A | 1 |
| Dostova, I | 1 |
| Verasammy, J | 1 |
| Bernal, SY | 1 |
| Kasselman, L | 1 |
| Bodnar, RJ | 1 |
| Vender, JR | 1 |
| Hughes, M | 1 |
| Hughes, BD | 1 |
| Hester, S | 1 |
| Holsenback, S | 1 |
| Rosson, B | 1 |
| Knapp, DJ | 1 |
| Overstreet, DH | 1 |
| Breese, GR | 1 |
| Broft, AI | 1 |
| Spanos, A | 1 |
| Mayer, L | 1 |
| Steinglass, J | 1 |
| Devlin, MJ | 1 |
| Attia, E | 1 |
| Walsh, BT | 1 |
| Malcangio, M | 1 |
| Tomlinson, DR | 1 |
| Ozdem, SS | 1 |
| Sadan, G | 1 |
| Usta, C | 1 |
| Taşatargil, A | 1 |
| Hoehn, K | 1 |
| Reid, A | 1 |
| Sawynok, J | 1 |
| Horton, R | 1 |
| Rothwell, NJ | 1 |
| Stock, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pediatric Pharmacokinetic and Pharmacodynamic Study of Oral Baclofen for the Treatment of Spasticity Associated With Cerebral Palsy[NCT00607542] | Phase 1/Phase 2 | 61 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for baclofen and Body Weight
| Article | Year |
|---|---|
Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy.
Topics: Absorption; Administration, Oral; Adolescent; Baclofen; Body Weight; Cerebral Palsy; Child; Child, P | 2014 |
24 other studies available for baclofen and Body Weight
| Article | Year |
|---|---|
Variability of Steady State Oral Baclofen Prescribing Practices in Pediatric Patients With Cerebral Palsy.
Topics: Administration, Oral; Adolescent; Baclofen; Body Weight; Cerebral Palsy; Child; Child, Preschool; Cr | 2020 |
Association Between Baclofen and Respiratory Depression in Patients With Chronic Kidney Disease.
Topics: Age Factors; Aged; Baclofen; Body Weight; Female; Humans; Male; Middle Aged; Propiophenones; Renal I | 2021 |
Factors affecting the ability of baclofen to reduce fat intake in rats.
Topics: Analysis of Variance; Animals; Appetite Regulation; Baclofen; Body Weight; Bulimia; Dietary Fats; Do | 2014 |
Postnatal alterations in GABAB receptor tone produce sensorimotor gating deficits and protein level differences in adulthood.
Topics: Acoustic Stimulation; Age Factors; Animals; Animals, Newborn; Baclofen; Body Weight; Brain; Disease | 2015 |
Effects of lisdexamfetamine in a rat model of binge-eating.
Topics: Animals; Baclofen; Behavior, Animal; Benzazepines; Benzodiazepines; Body Weight; Bulimia; Disease Mo | 2015 |
Changes in body composition after spasticity treatment with intrathecal baclofen.
Topics: Adult; Aged; Baclofen; Body Composition; Body Weight; Female; Humans; Injections, Spinal; Male; Midd | 2017 |
The effects of chronic intraperitoneal administration of the GABA B receptor agonist baclofen on food intake in rats.
Topics: Animals; Baclofen; Body Weight; Drug Tolerance; Eating; GABA Agonists; GABA-B Receptor Agonists; Inj | 2008 |
A model of binge-like eating behavior in mice that does not require food deprivation or stress.
Topics: Adiposity; Animals; Anti-Obesity Agents; Baclofen; Behavior, Animal; Binge-Eating Disorder; Body Wei | 2010 |
Effects of chronic systemic administration of the GABA(B) receptor agonist baclofen on food intake and body weight in rats.
Topics: Animals; Baclofen; Body Weight; Dose-Response Relationship, Drug; Drug Administration Routes; Drug A | 2010 |
Effects of GABAB receptor agonists and antagonists on glycemia regulation in mice.
Topics: Animals; Baclofen; Basal Metabolism; Blood Glucose; Body Weight; Eating; GABA-B Receptor Agonists; G | 2012 |
GABA(B) receptor agonist only reduces ethanol drinking in light-drinking mice.
Topics: Alcohol Drinking; Animals; Baclofen; Body Weight; Dose-Response Relationship, Drug; Drinking Behavio | 2012 |
Pharmacokinetics of a single oral dose of baclofen in pediatric patients with gastroesophageal reflux disease.
Topics: Administration, Oral; Baclofen; Body Weight; Child, Preschool; Female; Gastroesophageal Reflux; Huma | 2003 |
Intrathecal baclofen in subjects with spastic hemiplegia: assessment of the antispastic effect during gait.
Topics: Adult; Ankle; Baclofen; Biomechanical Phenomena; Body Weight; Brain Injuries; Cerebral Palsy; Electr | 2003 |
Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice.
Topics: 4-Butyrolactone; Adjuvants, Anesthesia; Animals; Anticonvulsants; Autoradiography; Baclofen; Behavio | 2003 |
The effects of baclofen on the feeding behaviour and body weight of vagally stimulated rats.
Topics: Animals; Baclofen; Body Weight; Feeding Behavior; Male; Rats; Rats, Wistar; Vagus Nerve | 2005 |
Baclofen reduces fat intake under binge-type conditions.
Topics: Analysis of Variance; Animals; Baclofen; Behavior, Animal; Body Weight; Bulimia; Dietary Fats; Eatin | 2005 |
GABA receptor subtype antagonists in the nucleus accumbens shell and ventral tegmental area differentially alter feeding responses induced by deprivation, glucoprivation and lipoprivation in rats.
Topics: Animals; Baclofen; Behavior, Animal; Bicuculline; Body Weight; Deoxyglucose; Dose-Response Relations | 2006 |
Intrathecal baclofen therapy and multiple sclerosis: outcomes and patient satisfaction.
Topics: Baclofen; Body Weight; Caregivers; Female; Follow-Up Studies; Humans; Infusion Pumps, Implantable; I | 2006 |
Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal.
Topics: Alcohol Drinking; Animals; Anxiety; Baclofen; Body Weight; Central Nervous System Depressants; Diet; | 2007 |
Baclofen for binge eating: an open-label trial.
Topics: Adult; Appetite; Baclofen; Body Weight; Bulimia Nervosa; Dose-Response Relationship, Drug; Drug Admi | 2007 |
A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats.
Topics: Animals; Baclofen; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dizocilpine Maleate; | 1998 |
Effect of experimental diabetes on GABA-mediated inhibition of neurally induced contractions in rat isolated trachea.
Topics: Acetylcholine; Animals; Baclofen; Bicuculline; Blood Glucose; Body Weight; Diabetes Mellitus, Experi | 2000 |
Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Baclofen; Body Weight; Injections, Spinal; Male; Morph | 1988 |
Chronic inhibition of GABA transaminase results in activation of thermogenesis and brown fat in the rat.
Topics: 4-Aminobutyrate Transaminase; Adipose Tissue, Brown; Animals; Baclofen; Body Temperature Regulation; | 1988 |