baclofen has been researched along with Aura in 70 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether intrathecal baclofen (ITB) changes mortality risk in persons with cerebral palsy (CP)." | 7.76 | Survival of individuals with cerebral palsy receiving continuous intrathecal baclofen treatment: a matched-cohort study. ( Day, SM; Krach, LE; Kriel, RL; Strauss, DJ, 2010) |
| "Baclofen is widely used to control spasticity in children with cerebral palsy." | 7.76 | Long-term oral baclofen treatment in a child with cerebral palsy: electroencephalographic changes and clinical adverse effects. ( De Rinaldis, M; Gennaro, L; Losito, L; Trabacca, A, 2010) |
| "The anticonvulsant action of progabide, an agonist of gamma-aminobutyric acid (GABA)A and GABAB receptors, was investigated in the kindling model of epilepsy in rats." | 7.68 | An analysis of anticonvulsant actions of GABA agonists (progabide and baclofen) in the kindling model of epilepsy. ( Morimoto, K; Nakamura, Y; Okamoto, M; Otsuki, S; Sato, K; Sato, M, 1990) |
| "Because of its abundance in the brain, its ability to produce hyperpolarizing inhibition of almost all neurons, its association with benzodiazepines, and the discovery that many convulsants inhibited its synthesis, gamma-aminobutyric acid (GABA) has often appeared to be the key to epilepsy." | 4.78 | GABA and epilepsy: their complex relationship and the evolution of our understanding. ( Snodgrass, SR, 1992) |
| "To determine whether intrathecal baclofen (ITB) changes mortality risk in persons with cerebral palsy (CP)." | 3.76 | Survival of individuals with cerebral palsy receiving continuous intrathecal baclofen treatment: a matched-cohort study. ( Day, SM; Krach, LE; Kriel, RL; Strauss, DJ, 2010) |
| "Baclofen is widely used to control spasticity in children with cerebral palsy." | 3.76 | Long-term oral baclofen treatment in a child with cerebral palsy: electroencephalographic changes and clinical adverse effects. ( De Rinaldis, M; Gennaro, L; Losito, L; Trabacca, A, 2010) |
| "In order to determine whether changes in synaptic inhibition are involved in chronic models of epilepsy, it is necessary to understand the factors which determine the kinetics of fast gamma-aminobutyric acid (GABA)ergic inhibition." | 3.69 | Analysis of the kinetics of synaptic inhibition points to a reduction in GABA release in area CA1 of the genetically epileptic mouse, El. ( Andreasen, M; Fueta, Y; Lambert, JD; Roepstorff, A, 1996) |
| "The anticonvulsant action of progabide, an agonist of gamma-aminobutyric acid (GABA)A and GABAB receptors, was investigated in the kindling model of epilepsy in rats." | 3.68 | An analysis of anticonvulsant actions of GABA agonists (progabide and baclofen) in the kindling model of epilepsy. ( Morimoto, K; Nakamura, Y; Okamoto, M; Otsuki, S; Sato, K; Sato, M, 1990) |
| "Treatment with ITB decreases spasticity in the upper and lower extremities and has been associated with improved function and decreased musculoskeletal contractures." | 2.43 | Intrathecal baclofen therapy in children. ( Albright, AL; Ferson, SS, 2006) |
| "There are few reports of spasticity treatment for people with ID, and none of functionally meaningful outcomes." | 1.36 | Spasticity treatment facilitates direct care delivery for adults with profound intellectual disability. ( Ayers, GD; Blair, CR; Charles, PD; Gill, CE; Konrad, PE; Putman, MS; Roberts, AG; Taylor, HM, 2010) |
| "Gabapentin is a clinically effective anticonvulsant with an unclear mechanism of action." | 1.32 | Gabapentin actions on Kir3 currents and N-type Ca2+ channels via GABAB receptors in hippocampal pyramidal cells. ( Bertrand, S; Lacaille, JC; Morin, F; Nagy, F; Nouel, D, 2003) |
| "To ascertain the prevalence of spasticity among adults living in a developmental center and to document the development of spasticity treatment plans for this population." | 1.32 | Spasticity in adults living in a developmental center. ( Charles, PD; Damian, MM; Noel-Spaudling, S; Pfister, AA; Roberts, AG; Taylor, HM, 2003) |
| "Substance P could also increase frequency but this usually succeeded or preceded a decrease in frequency." | 1.30 | Tachykinins may modify spontaneous epileptiform activity in the rat entorhinal cortex in vitro by activating GABAergic inhibition. ( Cody, C; Jones, RS; Maubach, KA, 1998) |
| "When baclofen (2 microM) was added to the picrotoxin containing medium, SLE's occurred both in the entorhinal cortex and in area CA3, suggesting that inhibition of inhibitory interneurons by baclofen could overcome the "filtering" of projected activity from the entorhinal cortex to the hippocampus." | 1.28 | Regional and time dependent variations of low Mg2+ induced epileptiform activity in rat temporal cortex slices. ( Dreier, JP; Heinemann, U, 1991) |
| "Baclofen was equally effective in antagonizing depolarization shift generation in mature and immature rat slices." | 1.27 | Postsynaptic actions of baclofen associated with its antagonism of bicuculline-induced epileptogenesis in hippocampus. ( Brady, RJ; Swann, JW, 1984) |
| "Baclofen has been reported to be epileptogenic in man, but many animal studies have demonstrated an anticonvulsant effect." | 1.27 | Baclofen. Its effect on seizure frequency. ( Fromm, GH; Roussan, MS; Terrence, CF, 1983) |
| "Baclofen can produce inhibition by increasing potassium conductance, and therefore may fail to appear efficacious in typical anticonvulsant screens due to techniques that cause rapid and massive increases in interstitial potassium." | 1.27 | Attenuation of epileptiform bursting by baclofen: reduced potency in elevated potassium. ( Sutch, CP; Swartzwelder, HS; Wilson, WA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (25.71) | 18.7374 |
| 1990's | 28 (40.00) | 18.2507 |
| 2000's | 14 (20.00) | 29.6817 |
| 2010's | 9 (12.86) | 24.3611 |
| 2020's | 1 (1.43) | 2.80 |
| Authors | Studies |
|---|---|
| De Rinaldis, M | 2 |
| Gallo, I | 1 |
| Oliva, MC | 1 |
| Trabacca, A | 2 |
| Martinello, K | 1 |
| Sciaccaluga, M | 1 |
| Morace, R | 1 |
| Mascia, A | 1 |
| Arcella, A | 1 |
| Esposito, V | 1 |
| Fucile, S | 1 |
| Aljuboori, Z | 1 |
| Archer, J | 1 |
| Huff, W | 1 |
| Moreno, A | 1 |
| Jea, A | 1 |
| Gould, T | 1 |
| Chen, L | 1 |
| Emri, Z | 2 |
| Pirttimaki, T | 1 |
| Errington, AC | 1 |
| Crunelli, V | 2 |
| Parri, HR | 1 |
| Tohid, H | 1 |
| Teichgräber, LA | 1 |
| Lehmann, TN | 1 |
| Meencke, HJ | 1 |
| Weiss, T | 1 |
| Nitsch, R | 1 |
| Deisz, RA | 1 |
| Krach, LE | 1 |
| Kriel, RL | 1 |
| Day, SM | 1 |
| Strauss, DJ | 1 |
| Charles, PD | 2 |
| Gill, CE | 1 |
| Taylor, HM | 2 |
| Putman, MS | 1 |
| Blair, CR | 1 |
| Roberts, AG | 2 |
| Ayers, GD | 1 |
| Konrad, PE | 1 |
| Losito, L | 1 |
| Gennaro, L | 1 |
| Vienne, J | 1 |
| Bettler, B | 2 |
| Franken, P | 1 |
| Tafti, M | 1 |
| Vorobyov, V | 1 |
| Schibaev, N | 1 |
| Kaptsov, V | 1 |
| Kovalev, G | 1 |
| Sengpiel, F | 1 |
| Yanovsky, Y | 1 |
| Misgeld, U | 1 |
| Bertrand, S | 1 |
| Nouel, D | 1 |
| Morin, F | 1 |
| Nagy, F | 1 |
| Lacaille, JC | 1 |
| Pfister, AA | 1 |
| Noel-Spaudling, S | 1 |
| Damian, MM | 1 |
| Albright, AL | 1 |
| Ferson, SS | 1 |
| Ghijsen, WE | 1 |
| Zuiderwijk, M | 1 |
| Lopes da Silva, FH | 1 |
| Ceulemans, B | 1 |
| van Rhijn, J | 1 |
| Kenis, S | 1 |
| Krols, R | 1 |
| Laridon, A | 1 |
| Van Havenbergh, T | 1 |
| LeTourneau, JL | 1 |
| Hagg, DS | 1 |
| Smith, SM | 1 |
| Brady, RJ | 1 |
| Swann, JW | 1 |
| Fromm, GH | 2 |
| Terrence, CF | 2 |
| Chattha, AS | 1 |
| Roussan, MS | 1 |
| Ghose, K | 1 |
| Holmes, KM | 1 |
| Matthewson, K | 1 |
| Velísková, J | 2 |
| Velísek, L | 2 |
| Sperber, EF | 1 |
| Haas, KZ | 1 |
| Moshé, SL | 1 |
| Stasheff, SF | 1 |
| Mott, DD | 2 |
| Wilson, WA | 5 |
| Piguet, P | 1 |
| Hosseinzadeh, H | 1 |
| Stone, TW | 1 |
| Watts, AE | 2 |
| Whittington, MA | 1 |
| Jefferys, JG | 3 |
| Kofler, M | 1 |
| Kronenberg, MF | 1 |
| Rifici, C | 1 |
| Saltuari, L | 1 |
| Bauer, G | 1 |
| Pfeiffer, M | 1 |
| Draguhn, A | 1 |
| Meierkord, H | 1 |
| Heinemann, U | 2 |
| Lambert, JD | 1 |
| Fueta, Y | 1 |
| Roepstorff, A | 1 |
| Andreasen, M | 1 |
| Maubach, KA | 1 |
| Cody, C | 1 |
| Jones, RS | 2 |
| Shoji, Y | 1 |
| Tanaka, E | 2 |
| Yamamoto, S | 1 |
| Maeda, H | 1 |
| Higashi, H | 2 |
| Traub, RD | 1 |
| Matejovská, I | 1 |
| Leresche, N | 1 |
| Asprodini, E | 1 |
| Cope, DW | 1 |
| Xiong, ZQ | 1 |
| Stringer, JL | 1 |
| Sokal, DM | 1 |
| Large, CH | 1 |
| Lin, J | 1 |
| Ritchie, GD | 1 |
| Stenger, DA | 1 |
| Nordholm, AF | 1 |
| Pancrazio, JJ | 1 |
| Rossi, J | 1 |
| Prosser, HM | 1 |
| Gill, CH | 1 |
| Hirst, WD | 1 |
| Grau, E | 1 |
| Robbins, M | 1 |
| Calver, A | 1 |
| Soffin, EM | 1 |
| Farmer, CE | 1 |
| Lanneau, C | 1 |
| Gray, J | 1 |
| Schenck, E | 1 |
| Warmerdam, BS | 1 |
| Clapham, C | 1 |
| Reavill, C | 1 |
| Rogers, DC | 1 |
| Stean, T | 1 |
| Upton, N | 1 |
| Humphreys, K | 1 |
| Randall, A | 1 |
| Geppert, M | 1 |
| Davies, CH | 1 |
| Pangalos, MN | 1 |
| Schuler, V | 1 |
| Lüscher, C | 1 |
| Blanchet, C | 1 |
| Klix, N | 1 |
| Sansig, G | 1 |
| Klebs, K | 1 |
| Schmutz, M | 2 |
| Heid, J | 1 |
| Gentry, C | 1 |
| Urban, L | 1 |
| Fox, A | 1 |
| Spooren, W | 1 |
| Jaton, AL | 1 |
| Vigouret, J | 1 |
| Pozza, M | 1 |
| Kelly, PH | 1 |
| Mosbacher, J | 1 |
| Froestl, W | 1 |
| Käslin, E | 1 |
| Korn, R | 1 |
| Bischoff, S | 1 |
| Kaupmann, K | 1 |
| van der Putten, H | 1 |
| Meldrum, BS | 1 |
| Primrose, DA | 1 |
| Snodgrass, SR | 1 |
| Karlsson, G | 2 |
| Kolb, C | 1 |
| Hausdorf, A | 1 |
| Portet, C | 1 |
| Olpe, HR | 2 |
| Asprodini, EK | 1 |
| Rainnie, DG | 1 |
| Shinnick-Gallagher, P | 1 |
| Siniscalchi, A | 1 |
| Avoli, M | 1 |
| Cook, CJ | 1 |
| Devine, CE | 1 |
| Tavener, A | 1 |
| Gilbert, KV | 1 |
| Nishi, S | 1 |
| Dreier, JP | 1 |
| Thompson, PM | 1 |
| Zebrowski, G | 1 |
| Neuman, RS | 1 |
| Burgard, EC | 1 |
| Sarvey, JM | 1 |
| Sato, K | 1 |
| Morimoto, K | 1 |
| Okamoto, M | 1 |
| Nakamura, Y | 1 |
| Otsuki, S | 1 |
| Sato, M | 1 |
| Miller, JW | 1 |
| Ferrendelli, JA | 1 |
| Segal, MM | 1 |
| Furshpan, EJ | 1 |
| Rush, JM | 1 |
| Gibberd, FB | 1 |
| Lee, RJ | 1 |
| Depaulis, A | 1 |
| Lomax, P | 1 |
| Olsen, RW | 1 |
| Bragdon, AC | 2 |
| Lewis, DV | 2 |
| Chamberlin, NL | 1 |
| Dingledine, R | 1 |
| Swartzwelder, HS | 3 |
| Sutch, CP | 2 |
| Ault, B | 2 |
| Ogata, N | 1 |
| Matsuo, T | 1 |
| Inoue, M | 1 |
| Gruenthal, M | 1 |
| Armstrong, DR | 1 |
| Nadler, JV | 1 |
| Wang, CM | 1 |
| Tamai, K | 1 |
| Aihara, M | 1 |
| Tanabe, Y | 1 |
| Goto, M | 1 |
| Slaughter, MM | 1 |
| Bai, SH | 1 |
| Anderson, WW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Inter-Rater Reliability of a Spasticity Diagnosis Algorithm[NCT01644123] | 72 participants (Actual) | Observational | 2013-04-30 | Completed | |||
| Using Telemedicine to Improve Spasticity Diagnosis Rates[NCT03211390] | 60 participants (Actual) | Observational | 2018-01-30 | Completed | |||
| Prevalence of Comorbid Spasticity and Urinary Incontinence in Residents of a Long-Term Care Facility[NCT03250988] | 60 participants (Actual) | Observational | 2018-01-30 | Completed | |||
| Validity and Inter-Rater Reliability of a Novel Bedside Referral Tool for Spasticity[NCT03209960] | 60 participants (Actual) | Observational | 2018-01-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for baclofen and Aura
| Article | Year |
|---|---|
Anti-glutamic acid decarboxylase antibody positive neurological syndromes.
Topics: Autoantibodies; Baclofen; Cerebellar Ataxia; Diazepam; Epilepsy; GABA Modulators; GABA-B Receptor Ag | 2016 |
Intrathecal baclofen therapy in children.
Topics: Baclofen; Child; Child, Preschool; Epilepsy; Humans; Infusion Pumps, Implantable; Injections, Spinal | 2006 |
The development of epilepsy in the paediatric brain.
Topics: Age Factors; Animals; Baclofen; Child; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Humans; Infan | 1994 |
GABA and epilepsy: their complex relationship and the evolution of our understanding.
Topics: Baclofen; Brain; Epilepsy; gamma-Aminobutyric Acid; Humans; Receptors, GABA-A | 1992 |
1 trial available for baclofen and Aura
| Article | Year |
|---|---|
Treatment of self-injurious behaviour with a GABA (gamma-aminobutyric acid) analogue.
Topics: Adolescent; Adult; Anorexia; Baclofen; Child; Clinical Trials as Topic; Double-Blind Method; Epileps | 1979 |
65 other studies available for baclofen and Aura
| Article | Year |
|---|---|
CNS adverse effects of intrathecal baclofen treatment for spasticity in children with cerebral palsy and epilepsy: a case report.
Topics: Baclofen; Cerebral Palsy; Child; Epilepsy; Humans; Injections, Spinal; Muscle Relaxants, Central; Mu | 2023 |
Loss of constitutive functional γ-aminobutyric acid type A-B receptor crosstalk in layer 5 pyramidal neurons of human epileptic temporal cortex.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adolescent; Adult; Animals; Baclofen; Carbazoles; Cyclic AMP | 2018 |
Placement of baclofen pump catheter through a C1-2 puncture: technical note.
Topics: Adolescent; Baclofen; Cerebral Palsy; Child; Child, Preschool; Epilepsy; Female; Humans; Infusion Pu | 2018 |
GABA(B) receptor-mediated activation of astrocytes by gamma-hydroxybutyric acid.
Topics: Animals; Astrocytes; Baclofen; Dose-Response Relationship, Drug; Epilepsy; Female; Hydroxybutyrates; | 2014 |
Impaired function of GABA(B) receptors in tissues from pharmacoresistant epilepsy patients.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Cerebral Cortex; Drug Resistance; Epilepsy; Epileps | 2009 |
Survival of individuals with cerebral palsy receiving continuous intrathecal baclofen treatment: a matched-cohort study.
Topics: Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Cohort Studies; Epilepsy; Fema | 2010 |
Spasticity treatment facilitates direct care delivery for adults with profound intellectual disability.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2010 |
Long-term oral baclofen treatment in a child with cerebral palsy: electroencephalographic changes and clinical adverse effects.
Topics: Baclofen; Brain; Brain Waves; Cerebral Palsy; Child; Electroencephalography; Epilepsy; Female; GABA- | 2010 |
Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric Acid, and Baclofen on EEG activity and sleep regulation.
Topics: Anesthetics, Intravenous; Animals; Baclofen; Behavior, Animal; Delta Rhythm; Electrodes, Implanted; | 2010 |
Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Baclofen; Clonidine; Disease Models, Animal; | 2011 |
Suppression of epileptiform activity by GABA(B) receptors in wild type and weaver hippocampus 'in vitro'.
Topics: Animals; Baclofen; Bicuculline; Crosses, Genetic; Disease Models, Animal; Epilepsy; Female; GABA Ago | 2003 |
Gabapentin actions on Kir3 currents and N-type Ca2+ channels via GABAB receptors in hippocampal pyramidal cells.
Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Baclofen; Barium; Calcium Channel Blo | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Spasticity in adults living in a developmental center.
Topics: Activities of Daily Living; Adult; Aged; Baclofen; Botulinum Toxins, Type A; Cerebral Palsy; Comorbi | 2003 |
Electrically evoked GABA release in rat hippocampus CA1 region and its changes during kindling epileptogenesis.
Topics: Animals; Anticonvulsants; Baclofen; Electric Stimulation; Epilepsy; GABA Antagonists; gamma-Aminobut | 2007 |
Opisthotonus and intrathecal treatment with baclofen (ITB) in children.
Topics: Adolescent; Adult; Baclofen; Belgium; Child; Child, Preschool; Dystonia; Epilepsy; Female; Follow-Up | 2008 |
Baclofen and gamma-hydroxybutyrate withdrawal.
Topics: Adjuvants, Anesthesia; Baclofen; Benzodiazepines; Delirium; Epilepsy; Female; GABA Agonists; Humans; | 2008 |
Postsynaptic actions of baclofen associated with its antagonism of bicuculline-induced epileptogenesis in hippocampus.
Topics: Animals; Baclofen; Bicuculline; Epilepsy; In Vitro Techniques; Membrane Potentials; Neural Conductio | 1984 |
Differential effect of antiepileptic and non-antiepileptic drugs on the reticular formation.
Topics: Action Potentials; Animals; Anticonvulsants; Baclofen; Carbamazepine; Cats; Dose-Response Relationsh | 1984 |
Baclofen. Its effect on seizure frequency.
Topics: Adult; Baclofen; Epilepsy; Female; Humans; Male; Seizures | 1983 |
Complications of baclofen overdosage.
Topics: Adult; Arrhythmia, Sinus; Baclofen; Epilepsy; Female; Humans; Muscle Spasticity | 1980 |
Axon terminal hyperexcitability associated with epileptogenesis in vitro. II. Pharmacological regulation by NMDA and GABAA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Axons; Baclofen; Culture Techniques; Epilepsy; Evoked Potentia | 1993 |
GABAA- and GABAB-mediated inhibition in the rat dentate gyrus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; E | 1993 |
The effect of calcium removal on the suppression by adenosine of epileptiform activity in the hippocampus: demonstration of desensitization.
Topics: Adenosine; Animals; Baclofen; Calcium; Calcium-Transporting ATPases; Electric Stimulation; Epilepsy; | 1994 |
Epileptic focus induced in rat by intrahippocampal cholera toxin: neuronal properties in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Baclo | 1993 |
Epileptic seizures associated with intrathecal baclofen application.
Topics: Adolescent; Adult; Anticonvulsants; Baclofen; Brain Injuries; Epilepsy; Humans; Infusion Pumps, Impl | 1994 |
Effects of carbamazepine and baclofen on 4-aminopyridine-induced epileptic activity in rat hippocampal slices.
Topics: 4-Aminopyridine; Animals; Baclofen; Carbamazepine; Electrophysiology; Epilepsy; Hippocampus; In Vitr | 1993 |
Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Entorhinal Cortex; Epilepsy; Female; GABA Agoni | 1996 |
Analysis of the kinetics of synaptic inhibition points to a reduction in GABA release in area CA1 of the genetically epileptic mouse, El.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Baclofen; Disease Models, Animal; El | 1996 |
Tachykinins may modify spontaneous epileptiform activity in the rat entorhinal cortex in vitro by activating GABAergic inhibition.
Topics: Animals; Baclofen; Bicuculline; Entorhinal Cortex; Epilepsy; Evoked Potentials; In Vitro Techniques; | 1998 |
Mechanisms underlying the enhancement of excitatory synaptic transmission in basolateral amygdala neurons of the kindling rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Baclofen; Bicu | 1998 |
'Dormant' inhibitory neurons: do they exist and what is their functional impact?
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; C | 1998 |
Bicuculline-induced rhythmic EEG episodes: gender differences and the effects of ethosuximide and baclofen treatment.
Topics: Animals; Baclofen; Bicuculline; Epilepsy; Epilepsy, Absence; Estradiol; Ethosuximide; Female; Incide | 1998 |
[Current data on bipolar disorders, epilepsy and spasticity. 4. Neuro-Forum, Dresden].
Topics: Baclofen; Bipolar Disorder; Clonidine; Epilepsy; Female; Humans; Male; Muscle Relaxants, Central; Mu | 1999 |
[Current data on bipolar disorders, epilepsy and spasm. 4th Neuro-Forum, Dresden].
Topics: Baclofen; Benzodiazepines; Bipolar Disorder; Clonidine; Epilepsy; Humans; Muscle Relaxants, Central; | 1999 |
Somatostatin inhibits GABAergic transmission in the sensory thalamus via presynaptic receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; C | 2000 |
Effects of postsynaptic GABA(B) receptor activation on epileptiform activity in hippocampal slices.
Topics: Adenosine; Animals; Baclofen; Dentate Gyrus; Electrodes, Implanted; Epilepsy; Excitatory Postsynapti | 2001 |
The effects of GABA(B) receptor activation on spontaneous and evoked activity in the dentate gyrus of kainic acid-treated rats.
Topics: Action Potentials; Animals; Baclofen; Dentate Gyrus; Depression, Chemical; Epilepsy; Excitatory Amin | 2001 |
Trimethylolpropane phosphate induces epileptiform discharges in the CA1 region of the rat hippocampus.
Topics: Action Potentials; Animals; Baclofen; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Diazepam | 2001 |
Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice.
Topics: Action Potentials; Animals; Baclofen; Behavior, Animal; Central Nervous System; Down-Regulation; Epi | 2001 |
Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).
Topics: Animals; Animals, Newborn; Avoidance Learning; Baclofen; Body Temperature Regulation; Delta Rhythm; | 2001 |
Gamma-aminobutyric acid and the search for new anticonvulsant drugs.
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Aminobutyrates; Animals; Anticonvulsants; Ba | 1978 |
GABAB receptors in various in vitro and in vivo models of epilepsy: a study with the GABAB receptor blocker CGP 35348.
Topics: Animals; Baclofen; Convulsants; Epilepsy; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniq | 1992 |
Epileptogenesis reduces the sensitivity of presynaptic gamma-aminobutyric acidB receptors on glutamatergic afferents in the amygdala.
Topics: Animals; Baclofen; Brain; Epilepsy; Evoked Potentials; Kindling, Neurologic; Male; Rats; Rats, Inbre | 1992 |
Modulation by GABAB receptors of spontaneous synchronous activities induced by 4-aminopyridine in the rat hippocampus.
Topics: 4-Aminopyridine; Animals; Baclofen; Dose-Response Relationship, Drug; Epilepsy; Evoked Potentials; G | 1992 |
Contribution of amino acid transmitters to epileptiform activity and reflex suppression in electrically head stunned sheep.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Baclofen; Bicuculline; Blinking; | 1992 |
Synaptic responses of guinea pig cingulate cortical neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; E | 1991 |
Regional and time dependent variations of low Mg2+ induced epileptiform activity in rat temporal cortex slices.
Topics: Animals; Baclofen; Brain Mapping; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Mag | 1991 |
Alteration of neocortical activity in response to noxious stimulation: participation of the dorsal raphe.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Baclofen; Cerebral Cortex; Cortical Synchronization | 1991 |
Long-lasting potentiation and epileptiform activity produced by GABAB receptor activation in the dentate gyrus of rat hippocampal slice.
Topics: Animals; Baclofen; Electric Stimulation; Electrophysiology; Epilepsy; Evoked Potentials; Hippocampus | 1991 |
An analysis of anticonvulsant actions of GABA agonists (progabide and baclofen) in the kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Baclofen; Dose-Response Relationship, Drug; Electroencephalography; Epilep | 1990 |
Characterization of GABAergic seizure regulation in the midline thalamus.
Topics: Animals; Baclofen; Bicuculline; Electroencephalography; Epilepsy; Female; Flurazepam; gamma-Aminobut | 1990 |
Epileptiform activity in microcultures containing small numbers of hippocampal neurons.
Topics: Animals; Animals, Newborn; Baclofen; Bicuculline; Cells, Cultured; Epilepsy; Evoked Potentials; Hipp | 1990 |
Baclofen-induced epilepsy.
Topics: Adult; Baclofen; Epilepsy; Female; Humans | 1990 |
Inhibitory processes in normal and epileptic-like rat hippocampal slices: the role of GABAB receptors.
Topics: Animals; Baclofen; Bicuculline; Epilepsy; Hippocampus; In Vitro Techniques; Male; Penicillins; Rats; | 1989 |
Anticonvulsant effect of muscimol injected into the thalamus of spontaneously epileptic Mongolian gerbils.
Topics: Animals; Anticonvulsants; Baclofen; Dose-Response Relationship, Drug; Epilepsy; Female; Gerbillinae; | 1989 |
Baclofen has a proepileptic effect in the rat dentate gyrus.
Topics: Animals; Baclofen; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Rats; Rats, | 1989 |
Ictal epileptiform events induced by removal of extracellular magnesium in slices of entorhinal cortex are blocked by baclofen.
Topics: Animals; Baclofen; Epilepsy; Evoked Potentials; Hippocampus; Histological Techniques; Magnesium Defi | 1989 |
Control of epileptiform burst rate by CA3 hippocampal cell afterhyperpolarizations in vitro.
Topics: Action Potentials; Animals; Baclofen; Epilepsy; Hippocampus; In Vitro Techniques; Membrane Potential | 1989 |
Baclofen suppresses hippocampal epileptiform activity at low concentrations without suppressing synaptic transmission.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; | 1986 |
Potent depressant action of baclofen on hippocampal epileptiform activity in vitro: possible use in the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Baclofen; Carbamazepine; Diazepam; Epilepsy; gamma-Aminobutyric Acid; Guin | 1986 |
Baclofen suppresses bursting activity induced in hippocampal slices by differing convulsant treatments.
Topics: Action Potentials; Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Epilepsy; Female; H | 1986 |
[An infant with kinesigenic reflex epilepsy which responded to baclofen].
Topics: Baclofen; Electroencephalography; Epilepsy; Female; Humans; Infant; Movement; Reflex; Wrist | 1988 |
Baclofen's suppression of epileptiform-like activity: a retinal model.
Topics: Action Potentials; Animals; Baclofen; Disease Models, Animal; Epilepsy; In Vitro Techniques; Membran | 1988 |
Seizure-like events in brain slices: suppression by interictal activity.
Topics: Action Potentials; Animals; Baclofen; Epilepsy; Hippocampus; In Vitro Techniques; Rats | 1987 |
Attenuation of epileptiform bursting by baclofen: reduced potency in elevated potassium.
Topics: Action Potentials; Animals; Baclofen; Bicuculline; Epilepsy; Hippocampus; In Vitro Techniques; Male; | 1986 |