baclofen and Ataxia
baclofen has been researched along with Ataxia in 12 studies
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 69-year-old woman with a history of hemodialysis-dependent end-stage renal disease presented to the Emergency Department with encephalopathy, ataxia, and dystonia after the addition of a recent baclofen prescription for back pain (10 mg twice daily)." | 3.85 | Baclofen Toxicity in a Patient with Hemodialysis-Dependent End-Stage Renal Disease. ( Katz, KD; Merrick, SS; Porter, LM, 2017) |
| "Male albino rats given a bilateral injection of Baclofen (Lioresal) (12 micrograms/rat) in the cerebral ventricles showed a behavioral syndrome of activation + ataxia, paddling, tail-pinch hyperresponse and anesthesia." | 3.66 | The role of monoamines for the central effects of Baclofen on behavior of rats. ( Smith, DF; Vestergaard, P, 1979) |
| "Disabling tremor or ataxia is common in multiple sclerosis (MS) and up to 80% of patients experience tremor or ataxia at some point during their disease." | 2.44 | Treatment for ataxia in multiple sclerosis. ( Mills, RJ; Yap, L; Young, CA, 2007) |
| "Agitation, convulsions and ataxia were also seen." | 2.39 | Baclofen poisoning in children. ( Cooke, DE; Glasstone, MA, 1994) |
| " Ketamine, PCP, and MK-801 enhanced catalepsy along inverted U-shaped dose-response curves likely because higher doses affected motor coordination, which limited their catalepsy-enhancing effects." | 1.35 | Cataleptic effects of gamma-hydroxybutyrate (GHB) and baclofen in mice: mediation by GABA(B) receptors, but differential enhancement by N-methyl-d-aspartate (NMDA) receptor antagonists. ( France, CP; Koek, W, 2008) |
| "Baclofen was largely ineffective in reducing withdrawal-induced tremors, although it was capable of producing sedation of a different type than that produced by phenobarbitol and ethanol." | 1.26 | The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey. ( Tarika, JS; Winger, G, 1980) |
Research
Studies (12)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Porter, LM | 1 |
| Merrick, SS | 1 |
| Katz, KD | 1 |
| Holstein, SE | 1 |
| Dobbs, L | 1 |
| Phillips, TJ | 1 |
| Heskin-Sweezie, R | 1 |
| Titley, HK | 1 |
| Baizer, JS | 1 |
| Broussard, DM | 1 |
| Jacobson, LH | 1 |
| Bettler, B | 1 |
| Kaupmann, K | 1 |
| Cryan, JF | 1 |
| Mills, RJ | 1 |
| Yap, L | 1 |
| Young, CA | 1 |
| Koek, W | 1 |
| France, CP | 1 |
| Tarika, JS | 1 |
| Winger, G | 1 |
| Dimitrijevic, MR | 1 |
| Sherwood, AM | 1 |
| Cooke, DE | 1 |
| Glasstone, MA | 1 |
| Dar, MS | 1 |
| Smith, DF | 1 |
| Vestergaard, P | 1 |
| Ebenezer, IS | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exploration of Brain Changes Due to a Targeted Ballet Program in Multiple Sclerosis[NCT04073940] | 30 participants (Anticipated) | Interventional | 2019-08-29 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
3 reviews available for baclofen and Ataxia
| Article | Year |
|---|---|
Treatment for ataxia in multiple sclerosis.
Topics: Ataxia; Baclofen; Cannabis; Humans; Multiple Sclerosis; Muscle Relaxants, Central; Phytotherapy; Ran | 2007 |
Spasticity: medical and surgical treatment.
Topics: Ambulatory Care; Ataxia; Baclofen; Dantrolene; Diazepam; Electric Stimulation; Electrodes; Electroen | 1980 |
Baclofen poisoning in children.
Topics: Ataxia; Baclofen; Central Nervous System; Child; Child, Preschool; Cohort Studies; Drug Overdose; Fe | 1994 |
Other Studies
9 other studies available for baclofen and Ataxia
| Article | Year |
|---|---|
Baclofen Toxicity in a Patient with Hemodialysis-Dependent End-Stage Renal Disease.
Topics: Aged; Ataxia; Back Pain; Baclofen; Brain Diseases; Confusion; Dystonia; Emergency Service, Hospital; | 2017 |
Attenuation of the stimulant response to ethanol is associated with enhanced ataxia for a GABA, but not a GABA, receptor agonist.
Topics: Animals; Ataxia; Baclofen; Dose-Response Relationship, Drug; Ethanol; GABA-A Receptor Agonists; GABA | 2009 |
Type B GABA receptors contribute to the restoration of balance during vestibular compensation in mice.
Topics: Adaptation, Physiological; Animals; Ataxia; Baclofen; Benzoates; GABA-B Receptor Agonists; GABA-B Re | 2010 |
GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice.
Topics: Animals; Ataxia; Baclofen; Body Temperature; Darkness; Female; GABA Agonists; GABA-B Receptor Agonis | 2006 |
Cataleptic effects of gamma-hydroxybutyrate (GHB) and baclofen in mice: mediation by GABA(B) receptors, but differential enhancement by N-methyl-d-aspartate (NMDA) receptor antagonists.
Topics: Anesthetics, Intravenous; Animals; Area Under Curve; Ataxia; Baclofen; Catalepsy; Data Interpretatio | 2008 |
The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey.
Topics: Alcoholism; Animals; Ataxia; Baclofen; Behavior, Animal; Drug Interactions; Ethanol; Humans; Macaca | 1980 |
Mouse cerebellar GABAB participation in the expression of acute ethanol-induced ataxia and in its modulation by the cerebellar adenosinergic A1 system.
Topics: Adenosine; Adenylate Cyclase Toxin; Animals; Ataxia; Baclofen; Behavior, Animal; Cerebellum; Dose-Re | 1996 |
The role of monoamines for the central effects of Baclofen on behavior of rats.
Topics: Anesthesia; Animals; Ataxia; Baclofen; Catecholamines; Clonidine; Dopamine; Injections, Intraventric | 1979 |
The effect of intracerebroventricular administration of baclofen on food intake in rats.
Topics: Animals; Ataxia; Baclofen; Brain; Dose-Response Relationship, Drug; Eating; Injections, Intraventric | 1990 |