Page last updated: 2024-10-23

baclofen and Anxiety

baclofen has been researched along with Anxiety in 44 studies

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"Baclofen did not lead to a differential change in cognitive biases compared with placebo, and trait anxiety levels did not moderate this."9.27Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein? ( Beraha, EM; Krediet, E; Salemink, E; Wiers, RW, 2018)
" A post hoc analysis stratifying according to whether there had been a comorbid anxiety disorder, revealed a beneficial effect of baclofen 30 mg/day versus placebo on time to lapse and relapse (P < 0."9.19Baclofen for the Treatment of Alcohol Dependence and Possible Role of Comorbid Anxiety. ( Addolorato, G; Baillie, A; Haber, PS; Leggio, L; Leung, S; Morley, KC, 2014)
"Previous studies from our laboratory showed that anxiety-related responses induced by nicotine (NIC), measured by the elevated plus maze, were abolished by 2-OH-saclofen (GABAB receptor antagonist) (1 mg/kg; ip) or the lack of GABAB receptors (GABAB1 knockout mice)."7.80Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches. ( Balerio, GN; Bettler, B; Pedrón, VT; Varani, AP, 2014)
"Adolescents have an increased vulnerability to nicotine and anxiety may play a role in the development of nicotine abuse."7.80Anxiety status affects nicotine- and baclofen-induced locomotor activity, anxiety, and single-trial conditioned place preference in male adolescent rats. ( Falco, AM; McDonald, CG; Smith, RF, 2014)
"We investigated the effects of baclofen, a selective GABA-B receptor agonist, on certain behaviours in rats after short-term hypoxia, as a model of experimentally induced amnesia."7.71Baclofen prevents hypoxia-induced consolidation impairment for passive avoidance in rats. ( Car, H; Nadlewska, A; Oksztel, R; Wiśniewski, K, 2001)
"Baclofen was superior to placebo in the treatment of anxiety, which is of particular interest in view of the recent theories on the mechanism of action of benzodiazepines."6.64A double-blind trial of baclofen against placebo in the treatment of schizophrenia. ( Andersen, B; Bahr, B; Eliassen, HM; Gulmann, NC, 1976)
"BHF177 exhibited pro-convulsion properties only in mice, but not in rats, indicating that this effect may be species-specific."5.39Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. ( Cates-Gatto, C; Finn, MG; Kaczanowska, K; Li, X; Markou, A; Risbrough, VB; Roberts, AJ, 2013)
"Data from a randomised controlled trial (RCT) (N = 104), in which AUD patients received placebo or baclofen (30 mg/day or 75 mg/day) for 12 weeks, were analysed to determine predictive effects of the following four clinical characteristics: alcoholic liver disease (ALD), baseline alcohol consumption, craving and anxiety."5.30Clinical Predictors of Response to Baclofen in the Treatment of Alcohol use Disorder: Results from the BacALD Trial. ( Baillie, A; Haber, PS; Morley, KC; Rombouts, SA, 2019)
"Baclofen (2 mg/kg) was sedative in both control treated and diazepam-dependent rats, but was ineffective at reversing the decrease in social interaction seen after diazepam withdrawal."5.28Diazepam withdrawal responses measured in the social interaction test of anxiety and their reversal by baclofen. ( Andrews, N; File, SE; Mabbutt, PS, 1991)
"Baclofen did not lead to a differential change in cognitive biases compared with placebo, and trait anxiety levels did not moderate this."5.27Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein? ( Beraha, EM; Krediet, E; Salemink, E; Wiers, RW, 2018)
" Baclofen has been shown to promote abstinence, to reduce craving, and to reduce anxiety in alcohol-dependent individuals, and it promises to be a useful agent, although clinical data are limited at present."5.24Randomized open-label trial of baclofen for relapse prevention in alcohol dependence. ( Arora, S; Elwadhi, D; Gupta, M; Rastogi, R; Verma, P, 2017)
" A post hoc analysis stratifying according to whether there had been a comorbid anxiety disorder, revealed a beneficial effect of baclofen 30 mg/day versus placebo on time to lapse and relapse (P < 0."5.19Baclofen for the Treatment of Alcohol Dependence and Possible Role of Comorbid Anxiety. ( Addolorato, G; Baillie, A; Haber, PS; Leggio, L; Leung, S; Morley, KC, 2014)
"Previous studies from our laboratory showed that anxiety-related responses induced by nicotine (NIC), measured by the elevated plus maze, were abolished by 2-OH-saclofen (GABAB receptor antagonist) (1 mg/kg; ip) or the lack of GABAB receptors (GABAB1 knockout mice)."3.80Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches. ( Balerio, GN; Bettler, B; Pedrón, VT; Varani, AP, 2014)
"These results showed that nicotine rewarding properties and negative aspects of nicotine withdrawal, such as anxiety-like effects and somatic manifestations, can be modulated by the GABAB receptor activity."3.80Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations. ( Aso, E; Balerio, GN; Maldonado, R; Moutinho, LM; Varani, AP, 2014)
"In an attempt to establish a relationship between food intake and fear/anxiety-related behaviours, the goal of this study was to investigate the effect of bilateral injections of GABAA (Muscimol, MUS, doses 25 and 50ng/side) and GABAB (Baclofen, BAC, doses 32 and 64ng/side) receptor agonists in the nucleus accumbens shell (AcbSh) on the level of fear/anxiety-like and feeding behaviours in 24h food-deprived rats."3.78Effects of GABA ligands injected into the nucleus accumbens shell on fear/anxiety-like and feeding behaviours in food-deprived rats. ( Borges, AC; Faria, MS; Ganzer, L; Januário, AC; Kochenborger, L; Lopes, AP; Marino-Neto, J; Paschoalini, MA, 2012)
"This study investigated the effect of GABAA (muscimol, MUSC) and GABAB (baclofen, BACL) agonist receptors microinjected into medial accumbens shell on feeding and the level of fear in free-feeding rats submitted to the elevated plus-maze (EPM), an animal model of anxiety."3.74GABAA and GABAB agonist microinjections into medial accumbens shell increase feeding and induce anxiolysis in an animal model of anxiety. ( da Cunha, IC; de Lima, TC; Faria, MS; Ferraz, A; Lopes, AP; Neto, JM; Paschoalini, MA; Steffens, SM; Vargas, JC, 2007)
"We investigated the effects of baclofen, a selective GABA-B receptor agonist, on certain behaviours in rats after short-term hypoxia, as a model of experimentally induced amnesia."3.71Baclofen prevents hypoxia-induced consolidation impairment for passive avoidance in rats. ( Car, H; Nadlewska, A; Oksztel, R; Wiśniewski, K, 2001)
"Baclofen has been suggested as a potential pharmacotherapy for alcohol use disorder, but the clinical data are conflicting."2.84Biobehavioral effects of baclofen in anxious alcohol-dependent individuals: a randomized, double-blind, placebo-controlled, laboratory study. ( Amodio, JP; Bollinger, JW; Farinelli, LA; Farokhnia, M; Lee, MR; Leggio, L; Lionetti, TA; Schwandt, ML; Sewell, L; Spero, DE, 2017)
"Depression was assessed with Montgomery-Ashberg scale."2.80[Double blind placebo controlled randomized pilot clinical trial of baclofen (Baclosan®) for alcohol dependence]. ( Alexeeva, YV; Berntsev, VA; Chekhlaty, EI; Kiselev, AS; Krupitsky, EM; Neznanov, NG; Popov, YV; Rybakova, KV; Zubova, EY, 2015)
"Baclofen has shown promise in treating substance use disorders and also reduced binge frequency in an open-label trial."2.77Baclofen reduces binge eating in a double-blind, placebo-controlled, crossover study. ( Boan, J; Corwin, RL; Peters, KF; Ulbrecht, JS, 2012)
"Baclofen was associated with a significant reduction in state anxiety (F(1,73)= 5."2.75Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial. ( Flannery, BA; Gallop, R; Garbutt, JC; Kalka-Juhl, L; Kampov-Polevoy, AB, 2010)
"Quantitative measurements of spasticity were also taken at each session."2.67The supraspinal anxiolytic effect of baclofen for spasticity reduction. ( Hinderer, SR, 1990)
"Baclofen was superior to placebo in the treatment of anxiety, which is of particular interest in view of the recent theories on the mechanism of action of benzodiazepines."2.64A double-blind trial of baclofen against placebo in the treatment of schizophrenia. ( Andersen, B; Bahr, B; Eliassen, HM; Gulmann, NC, 1976)
"Baclofen is a γ-aminobutyric acid B (GABA-B) agonist which is used increasingly as an off-label treatment."2.58Baclofen: its effectiveness in reducing harmful drinking, craving, and negative mood. A meta-analysis. ( Jones, A; Rose, AK, 2018)
"Baclofen is a new and promising pharmacological compound for the treatment of alcohol dependence (AD)."1.46Speaking fluently with baclofen? ( Beraha, E; Bodewits, P; van den Brink, W; Wiers, R, 2017)
"BHF177 exhibited pro-convulsion properties only in mice, but not in rats, indicating that this effect may be species-specific."1.39Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. ( Cates-Gatto, C; Finn, MG; Kaczanowska, K; Li, X; Markou, A; Risbrough, VB; Roberts, AJ, 2013)
"Baclofen (2 mg/kg) was sedative in both control treated and diazepam-dependent rats, but was ineffective at reversing the decrease in social interaction seen after diazepam withdrawal."1.28Diazepam withdrawal responses measured in the social interaction test of anxiety and their reversal by baclofen. ( Andrews, N; File, SE; Mabbutt, PS, 1991)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19904 (9.09)18.7374
1990's7 (15.91)18.2507
2000's9 (20.45)29.6817
2010's22 (50.00)24.3611
2020's2 (4.55)2.80

Authors

AuthorsStudies
Agabio, R1
Baldwin, DS1
Amaro, H1
Leggio, L3
Sinclair, JMA1
Zou, HW1
Li, ZL1
Jing, XY1
Wang, Y1
Liu, YJ1
Li, LF1
Farokhnia, M1
Schwandt, ML1
Lee, MR1
Bollinger, JW1
Farinelli, LA1
Amodio, JP1
Sewell, L1
Lionetti, TA1
Spero, DE1
Beraha, E1
Bodewits, P1
van den Brink, W1
Wiers, R1
Zarrabian, S1
Nasehi, M1
Farrahizadeh, M1
Zarrindast, MR1
Rose, AK1
Jones, A1
Beraha, EM1
Salemink, E1
Krediet, E1
Wiers, RW1
Rombouts, SA1
Baillie, A2
Haber, PS2
Morley, KC2
Sweeney, FF1
O'Leary, OF1
Cryan, JF2
Varani, AP3
Pedrón, VT1
Bettler, B1
Balerio, GN3
Aso, E1
Moutinho, LM1
Maldonado, R1
Falco, AM1
McDonald, CG1
Smith, RF1
Stratton, MS1
Staros, M1
Budefeld, T1
Searcy, BT1
Nash, C1
Eitel, C1
Carbone, D1
Handa, RJ1
Majdic, G1
Tobet, SA1
Leung, S1
Addolorato, G1
Li, X2
Kaczanowska, K2
Finn, MG2
Markou, A2
Risbrough, VB2
Krupitsky, EM1
Rybakova, KV1
Kiselev, AS1
Alexeeva, YV1
Berntsev, VA1
Chekhlaty, EI1
Zubova, EY1
Popov, YV1
Neznanov, NG1
Li, C2
Yan, Y1
Cheng, J1
Xiao, G1
Gu, J1
Zhang, L1
Yuan, S1
Wang, J1
Shen, Y1
Zhou, YD1
Lu, Y1
Li, CJ1
Chen, C1
Luo, P1
Zhou, M1
Xu, XL1
Lu, Q1
He, Z1
Guo, LJ1
Gupta, M1
Verma, P1
Rastogi, R1
Arora, S1
Elwadhi, D1
Kheifez, IA1
Molodavkin, GM1
Voronina, TA1
Dugina, YL1
Sergeeva, SA1
Epstein, OI1
Roohbakhsh, A1
Keshavarz, S1
Hasanein, P1
Rezvani, ME1
Moghaddam, AH1
Garbutt, JC1
Kampov-Polevoy, AB1
Gallop, R1
Kalka-Juhl, L1
Flannery, BA1
Lopes, AP2
Ganzer, L1
Borges, AC1
Kochenborger, L1
Januário, AC1
Faria, MS2
Marino-Neto, J1
Paschoalini, MA2
Corwin, RL1
Boan, J1
Peters, KF1
Ulbrecht, JS1
Cates-Gatto, C1
Roberts, AJ1
Sokal, DM1
Giarola, AS1
Large, CH1
Amikishieva, AV2
Semendiaeva, SN1
Knapp, DJ1
Overstreet, DH1
Breese, GR1
da Cunha, IC1
Steffens, SM1
Ferraz, A1
Vargas, JC1
de Lima, TC1
Neto, JM1
Semendyaeva, SN1
Jacobson, LH1
Jamous, A1
Kennedy, P1
Psychol, C1
Grey, N1
Andrews, N2
File, SE4
Car, H1
Oksztel, R1
Nadlewska, A1
Wiśniewski, K1
Gulmann, NC1
Bahr, B1
Andersen, B1
Eliassen, HM1
Shephard, RA1
Wedlock, P1
Wilson, NE1
Zharkovsky, A2
Hitchcott, PK1
Mabbutt, PS1
Gulati, K1
Hinderer, SR1
Rägo, L1
Kiivet, RA1
Harro, J1
Pŏld, M1
Quintero, S1
Henney, S1
Lawson, P1
Mellanby, J2
Gray, JA2
Buckland, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-Blind, Placebo-Controlled, Randomized Human Laboratory Pilot Study of Baclofen in Anxious Alcoholics[NCT01751386]Phase 239 participants (Actual)Interventional2012-12-03Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Total Amount of Alcohol Consumed During the Alcohol Self Administration (ASA) Session

Amount of alcohol was measured as the number of mini-drinks each participant decided to drink (0-8 mini-drinks). The alcohol content of each mini-drink was calculated based on the participants' total body water, and was designed to raise the blood alcohol concentration by 0.015 g/dL. (NCT01751386)
Timeframe: 2 hours

Interventionmini-drinks (Mean)
Baclofen4.11
Placebo4.5

Reviews

2 reviews available for baclofen and Anxiety

ArticleYear
The influence of anxiety symptoms on clinical outcomes during baclofen treatment of alcohol use disorder: A systematic review and meta-analysis.
    Neuroscience and biobehavioral reviews, 2021, Volume: 125

    Topics: Alcohol Drinking; Alcoholism; Anxiety; Baclofen; GABA-B Receptor Agonists; Humans

2021
Baclofen: its effectiveness in reducing harmful drinking, craving, and negative mood. A meta-analysis.
    Addiction (Abingdon, England), 2018, Volume: 113, Issue:8

    Topics: Affect; Alcohol Abstinence; Alcohol Drinking; Alcoholism; Anxiety; Baclofen; Craving; Depression; GA

2018

Trials

10 trials available for baclofen and Anxiety

ArticleYear
Biobehavioral effects of baclofen in anxious alcohol-dependent individuals: a randomized, double-blind, placebo-controlled, laboratory study.
    Translational psychiatry, 2017, 04-25, Volume: 7, Issue:4

    Topics: Adult; Alcohol Drinking; Alcoholism; Anxiety; Baclofen; Biobehavioral Sciences; Craving; Double-Blin

2017
Can baclofen change alcohol-related cognitive biases and what is the role of anxiety herein?
    Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:8

    Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Anxiety; Anxiety Disorders; Attentional Bias;

2018
Clinical Predictors of Response to Baclofen in the Treatment of Alcohol use Disorder: Results from the BacALD Trial.
    Alcohol and alcoholism (Oxford, Oxfordshire), 2019, May-01, Volume: 54, Issue:3

    Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Anxiety; Baclofen; Craving; Dose-Response Rel

2019
Baclofen for the Treatment of Alcohol Dependence and Possible Role of Comorbid Anxiety.
    Alcohol and alcoholism (Oxford, Oxfordshire), 2014, Volume: 49, Issue:6

    Topics: Adult; Alcohol Abstinence; Alcoholism; Anxiety; Baclofen; Double-Blind Method; Female; GABA-B Recept

2014
[Double blind placebo controlled randomized pilot clinical trial of baclofen (Baclosan®) for alcohol dependence].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:6

    Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Anxiety; Baclofen; Depression; Double-Blind M

2015
Randomized open-label trial of baclofen for relapse prevention in alcohol dependence.
    The American journal of drug and alcohol abuse, 2017, Volume: 43, Issue:3

    Topics: Adult; Alcohol Abstinence; Alcohol Drinking; Alcoholism; Anxiety; Baclofen; Craving; GABA-B Receptor

2017
Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial.
    Alcoholism, clinical and experimental research, 2010, Volume: 34, Issue:11

    Topics: Adolescent; Adult; Alcohol Drinking; Alcoholism; Anxiety; Baclofen; Depression; Double-Blind Method;

2010
Baclofen reduces binge eating in a double-blind, placebo-controlled, crossover study.
    Behavioural pharmacology, 2012, Volume: 23, Issue:5-6

    Topics: Adult; Anxiety; Baclofen; Binge-Eating Disorder; Cross-Over Studies; Depression; Double-Blind Method

2012
A double-blind trial of baclofen against placebo in the treatment of schizophrenia.
    Acta psychiatrica Scandinavica, 1976, Volume: 54, Issue:4

    Topics: Adult; Aminobutyrates; Anxiety; Baclofen; Chlorpromazine; Clinical Trials as Topic; Drug Evaluation;

1976
The supraspinal anxiolytic effect of baclofen for spasticity reduction.
    American journal of physical medicine & rehabilitation, 1990, Volume: 69, Issue:5

    Topics: Adult; Anxiety; Baclofen; Drug Evaluation; Humans; Male; Muscle Spasticity; Random Allocation; Spina

1990

Other Studies

32 other studies available for baclofen and Anxiety

ArticleYear
The GABA(B1) receptor within the infralimbic cortex is implicated in stress resilience and vulnerability in mice.
    Behavioural brain research, 2021, 05-21, Volume: 406

    Topics: Animals; Anxiety; Avoidance Learning; Baclofen; Behavior, Animal; Disease Models, Animal; Disease Su

2021
Speaking fluently with baclofen?
    BMJ case reports, 2017, May-11, Volume: 2017

    Topics: Alcohol Abstinence; Alcohol Drinking; Alcoholism; Anxiety; Baclofen; GABA-B Receptor Agonists; Human

2017
The role of CA3 GABA
    Progress in neuro-psychopharmacology & biological psychiatry, 2017, 10-03, Volume: 79, Issue:Pt B

    Topics: 2-Amino-5-phosphonovalerate; Animals; Anxiety; Avoidance Learning; Baclofen; CA3 Region, Hippocampal

2017
Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c mice.
    Neuropharmacology, 2014, Volume: 81

    Topics: Analysis of Variance; Animals; Animals, Newborn; Anxiety; Baclofen; Benzylamines; Defense Mechanisms

2014
Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches.
    Neuropharmacology, 2014, Volume: 81

    Topics: Analysis of Variance; Animals; Anxiety; Baclofen; Disease Models, Animal; Dorsal Raphe Nucleus; Dose

2014
Attenuation by baclofen of nicotine rewarding properties and nicotine withdrawal manifestations.
    Psychopharmacology, 2014, Volume: 231, Issue:15

    Topics: Animals; Anxiety; Avoidance Learning; Baclofen; Conditioning, Psychological; GABA-B Receptor Agonist

2014
Anxiety status affects nicotine- and baclofen-induced locomotor activity, anxiety, and single-trial conditioned place preference in male adolescent rats.
    Developmental psychobiology, 2014, Volume: 56, Issue:6

    Topics: Animals; Anxiety; Association Learning; Baclofen; Behavior, Animal; Cholinergic Agents; Conditioning

2014
Embryonic GABA(B) receptor blockade alters cell migration, adult hypothalamic structure, and anxiety- and depression-like behaviors sex specifically in mice.
    PloS one, 2014, Volume: 9, Issue:8

    Topics: Animals; Anxiety; Baclofen; Cell Movement; Depression; Embryo, Mammalian; Female; GABA-B Receptor An

2014
The GABA(B) receptor positive modulator BHF177 attenuated anxiety, but not conditioned fear, in rats.
    Neuropharmacology, 2015, Volume: 97

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Baclofen; Buspirone; Conditioning, Classical; Dose-Response R

2015
Toll-Like Receptor 4 Deficiency Causes Reduced Exploratory Behavior in Mice Under Approach-Avoidance Conflict.
    Neuroscience bulletin, 2016, Volume: 32, Issue:2

    Topics: Analysis of Variance; Animals; Anxiety; Avoidance Learning; Baclofen; Disease Models, Animal; Explor

2016
Activation of GABAB2 subunits alleviates chronic cerebral hypoperfusion-induced anxiety-like behaviours: A role for BDNF signalling and Kir3 channels.
    Neuropharmacology, 2016, Volume: 110, Issue:Pt A

    Topics: Animals; Anxiety; Baclofen; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Carotid Arte

2016
Involvement of the GABA-B system in the mechanism of action of ultralow-dose antibodies to S-100 protein.
    Bulletin of experimental biology and medicine, 2008, Volume: 145, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Antibodies; Antidepressive Agents; Anxiety; Baclofen; Depression; Diaz

2008
Role of endocannabinoid system in the ventral hippocampus of rats in the modulation of anxiety-like behaviours.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:5

    Topics: Amidohydrolases; Animals; Anxiety; Baclofen; Behavior, Animal; Benzamides; Bicuculline; Cannabinoid

2009
Effects of GABA ligands injected into the nucleus accumbens shell on fear/anxiety-like and feeding behaviours in food-deprived rats.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:1

    Topics: Animals; Anxiety; Baclofen; Behavior, Animal; Bicuculline; Eating; Fear; Feeding Behavior; Food Depr

2012
GABA(B) receptors involvement in the effects induced by nicotine on anxiety-related behaviour in mice.
    Pharmacological research, 2012, Volume: 65, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Baclofen; Behavior, Animal; GABA-B Receptor Agonists; GABA-B

2012
Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice.
    Neuropharmacology, 2013, Volume: 70

    Topics: Animals; Anxiety; Baclofen; Chlordiazepoxide; Dose-Response Relationship, Drug; GABA-B Receptor Agon

2013
Effects of GABA(B), 5-HT(1A), and 5-HT(2) receptor stimulation on activation and inhibition of the rat lateral amygdala following medial geniculate nucleus stimulation in vivo.
    Brain research, 2005, Jan-07, Volume: 1031, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Amygdala; Animals; Anxiety; Baclofen; Evoked P

2005
[Effects of baclofen on anxiety level, sexual motivation and olfactory perception in male mice with different psycho-emotional statuses].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2006, Volume: 92, Issue:9

    Topics: Aggression; Animals; Anxiety; Baclofen; Emotions; Female; GABA-B Receptor Agonists; Male; Mice; Mice

2006
Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal.
    Alcoholism, clinical and experimental research, 2007, Volume: 31, Issue:4

    Topics: Alcohol Drinking; Animals; Anxiety; Baclofen; Body Weight; Central Nervous System Depressants; Diet;

2007
GABAA and GABAB agonist microinjections into medial accumbens shell increase feeding and induce anxiolysis in an animal model of anxiety.
    Behavioural brain research, 2007, Dec-03, Volume: 184, Issue:2

    Topics: Analysis of Variance; Animals; Anxiety; Baclofen; Behavior, Animal; Disease Models, Animal; Dose-Res

2007
Effects of baclofen on anxiety, sexual motivation, and olfactory perception in male mice in different psychoemotional states.
    Neuroscience and behavioral physiology, 2007, Volume: 37, Issue:9

    Topics: Aggression; Animal Communication; Animals; Anxiety; Baclofen; Dose-Response Relationship, Drug; Emot

2007
Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodents.
    Neuropharmacology, 2008, Volume: 54, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Baclofen; Behavior, Animal; Benzodiazepines; Body Temperature

2008
Psychological and emotional effects of the use of oral baclofen: a preliminary study.
    Paraplegia, 1994, Volume: 32, Issue:5

    Topics: Adolescent; Adult; Affect; Anxiety; Baclofen; Emotions; Humans; Male; Muscle Spasticity; Psychiatric

1994
Handling history of rats modifies behavioural effects of drugs in the elevated plus-maze test of anxiety.
    European journal of pharmacology, 1993, Apr-22, Volume: 235, Issue:1

    Topics: Animals; Anxiety; Baclofen; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo

1993
Baclofen prevents hypoxia-induced consolidation impairment for passive avoidance in rats.
    Pharmacological research, 2001, Volume: 44, Issue:4

    Topics: Amnesia; Animals; Anxiety; Avoidance Learning; Baclofen; Disease Models, Animal; Exploratory Behavio

2001
Direct evidence for mediation of an anticonflict effect of baclofen by GABAb receptors.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:3

    Topics: Amino Acids; Amino Acids, Neutral; Animals; Anxiety; Baclofen; Behavior, Animal; Conflict, Psycholog

1992
Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal.
    Progress in neuro-psychopharmacology & biological psychiatry, 1992, Volume: 16, Issue:1

    Topics: Animals; Anxiety; Baclofen; Chlordiazepoxide; Diazepam; Ethanol; Flumazenil; Interpersonal Relations

1992
Diazepam withdrawal responses measured in the social interaction test of anxiety and their reversal by baclofen.
    Psychopharmacology, 1991, Volume: 104, Issue:1

    Topics: Animals; Anxiety; Baclofen; Diazepam; Drug Tolerance; Interpersonal Relations; Male; Rats; Substance

1991
Effects of baclofen and nitrendipine on ethanol withdrawal responses in the rat.
    Neuropharmacology, 1991, Volume: 30, Issue:2

    Topics: Aggression; Animals; Anxiety; Baclofen; Diet; Dose-Response Relationship, Drug; Ethanol; Exploratory

1991
Central- and peripheral-type benzodiazepine receptors: similar regulation by stress and GABA receptor agonists.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:4

    Topics: Animals; Anxiety; Baclofen; Behavior, Animal; Benzodiazepinones; Binding Sites; Brain; Flunitrazepam

1989
The effects of compounds related to gamma-aminobutyrate and benzodiazepine receptors on behavioural responses to anxiogenic stimuli in the rat: punished barpressing.
    Psychopharmacology, 1985, Volume: 85, Issue:2

    Topics: Amobarbital; Animals; Anti-Anxiety Agents; Anxiety; Baclofen; Bicuculline; Carbolines; Chlordiazepox

1985
The effects of compounds related to gamma-aminobutyrate and benzodiazepine receptors on behavioural responses to anxiogenic stimuli in the rat: extinction and successive discrimination.
    Psychopharmacology, 1986, Volume: 88, Issue:3

    Topics: Animals; Anxiety; Baclofen; Behavior, Animal; Bicuculline; Chlordiazepoxide; Discrimination Learning

1986