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baclofen and Anesthesia

baclofen has been researched along with Anesthesia in 26 studies

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study is to describe the efficacy and adverse events of neuraxial anesthesia for post-operative pain control in non-ambulatory children with cerebral palsy with pre-existing intrathecal baclofen (ITB) pumps undergoing hip reconstructive or palliative surgery."8.12Neuraxial anesthesia for post-operative pain control after hip surgery in children with cerebral palsy and pre-existing intrathecal baclofen pumps. ( Ball, MA; Davids, JR; Davidson, LT; Kephart, DT; Kulkarni, VA; Tumber, S, 2022)
"A 34-year-old man with adrenoleukodystrophy (ALD) was scheduled for pump system insertion of intrathecal baclofen therapy under general anesthesia."7.83[Anesthetic Management of an Adrenoleukodystrophy Patient for Intrathecal Baclofen Therapy]. ( Arai, T; Hashimoto, Y; Ogata, T; Okuda, Y; Takahashi, K; Yamamoto, Y, 2016)
"The purpose of this study is to describe the efficacy and adverse events of neuraxial anesthesia for post-operative pain control in non-ambulatory children with cerebral palsy with pre-existing intrathecal baclofen (ITB) pumps undergoing hip reconstructive or palliative surgery."4.12Neuraxial anesthesia for post-operative pain control after hip surgery in children with cerebral palsy and pre-existing intrathecal baclofen pumps. ( Ball, MA; Davids, JR; Davidson, LT; Kephart, DT; Kulkarni, VA; Tumber, S, 2022)
"A 34-year-old man with adrenoleukodystrophy (ALD) was scheduled for pump system insertion of intrathecal baclofen therapy under general anesthesia."3.83[Anesthetic Management of an Adrenoleukodystrophy Patient for Intrathecal Baclofen Therapy]. ( Arai, T; Hashimoto, Y; Ogata, T; Okuda, Y; Takahashi, K; Yamamoto, Y, 2016)
"The hypertension and tachycardia after intraperitoneal administration of baclofen, 5 mg kg-1, to conscious rats was prevented by a midcollicular decerebration but not by a brain transection rostral to the hypothalamus."3.66A hypertensive response to baclofen in the nucleus tractus solitarii in rats. ( Persson, B, 1981)
"Male albino rats given a bilateral injection of Baclofen (Lioresal) (12 micrograms/rat) in the cerebral ventricles showed a behavioral syndrome of activation + ataxia, paddling, tail-pinch hyperresponse and anesthesia."3.66The role of monoamines for the central effects of Baclofen on behavior of rats. ( Smith, DF; Vestergaard, P, 1979)
"baclofen has a significant inhibitory effect on the micturition reflex, depressing detrusor contraction strength and micturition efficiency, while increasing bladder capacity."1.30Modulation of detrusor contraction strength and micturition characteristics by intrathecal baclofen in anesthetized rats. ( Constantinou, CE; Perkash, I; Watanabe, T, 1997)
"Muscimol was without effect in pylorus-ligated rats, whereas baclofen produced a significant decrease in acid secretion, which was fully prevented by phaclofen."1.28Central GABAA excitatory and GABAB inhibitory receptors regulate gastric acid secretion in rats. ( Bernardini, MC; Blandizzi, C; Del Tacca, M, 1990)
"Pretreatment with bicuculline, a GABAA-receptor antagonist, in the doses of 1 and 3 mg/kg, subcutaneously, had no influence on the gastric acid response to baclofen."1.28Effects of GABA antagonists and structural GABA analogues on baclofen stimulated gastric acid secretion in the rat. ( Goto, Y; Hara, N; Hara, Y, 1990)
"Baclofen i."1.26Central cardiovascular and biochemical effects of baclofen in the conscious rat. ( Henning, M; Persson, B, 1980)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19909 (34.62)18.7374
1990's12 (46.15)18.2507
2000's1 (3.85)29.6817
2010's3 (11.54)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Kulkarni, VA1
Kephart, DT1
Ball, MA1
Tumber, S1
Davidson, LT1
Davids, JR1
Chang, CH1
Grace, AA1
Hashimoto, Y1
Takahashi, K1
Yamamoto, Y1
Ogata, T1
Arai, T1
Okuda, Y1
Kowalczyk, T1
Konopacki, J1
Bocian, R1
Caban, B1
Soto, C1
Martín-Cora, F1
Leiras, R1
Velo, P1
Canedo, A1
Persson, B2
Henning, M1
Sawynok, J1
Labella, FS1
Bousquet, P1
Feldman, J1
Bloch, R1
Schwartz, J1
Menon, MK1
Clark, WG1
Vivonia, C1
Blandizzi, C2
Colucci, R1
Carignani, D1
Natale, G1
Lazzeri, G1
Crema, F1
Del Tacca, M2
Watanabe, T1
Perkash, I1
Constantinou, CE1
Saito, T1
Yamamoto, I1
Huang, XL1
Yukawa, N1
Osawa, M1
Takeichi, S1
Smith, DF1
Vestergaard, P1
Quevedo, J1
Eguibar, JR1
Jiménez, I1
Rudomin, P1
Morikawa, K1
Hashimoto, S1
Yamauchi, T1
Kato, H1
Ito, Y1
Gomi, Y1
Lin, WC1
Watanabe, K1
Yano, S1
Florentino, A1
Varga, K1
Kunos, G1
Bernardini, MC1
Kaneko, T1
Hicks, TP1
Hara, N2
Hara, Y2
Goto, Y2
Natsume, Y1
Kontani, H2
Nakagawa, M1
Sakai, T1
Kawabata, Y1
Koshiura, R1
Giuliani, S1
Capasso, M1
Maggi, CA1
Meli, A1

Other Studies

26 other studies available for baclofen and Anesthesia

ArticleYear
Neuraxial anesthesia for post-operative pain control after hip surgery in children with cerebral palsy and pre-existing intrathecal baclofen pumps.
    Journal of pediatric rehabilitation medicine, 2022, Volume: 15, Issue:1

    Topics: Anesthesia; Baclofen; Cerebral Palsy; Child; Humans; Infusion Pumps, Implantable; Muscle Relaxants,

2022
Inhibitory Modulation of Orbitofrontal Cortex on Medial Prefrontal Cortex-Amygdala Information Flow.
    Cerebral cortex (New York, N.Y. : 1991), 2018, 01-01, Volume: 28, Issue:1

    Topics: Amygdala; Anesthesia; Animals; Baclofen; Bicuculline; Electric Stimulation; Emotions; Excitatory Ami

2018
[Anesthetic Management of an Adrenoleukodystrophy Patient for Intrathecal Baclofen Therapy].
    Masui. The Japanese journal of anesthesiology, 2016, Volume: 65, Issue:4

    Topics: Adrenoleukodystrophy; Adult; Anesthesia; Baclofen; Humans; Injections, Spinal; Male

2016
Theta-related gating cells in hippocampal formation: in vivo and in vitro study.
    Hippocampus, 2013, Volume: 23, Issue:1

    Topics: Anesthesia; Animals; Baclofen; Bicuculline; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Carbac

2013
GABA(B) receptor-mediated modulation of cutaneous input at the cuneate nucleus in anesthetized cats.
    Neuroscience, 2006, Volume: 137, Issue:3

    Topics: Anesthesia; Animals; Baclofen; Bicuculline; Cats; Depression, Chemical; Electric Stimulation; Evoked

2006
Central cardiovascular and biochemical effects of baclofen in the conscious rat.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:6

    Topics: Anesthesia; Animals; Baclofen; Blood Pressure; Brain; Catecholamines; Dopamine; Heart Rate; Male; No

1980
A hypertensive response to baclofen in the nucleus tractus solitarii in rats.
    The Journal of pharmacy and pharmacology, 1981, Volume: 33, Issue:4

    Topics: Anesthesia; Animals; Baclofen; Blood Pressure; Glutamates; Heart Rate; Hypertension; Male; Medulla O

1981
Naloxone antagonizes inhibitory and unmasks excitatory effects of baclofen.
    The Journal of pharmacy and pharmacology, 1981, Volume: 33, Issue:9

    Topics: Anesthesia; Animals; Baclofen; Male; Mice; Mice, Inbred Strains; Motor Activity; Naloxone; Reflex; S

1981
The central hypotensive action of baclofen in the anaesthetized cat.
    European journal of pharmacology, 1981, Dec-03, Volume: 76, Issue:2-3

    Topics: Anesthesia; Animals; Baclofen; Blood Pressure; Brain; Cats; Female; Glutamates; Glutamic Acid; Heart

1981
Interaction between phencyclidine (PCP) and GABA-ergic drugs: clinical implications.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:1

    Topics: Aminooxyacetic Acid; Anesthesia; Animals; Baclofen; Dextroamphetamine; Diazepam; Drug Interactions;

1980
Role of peripheral GABAB receptors in the regulation of pepsinogen secretion in anaesthetized rats.
    European journal of pharmacology, 1995, Dec-27, Volume: 294, Issue:1

    Topics: Anesthesia; Animals; Baclofen; Capsaicin; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists;

1995
Potentiation by baclofen of gastric acid secretion stimulated by secretagogues in vagotomized rats under anesthesia.
    Research communications in molecular pathology and pharmacology, 1996, Volume: 91, Issue:2

    Topics: Anesthesia; Animals; Baclofen; Bethanechol Compounds; Body Temperature; Dose-Response Relationship,

1996
Modulation of detrusor contraction strength and micturition characteristics by intrathecal baclofen in anesthetized rats.
    The Journal of urology, 1997, Volume: 157, Issue:6

    Topics: Anesthesia; Animals; Baclofen; Dose-Response Relationship, Drug; Female; Injections, Spinal; Muscle

1997
Effects of muscle relaxants on EEG, ABR and EMG in rabbits.
    Human & experimental toxicology, 1999, Volume: 18, Issue:12

    Topics: Acoustic Stimulation; Anesthesia; Animals; Baclofen; Dose-Response Relationship, Drug; Electric Stim

1999
The role of monoamines for the central effects of Baclofen on behavior of rats.
    Journal of neural transmission, 1979, Volume: 46, Issue:3

    Topics: Anesthesia; Animals; Ataxia; Baclofen; Catecholamines; Clonidine; Dopamine; Injections, Intraventric

1979
Differential action of (-)-baclofen on the primary afferent depolarization produced by segmental and descending inputs.
    Experimental brain research, 1992, Volume: 91, Issue:1

    Topics: Anesthesia; Animals; Baclofen; Cats; Electric Stimulation; gamma-Aminobutyric Acid; Interneurons; Ne

1992
Inhibitory effect of inaperisone hydrochloride (inaperisone), a new centrally acting muscle relaxant, on the micturition reflex.
    European journal of pharmacology, 1992, Mar-31, Volume: 213, Issue:3

    Topics: Anesthesia; Animals; Atropine; Baclofen; Brain; Male; Mandelic Acids; Muscle Contraction; Muscle Rel

1992
Dual effects of baclofen on gastric acid secretion depending on the basal secretory activity in conscious and anesthetized rats.
    Research communications in chemical pathology and pharmacology, 1991, Volume: 72, Issue:3

    Topics: Anesthesia; Animals; Baclofen; Chloralose; Electric Stimulation; Gastric Acid; Male; Rats; Rats, Inb

1991
Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat.
    Brain research, 1990, Dec-10, Volume: 535, Issue:2

    Topics: Anesthesia; Animals; Baclofen; Blood Pressure; Dizocilpine Maleate; Dose-Response Relationship, Drug

1990
Central GABAA excitatory and GABAB inhibitory receptors regulate gastric acid secretion in rats.
    European journal of pharmacology, 1990, Feb-27, Volume: 177, Issue:3

    Topics: Anesthesia; Animals; Baclofen; Bicuculline; Central Nervous System; Dose-Response Relationship, Drug

1990
GABA(B)-related activity involved in synaptic processing of somatosensory information in S1 cortex of the anaesthetized cat.
    British journal of pharmacology, 1990, Volume: 100, Issue:4

    Topics: Anesthesia; Animals; Baclofen; Bicuculline; Cats; Electric Stimulation; Electrodes; Female; gamma-Am

1990
Effects of GABA antagonists and structural GABA analogues on baclofen stimulated gastric acid secretion in the rat.
    Japanese journal of pharmacology, 1990, Volume: 52, Issue:2

    Topics: Amino Acids; Anesthesia; Animals; Baclofen; Bethanechol Compounds; Bicuculline; GABA Antagonists; ga

1990
Direct evidence indicating that a GABA-mimetic stimulates acid secretion through central mechanisms.
    Japanese journal of pharmacology, 1990, Volume: 53, Issue:2

    Topics: Anesthesia; Animals; Baclofen; Brain; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gas

1990
Effects of central nervous system-acting drugs on urinary bladder contraction in unanesthetized rats.
    Japanese journal of pharmacology, 1989, Volume: 50, Issue:3

    Topics: Anesthesia; Animals; Baclofen; Behavior, Animal; Central Nervous System Agents; Diazepam; Male; Morp

1989
The effect of baclofen on the urinary bladder contraction accompanying micturition in anesthetized rats.
    Japanese journal of pharmacology, 1988, Volume: 46, Issue:1

    Topics: Aminooxyacetic Acid; Anesthesia; Animals; Baclofen; Diazepam; Electric Stimulation; Injections, Intr

1988
[Effect of gamma-aminobutyric acid on cardiac inotropism in the anesthetized guinea pig].
    Cardiologia (Rome, Italy), 1987, Volume: 32, Issue:9

    Topics: Adrenalectomy; Anesthesia; Animals; Baclofen; Barbital; Blood Pressure; GABA Antagonists; gamma-Amin

1987